Document VJ77DQBNNvJGYoOLNQLGn0vxw

FILE NAME: Oil Industry and American Petroleum Institute (API) DATE: 1950-1952 DOC#: API185 DOCUMENT DESCRIPTION: Minutes of the Medical Advisory Committee  ? p. i MifrUTES QF THE MDICAL ADVISORY committee ^ '`*\ `w. :y' 4 , . /'i API 06763  ? *3- jmeiffiim Company of America Share of Expense as Itemi 2ed Beceipts 1950 ............. $ 4,000.00 4,000.00 American Petroleum Institute Share of Expense as Itemized .......... .................... Funds Bec eived in 1949 for Use in 1950 .............. ...... E. I. duPont deNemours and Company Share of Expense as Itemized ........... .................. Receipts 1950 .... ................ ........................ 1,500.00 1,500.00 4,000.00 4,000.00 Pennsylvania Salt Manufacturing Company Share of Expense as Itemized .......... ................... Funds Received for 1948 Appropriation 2,000.00 Funds Received for 19^9 Appropriation 4,000.00 'XoS'o'.oo Receipts for 1950 .................. 4,000.00 4,000.00 4,000.00 Permanente Metale Corporation (Kaiser Aluminum and Chemical Corporation) Share of Expense as Itemized .............................. Receipts 1950 .............................................. 2,500.00 2,500.00 Reynolds Metals Company Share of Expense as Itemized .............. ............... Receipts 1950 .............................................. 4,000.00 4,000.00 Universal Oil Products Company Share of Expense as Itemized .............................. Balance due on 1950 Share of Expense 1,000.CO Total Sum Due .............................................. 1,000.00 1,000.00 API 05083 -k - the rate of induction of tumors in the test animals, then any tool based purely on the concentration of polycyclics will be seriously limited in general applicability. Epidemiological Studies. Efforts to expedite the collection of case records and other pertinent information on an industry-wide basis will be continued. At the present rate of reporting, there should be sufficient a c c u m ulation of information by the time of the spring m e e t i n g in 1952 to permit a preliminary tabulation of the data. m E. E x p e r i m e n t a l S t u d y of E f f i c a c y of V a r i o u s C l e a n s i n g A g e n t s and Skin Creams. As soon as the current tests w hich employ r i nsing with white oil and washing with detergent solution have been completed, n e w e x p e r i m e n t s will be s t a r t e d to compare h y d r o c a r b o n solvents, such as technical white oil, with the viscous m e d i c i n a l white oil currently employed as a rinsing material. Further tests with other on the basis of the results skin creams will be designed ,i \\ of the c u r r e n t t e sts v/ith Ver e x . F, D i l u t i o n of C a r c i n o g e n i c Oils. Sixteen of the participating companies have already started or completed collection of representative production blends containing carcinogenic streams from catalytic ' ^ cracking or recycle coking, together with data on the com position of these blends. The maj o r i t y of the members V February 1, 1952 Y-, G. '. Davidson, Vice-President, -Iqr.dard Oil Company of California, Bush Street, San Francisco 20, California. -r. H. W. Ferguson, Vice-President, tumble Oil & Refining Company, p7o. Bex 2180, l-custon 1, Texas. <r. J. ?. Langfiet, Vice-President, Pure Oil Company, East Wacker Drive, Chicago, Illinois. af r, |V `> i f -''1 L atd r- 1 1 M l litsjftj K *1 K r/ hf W y `rYCt nub gentlemen: Please refer to Mr. Gunn's letter of January 23 advising that Mr. Stewart had appointed you gentlemen, along with the under signed, as a committee to review the work of the Medical Advisory Committee, Department of Safety, and to report to the General Com-ittee at the San Francisco meeting in May. For your ready reference, I am attaching hereto a copy of Item XII of Minutes of Meeting of the General Committee, held on November 6, 1951 at the Conrad Hilton Hotel, Chicago. Since the meeting in Chicago, a Research Project MC-1 Advisory Committee has been appointed by Dr. Newquist (The Texas Company), Chairman of the Sub-Committee cn Carcinogenicity, by direction of the Medical Advisory Committee in their meeting on November 3 1951 in Chicago. The purpose of this committee is to afford a "closed bond of understanding between committee members and research workers." This committee met in Cincinnati on November 26, 1951, with Dr. Kehoe and his associates, and many of the problems cr objections (brought out previously by some Medical Advisory Committee members) to a trend by Kettering Laboratory to expand the scope of the project beyond its original outline were settled to the satisfaction of the Medical Advisory Committee. As a safeguard to keep the project at Kettering Laboratory running in a manner that would be satisfactory to the refiners, periodic