Document VJZv3rEL772LxGDLe6598JoNq
Monsanto
f'hOM (NAMt & LOCATION)
REFERENCE
TO
E. P. Wheeier - Medical Dept.
January 21, 1969
Aroclor(Wildlife) vs. Pesticides
W.' R. Richard WRICH
^
cc: S. TuKer - JFQ,
*S^..T&ergen HBERG"'- '
' R/E. Keller - JFQ
K. Johnson
, ip 'C. Pat on - CPATO
K. A. -Wells - KWELL
, jrT
R. E. Kelly - RKELL
Recently I.asked Jack Garrett to put on paper the formulae for common chlorinated hydrocarbon insecticides since many of us. have wondered whether or not any of them were likely candidates for metabolizing to PCBs. Jack's comments follow:
"As you know,.Mr. A. Richardson of Shell in Great Britain did some work on the extracts of marine bird eggs (using the specimen shag or phalacrocorax aristotelis). Mass spectroscopy of a fraction from a silica gel column showed the presence of a compound of molecular weight 426. Gasliquid chromatography-mass analysis indicated compounds of mass 324, 358, 392 and 426. These molecular weights correspond to 5* 6, 7 and 8 chlorinated biphenyl. The Swedish work indicated the same resu-lts-,--howev-er all workers suggested that the material found in non pre treated specimens was the higher chlorinated biphenyl.
There are a great many peaks that fall close to the socalled PCB peaks in the-GLC-EC readouts that are identified as chlorinated pesticides and/or their identified metabolites. I have listed below several pesticides and pesticide metabolitesalong with their structure and molecular weight:
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The molecular weights are only approximate based on C=12j .H=l, 0=16, CL=35-5*
We are not sure what happens to these pesticides--at least not all of them-- In the avarian metabolism. It is possible that some metabolites form in marine birds from chlorinated pesticiees that correspond to the peaks found by GLC-EC and also to the molecular weights. The more confusing aspect of this problem -is the chance that the ultimate problem is the result of the metabolism of marine food species (fish and other marine bird food organisms) possibly further metabolized by the bird itself."
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