Document VJnmd6zN5kkm00n5Z7DERzYp4
REGULATORY TOXICOLOGY AND PHARMACOLOGY 2 1 , 211-215 ( 1995)
1Talc: Consumer Uses and Health Perspectives
Bethesda, Maryland, January 3-February 1, 1994
Co-Sponsored by: The International Society of Regulatory Toxicology & Pharm acology
and The United States Food and Drug Administration
Rapporteur
C. Jelleff Carr Professor Emeritus, DepaUrtnmiveenrtsoitfyPohfaMrmaraycloalnodg,yBaanldtimExopree,riMmaenrytalalnTdh2e1ra20p1eutics, School of Medicine,
Received October 1, 1994 WGJJSWHCADGoCTEJCJCDDRACJPDKWMMKKKMAOOorAoHeHOOR.adahoaahaIaeauee.ktMiiSSiaLhhJTNoAURBccrbtnlvnrsynonrrDEEEDLnRnnnEhBOyhhhIGlErRnieilmiinLPPSI,nFasseIoaSiRiaaLLaneAaaCHEAHaTLDeeaBtenlBpiDvDTrOeensMtEDIOlEtm.LosooFAMaCAallEWLeiPzTdBa.hFT.BPBnLpaouFnkrg.T.HaEvFH.DCEDDChr.eAa.rSAraJlapEeFreF.KaB.EoehSBC.rrBoeeiUlmtozLJrnrdelDliALRUrHewlapiuF,i.nacrrESr,a,eaeasloUaaLaTrsipad.TLBarIioTetcDRy,,lmnp,SgIShocn,ehIlJCkurr,EUOwohda,a.U,SNaES-gh,stoecezW,,ooGesUTnl,RiN,E,vtnDS,.enos,lyiSHaPaSIltHwpUC,.LoGn.EihU,C,SIesecnn,Su.,stpfo,UEECaoT,siUdyesniimuloU.,k.Te,tFeze,UiRSlcEkHthio.,ws,eMJdeucFnornhSaovo..,Dmes.SiorAUdghmKifte.SoSekorte,UCet,Fvi.ahesamMrgyeJoedP..f,lbFhamePtlnSIyonisiFneordaiilnFrctreroRU&,ii.ioCni,aorssoiho,ttCcs,rcvoL&orodRekyoIFrsoCnieicnh.CeeoIdonUoasctcyiD,n,ldnetoioirlysa&l,edatDaf,emouv,gRaa&NcsnoerooflMa&&rn,elodK.iaruvI.&rrpindgrK,reSDternkfveE&uinDgyijmaco&aw&sJsslDCncaer&grW,Dhon&neirt.Aro.DarenuG&etlrCg,iDayuGRAasyrhDYrCintdTsguJ-el,DagSnsiiuoraPaeneduoaosmgrPtpoSorckmSAtg-mlyywsaArisrammuhtrac&noso,KAatink,hodpnblAgprohSnnmdMgnbNin,moTedaoA.ilnomoanocuS,simsdleegAlftNmemsfeneeosdniohoeilidotimPClntcsdgCsiwsdNgen,l,ioelners,Crinti,henoieormsinoaiwoovrdCMacWisoPnnNsr.TvJirIC.naeistlf,,a,,ntn.i,tootiiseioa,t,sueontroaslPosloCYcCgCtrllMrNiblurdamCortrroisPfon.eaCnsuokrsaoo,miaaihtrtCege,ePsniitnb,ac,rothiecalnltsinSwiluiryokuea,alcuOtinuncoveNdcnWacRioiomCrnmnilobistgctaonoehWintleohnueY,,cSlnatPialetbc,niCrnHisoeorae,,toocrInracstCi,ro,hat,ronnWwainohrheRaoshVcuP.KHtk,cF,NloW,Cah,iaPtdiuoiria,n.ri,oCnlaMiDerSyc,ueeWt,cWlotsangNlgaaOane,hnawkcAhN,COdsgtaislisavt,rteioNihhnuMtntNs,erenaohinshwoAniYii,lcfyrewsLlshioagnli,--na,,tiotoleweItinsatglaC,dnoNY,nrDolNa,aYntdnEickngoDJinoMensCIesto,.dp-ertn,nyow,tiCwroSkNanari,c,nDSkdnsarg,.K,,ekDY,eeYC,yl,GwiNmeyoalSWoCUDMamernkreiJnCmkoioksiwie,s,lrd,alccalrogNNhsmNosniYgiaeone,gayeoyrswawnNritBknn,herYYNwaCooneraJrwckrkehorJ,lsieenWryasaesyhing
and' PHreesaelnthtePde, risnppecatritv,east, tNheIHI,ntBeernthaetisodnaa, lMSDoc. iJeatnyuoafrRye3glu-FlaetobrryuaTroyxi1c,o1lo99g4y. and Pharmacology/U.S. FDA Workshop on Talc: Consumer Uses 211 All riCghotpsyorfigrhetp(rco>d1u9c9t5iobnyiAn0ca2an7dy3e-mf2oi3rcm0P0/rr9ee5sses$,rv6Ie.n0dc0..
