Document VMGO49Bqe4y669vNyVEZONR8

July 28j 1967 Mr. Ton Soholdt . Kitkaaftr Mercury Corporation Plant Mo. 2 Cedarburg, Visoonsln - Doar Mr. Sohmldti x Dava Botnar hat atkad ma to forward toxloity information for our fluid* Pydraul 625. Zn appropriata animal toxloity studios, wa hava obtalnad tha following datai <W team, Tha Oral X&50 thU fluid waa plaoad at >4*3 grant par kilogrta with lowar and uppar limits of 3z*a to 36.5 grant par kliogras. Thit indloataa that tha ooapound it ralativtly hamittt froo a standpoint of oral lactation. Tha Minima bathal Bata in rabbits for this fluid wto 4.25 to 3.00 grant par kilocran. Tha aainala in this axparinant did not appaar ta davalop any paralytla syaptoaa. Thaaa data indloata oonaldarabla dlffaranoa batwaan tha rat and rabbit work alaa* Thaaa data indloata that thia fluid la only aiightly toxie from a standpoint of oral ingaatlan to rabbits. to MM&L Thia fluid waa alaa tasttd for akin and aya irritation. Thaaa taata indloata that thia fluid la a rathar aild akin irritant withha soar* af 0.3 oat of a poaalbla 8.0 and a slid aya irri tant With a soora of 10.0 out of a poaalbla lio.o. DSW 018671 STLCOPCB4005215 Hr* Tom Schmidt 2- July 28, 1967 Animals wsro exposed to saturstod atmosphere* of ths vapors at room temperature. Thors was no svldenoo of sedULoltp, but probably vary littlo vapor was oarrisd over into ths ohamber. Ths animals wsrs than exposed to a vapor inhalation of ths fume* volatilised by dropping liquid onto a surfaos hsatsd to 200f. Rats wort sxpossd for tight hours to a moderate concentration* This oaustd salivation and nasal disohargs. Thors wsrs no svidsnos of toxloity with ths exoeptlon of local ,, irritation. This was a rathsr largo vapor oonosntratlon inasmuch as ths oondsnsats eaassd ths fur of ths animals to bsooas dan*. Vs, than, sxpossd ths rata to suoh a hsavy oonosntration that thsy wsrs obsoursd in ths ohambsr. This oaussd nasal disohargs and redness of ths tyts and noss. Ms systsoio dasags occurred. Ths interpretation of ths abort data la that Pydraul 625* from ths aouts point of visa* doss not possess a groat amount of toxloity. MowavsT; from ths structure of tha satsrial and other data* ws would warn sgsiast repeated or ooatlnuouo skin oontsot as well as Inhalation of ths fumes at above room tempersture. Mr. Boomer commanted that one of your employees has developed s fora of deraatltle. Za ths animal experiments sumarired above and in tha manufaoturtng and use experience, there has been no Indication that fydreul 625 causes irritation, per so, nor sensitisation. The fluid dost have good solvent properties and oan lead to tha drying of tha skin and subsequent cracking if there la prolonged or repeated exposure, the fluid acts nxtoh like eemami paint removers or thinner* in this resoeot. Veil onommsnlln all of our builttins and on our label that gead biadllag praetioe Ineiudsa tha avoidance of prolonged and |apeatedotmtaot. Zf S eaa be of any further aaalstanoa* plaaaa let me know. tty truly yours* j RBClOjS X. Barnet Kelly* B.B. Modloel Director OSW 018672 'P.S. We woufi find out the nature of the alleged iWEWttttd ftatte8J&RinMR*aB H^pMMMIlty ttat'Wkfcnntt WfcteurWe are to the Pydraule containing Aroclor causing chloracne. Can you check with Schmidt without alarming him as to the reason for our Interest? STLCOPCB4005216