Document Vjk4rmpE0kBKK3rDL874zRjq8

Attachment 2 AR 226-1772 CANCER PREVALENCE IN SUBJECTS EXPOSED TO ALKYLATED SUBSTANCES (PFAS) James Dahlgren MD', Ayman B forehir MD", Ray Warshaw?, Harpreet Takhar MPH? * 1. UCLA Schoolof Medicine. 2. Comprehensive Health Screening Services. 3. Dahlgren Medical Group Please address comespondence to: James Dahlgren, MD 2811 Wilshire Blvd. Santa Monica, CA 90403 Voice: 310-449-5525 ext. 226 FAX: 310-449-5526 dehleren@envirotoxicoloay com Key words: PFOA, PFOS, PFAS, C3, easier, prevalence, environmental, exposure, Auorochermicals Session: Perfluorinated substances i LE 1824 Perfluoronaiad sikune substances Perflucroociaronic cid (PFOA) (PEAS) are man-made chemicals and perfluoroociznozte sulfonate that include (POS). PFOA is also referred 0 43 5. osher fluorochemicals PFOA is a key ingredient agent in the production ofTeflon and is biopersstent and bioaccumulztes. There has been and documented chronic exposure fuorinaied conaminans. fo PFOAofthe residents ness a plan using CS and other eOxspeosseidm pwoapsu1l0atCioonmp(arerseidceanntcse)rtoditshtartiboufttihoen ainnddusctarnycecranpcreervarleeginscteryrdaascaifnr2omREsnO. pocecrufpoamtieodnaalqeuxepsoisieodnnpaotpeuloanti5o5n4arnedsifdeinntsallfiyovitnhgengeeanrearaPlFpOopAulfaactiilointy:(SCEaEnRc)e,r Wreegisy TdahteaSfEoEmRtdhaetCa8wabsecuuspeatdifoonrslcowmeprakreirssonwatso othbetagienneedravli potphuelaftrieoend,omof informasion set. The overall cancer prevalence rate is higher in the PFOA-exposed population when - scaonmdpaarrceizdattoiotnheogetnheeraglenpeorpaullaUtSio.n.poRpeusliadetnitoncsanscheorwpnreivnaTleanbclee rates after 1. The residents fom 28e 24-65 haveasignificantly higher `general population (data not shown). rateof prevalence cancer when compared to the Ou findings indicate that prevalence findings o the the exposed population (residents) PFOA exposed workers (Table 1), have similar cancer Prostate cancer in the workers was proportionately elevated among young age males. oThtee daieschlbeutfiionndionfgscaonfecleersvaitnetdheprreesviadleenntcsearndtswoofrakteyrpsiicsadlifcfaenrceentrstshaunchexzpseHcoteddg,kiOnf's, Leukemia, znd Meliple Myeloma. `Tehxipsosdeadapospuuglsaeisitosntsha(twaerxkperosanedtroesFiFdeOnAts)an2dndPmRaOyS bmeaaynailtmeprocratnacnterrdisiksufabcuttoirofnorinan excessofcancer cases. . LE 1825 g ETT LJe d Ln . 4. ld de os x Jes siz in elise Enns }|2[82H0TEeHasH geessHnegeary RARE oo