Document VjnQR9vkVEznL8Jz8q92mJN4o

FILE NAME: Oil Industry and American Petroleum Institute (API) DATE: 1949 Mar & Apr DOC#: API058 DOCUMENT DESCRIPTION: Meeting Minutes with Attachments MEETING OF THE TECHNICAL ADVISORS OF THE SUBCOMMITTEE ON CARCINOGENICITY MEDICAL ADVISORY COMMITTEE AMERICAN PETROLEUM INSTITUTE January 31 3949 N e w Y o r k , `N.Y.- A meeting of the Technical Advisors of the Subcommittee on .rcinogsnicity was h e l d in the A,P*I.. B o a r d Room, 30 R o c k e f e l l e r k C i t y , a t 1 0 : 0 0 A , M e , J a n u a r y 3 1 , 1 9 4 9 o R,, Co A . E- No A > > . ~ * -J Jo Ev tx . -*>* V/ Cele Deoley Go thard Hcag H e r tei; Mackenzie Ho Go 11* Fischer, H o P.. L a n k e I m a Wo A .. M y e r s f o r C u A, Svina F .. A Viav-'i t k , 3., W i l s o n fo M e river V/eody Ac ring Chairman Lv itera v;ere received tc attend: from the following regretting O *r* W, c. Ro s, Ho Ho Adams Beard f Jr Eons ih Suidsma their inability Review of Discussion 1 Purpose of Meeting T h e a c t i n g c h a i r m a n r e a d hi s letter of J a n u a r y 7, 1949, to Mr. D,, Y, Stroop {copy attached) outlining the purpose of the meeting to the effect that the technical advisors would redefine the objectives of the program to be co-ordinatsd by Dr, Horton and aid him with the selection of samples suitable for study by the Kettering Laboratory of Applied Physiology, University of Cincinnati, College of Medicine, under the direction of Dr, R, A, Kehoe, The group con curred in this* - - 2o O b j e c t i v e s There appear to be two main objectives, which were worded as follows: (a) It is tions thereof compounds properties and the type create them and, if so, desired to establish, in what are present that may possess of processes that may either under what conditions, crudes and frac carcinogenic concentrate or 911230 BintulM 01593 (b) E s t a b l i s h a n a l y t i c a l p r o c e d u r e s that will permit; distinguishing between fractions, according to biological testing, that possess carcinogenic properties and those that do n o t a It would be useful if an index could be devised whereby a refiner could meas ure the degree of carcinogenicity in fractions that are being handled in a refinery or in products that are delivered to the trade. Mr. M a c k e n z i e p r o p o s e d that p r i o r i t y be g i v e n Item (b) b e c a u s e a s u i t a b l e and r e l i a b l e a n a l y t i c a l p r o c e d u r e w o u l d cbviatcthe n e e d for b i o l o g i c a l t e s t i n g of a n u n n e c e s s a r i l y large number of samples The analytical procedure would screen the inactive or the least active from the most active materials for biological testing and would serve to avoid overtaxing the capacity of available facili ties. The group agreed to the objectives as outlined, and to Mr, Mackenzie*s proposal, 5: S e l e c t i o n of S a m p l e s for T e s t i n g (a) C r u d e s T h e t h o u g h t was e x p r e s s e d that the testing of various types of crudes from different sources {domestic and foreign vyould p r o d u c e i n f o r m a t i o n of v a l u e to the p r o d u c i n g a n d operating compa n i e s . H o w ever, it w a s thi of the group ing of crudes s h o u l d be d e f e r r e d until, the e x a m i n a t i o n of feed stool from various sources to a variety of conversion processes and the study of products resulting therefrom discloses specific proportion that, s h o u l d be t r a c e d to c r u d e source, i n w h i c h case selected crude; should receive closer scrutiny in the future, (b) P r o c e s s e s It appears that conversion processes, both thermal and catalytic, deserve prime attention. These were listed as follows: Thermal <=> Gas Oi l . Resids Reforming Coking Gas Reversion Steam Cracking In this connection, Br, Les Beard, in his letter of January 13 to Ho G. M. F i s cher, s u g g e s t e d that seri o u s c o n s i d e r a t i o n s h o u l d be g i v e n to "thermally cracked residuum from processes operating at high tem peratures a n d on aro m a t i c charge stock. If r e q u e s t e d to do so, I be lieve that it would be possible for us to supply you with a sample of vapor phase (DeFlorez) tar from an old DeFlorez unit operating on Mirando charge with a transfer line temperature of about 900," 911230 BinEulM 01594 4- 8iiapr.es T e s t e d d t das H e t s e r i n s Lacorator;- Dr. H e r t o n reviewed the results of the studies by the Kettering Laboratory of A p p lied Physiology. College of