Document VGgoxm54xRNymJ6XpOpxozd6w

V i i t I i l .j i A-TT/amenr HT SYMPOSIUM ON CERTAIN CHLORINATED HYDROCARBONS Harvard Sciiooi. of ITiii.jc Hf.ai.tii, Boston, Mass. JUKR30, 15/37 ' Program I. Tl>o problem of possible systemic effects from cabin chlorinated hydro* carbons. CU'ir. K. Drinki:*, M.\m:i.rixK Wakrcx axo GitASvn.i i: A. Rcxxitt tMfottmnU of ftfittfoty, HotitoJ M:tlof 1'nltir IhoUb okJ ' f/HMrr lltJhll S<L*I, tl.-tt.-n, lion. of 2. Demonstration of laboratory methods for ventilatingoperation* employing chlorinated hydrocarbons. A discusssion of permissible concentrations of such compounds in the sir. , C. ). Vaoi.ou.M.M.E. . A ooitUnt ftoftnot tf loiotftUI lljfittit, UonttJ Moot of I'oKlt Iholtk . AKn .> .. , J'mtit* T>jt!.vKC, Ch.D. * ftofmot of lojuittiol HonorJ Sth&t of I'oKlt [IttUk 9. A description of the lesions found in th liver of animals subjected to Various chorinatcd hydrocarbons. ; C*axvilu:A. Ucxsktt, MJ). . Attothk fa toiloh-fy, ITonotA HtJUol ,, ' . 7,i r. < (The second and third papers will Appear elsewhere. Copies ` e( them will bo tent to sll who attended the tym|Niuro.) HONS 097400 V. ArfV.Jrf ATrflcn wwr 2T 30S JOUIIXAI. or INllUSTlUAL IlVCIl'-SK ANB TOXICOJ.OGY |.5e;/(. /Mr ttmt they developed ncnr mure often c.inl more severely a/tri they starts) compounds. Ji iri.iv be that it was in (lie * Method of the handling. Mu. r.){. K.umj.h: You cay that (be eonditicn Jnnvaxr.4 with (he Increased cl.lorino eontrnt and nr arc attributing (he neno pri* mnifly (o the chlorine radical. Jf Hint is (rue, wlul ere nr (v nnweiate irnefar as these various other constituents etc eon* earned, turli ns various |d;iclicir>mg, agents? Dow tiiucli do v.c know about those insofar as development of r.cnc Is concci m d? Bnmn of these compautui* have a half i!nrcn con* itUurnts In them other than chWnndiphrnyl and eMorenaphO.alene. \V r.re at tlto present time rniwidcring (ho ehloionaphthaltJio as the bade dement responsible for the acne rendition which we have. We know very tittle about what the other mate* elate may or may not do. Pr. JoiiR A. Hookey: 1 don't know about these other materials. Perhaps Dr. ftehwsrf* would know aomethiug more bout them. pit. Louie ScnwAtirt! It Is welt known In Industry that there are many compounds the! tauM sent. For Instance, paraffin aenee and oil muck hove been known for a kmg time. Paraffin aenea, wax ernes, are eftn}dy a mechanical plugging of the lot* llcles of the skin b> the minute pm tides of wax that fall on the skin. 1 think that (ho ^ aen eaured by there chlorinated nr.ph* thalenes and diphenyls. heeuc tt is caused try both--1 was down at the wnn Chemical Company where they make chlorinated dt* phcityla am) they have acne (here just the came as over at Wyandotte where (Jury inr.ko (he ehlorfrialcd naphthalenes*"! Mieve that tlmt Is enured by tlm a*mo (MnrM a blocking up of the follicles of (he shin, the formation of (lie eornerfone and (hen the * romcdtme (tecotnus Infected turd forms a pustule, They don't all pustulate t**** they don't all Ijucwmc infected. Many of these men never have any pustule*. TTwsy just have little white elevations on their skin. - In those people who ate In the acne age, (tie youngsters of it, SO, SS and 23, ac/io vulgarI* is most rpt to occur. Thu rW*aec* <nu glands me most ;.etk< and they wem to have it much more than the older people in whom (ho sebaceous gInndft are not a active. Wo beep a i Upping, o( alt articles relating to Indii&tml dermatitis in my office rml J recently ir-ul an r.nh-tc in r. German siue In which they report in Germany a simitar acne condition from chlorinated phenols nnd chlorinated iiniKiict and solid wrvts. It retina that ibis arno-iikc coiidi* lion is not peculiar to halowax or chimin* sled naphthalene* or diphenyls but can occur with any condition that blocks up the sebaceous follicles of tho akin. Dn. Horst* rvfur.'nKH (Special Agent, Slate of Connect icu Department of Jailer, Hartford, Court.): f cm full of questions. As r-statistician ) urn a little bit suspicious of averages, xo J should think that we should toke maxima s well as overages in getting At tho threshold tloso or the dangerous Im pregnation of tho atmosphere with these poisonous compounds. 