212 C. JELLEFF CARR TJJJJSACJJJGSSBGFKMLCBPLTJGGFEREKMLNKMRBEINRRJJAADDDACRMRGDGDMMSWRBMOAOaOCHRooHAoeOAattRRILeROTlaoEr.I.dlO..oolrruAeeaaoheeoooAaeNCnaaSNCaHOiHlafAOaahhOyeiFRhOURUEOUIaaWrwBPWNokvrRnngtnabntrLnnnonlbwERHDrLfrKMrIRrNpnNNnOnnTPOMnnnOICiRMCnEhnihCrCDfeliaceaejBIaamreat.PyrIJISnAtvYnhknnEHTa.lLiKLdLfakEGRPOEiKarOacyusElHreOtAeMHllPelADCi.Wa.eHiRaLDGeerYBlLAPEnMtnTdECRrESyrrLddFGLRdGtrnRSTNSVSJC.SOi.mD.Ms.naMyHRleINSo.NcSeoriM..Id.n.APccacE.OMteoTLTeacJoPD..JOLoKyEJ.rChFWHWoLGtEMrpiepo.GASK.n.MRaehEG..MnBenT.mbW.iDuScs,..rrsMr.L'Aiek.aOarglaubR.MTPdwSa.iHWElpGrTw.eLe.mgVy..eeosLJgoioRoSMil.lL.MNrpHlneaiOneeSEHm.,odn,eVSLchrAntGkrMnfoM.lolCeHnHeleloEcaGcuiEHEetaCornOrHo.sN,KgTRsOSCashGooRaaIEEokDa,bEunLe,srnOen,TSNtmrdiRintCdHLedsrtRa,ie,soEEehaaFTTlavdRTbyUUlHgl,iMnablSEl,goo,erWereA,,XmsKNLcH,tdsNtDeHnrFr,a,eAJbnraSsleyoS&JaNe,TGShLasG,ntC.ahsrotr,Nui,,UeIrr,otRiyET,tEOaESmMH,lnreEee,L,etllretHMs,,zth,nHEtweCt,bdnRcezCoiB,ihnU.g.sRlRALo,shrLnyNFFrU.gAJ,il,sule,U.UateneeyReKrozNSslc.c,oeg,ltotUniTr,rF,a*NeoeFw,T,tuuav,U,,zr.no,eUnUim,,cn.,e.,,gabaJCSPCE.oo.JTn,ie,,PnesSMea,T.NBhhomzstnSPUSSa.eohnUommDTSIn.,M,l.bLo.SGt.oeoSCSssi,,nr.rhNUeoolrSo,etnn..Schcenoii,anEnobBV,utSs.oCUhahkh.tL,,rLntEonnoibgaeFene,.o,SUBrhJ.snidaedns.FtpcaRFCnYiMmPldrTeaSnUrncPoemahieceurgaFusTlaoTUo.oxnutyF&.ktPFuICrv&nptoy,.,iuuo,tGne,i.elUurrecscihnzrxoynSreeneaons,ghilPe.eeAeoFertooorUoonmcoPlooooSPedrevtloWlKoodcrceuNSF.lo&sidreGyhdg,nATrJieeotrSdmtodnDalecione,slC&.esUnld.hrsncna.rdbscats-iKiioosivaloFar,sde&,,o&mmStCrtlaer,redcecaccueCi,nlIrFo,&eir&hniceuEseoaocUmnowyh<ndsb&n.sotaOSsyiaJBlIRai&atuccoloIr&e,errutMfor6dtyCmliutpntGtlibnvncilnDcTooioteloFulgntCCRiaeltsrei&eeamsDvCDlolApcs&t&JeUlipeo.yytaSoocDsYrtd&mieghbrlaE&isufiorci,enkro&DaeD,daoa,lcCAoetettoo.grtrrmomuicfeUe&okumMeCnv,ynnorD&o,eroryliEevnnsaGl,nuJuPrhIiIr,nhrnanreI&dDooLWirsrngsunJErtsimftndeeenanCTnco,CboultggulovrvnivnovEikoirliBaminImolg,aoeaTslrGdDogecnrcclynitmuLVlogaDAgahceee,&hnaeoIJfiotsonmD,unriAvyeAknrtuha.ri,.Lhrno-fep,gthviincyDAraioliulrnRt,mile,,r,cdNopAergetaACilnclIgumeensdom,ooobdrsatTCiaUu,cpIOmcernDcauCnsnSrmsdBCoaolMAadrrt.,uTirMiedaeng.ilmdnsfmngmleN,sto,ooiosA,g,laitR.succueos.cgknmn.banrorngewoao,diryttmwsiaNNmSyir..Wto.iSEncABtgheyleoiueiNAfoiodnnyKe,latttrina',rtm.lnMCamn,iyl.nnIifneA,nsyhaaocs,deeiede,,signki,nor,amrmrWitCenntsdatMnee&NtoYN,ng,nBiiripsierolsnwMwtiiiiid,tLgfCHCatIuunIrtcesIsioaowmIsc,rgo.AozCnigtitUhisieioioidlEgnoeIs,nnlenm.fatnoetnrMnHmth,nloysJCslnoroanondeohernNa,inrJrrort.ledclowiswicarrcb,Ha.YtntccdCsioiso,rvnleanNBwn,snasnktac,aioareete.tdrr,bL,n.rm.DasCettei.oosyn,aoi.opNa,,h..ayloC,lsa,airapatrirtnunrCNsatoFlgPVe,Ri6stwRr,l.YnYsiooniirtaiArulllANSisnatuirdeoLtltMnnedo,noeYawttosieaPWrotniMsakiEeoLa,lotoi,loeNinoIgmaoCsoatnserrrswnntoaaaodlih,tontononncIeriicyrrtcrlaraeoYFagotsa.laMMaasnnnsJnnr,tsaceo,grtiiokkent,ncn,nkkokdPahnse2nnrtsiVniwnoaRo.ltrtthrewiowcs.trn,.rC,,iWnCvn.Y,k,aedirireitCRBat.nG.a,ysaaedro.nah.areSeOofi,coDiii,,eC,isaatNos,NhuNiPTRoOhksnslnoglcosoonJlaaLnsoi,oa2BhnMtunnrtalllftrsMk,nNclCWeaok.aerWoEnceoWrees.noeckefesdhnismioigl,Rk,anostiaCgoyotx,gkmrt,ntt,ceyrsewhG,nw,ecWira,,srRo,o.taaicdnoa,Pnaoavtmdys,kandnaelWNiatNM,wysCpnAonBoChasnMenciiseWhcslvsNuWWinide,eMtnltYhoOviYia,nsshkecihuteetsiygeooBalcaaoccsntaoMsRwlceaCieisfaYiviow.owioairsMhtlnhtslsaatcnrrg.Anndnonon,wooisneokiSsreeCrorahiseioDnyh,lrignces,agnogrc.sohk,IJnkslcllitMahlprrriyloeoYiydln,euaatCtsl,iChtnsetnkiaks.oIg,sMiCYrsoslkaco.loonwncdotinnba,viaBrgsIealinvtaGn,notDtr.oncnoginsrolMcsigauraii.tnrilaNdnunlelr.ldiukSco,oe.i,tgeCnytri'clrosdan,afkR,ronoueeamoeynnDgtlosehyDDrltiSoan,,OoEintwr,ri,.,i,aarluceCnCogC.nakyni,nSMdfnFMsDhrNsWgifnilndiyDokDeaiYglallat,cCAaedolaiatoalonCBmeCltwrarnfrWlsnrsdfyirmyndaakhd,olJla.dinaiaaoaernVsn,nknsrWShged,,s,NdLitreanoNRNme6ysgnoweheot,3cwowinUkDJnntvegJG,CYirtelDooslreernCs,kyeMy ary
TALC: CONSUMER USES AND HEALTH PERSPECTIVES
JARAEBRWENonreiFcivnNnnlFhelRasEaGirtElaWrl.dYmLdyWo.JYZZZ.WlyoaaWavluvyzkeiureeaNnan,idlD-rcUGFsOEik,akSRan,CNiK,iR,Uv,aAILRe,C.rmSuErtUaes.zTein.reTFStr-cnyi,.oecWaoAoCracfa.dnPoAMl&MlsaaHmmat.ciDeereeeWayr,tnriilluIcctaotnshsganlcv,ACdAF.e,,IcondonCtCr,muicporIon.ioa,nnldnlrncTeaiaA.bsg,htttulieirlAroorieaPannyteltn,,,aaiFocrNNDneknotaee,,a,rywwMkI,vWnsiGJ,acUYae.eMro,ersoyr,shBrlokeaCgirn,nyniootagNdaonteknonwlaney,cnYtD,iocNCurekt w
' York
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EXECUTIVE SUMMARY
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REFERENCE RoCtho.m, Bano,stKon. .J. (1986). Modern Epidemiology, p. 17. Little, Brown &