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INTERNAL CORRESPONDENCE 'l-3CO from R, D. Panson at Harmarville to Dr. H. N. MacFarland at Harmarville subject TOXLINE SEARCH - TERATOGENIC EFFECTS OF BENZENE, TETRAETHYL LEAD, VINYL CHLORIDEHYDROGEN FLUORIDE. date November 11 1976 reference 5.2.0 ,6 0.0 4.9.5-5 A Toxline search on the subject inquiry found references indicating that: 1. Benzene and vinyl chloride are teratogens. 2. Hydrofluoric acid and tetraethyl lead are not teratogens. Seventeen pertinent references were retrieved ON-LINE; a larger number were retrieved OFF-LINE and will, arrive on Friday from the National Library of Medicine. Nine of the seventeen references, although they referred to teratogenic studies on animals or epidemiological studies, didn't give the results of the studies. The Toxicology Department has ordered these nine publications in addition to some others. Words searched in this study were: ALL TERATO:, PREGNANCY, PREGNANCIES. is recommended that the parameters of the search be expanded to include __ REPRODUCTION, REPRODUCTIVE, FETUS, FETAL, EMBRYO, EMBRYONIC AND EFFECTS* It Attached is Table I summarizing the results of the Toxline Search along Attachments CUSAROSS 02610 Table 1 / /^/c/'?L TERATOGENIC EFFECTS OF BENZENE, TETRAETHYL LEAD, VINYL CHLORIDE, HYDROGEN FLUORIDE Toxline Literature Search, 11/3/76, 11/10/76 Name of Chemical Benzene i Hydrogen Fluoride (Hydrofluoric Acid) Polyvinyl Chloride Plastic Tetraethyl Lead Vinyl Chloride Teratogenic Effects * * * Yes + Yes Yes No * No Yes * * * * * Yes Animal Rat Mouse Rat Animals Rat Animals Rat Russian Japanese Russian Russian Russian Russian Russian - Mouse Rat Human (epidemiology) Human Human, Human Human Human Rat Mice Hamsters Russian (Maltoni *Toxline reference indicates either tetratogenesis study was conducted or other data is available (i.e. epidemiological). Reference abstract makes no mention of results. Original publications have been ordered. +Study deals more with reproductive function. Original publication will be ordered. CUSAROSS 02611