Medicine, uni= varsity of Cincinnati, on eight samples which had been selected some time ago by the Subcommittee on Carcinogenicity. The results were r e p o r t e d i n d e t a i l u n d e r date of N o v e m b e r 5 f 1943, b y Dr. F, F- Keyroth.O n l y one sample, O i l No, W -3535 (a c l a r i f i e d o i l f r o m ''catalytic c r a c k ing) d i s c l o s e d a h i g h order of carcinogenic activity Another oil. W-35 3 1 , {a r e s i d u a l f r o m U.TI0X*ZuCL1 cracking) p r o d u c e d only ens tuner of a low g r a d e of c a l i g n a n c y e a third oil, No, 11930, (a l o w - t o i l i n g d i s tillate f r o m c a t a l y t i c cracking) p r o d u c e d c h a n g e s in the s k i n cf two animals which gave a moderate evidence of malignancy.- In this con nection, Dr. E o r t o n s t r e s s e d the need for s u b j e c t i n g as m a n y animals a3 possible to a pathological er.aminaticn in order to avoid errors that f r e q u e n t l y a r i s e f r o m gross o b s e r vation, Ke cited a n example- w h e r e lesions t hat h a d b e e n r e p o r t e d as tumors b y visual inspection. (Oil No. 3551': w e r e f o u n d to be r e v m a l i c runt w h e n areas cf the shir. were examined microc ecuiealiywas found that was not detects: anim als r e s u lts G r o s s e: 3a n cle s The g r o u p a g r e e d char the l a r g e s t p o s s i b l e nur.ho? of V*%.V1 -r*i^a4*reive o patSaclrgid* o x o m i n a t i o n i n order re make the vJ'jf-* '-*e> v,^ jlcgicni testing a:.: r:liao.'.h a n d v e e f u l as possible '2i o n a o r e a r s to be ut-jcua cc for ;udrdn:: the results cf Wii __zin h _ , ih . w -3 i f - ' J .:j .L . 2.^.1 ;:v * 1- , sa m t Iss s Vvii oe r.e^ . j i - . L ' . . . . . e l , u v' -- ,, . . i c . j . . . - . . . o ^ c ,.. c . i a : w -.0 .-3 . Mr. Warrick, who had been instrumental in obtaining thoes samples s t a t e d that s u c h inf'e r m a t i o n h a d net bee n r e q u e s t e d , as it uas doubted that it w o u l d have b e e n furnished; hov;ever, he ag r e e d to acquaint Dr, H o r t o n v/ith h i s c o n t a c t s in p r o c u r i n g these s a m p l e s a n d Dr. H e r e o n will attempt to obtain whatever information the respective companies m a y b e in a p o s i t i o n to disclose to h i m - products sources, gas tar, 5- Products from Other Industries In o r d e r to permit d r a w i n g s u i t a b l e comparisons be tv?sen. derived from petroleum end products from other related it is r e c o m m e n d e d that samples be o b t a i n e d of coal tar. water and shale oil (domestic and foreign' for study.~ - S F unds Available In view of the possibility that npproprlated funds m y not b e a d e q u a t e to f i n a n c e the work to be u n d e r t a k e n by the Kettering Laboratory when the full program goes into effect, the question was r a i s e d as to h o w m u c h m o n e y wa3 available. A c c o r d i n g to i n f o r m a t m n supplied by Mr. Strocp, the Kettering Laboratory received a grant of 911230 BinEulM 01596 V $25,000 in 1948 which appears to be sufficient to cover their operat ing expenses u n t i l J uly 1, 1949, A n a d d i tional $25,000 is on deposit w h i c h ca n t h e n be m a d e a v a i l a b l e if needed. In addition* Mr, Str o o p has included in his list of subscriptions a request for $25,000 to be r e a d y for D r K e h o e o n J a n u a r y 1, 1950, to cover the s i x m o n t h s 1 p e r i o d to J u l y 1, 1950. Dr* H o r t o n i n d i c a t e d that h e e x p e c t e d to h a v e l a b o r a t o r y f a c i l i t i e s a v a i l a b l e b y Jun e 1, 1949, an d that the biological laboratory will be in a position to handle about one hund red samples, with provisions for approximately 4,500 mice* mendations ratory may Horton may It 13 anticipated that in order to carry out the r e c o m arrived at by the technical advisors, the Kettering labo require the services of an additional pathologist, and D r 0 require the addition of another member to his staff, The m o o t i n g a d j o u r n e d at 12;45 PoI<L 2/8/49 Hoxy Dowling Acting Secretary 911230 BinEulM 01597 ( `c o p y ) STANDARD OIL DEVELOPMENT COMPANY Research and Development Department 15 Vest 51st Street New York 19, N.Y. January 7, 19^9 M r . D. V. Stroop American Petroleum Institute . 