meetings of the Re search Project MC-1 Advisory Committee are to be held, every two or three months, at Kettering Laboratory. The next meeting is scheduled *or February 26-27. The makeup of the Research Project MC-1 Advisory Committee is ss fellows: Medical Doctors: M. N. Newquist, Chairman Kieffer Davis (Phillips Petroleum Company) Richard Eckardt(Standard Oil Development Co.) T. M. Frank (Pan American Refining Corp.) C. R. Hine (Shell Oil Company) E. K. Linder (Atlantic Refining Company) API 05240  BgDG7 DATA FOR AMERICAN PETROLEUM INSTITUTE Tnvestlgation cf Cutaneous Carcinogenic Materials "he Kettering Laboratory tunated budget from July 1, 1952 to July 1, 1955 ^^ftnsatlon for Personnel Supervision i>5 oO.j j ( P Chemical technology Principal investigator Research chemists Total $ 8 ,000.00 I S ,5'ju 2 J , 5 0 '-' . 0 0 Biological Testing Gross pathology and records Microscopic pathology Technicians (animal tests) Post-mortem examinations Preparation of microscopic slides Total 2 ,000.00 2 ,200.0. 3 .700.00 1 .200.00 3 , 5 0 0 .oo 13,300.00 Epidemiology * Principal investigator Total 5 ,300.0.. 5,000.00 Other Personnel (indirect) Administration (General aministration, accounting, etc.) Other Secretarial and clerical Library Animal Care Glass-vare washing Draughting Janitor and sundry Total ^ 4,500.0. 13,900.00 Total Compensation for Personnel 20,550-00 54,350.00 Miscellaneous Expense Scientific supplies 7.000. 00 General supplies and replacements 5,520.00 Annuities and pensions Travel Animals and food 4,260 .Q'J 5.000. 00 4 ,c3j .00 Maintenance , heat, light, power , telephone service 5 .700.0. Stationery, postage, office supplies , and medical art 1 , 0 7 0 .JO API 05252 i -5 - As of October 1950i a grant of $10,000 per year was initiated the Procter and Gamble Company in partial support of the irritation ^ s e n s i t i z a t i o n studies. This endowment continues. Several months a*10 the Monsanto Chemical Company contributed $5,000 towards the gen- *g0- support of the project during the year 1951. Monsanto has efde an add'it'i'onal' cont`ri"buti`on of- -$-3-,0-0-0 for the year 1952. Addi- nal support is available under the terms of a contract with the a ited States Air Force for the work on percutaneous absorption of JJquid organic compounds. This will probably not exceed the sum of 000 in 1952. A further grant of $3,000 has been made for the -ear 1952 by the Abbott Laboratories. T Two other pharmaceutical compa res have expressed interest recently in the support of the program ** The fundsa made available a soa far P towards VAt.va 1^3a thins work .mmU have been _ __ _ _ .w.ii thou. 1 -t strings except in the case of the Air Force in which instance they are earmarked for work in the absorption section of the program. A tabulation below summarizes the situation with respect to funds now available for 1952 including that represented in the recent pecommendation of the A.P.I. Medical Advisory Committee. Sponsors Amounts Monsanto Chemical Company $ 3,000.00 Abbott Laboratories 3,000.00 U. S. Air Force (approximately) 10,000.00 Procter and Gamble Company 10,000.00 A. P. I. 5,000.00 Total $31,000.00 The total sura shown above is not sufficient to support the en tire program which we have in mind, and it allows nothing for future development, but it is hoped and believed that additional sums can be obtained. Meanwhile the work will be retarded somewhat to fit the funds available. API 05304 A merican P etroleum Institute 3 0 W EST so TM STREET NEW YORK 2 0 . N. Y. April 30, 1952 yj. T. J. Sullivan, Vice President Gulf Cil Corporation p.C. Bex 1166 Pittsburgh 30, Pennsylvania Epidemiological Survey Subcommittee on Carcino genicity Medical Advisory Conmittee __________ API_____________ Pear Mr. Sullivan: I am enclosing a progress report of the activities of the Subcommittees on Carcinogenicity of the Medical Advisory Committee, API. Inasmuch as Mr. G. A. Davidson plans to present the report to the General Comittee of the Division of Refining in your absence, I am taking the liberty of sending 65 mimeographed copies directly to Mr. Davidson. In connection with the study of the carcinogenicity of petroleum and petroleum products, our subcommittee considered originally that an epidemiological study should consist of two parts: (1 ) the study of the incidence of cancer among employees of the petroleum industry and, (2 ) the study of cases of cancer (mostly skin cancers) among employees of customers where the cancer was allegedly due to exposure to petroleum products. Item one is already underway. Item two is so Involved that we have done nothing about it. We have, of course, been alerted by recent verbal reports of alleged skin cancer cases occurring among customer employees but we believe this situation should have the careful