Document VJeMb3Ggb1ZJMjqxBeKmkMa2Z

c^ctcnti' ~L 'hQ'CiatJ 1474S.VANDEVESnSE-^v2_ - yr Tnrrv 1f\ twin. February 19, 1951 CERTIFICATE OF ANALYSIS susassr -- The ok l^atl Bose <rf 3^draul F-9 when fed orally to Mew ZeeLnf. trte ^atHWts. ZEsojeffiS Bo. K-SE TEST 50E - Jbnsjitg Y5*bEj=3l1 Caapas^ St. Louis, Missouri. EXPERT m*JKTT. 55CESIESS - The SEtTwhw ieiissQ. Bose 0S-ZL.D.) of Pydraul F-9 was found by the jr.L~ ttp of rrrafl single doses of the undiluted co^oasL jnxcto i*se stssacds of healthy nature New Zealand white rabfc.-*= a^y wsam of a -lu-Tiraei catheter. The aTfirli *~s- sbssrwi oscasionally for outward signs of toii;rf~* anri lasa reoeLufiz^ a lethal dose were autopsied and the fnienal organs mw" -pfl wacroscoplcally. xa BESUL2S -- The m=^= Zeal anr. per fcTl? 3eSaaL Dcse szf pydraul F-9, when fed orally to New te r-sT'. frfl tsj was oetveen 0,k$ and 0.67 *d111liters K of oody ^rr_. SCIENTIFIC ASSOCIATES Bit FRED M. YOUNGER -------------- CONSULTANTS TKD 2ZE 33 C DEE ibc used when requested by physicians and heal y -limn of advertising without written permission. i~. CEBtnEA l A N D P H A R M A C E U TI C A L I N D U S T R I E S STLCOPCB4Q91766 Monsanto Chemical Con entific Associates Cert THE MINIMUM LETHi ORALLY TO Animal Weigh mal Number Kg. HJSSION - *aul F-9 was relatively sic ) to 0,67 milliliters perss lals receiving a le thal doc rs but developed mild lethi e was some diarrhea at fee >gram of body weight. )it No, 9i which died on tr suit of lowered food consi and 12, also temporarily l oscopic examination of the lal dose showed a mottled_e srwise, there were no specs --x>uis, Mo, - Analysis (2-19-51) 2. .1 F *FIDRAUL F-9" WHEN FED AHD WHITE RABBITS Of sight 1- . :: Fate -- Length of Survival Died -- i*th Day Died -- 3rd Day Died -- 5th Day Died -- 3rd Day Died -- 3rd Day Died -- 5th Day . Died -- 4th Day Died -- 5th Day Died -- 8th Day, 15,0^ Weight Loss Survived -- 8*556 Weight Loss, later regained. Survived -- 6,0% Weight Loss, later regained. Survived -- 1.5% Weight Loss, later regained. on rabbits when the M.L.D, of Tjt x>f body weight is considered, cs ^snd acted normally for the first 1*8 ~ Hdss of appetite after this time, ; -- ;?rve~Ls above 2,1* milliliters per -- -iiay, suffered a 1$% weight loss as 37.. The survivors, Rabbits No. 10, Ight for the same reason. sy--*al organs of those animals fed a sc san -the livers in two rabbits. S-T'v n-rmalities noted. k '4iiJ' sf i STLCOPCB4091767