50 West 50th Street New York City Dear Mr. Stroop: You will recall that among the reconanendations adopted at the meeting of the API Medical Advisory Committee Sub-Conmittee on Carcinogenicity on November 11, 19UQ, at Chicago, Item k (appearing in the minutes) reads as follows: "That the fundamental chemical and physical studies that are indicated to investigate the operational technical aspects of this problem may require considerably more money than anticipated! and it is recommended that the technical advisers group consider the problem again and present their recommendations to the Sub-committee on Carcinogenicity." In this connection, Dr. MeIver Woody, Chairman of the Sub-committee on Carcinogenicity, has written me as follows: "Now that Dr. A. Wesley Horton has been selected by Dr. Kehoe to investigate the chemical aspects of the problem, it will be greatly appreciated if you would call a meeting of the technical advisers to confer with Dr. Horton on methods of selecting samples for future testing, taking into account the nature of the crude, its source, the temperature conditions, etc." As I understand the situation, it is desired that the technical advisers redefine the objectives of the program to be coordinated by Dr. Horton and aid him with the selection of suitable samples for study by the Kettering Laboratory of Applied Physiology, University of Cincinnati, College of Medicine, under the direction of Dr. R. A. Kehoe. I shall be glad to conduct this meeting in response to Dr. Woody's invitation and would suggest the date of January 31# 19^9# In the API Board Room on the 20th floor at 50 West 50th Street, New York City, at 10:00 A.M. Since the group will wish to arrive at definite conclusions and recommendations, it Is hoped that the technical advisers will find J.t convenient to attend this meeting in person. If you are in agreement with this method of putting into effect the recommendation adopted by the Medical Advisory Committee, I shall appreciate your extending an invitation to Dr. Horton and the associate members of the Medical Advisory Committee to attend this meeting and to others who you feel would be interested in participating in the discussion. . Please advise. HGMF:HC CC: Dr. Mcl.Woody Dr. J.P.Holt Very truly yours, /s/ H. G. M. Fischer H. G. M. FISCHER 01598 n _r'. iti MIHUTES SUBCOMMITTEE OH CARCIHOQBNICITT March 11. 1949 \(ju! CONFIDENTIAL A neeting of the Subcommittee on Carcinogenicity was convened at 10 A.M., Friday, March 11th, 19*9, at 15 Vest 51st Street, Hew York City. MEMBERS FSESEHTt A.E. Hoag J.P. Holt VJGt. Levis M.H. Hewquist Mclver Voody QUESTS: . H.S. Bonsib A.E. Dooley H.Q.M. Tischer H.P. Lankelma K.Q. MacKenzis A.V. Horton J.J. Phair D.V. Stroop University of Cincinnati University of Cincinnati American Petroleum Institute TOTAL IH ATTEHDASCE - 13 MEMBERS ABSEHT* L.E. Curtis T.M. Prank T.J. Kelly C .A* Swan L.C. Beard A,J, K eewiag, nJr t H.H. Zuldema Dr. J.J. Phair, Professor of Preventive Medicine, University of Cincinnati, was introduced. Minutes of the meeting of February 1st were approved. Dr. Horton reported that his laboratory equipment is being assembled and his new facilities will be available about May 1st. In the meantime, he lls visiting refineries and studying the various types of catalytic cracking units and their operation for the purpose of making the proper choice of samples. ~ He stated that Shell had offered to cooperate in a pilot-plant cpration to yield samples which could be used to determine effects of variables, sujch as natures of *' 911230 BtafeulM 01588 feed, temperature, rate o f through-put, etc. He thought this approach to the problem might yield valuable data and samples that could be studied concurrently with: (a) the search for an analytical tool, and (b) the animal testing of the list of materials recommended by the technical advisors to the Subcommittee In Its January 31st, 19^9 meeting. Dr. Bolt said that before deciding on the Inclusion of the pilot plant approach, the technical advisors should be consulted. Hr. Fischer felt that the pilot plant phase, while of scientific interest, might not answer the practical problems because of the great variations in feed stocks. He feared that it might bog down the animal testing program andi believed that it should receive a low priority until answers to the practical phases of the problem had been obtained. Mr. Bonsib agreed with Mr. Fischer's comments because of the maijiy variations in feed stocks. Dr. Horton replied that refinery samples would present these saijie variations and complications. It was his plan to get the pilot plant runs on three selected feeds containing; 0, 30 and 60 per cent aromatics respectively. Mr. lankelma, while