consideration of the Divisions of API which would be concerned. Your advice in this connection would be greatly appreciated by our Subcommittee. A^ a/ 4 Very truly yours, /s/ M. N. Newquist M. N. NEWQUIST, Chairman Subcommittee on Carcinogenicity MSN :EMS C o p ies : Mr. G. A. Davidson - Standard Oil of California Mr. E. W. Ferguson - Humble Cil and Refining Company Mr. J. P. Largiitt - The Pure Oil Company Mr. W. T. Gunn - API Members and Associates, Medical Advisory Committee, API API 05309 -2- gOjsreheBsive program of research at Kettering Laboratory. This program aSitated a capital grant to Kettering Laboratory of $ k 0 ,0 0 0 for the uc _oDstruction of animal quarters. (See attached list of expenditures.) The ipanied research program got under way late in 19^9 . 0 2 CTIVZS - The research program includes the following primary objectives: 1. The determination of which refinery streams and products are carcinogenic and to identify if possible the causative agents in such streams and products. 2 . Development of reliable analytical techniques for quick and inexpensive determination of the carcinogenic potency of any stream or product. 3. Investigation of protective measures which might be applicable to man. k . Epidemiological studies to determine the incidence of cancer among employees of the petroleum industry as compared to the general population. m ascEss t o w a r d s a c c o m p l i s h i n g t h e o b j e c t i v e s l. Identification of carcinogenic streams or products and causative agents. To date 110 different petroleum fractions from representative processes !mve been tested on mice. Fractions of four different crudes are also being studied. Products of catalytic cracking and thermal cracking of catalytic gas oils have been sampled fairly completely. Vacuum distillates including lube stocks are also under study. A sufficient variety of samples is on hand to consummate this phase of the program. m in O It has been demonstrated that seme carcinogens exist in the M CL < original crude oils and that certain refinery processing cf oils concentrates *nd/cr synthesizes carcinogenic materials. High boiling gas oils from catalytic will require more time and effort than originally anticipated. Without lytical tool, any laboratory proof of carcinogenicity rests upon animal jC ' .,nC which is expensive and time-consuming (three to twelve months required ^ ?oCh test on mice). . 3. Preventive Measures - Animal experimentation and practical rience in industry where occupational cancer hazards have existed indicate z this hazard can be controlled by minimizing exposure and by adequate (i-'cal supervision which will include periodic physical examinations. C l Minimizing exposure entails: a. Identifying the sources of exposure. b. Informing the persons who may be exposed, of the hazard involved and of preventive measures. c. Providing of protective equipment or facilities where exposure is otherwise unavoidable. i. Good personal cleanliness. - Skin cancer if detected early is curable. An adequate medical program will insure early detection. ' k . Epidemiological Survey - It is not possible to transfer directly the data from the mouse testing experiments into figures representing relative carcinogenicity of the various fractions for man. From a scientific standpoint it would be desirable to test carcinogenic potency on several higher species of animals including man. However, such testing is not feasible at the present time. Interpretation of the significance of the experimental data, therefore, rust await procurement of data on fainwn cases from epidemiological surveys. An epidemiological survey will develop the facts concerning the incidence of m eacccr among petroleum workers and, if correlated with the occupational history, rH n in o should disclose whether any particular occupation in the petroleum industry is 0. associated with an occupational cancer hazard. In addition, it will detect any < w>ase in cancers which may he the result of failure of protective measures, jthout such information a problem of major magnitude could develop undetected ^ protection of the petroleum industry from unsubstantiated claims for .pensation for alleged occupational cancer would he almost impoasihle. This ^ 3e of the program must he continued for a number of years in order to he of This study is now underway and the annual cost is low. INCLUSION - Occupational cancers comprise a very small percentage of the total '.usher of cancers. Eowever, experience in the British coal tar industry where over 1,^00 cases of skin cancer were diagnosed in a 20-year period, and experience from contact with British shale oil where over 1,500 cases of skin cancer were diagnosed in a similar period, indicate that a cancer hazard may assume a serious magnitude in industry