Document VORNdmLLYErVqz7pJgjD18OZ

COTTER-COTTER--CADMIUM POISONING 499 In this case, in addition to hepatic damage and damage to bone marrow, there was also evidence of renal damage: L,, -.ivcr 1* abnormal cholesterol ratio [ high serum globulin Kidneys j^igh serum nonprotein nitrogen ^albumin and casts in urine Bone marrow anemia high reticulocyte count basophilic stippling anisocytosis Table 7.--Laboratory Data at Onset of Poisoning Substance or Test Amount or Reaction Blood sugar ............................... Serum nonprotcin nitrogen............................................................................ Serum cholesterol .................... ........-............................................................... Free cholesterol ................................................................................................ Cholesterol esters .......................................................... Serum phosphorus ..i...................................................................................... Serum uric acid................................................................................................ 88 107 225 135 2.9 6.5 mg./lOO cc. 90 Serum alkaline phosp'hatase. 5.4 Bodansky units/100 cc. Serum total proteins. Serum albumin ___;. Serum globulin ........ Serum euglobulin ___ Serum pseudoglobulin 7.4 4.4 3.0 Gm./lOO cc. 0.2 2.8 Serum calcium .......... Serum sodium ........... Serum halogen .......... Serum carbon dioxide, 5.9 150 110.6 25 mEa./l. Blood lead .............................. ................................ ........................................ Urine lead .................,..........................:........................................................... 0.05 mg./lOO Gm. 0.08 mg./I. / Blood cadmium ................................................................... Urine cadmium ............................................................... Albumin and hyaline casts......................'........................ 0.28 mg./lOO Gm. 0.24 mg./l. 2+ Hematological Findings R. B. C. ........................................................................ Hgb.................................................................................. W. B. C.......... ........ ....................................................... Differential count Neutrophils ............................................................. Lymphocytes .......................................................... Monocytes ............................................................... Eosinophils ....................... ..................................... Reticulocytes .......................................................... 4,000,000 12 Gm. 6,000 65 32 1% 2 2.3 Marked anisocytosis and stippling ot R. B. C. Case 3.--J. R., a 31 year old white man, had worked as a color pulverizer for three years. When seen he was powerfully built, was in no apparent distress and had a pulse rate of 62 and normal respirations. He. complained that he had been working in an atmosphere laden with color dust, wearing only a cotton mask with a simple filter, and that he had been feeling tired and weak for some time. Bothjead and cadmium were found in his blood and urine at this time. The complete laboratory findings are presented in table 7. After he had been removed from further exposure for six months, he . felt perfectly well and had no further complaints. In this case the patient was exposed to both , lead and cadmium. Perhaps the nature of the clinical picture reflected this! It is interesting that within six months after exposure had ceased, the blood and the urine were negative for both metals; basophilic stippling had disappeared, and the urine contained no albumin or casts , (table 8).