agreeing with Mr. Fischer, believed that sooner or later this phase would have to be a part of the study. Mr. Mackenzie thou^it that the nature of the charge stock was of minor importance compared to operating conditions; and that one run on a paraffinic stock should settle the question of the effects of time and temperature. Mr. Fischer said that his company had tested samples from different feed stocks and had concluded that fluid-catalytic cracking operations prese:nted a carclnogeniclty problem. He recommended that the analytical study be diven priority.. Dr. Horton urged that Shell's offer be considered because of the; time required to prepare the samples. He pointed out that oil 3632.was being fractionated and that the fractions would be tested on animals, in attempt was being made to Isolate the carcinogens in hope of obtaining an analytical tool. It was the unanimous opinion of the Subcommittee that the analytical work on oil 3632 should go ahead. . Dr. Horton said that this analytical work may be long and complete; he thought that the other phases should not be delayed. ~ j Dr. Holt divided the problem into four aspects: ~ - 1. Doe8 a problem exist? That was the question two or thfee years ago. York to date Indicates that there Is a potential problem. -2- 911230 BinEulM 01589  Where does it exist; in what operations, oils, fractions, materials, etc. is there a hazard that requires protective measures? 3* Can these operations he changed to control the problem! U. Development of a technique to eliminate animal testing. If a study of the processes were added, there would not be sufficient facilities available. He recommended that a list be made of all samples tjo be studied and that the Subcommittee then schedule them for priority in testinjg. Kr. iischer said that such a list of samples had been approved at the last meeting of the technical advisors and that Dr. Horton was to collect the samples listed and report to the Subcommittee. The proposed schedule of testing them and the analytical work on oil 36J2 should be continued concurrently. His personal view was that samples obtained from a pilot plant run should be placed way down on the list. Dr. Horton estimated that when the new facilities are available! about June 1st, U ,500 mice could be handled which would mean that 150 to 200 samples could be undergoing tests at one time. Dr. Hoag said that the first oils to study were those to which c l osur e s are now occurring, in order to determine control measures. Dr. Hewquist was of the opinion that, while it was very important to test various oils in order to determine which ones present a hazard and call! for protective measures; nevertheless, the analytical work should be continuedj, Also, because of the limited number of samples that can be tested, the pilot plaqt studies should get under way. . Dr. Voody said that this question would be up for discussion again at the April meeting in Detroit and that, in the meantime, Dr. Horton would qiscuss it with Dr. Xehoe and Dr. Heyroth. Dr. Holt proposed that Dr. Horton prepare a summary showing the itotal number of samples that may be desirable to study at Cincinnati between July 19^9 and July 1951 and the order in which they should be studied. Dr. Horton agreed to submit such a list b y May 15th. Deporting on the national Cancer Conference recently held in Memphis, Dr. Hoag said that Dr. Holt and Mr. Tischer were to be congratulated on their handling of the subject. Dr. Hewquist added that the cancer question was ndw an open story. He also commended Dr. Holt for his presentation; no hysteria waq aroused and what was said was not embarrassing. __ Dr. Voody submitted a revision of our confidential memorandum of April 2nd, 19^8 proposed by Dr. Curtis. On page 3 the third sentence in the lest paragraph was changed to read as follows: 91123U BintulM 01590 "Experiments in the laboratory have shown that certain of tjie high-boiling materials from these newer processes cause thej de velopment of tomors and cancers on mice." and the foot-note was omitted. Dr. Phair said that he planned to get acquainted with the medical directors of the various companies to see what medical records are available and to determine whether epidemiological techniques could be applied to advantage. The long "incubation period" was one of the factors that complicated the problem. The adoption of control measures might be better than attempts to eliminate the hazard. In re sponse to a question from