Document VKO3KzE7KQmke3x27mdXpqe78

Industrial Hygiene Digest - 12 August, lQliO 951 The Physlologteal Response of Animals to Respiratory Exposure to the Vapora of Dlls opr Gpylamlne. J.F.Treon, H. Sigmon, K.V.Kltzalller, and F.r. Leyroui. J. irJ. Byg. A Tox. ^1, 112-3Y5 (May, 19**9). Deaths occurred among animals exposed for seven hows per day on one or nore successive days to air hearing the vapor of diIsopropylamlhe. The lowest lethal concentrations were l.Oo ng. per liter for the rabhlt and guinea pig, 212 Eg. per liter for the rat and 8.95 Bg. per liter far the cst. In the last Instance, the period cf exposure was less than three hours. The effects of exposures to concentrations lover than 1.06 ng, per liter were not Investigated. The vapor caused severe pulmonary irri tation, with extensive Injury to the epithelium and mucoea of the upper .respiratory passages and hranchl of all species of animals. Hydropic -------degeneration end cloudy swelling of the corneal epithelium occurred when animals were exposed "to-e-rtS mg.-or. more per liter. -- Authors1 Summary 952 Inability of 2-3 Dlthlopropeaal (BAD) to Protect the Liver Against Toxic Action Of Uranium nitrate. W. de B. Mac Wider. Proc. Soc. Exp. Biol. 66. lid "(19W. ' ~~ The author has shown that doses of BAL (10^,benzyl benzoate ' 20^, In peanut oil) equivalent to 15 mg. per kilo, when administered subcutaneously far eight days to dogs, were Ineffective against, the hepatotoxlc action of b mg. per kilo of uranium nitrate. Rather, It tended to Increase the toxic effects. The livers showed diffuse necrosla with advanced fatty degeneration. -- Brit. J. Ind. Med. 953 Observations on the Percutaneous Absorption of Tozaphena In the Rsbblt and the Dog, II B.W. Lackey. J. Ini. Hyg. A Tox. >1, 155-137 (May 1949). Evidence Is presented that eublethal amounts of Toxapbene are absorb ed through the skin of both the dog sad the rabbit when the poison la applied as s dust. Rabbits treated by Inunction with heavy dally dosage of Toxapbene dissolved In mineral oil or dimethyl phthalate succumbed In 2 to 5 days, whereas dogs under similar treatment for periods of 10 to 22 days appeared In goad condition. -- Author's Summary 9% Methionine In Selenium Poisoning. 1.0. Tela and V.H. Cheldelln. J. Blol. Chem. 17&. HI9-828 (Nov. 1918). Tests of the toxicity of eelenate show that it Inhibits the growth of yeast, and that methionine counteracts the toxic effect of eelenate. No other compound tested displayed this reversal. Only the naturally occurring laevo farm of the optical leoaera of methlcnlne was active. Earlier experiments with animals shoved that methionine, added as a supplement to a diet containing &t> of casein, protected young white rata against selenium Intoxication. Diets rich In casein also afforded pro tection. -- Condensed from Bull. Byg. :/ } Y . 71 * k\ V. \ \ ii*