Document VGxMO1OQa2xyevGMLXBd8OXQZ

Medical Department June 29, 1970 Toxicity Statement on PCS John Nason JNA30 V. B. Papageorge, WFAPA Bill tails me you want a brief statement on the toxicity of PCS'a to be Included in coaaaents made at a seminar to be held next month In Massachusetts. I suggest the following: "At the end of twelve months of two-year feeding studies In rats snd dogs* the three compounds undeiCnvestigstIon (biphenyl chlorinated to the extent of 42)1, 54Jt and 60Jf respectively) appeer to be aS about the same order of toxicity as EOT in rats and dogs. Dlls la reassuring in that DOT is probably the least toxic Insecticide to mammalian species. Further,there Is general agreement that DDF has not presented a hazard In animals or man In spite of its presence In the envlroraaent." Bill thought you might object to the comparison of DOF but it Is the material which is similar In the types of tests being done. X don't know off-hand of any Industrial chemicals that would be familiar to the majority of people that X expect would attend the seminar and would also produce effeots In emnlaala at the same levels In feedings. If you want the statement amplified to get Into the 'parts per million In the diet, ate.", X can do It but I think It depends on who la going to present the statement as to whether or not the details need to be Included. An after-thought--will whoever uses the information point out that the appropriate governmental agencp such as the 0. S. Food and Drug Administration,have been given Interim or progress reports on the studies referred to abovet KPWsJu Ulmer P. Wheeler "tms 099660