Dr. Hewquist, Dr. Phair said that a cancer registry for the petroleum industry was an inherent objective of the control program. He added that he h a d doubts as to the successful enforcement of laws requiring the reporting of cancer cases, as has been proposed by some investigators. The next meeting of the Subcommittee >will be held in Detroit Apr^Ll 1st, 19*+9. A.S Dooley Secretary Mclver Woody Chairman 911230 $iniulM 01591 22J hi i n riu u AMERICAN PETROLEUM INSTITUTE SUBCOMMITTEE ON CARCINOGENICITT SPRING MEETING Minutes of Meeting April 1, 191*9 Boole-Cadillac Hotel Detroit, Michigan MEM p>:k S pwagTENT -Marshall Clinton -1.E. Curtis 'T.M. Trank .. J.P. Holt *-T.J. Kelly t-'M.N. Newquist j- Mclver Woody 71SITORS -- 7.C. Baird t-T.T, Boys ^Kieffer Daria >- A.E. Hoag EJE. Linder ^E*P* Luongo R. Clinton Page B,B. Reere GUESTS S.J.M. Auld R.D. Bent J.W. Hammond R.A. Kehoe V.L. Simpson J.B. Stacker H.G.S. ran&aalte H.R. Warrick ADVISOR D.V. Stroop - API MEMBERS AnsncNT W.R. Leris . 0 C.A. Swan ASSOCIATES PRESENT -L.C. Beard, Jr. R.S. Bonslb ^A.E. Dooley i^-H.G.M. Tischer H.P. Lankelma ^ K.G. Mackenzie ^ H.H. Zuidema <- E.V. Adams ^ R.C, Cole - N .J . Gothard H.M. Landon -- -T.M. Watkina Institute of Petroleum, London . Atlantic Reflnlng Company, Philadelphia Humhle 011 Company, Houston Unirersity of Cincinnati Detroit Institute of Cancer Research Pure 011 Company, Chicago Shell 011 Company, Curaao, Neth. Antill. The Texas Company, New York TOTAL IN ATTENDANCE - 36 v 911230 BinfiulM 01584 Hew members of the Subcommittee and guests were introduced. Minutes of the three previous meetings, November 11th, 19^8, February 1st, 1949 and March 11th, 1949 were approved after a change was made on Page 3 Dine 9 of the March 11th, 1949 minutes by substituting the word "suggested" for "approved". Dr. Kehoe stated that of the $40,000. capital funds provided by the API, $30,478. had been applied to building costs and $8,264. had been put into special equipment, leaving a balance of $1 ,258. to provide additional equipment as needed. Of the API grant for current expenditure, there remained a balance of $22,598. as of December 31st, 1948, of which about $14,660. would.be used during the first six months of-this year, giving a balance of some $7,000. as of July 1st, 1949. Current expenses from July 1st, 1949 to June 30th, 1950 were estimated at $122,600, of which about 25$ would be covered by from payments from individual companies for testing their sajqples, leaving 6ome $90,000. to $100,000. to be provided by the PI. Thanks to the PI grant for capital expenditures, which came in the nick of tim facilities would be available by July 1st for a colony of 10,000 mice which would permit simultaneous studies on 175 to 200 samples. The FI would have first claim on these facilities; but after that, samples submitted by any individual company would be accepted for testing provided that they would not interfere with the PI schedule. In addition to Dr. Kehoe, Dr. Heyroth and Dr. Dutra, 11 other persons would be required. Of these, Dr. A. Vesley Horton wan already engaged in securing the necessary refinery and chemical data. Dr. J.J. Fhair would start work on the . epidemiological phases of the problem after July 1st. Other personnel would iirelude! a chemist to assist Dr. Horton; a record clerk to maintain complete records on all the mice; three technicians to do the actual application of samples to the mice; one technician to prepare tissue sections for the pathologist; and two animal caretakers. A principal investigator was yet to be selected. This investigator would have to be an excellent pathologist, as well as a good administrator because he would be responsible for: a. Supervising application of the samples to the mice. b. Establishing standard criteria for: 1. Determining existence of tumors. 2. Differentiating between tumors and dermatitis. 