before control measures are instituted. B r i t i s h statistics are probably more accurate than those in the United States because reporting of cases to the Government is required and enforced. Medical literature and unpublished reports both in this country and abroad incriminate certain petroleum products which, having been demonstrated on animals to have a low degree of carcinogenicity, have caused human skin cancers after exposure of many years duration. The importance of such observations to the petroleum industry emphasizes the necessity of a continuing program to develop the facts as well as to promote any precautionary measures that may be indicated. In this connection certain petroleum companies in the United States have already Instituted precautionary measures within their own organizations. In Great Britain it is now mandatory that white lubricating oil be used in one phase H m iof) cf textile manufacturing. Cu It is planned that the research project (MC-1) at Kettering < laboratory will proceed along lines of the objectives set forth above. Such lUiuaj^ K # M. Mewquiat - 2 - August 7 1952 d* Research Gonmittse to publish if it thought desirable in the I.P. Journal a summary of the work done in Aaarica Such a step would prove most embarraeaing not only te Uttering Laboratory, but the whole American Petroleun Industry. I had thought that in transmitting our reports confidentially to gol* uld we had sufficiently safeguarded thi s natter. A pparently 9ur "British cousins" are unable to either understand or to t r a n s late the "Am e r i c a n language" into the "Sngl i s h language". I would strongly urge that you immediately communicate tfith Col. Auld, pointing cut that as yet the K e d i e a l Advisory C glttee has made no publication, and specifically ask that the work 1* me r i c a rem a i n confidential wi t h i n R e s e a r c h G r o u p Mo. 2. I would also suggest that your letter be also transdarte.d lato French, w h i c h I u n d e r s t a n d is pretty w e l l k n o w n by mos t Englishten. Very truly youra, linn a. t. is4iadan E. G. KACSIZg KOM-FKL cc: Nr. D. V. Stroep Or. I. K. Linder \ w U S u 'Th/ I y API 05379 - 6 - Dr. Beard suggested that it probably would be helpful if pr . ?hair could or would review critically the literature on cancer as related to petroleum with particular emphasis on keeping she members of the committee informed of any new articles which are appearing in the literature on this subject by circulating to the members of the committee a critical abstract of each of these articles. Dr. Phair folt that this could well be done by himself ar.d is presumably planning to undertake such a critical abstracting of current literature for the committee. ACTION While Dr. Phair is favorable to such an undertaking he hesitated to commit Kettering Laboratory in the absence of Dr. Kehce. Therefore, this matter awaits official clearance from Kettering Laboratory. ITDM 6 ' Dr. Beard told the group of the activities of the Sub Panel on Lubricants and Process Products Hygiene of the API Lubrication Committee. A small subcommittee has been formed to discuss the advisability of labelling petroleum products in order to warn customers of potential hazards. Solvents prepared from petroleum should probably bear labels which are in conformity with those recommeoded by the Manufacturing Chemists' Association. Other materials, such as lube and cutting oils, should probably bear a simple label which indicates that the oil may cause skin irritation, that it should be kept off cf the skin and that if it cannot be kept off of the skin, it should be washed off as soon after contact API 05388 falA'Mkc), practicable. Mr. 3 hings practicable W*2 their day washing Mackenzie emphasized the need of making such so that workers would not be spending half things cff of their hands. ACTION None taken (kotlfyw 'ftisVMn Dr. Landon reported that a verbal summary of the repo] 0f the RPA Committee was given to the General Committee, Division 3f Refining, in May of 1552. As a result, the General Committee, division of Refining, addressed a letter to the chairman of the jledlcal Advisory Committee asking that the Committee recommend ainimum standards for medical care, qualifications of medical directors and minimum standards for adequate medical records. This letter will presumably be presented to the Medical Advisory Committee at its next meeting. It was the feeling of the RPA Com mittee that the General Committee, Division of Refining, recognizes the importance of the carcinogenic problem to the petroleum industry and the general recommendations of Dr. Kehoe that the petroleum in dustry must develop the adequate medical and industrial hygiene measures to control this problem. However, the General Committee, Division of Refining, went further