Document VMw0a1DkORDYamQpbdep8dmK

MANUFACTURING CHEMISTS ASSOCIATION 1825 CONNECTICUT AVENUE, N.W., WASHINGTON, D.C. 20009 TELEPHONE (202) 328-4200 TELEX 89617 (MCA WSH) October 24, 1978 Vinyl Chloride Audi/t Task Group (ATG) Dr. Z. G. B^L7 Chairman Dr. JE---J^r^Senya Dr. G. K. Hatfield Dr. R. K. Hinderer Dr. C. D. Kary Dr. T. R. Torkelson PPG Industries, Inc. Ethyl Corporation Diamond Shamrock Corporation The BFGoodrich Company, Chemical Division Shell Chemical Company The Dow Chemical Company Members: The Chairman, Dr. Z. G. Bell has called a meeting of the ATG to convene at 10 a.m. on December 4, 1978 in Room 407, MCA Offices. An agenda for a series of meetings and/or work sessions, to be conducted from the morning of December 4th through December 7th, is attached. Because of the tasks which confront the ATG, the Chairman has requested that each member be notified of the following work sessions: 1 Monday, December 4, 1978 Tuesday, December 5, 1978 Wednesday, December 6, 1978 Thursday, December 7, 1978 10 a.m.-5 p.m.; 7 p.m.-10:30 p.m. 9 a.m.-5 p.m.; 7 p.m.-10 p.m. 9 a.m.-5 p.m.; 7 p.m.-10 p.m. 9 a.m.-5 p.m. Should you have questions regarding these meetings, please contact me at your earliest convenience. Sincerely, U36 JTS:ep Attachment tj. T. Seawell Project Manager Vinyl Chloride Research THE WRITERS DIRECT DIAL NUMBER IS (202) 328- 4258 I Manufacturing Chemists Association VINYL CHLORIDE AUDIT TASK GROUP December 4-7, 1978 MCA Offices, Room 407 10 a.m. Washington, D.C Proposed Agenda 1.0 Continuation and Completion of Review of and Critique on the Draft Report Prepared by Dr. W. M. Busey of Experimental Pathology Laboratories, Inc. 2.0 Development of Strategy on How the Audit Task Group (ATG) Should Proceed with Respect to the Continuation of Its Work: 2.1 Examples of Topics Requiring Resolution: 2.1.1 Should the first order of business be an audit of air concentrations in exposure chambers? if we proceed according to the Environmental Protection Agency's guidelines this will be the dominant factor in the validation of this study and the findings could largely govern the future course of action. 2.1.2 Are the data which could evolve from 2.1.1 to determine whether or not attempts are to be made to salvage certain critical phases of this overall study. 2.1.3 A complete or partial audit of entries on gross autopsy sheets and how these entries were subsequently followed up during histo pathologic work. 2.1.4 What will be the criteria which will govern future meetings of the full Task Group, e.g., the progress of special team assignments. EPL 01437 i .0 The Development of Assignments for Special ATG Teams, for example: 3.1 Investigations Which Might Prove Advisable and Necessary As A Result of Dr. Busey's Findings 3.2 Investigations Which Will Prove That the Over all Handling of Control Animals Did or Did Not Conform to the Protocol 3.3 A Full or Partial Audit of Air Concentrations in the Exposure Chambers 3.4 Investigations of the Possibility of Missexed Animals (Which Occurred During the Trichloro ethylene Study) 3.5 An Itemization of Those Areas Wherein Further Histopathologic Work Should Be Conducted 3.6 The Preparation of A Summation of Total Animal Accountability Which Will: 3.6.1 Serve to Guide Possible Audits of Various Phases of This Toxicological Investigation and Enable More Enlightened Courses of Action, and 3.6.2 Form An Integral Part of the Audit Report EPL 01438