3* Establishing whether tumors are benign or malignant,. Dr. Newaulst asked about the method of selecting sanples for testing. Dr. Eehoe replied that this would be the duty of Dr. Horton, working with the Subcommittee and its technical advisors. ~ . Mr. Beard asked whether results of tests of samples submitted by indi vidual companies would be available to the FI. Dr. Eehoe said they would be available only with the consent of the particular company and then only on a confidential basis. Mr. Elscher thought the proposed program was well organised but wondered whether the personnel proposed by Dr. Kehoe would be sufficient to carry on all the necessary work. -2t. 911230 BinEulM 01585 Dr. Hewqulst thought experiments on primates should he started at an early date because of the time required to get results. Dr. Kehoe replied that investigators of carcinogenicity of petroleum and its products had two objectives: first, to find a tool for determining potencies; and second, to determine whether results of animal tests are applicable to man. The first phase -required a group of stable, non-variable animals, such as the highly inbred CoH mouse strain* This stability and lack of variability between the individual animals was not found in primates. As to the second phase, there was no definite evidence as yet that the results obtained in mice were applicable to man* It might be necessary to use other animals to establish the relationship. In that case, the laboratory had other animals available and, while it was not anticipated that monkeys would be used at first, this might be done later. Human experiments could not be set up until a good deal more information and knowledge was available, and even then only carried out under his personal responsibility. Dr. Slums on pointed out that since susceptibility varies between in dividuals and since humans are not homogeneous, any tests on humans would have to be done with statistically significant groups (many thousands) and that there fore, as far as establishing potencies is concerned, this approach would not be practical, furthermore, a carcinogen too low in amount to produce a local reaction, might be absorbed and produce a carcinoma elsewhere in the body. Col. S.J.M. Auld. Chairman of the Research Group of the Institute of Petroleum, London, described the carcinogenicity problem in England and asked for an exchange of information between the API and the Institute of Petroleum. Mule spinner's cancer was still a problem in England, 20 deaths having occurred in 19h?. After the earlier work in the nineteen twenties, there had been a lull but the subject was brought up again after the war, largely due to the action of the trade unions. The University of Birmingham had started research work and had found that extracts from so1vent refining operations produced skin conditions which were "core than a mere dermatitisN* More recently suspicion had been cast on some cutting oils and some motor oils from Scotland (not shale oils). The publicity attending the use of mineral oils as cooking oils during the war caused the Government to enter the picture with the result that the Medical Research Council (a government group) and the Institute of Petroleum (which succeeded the Petroleum Board) were now cooperating as a joint committee* Under the direction of Messrs. Squlers, Cook, Ferguson, Voodhouse, Irvine and Auld, a lon^-range research study has been started, beginning with an investigation of these three crudest Venezuelan crude - naphthenic type Middle East crude - Kuwait Mid-Continent crude (USA) - of importance in lubricants. A certain amount of support was given still to the unfortunate formula by Twort regarding refractivity; but later work indicated that the higier the aromaticity, the higher the carcinogenicity* The industry in England had made white oils available but there has been little demand for them as yet. There was no evidence that solvent refined oils are carcinogenic. Shale oils were going out of the picture* Some preliminary idea on potency of oils might possibly be had by determining their effects on plants. It appeared that the fractions which sire the most active plant poisons are those that seem to possess the highest carcino genic potency and that perhaps by fractionating the oils and testing these 911230 BintulM 01586 fractions on p l a n t s some i n d e x of c a r c i n ogenicity might "be develo p e d . Dr. Woody read a letter from the American Cancer Society requesting the API to report the amount of money it was spending on cancer research, so the Society could include It in their report of grants-in-aid for cancer research. Mr. Stroop was asked to obtain information on how this data would be used by the American Cancer Society. Action bv the Subcommittee - It was voted to recommend to the Medical Adiv8ory Committee that! 1 - Information on carcinogenicity be exchanged with the Institute of Petroleum. 2 - The budget for the year beginning July 1st, 19**9 for the program at Kettering laboratory be in creased to $100,000.00 A.E. Dooley Secretary Mclver Woody Chairman 911230 BinEulM 01587