than the simple problem of carcinogenesis and included, presumably, all of the medical problems of the petroleum industry in their request. ACTION None taken ITEM 3a Dr. Phair indicated that he has now received about 900 historical records. Apparently he is receiving very few current API 05389 - 8- ^gc0rds and asked the cooperation of the Committee to stimulate the varioU3 medical directors to send in their current records of ,,ancer cases. He indicated that since April, only 35 or 36 records jjave been sent to him. He stated that up until the present time :v,ere has been no real call on his services in a consultation capacity. Discussion by the Committee indicated that Dr. Newquist would provide the stimulus to the various medical directors to send their current cancer cases, and that following the action of the Medical Advisory Committee, on the request of the General Committee, Division of Refining, much of the work cf Dr. Phair may 'oe implemented because some of the companies which do not new have adequate medical records may begin to develop them on the recommends" tion of the API as to what constitutes adequate medical service, adequate medical personnel and adequate medical records. ACTICN The Chairman of the Subcommittee on Carcinogenicity will aid the epidemiological studies by stimulating the various medical directors in the petroleum companies to submit the data re quested by Dr. Phair. ITEM 3b Dr. Newquist mentioned the need for epidemiological studies among the employes of customers of petroleum products since mest of the cases are apparently occurring among users rather than among manufacturers. He indicated, however, that the collection of such data would require great tact. Dr. Phair felt that the Univer sity of Cincinnati could probably make such studies at the proper time and in a proper manner. API 05390 ACTION It was the consenus of the RPA W tj-!)fi;'s fa - 9- Committee that the University of Cincinnati should undertake epidemiological studies among customers at an appropriate time. This matter is subject to further action by the Subcommittee on Carcinogenic ity. Under item 9 on the agenda Mr. Shepardson presented a table of data collected by the Standard Oil Development Company and New York University which indicated that there are at present 4 methods which will predict tumor potency within what it is believed to be a useful range of accuracy. These 4 methods involve: (1) ultraviolet absorption at 360^ ' of a 650*1000?. cut of the oil, (2 ) polarographic determinations which depend upon the diffusion current at two voltages, (3 ) the caffein number which depends upon the ultraviolet absorption at two wave lengths of caffein extract of the oil, and (4) the high aromatics characterization which is a more complicated method and was not discussed in detail. He in dicated that the Development Company is in the process of checking these four methods in three different laboratories in order to determine their reproducibility from laboratory to-laboratory. He urged that the University of Cincinnati give serious consideration to checking these methods also since they have been found to be so useful by the Development Company. He indicated willingness to provide to the University of Cincinnati the details of each of the methods as soon as it had been determined that they were reproducible from laboratory to laboratory. ACTION Dr. Horton has already been in communica \n tion with Mr. Shepardson on the above o subject and he will give it further study in connection with Kettering's effort to a. < develop an analytical tool. s. J. M. AULD 25 VICTORIA STREET LONDON S.7. 1 AIR VAIL 29 th August, 1952 Dr. V. N. New^ulst The Texas Company 135 E a s t 14.2nd Street New York 17, N. Y. Dear Dr. Newquist, I hasten on m y retu r n from h o l i d a y to reply to your letter of August 1 3 th and to reassure you In respect of the proposed report. There was no Intention to make and there definitely will he no statement made nor excerpt included, regarding any of the work which has been the subject of mutual exchange of information between the Research Group and the Kettering Laboratory. It was my intention merely to describe in general terms for the benefit of the sponsors, the organization of the correspond Ing American activities and refer to any already published work. You are aware there has been some of the latter and there will be more - generally In connection with the work at Hew York University as published in the Journal of Industrial and Engineering Chemistry. How that you have drawn m y attention to the matter, too, I will make a point of sending you a draft of any material which refers to American activities. I hope there will shortly be an opportunity of your coming to this country and meeting for diseuaslon some of the people who are specially concerned in this work. vk'hciAi ifdt/sik, With kind regards, Yours sincerely, (signed) 3JMAuld SJVAeGBM tfcix' c c : D r . 