Document VnZ7v8Jr9276QMLDX82kQ2yK

SUMMARY OF FILE COP PROPOSED PLANS FOR EPIDEMIOLOGIC. MEDICAL. AND TOXICOLOGIC STUDIES PRESENTED AT THE NIOSH/CDC BRIEFING FOR MANAGEMENT AND LABOR REPRESENTATIVES FROM THE VINYL CHLORIDE AMD POLY VINYL CHLORIDE MANUFACTURING INDUSTRIES . CLEVELAND, OHIO FEBRUARY 12, 1974 EPIDEMIOLOGY .* 1 2 It was agreed that: 1, There appears to be a major health problem in the production of PVC from the monomer vinyl chloride (VC); 2. In consideration of the potential scope and seriousness of this problem, NIOSH/CDC take the leadership in the govern^ ment to investigate the problem, assign it top priority, and immediately to provide or seek the necessary personnel and funds for implementation. This implementation shall include cooperation with interested groups in government, industry, labor, and elsewhere; 3. The Division of Field Studiea and Clinical Investigations (DFSCI) within NIOSH/CDC take the lead in undertaking such steps' * a- s- necmessar*y* t*o- - determine the f* ullvmex.t-eI'-Ln' t. _ of _ t'Vh- e -1 4. Consumer uses of FVC products. Oc)^:6/;0 -2- In the light of the unusual frequency of angiosarcoma of the liver In a single polymerization facility, first priority should be given to early ascertainment of the disease experience of the foregoing Group 2. The Immediate program should have the following elements: 1, UFSCI/NIOSH In cooperation with the Office of Occupational Health Surveillance ar.d Biometrics (OOBSB) would be In volved In: a. Assisting Tabershaw/Cooper Associates In any way possible to complete the mortality study of workers at the B. F. Goodrich PVC operations In Louisville. b, A governmentally-sponsored epidemiological study of the health hazards associated with the production of PVC. (1) - An attempt will be made to: (a) Document the incidence of angiosarcoma of the liver in workers in facilities other than the B. F. Goodrich plant in Louisville; (b) Document the incidence of 'malignant and non- malignant disease in PVC workers; 1 . t . - . * - ...... ,, (c) Define the real or potential hepatotoxins . among the materials used in the production ' *' : ;. , '' v Document the state of'environmental control f .-'"'in the VC/PVC operations, involvlngsampllng .y and analysis, vorkpractices, ventilation - %deeign, etCi 1 .. - . ?: *?&*,"*'<%>'y-*' (2) Five criteria are to be used (listed in descending order of priority) to determine which plants will be studied: - - "*... (e) PVC production history of 15 or more years; 62.1 B -33- (b) Size of work force; . (c) Polymerization involving vinyl chloride with and without vinylidene chloride; ** (d) Location in States where vital statistics information is readily available; and (e) In-plant medical program. Note: Already contact has been made with 18 of th 37 known PVC facilities. Using the above criteria, there is a clustering of plants in the tri-State area of Ohio, Kentucky and Pennsylvania. (3) Concurrently, rosters will be developed of both pres ently employed workers in VC/FVC operations as well as those employees who have moved within or out of the industry. e. . A determination' of the extent of use and distribution of PVC among users of the polymer to estimate the exposure to VC or PVC under such circumstances (Contract mechanism). 2. CDC will follow through with Its surveillance program in the development of a registry for the identification, review, and workup of cases certified as having angiosarcoma, other liver cancers, and other diseases that may appear to be pertinent on .death certificates. At the" start, this will entail tracing such ; cases frwa death certificates recorded for recent years at the i y Hatiohsl^inter fdrJBealth Statistics and in vital record de- . r^partsmts ^thin'inUVidual states. Sufficient d^tail will he :obtained for eacii^confirmed"case" to 'permit evaluation" of''case incidence with respect to. geographic distribution/ secular '/ \15!