1 just wanted to drop that ns a hint lor this committee to consider in Ms work. )n spite of what you told at luncheon, Dr. Drinker, J s'.ill think it is rather importnnt to determine how the plugging of the (Hires actually docs occur, whether they are plugged as Dr. Schwarts has suggested, /rom the particles falling on the outside of (bo skin or whether they mo plugged, an so many doctors have informed me, from inside s it were. The fumes oio breathed, tho substance gets into the bicod stream. It Is thrown off through the pores of the akin and the pores are plugged. ! think It i* rattier important to determine (hat Ik-crum M seems to me, from the flight knowledge that > 1 have of (he industrial application of halo* wax compounds in insulating, wires, that (he plunging of the skin, if it it just an out* side plugging, may take plncr either from handling a solid xnlwtimee or from the coating on the wire nfter It becomes mid. 1 haven't heard anybody say anything about those Maxvu buxrU* eases of very severe dermatitis and I am not so sure but what them wax some question of liver dam* ago there. Nobody bar raid anything about them at all. There is no question there MQNS 0974Q I t /iHb- LLL t+t, fp, uq. 7\ LFFIvCTS Or OIILOKINATUD JlYDltOC.M'.HONS 307 I i hand, (torn Dr. Hrmkci't work one would to Attempt to pel tl.fr confentmtiom low. 1 judge Hint the straight clilcinaph Wc raw this morning that the effect of these I thalene wav nearly as Ionic at least as (bo products waa on the liver and tht if tome mixture of l( with n email amount of elilo- one working in there products developed r/nated di|ili>'iiyl. liver dnimiije from cornu other source the Jw the ri'iaknicr faetoiy where we had ehancca of hi* having rerimis (rouble was OUr me* there is no chlorinated diphenyl inerciucd. Tlttiifmc, inasmuch as there is used and i>n nimt of tin) type described in no tost to (oil nhclhcr n person has had liver the repot la on the insulated wire factories. diatc, certainly in (bo preliminary mvdicul examination of npplu.-mls for work tho his aV ))n. It. Kmmi.vt Ki:m.y (Monsanto CJkim- tory si least should he pone into very care IceJ Co., Bt. l/ufa, Mo.): ) can't contribute fully for a history c>l picviou* liver disease*. Anything to the lahoi story stud le* hut there There are oilier tbJnpj that rhoulJ bn hoe been quite a little human expeiimcnla- taken into cousddfraifon nlto. One f the tloii in the Inst several years, r<peci.il)y nt history of nyphili*, beenuve syphilis does our jdaot* where ne have been manufaclur- have an effect on the liver. If there fa any Inc this chlorinated diphenyl. It lias been history of syphilis I don't think (hat that our observation that itlthouph on one ocea* man should le hired. A Kahn test should slon we did have a more or less extensive be taken and I think (hat il would l*c n good series of skin eruptions v. hh h we wcie never plan to lake Kahn tents on men el slated Able to attribute as tocaure, whether it mam intervals, because they might develop Impurity in the benren* v;e were using or to syphilis after they are hired. the chlorinated diphenyl, we I svn never had I think those things should be done even . Any systemic react Iom at nil in our men. though wc feel (hut if the roncentratirHi of b*" \Vo have examined them very closely both them vapors in the nit fs kvpt a* low ns wee from what laboratory teds we thought recommended this morning, tho chances of might help us and from the clinical view having toxic effect* are very small. point. Alsu from chlorinated diphenyl Ion? there have been no ease* of systemic Mn. K. 11. Kaimtk: f would like to clarity imisoniof, reported. a point of Dr. Hookey'*. ) don't hollow that we can tiansposo the You mentioned nt the beginning of your laboratory results into the actual humans talk that your cNp.-rleneo in acne condition without (raying ronsidomhlo sllontion to was more pronounced from the compound* tho volatility ct diftc'renl suhstanrvs and the of various material# with chlorojmphthalcne way they e.re being used. than with the etraight chlorunaphthqlctiea. Did you mean by that, that the acno condi Dn. don.v A. lieoxsr (Consulting Der tion actually wus more pronounced with the matologist, llalowex Corpomtion, Detroit, compounds than with the Mrafghl eldoro- Mich.): I have had eoniiderahle cx|rcricore naphthalene or was that due to the fart that with the dermatological angle of this prob you were In a plant operated in a different lem. The experience at (he llalowex plant fashion? In other words, you hatnllrd your . at WyandotIc definitely was that the derma- numerous wire compounds in more 6( a toeie did Increase when compounds were batch operation. That is my understand used rather than the straight chlorinated ing from .Mr. Hrown. naphthalene*. )a ft a fact Unit the straight chloronnpb- hew the dtauadou we have heard today thelcnc* are less Jiunnful in ro far as arne I think the observation J>r. Drinker made le concerned or ie It because of tho handling that the ehancca are that dermatological of hatch compounds? problems wilt disappear alaoR with the oilier la probably tine. However, J think that Du. John A. HooKur: That fa a question certain precautions, eartniu hitiuranee mens- that would he difficult to nnsw'cr. t based _ urea, you might ray, should he taken in my statement on the fact t)mt in taking a hiring men who ate going to work with general survey of theta cases after I started three products, even though we me going working with them (ho men in the plant mid I 1 i I i i i i < i f .i MQNS 097402 "MV?*-"