2. '. L i n d e r ' ) Mr. D. V. Stroop ) ft.om * * * - 9 - 5 - 5 2 KSM ' ) API 05400 FIGURE ^ - MALIGNANT TUM O RS AS REPORTED B Y SE X . AND PRIMARY S I T E 1 COMPARED WITH U.S.A. MORBIDITY AND MORTALITY ESTIMATES SEX Site MALES FEMALES BOTH SEXES Per Cent Number of Reported Total U.S.A.'"' U.S.A.'"""' Per Cent Per Cent Cancer Cancer Cases Deaths Number Reported Per Cent of Total U.S.A.* U.S.A ;;h:* Per Cent Per Cent Cancer Cancer Number Cases Deaths Reporte Per U.S.A Cent Pur Cunt of Cancer Total Deulliu Buccal Cavity Digestive Sys. & Peritoneum Respiratory System Breast Genital Organs Urinary System Skin and Soft Tissue Bones Brain Lymph. & Hema topoietic Sys. Other Sites TOTAL 73 8.9 10,0 272 33.0 36.0 118 Hi. 3 8.0 1 0.1 63 7.6 1 2 . 0 5.2 7.0 155 10.0 17.0 13 1.6 \ 10 29 ' 2 . 2 1 3.5 39 il.7 J 1 0 . 0 Q2lp 100.0 100.0 If .7 If7.7 15.If 0.2 13.0 6.6 2.2 1.3 2 .If ) ) 6.5 100.0 1 2.7 2.0 1.2 0 21.6 23.0 38.7 ! 2 5.If 2.0 3.9 N 13 35.1 19.1 If 1 0 . 8 / 51.0 23.5 1 2.7 3.0 3.If 6 16.2 11.0 1.5 1 2.7 1.1 1.5 \ 1 2.7 ; 8.0 ) 6.2 37 100.0 100,0 100.0 7if 200 120 Ilf 67 Iflf l6l 1 if 18 29 tfO 06l 8.6 32.5 2. if3.2 13.9 9.6 1.6 9.7 7.8 10.3 5.1 5.0 10.7 1.0 1.6 0.1 2.1 2 .Ai ---w* 3.If if.6 100.0 7 -If 100.0 Primary site of development of cancer among white males and females according to Dorn, Harold F.: Illness from cancer in the United Statos. Reprint No. 2537, Public Health Reports. (3 ased upon morbidity records collected from ton large cities in the United Statos between 1937 and 1939) ^ C a n c e r doaths by site in the United Statos for 19lf0 a3 prepared by the sfcntistical Research Section, American Cancer Socioty, utilizing statistics from the National Office API 05484 si- The attached agenda of the neeting, which had been distributed by Dr, Newquist prior to the meeting, was used as the program. ITEM 1 The report of the Subcommittee on Carcinogenicity to be presented to the Medical Advisory Committee on September 25 1952, was reviewed. This report, which had been sent to members of the ^Subcomr.ittee on September 11, 1952, had received approva' by the Subcommittee. The final tabulation of the voting on epidemiological studies of cancer among employes of customers was as follows: epi' t/ f L e * ? l) z-l2 .^ 1 Cciciferitfijg. Do you recommend that Kettering Laboratory, University of Cincinnati, make epidemiological studies of cancer Li'i among employes of customers? Yes 12 No 12 Not voting 1 If yes, what is your opinion on the following points? a. Random selection of plants for survey. Yes 3 No 6 Not voting 3 b. Limit surveys to plants where cancer cases are allegedly due to petroleum products. Yes 6 No 0 Not voting fe c. Maintain a cancer registry wherein only cancer cases proven to be due to exposure to petroleum products would be recorded. Yes 5 No 2 Not voting 5 DR. HORTON'S RSFCRT - Dr. Horton used as the basis for his discussion the memorandum from Kettering Laboratory, dated September 2ip, 1952, which had been distributed to members of the Medical Advisory API 05508 Medical Advisory Committee of the coding system which he is using or the case record cards, Dr. Me hoe and Dr. Phair reported that the Kettering Laboratory would be willing to undertake a critical review with abstracts of the literature on cancer as related to petroleum and that the annual cost of such bibliographic service would be 3i4.l4.30. The Chair'.an of the RPA Committee then further emphasized the necessity of medical directors of petroleum companies ^who have membership on the Medical Advisory Committee ji' submitting their cancer cases to Dr. Phair if his work is to have any significance. If they are unwilling to submit tneir records, then this should be brought out in the open and the epidemiological side of these studies dropped now rather than attempting to continue when the lack of sufficient cases doom the project to failure before it starts. ITZM 2a ' The inquiry from Mr. G.G. Rumberger, Marathon Corporation, dated August 26, 1952, to Mr. 2. 0. Mattocks concerning possible carcinogenicity of petroleum waxes and Mr. D. V. 3 troop's reply were presented for information with the verbal comment that contributors to the API Fundamental Research Project are not thereby entitled to reports on other API research projects. Copies of this correspondence were sent to members of the Medical Advisory Committee ITEM 2b Dr. Newquist's letter of August 13 1952, to Col.S.j. Auld concerning possible reporting in England of the research work at Kettering Laboratory was presented for information. A copy of this letter was sent to each member of the Medical Advisory Committee. API 05513 ? f\A i^ iodded tPi~ Q-ttip