-; trends, and occupation. As the surveillance program develops, ; . additional sources of case ascertainment will he used including ^'contacts with tumor registries, jcancer treatment centers,' and ; ^ 7' industry groups. v<&v.r. - ``' 72^-. ': ' 7.,- .7'-7. 7 . ; :____7 3.' . NIOSH/CDC will cooperate with other Federal agencies, such ; as the Food and Drug Administration and the Consumer Product Safety Commission in obtaining information on the use (past and present) and distribution of VC/PVC in aerosol sprays and other household products. NIO!& will also work closely- . with the National Cancer Institute regarding the state of knowledge of hepatic cancer. t Note: All of the above activities are to proceed apace and concurrently. 62 -4- A major Immediate concern both for VC-related industries and for the government in its projected epidemiologic investigation of the angio sarcoma question will be screening of industrial populations for clinical evidence of disease potentially related to the VC* polymerization process. Such disease encompasses not only angio sarcoma of the liver, but also non-malignant hepatic conditions (cirrhosis), and perhaps other types of cancer and non-hepatic .disorders as well. To consider what medical screening procedures are appropriate in this setting, NIOSH/CDC plans in the near future to convene a panel of medical consultants specializing in liver disorders. This panel will review the clinical and pathologic material accumulated to date concerning VC related disease in this country and abroad, and will make specific recommendations to the government with respect to medical screening and followup of potentially at-risk industrial populations. TOXICOLOGY NIOSH/CDC will take the lead role in determining needs for experi mental animal toxicologic studies. Before developing the protocols, it will be necessary to evaluate the world literature on toxicology and to review the potocol and results of recent and current experi ments conducted in the U.S. and Italy. In developing research protocols, NIOSH will work with members of the HEW Committee to Coordinate Toxicology and Related Programs. Many factors and parameters will have to be considered in the development of the. .. experimental design of the study, including species differences , fate of the Inhaled or absorbed VC; dehalogenization of - if#--- VC,alkalating properties and mechanisms, gas-off products of Pye, toxicology of PVC dust, andeffectsof low-level exposures to VC NIOSH does not envision the experiments being done in-house, be rather in one of the other government facilities or by private IT; contractors., . -y 'f - ; itjgfl B Attenflees at NICSH/tDC brieflng on vinyl chloride, Cleveland; 2/12/74 t * From Industry V. M. Illff, Unlroyal Chemical Division* Painesville, Ohio B. B. Leach* Uniroyal Che-ical Division* Painesville* Ohio K* B* Katsenmeyer* B. F. Goodrich* Akron* Ohio Herman Waltemate* B. F. Goodrich Chemicals* Cleveland* Ohio 1, S. Mather* B. F. Goodrich Chemicals* Avon Lake* Ohio B. Cohen* Great American Chemical Corp., Fitchburg, Mass* John C* Floros* Great American Chemical Carp.* Fitchburg* Mass* O. Paul Cohen* Great American Chemical Corp** Fitchburg* Moss* Carl H. Dernehl* Union Carbide Corp.* Hew York City - - , - Laurence H. Ballou, Firestone Tire & Rubber Co** Akron*. Ohio George L. Wilson* Firestone Tire & Rubber Co.* Akron, Ohio . ' ..Firestone Tire h Rubber Co.* Potts George RoushJt.* Jfonshnto Company, St* Louis* Mo. 'Bour't,'.'Mb(Mmio Company* SpringsielAi;^liss* . , pW.L. Small* Monsanto Company, Texes City* Texes'' 'V-i__ _________ ^ ^Theode Torkelsbn, Dow Chemical Co.* Midland* Mich*.'' ' , C* A* Christian*'Dow Chemical Co.* Freeport* Texas - " * " Do A. Rausch* Dor Chemical Co*, Midland* Mich. ^ Charles B* KTamer* Dow Chemical Co** Midland, Mich* George Harris* Liberty Mutual Insurance Co** Cleveland* Ohio 9 - -v , 'i , 'tV JV n -2- From Industry (continued) ft W. E. Rinehart, Ethyl Corp.f New York City ft A.'B. tlndquist, Stauffer Chemical Company M. H. Johnson, M), B. F. Goodrich Co. V. R. Hiller, Goodyear Tire t Rubber Co. Herbert H. Krster, Hooker Chemical Co. F. R. Klebaeher, 01In Corp.-FTC ReaIns J. F . Gabbett, Conoco Chemicals Stanley J. Anton, Panaaote Co. Roy W. McCune, Pantaaote Co. of New York, Inc. J. R. Mudd, General Tire & Rubber Co. Henry Raempolueh, Pantabote Co. of Hew York Albert Rover, Diamond Shamrock Co. J. Robert Mehall, Diamond Shamrock Co. Richard Haler, Stauffer Chemical Co. ` ^ Vernon, Ai^Product^lf'....... : : ' 'VifAsmaK-SSwSSsaft.'-' -: ' 1 T- <\ ^ " yVci. , "'"*vS'^'V : J. C. Pal Insky, Universal PTC Resins Inc. James.?. Turner, Manufacturing Chemists Association R.-W. Hodrell, Goodyear Tire & Rubber Co. Clifford A. Johnson, M), Goodyear Tire k Rubber Co. Wayne T. Brooks, Organization Resources Counselors R. If. Wheeler Jr., Union Carbide Carp. . -3- i From Industry (continued) !--r"~ i Harry A. Lloyd, Georgia Pacific Carp., Plaquemine, La, R.'B. Howard, Shell Chemical Co. < Kenneth Q, Johnson, Manufacturing Chemists Association, Washington, D.C. J, H. Johnston, Imperial Oil Limited, Toronto, Ontario, Canada * L. F, Sargert, PPG Industries, Pittsburgh, Pa. V. A. Knapp, Allied Chemical Corp., Morristown, N. J. F. M. Toca, MS, Gulf Oil Corp., Pittsburgh, Pa. Zeb G. Bell Jr., PPG Industries, Pittsburgh, Pa. Lloyd M. Wdlker, Western Electric, Columbus, Chio H. V. Hendricks, Exxon Corp., Hew York City J. R. Livingston Jt., Exxon Chemical Co., Linden, N.J. From LabornUnlons George Perkel, Textile,Workers Onion of America- " ' ' ", ", ' Jeanne Stallman, Oil, Chemical and Atomic Workers - I : ., ' - VfA Steve Wodka, Oil, Chemical and Atomic Workers. , Tony Masxocchi, Oil, Chenical and AtomLc .Workers -` :g 5* '*''' I VsT'V-'k^ Louis S. Bellcxy^United Rubber Workers - `U L*L" LJ;- -.^v Warren J . Smith, Ohio tfLCIO & y^'-Vi^vV^ >:,y:'; ' i Salvatore J. Falletta, International Chemical Worker a Union Sheldon Samuels^ vIndustrial .U.n.ion Department, APL-CIO >* **jr*,; , . 3., ''I .* i' . t'm *- *55. ^ > L- From Colleges and Universities Henry A. Anderson, M>, Mt. Sinai School of tfedicine, New York (Irving J. Selikoff, M>, Mt. Sinai School of Medicine, New York RutfeWilik, MD, Mt* Sinai School of Medinlne, Hew York David A. Fraser* University of North Carolina Robert L. Harris* University of North Carolina Samuel S. Epstein* Case-Western Reserve Medical School Rudolph J. Jaeger, Harvard University School of Public Health From Government Robert L. Knarr* OSHA* Cleveland, Ohio John Fierro* Ohio Department of Industrial Relations Gray Holcomb, Ohio Department of Industrial Relations Gary Bryner* Ohio Superintendent for Safety & Hygiene Jon M* Cope* Ohio Department of Industrial Relations Warren Piver* National Insitutute for Environmental Health Sciences John Nussbaum, The Plain Dealer* Cleveland* Ohio Jane firodia* The New York Times, New York City : Tom Feare* Chemical and Engineering NewsWashington* D* C. Rick Snider* Occupational Hazards magazine* Cleveland* Ohio Hank Cox, Bureau of National Affairs, Washington, D* C* Arthur Zimmerman, McCray-Hill News Bureau Robert Warmstedt* Business Week