Document VGOa3Rpz6Ygwx6YMzM7d4VbZo

fyi/\ru. <-f O iin i -4 It August 31, 1961 Vilhela C. Hueper, M.D. 9307 aockville Pike Betheada. l4, Maryland Deer 3111: ** I enjoyed very much my visit vlth you and always welcome tha opportunity to talk with you, although I felt quite badly about the way certain natters axe developing. During our visit, you mentioned the 3raun-Truoa study, and I aa enclosing the evaluation I had prepared Jovender 18, I960 which I had used at a teaching seriilnar on this subject. As you will notice, this is an analysis, a.Inoat . line by line of the report, and I think it would be beat to have the report be fore you as you read ray review so that you can see what I had In siad and where it applies. Let me say, you have ay pernissioa to quote any part of the evaluation of this epidemiological study. I do not think the sentences are written for direct quotation, but X am sura you can get the essence without any difficulty. In ny opinion the study does not disprove the relationship of the associa tion between lung cancer end asbestos exposure because of certain inherent weaknesses of the study itself. This relates to the large dilution factor which exists relative to the age distribution of the cohort, 66$ being in the age group of 20-4k, in the insufficient period of time in which the cohort was followed in order to approximate the 20 year latent period for this age group, end finally, the limitation in the selection and manner in which the controls were used. In addition to this, anyepldemiological study which hss to hose s statistical Interpretation on the presence or absence of one case certainly is exceedingly weak. Knowing all the limitations and problems of epidemiologic investigations, the fact that such reliance bod to be placed upon one cose from which they derived the conclusion that the association of lung cancer and asbestos did not exist, raises considerable doubt as to the validity of this, conclusion. I aa aura you cat xhe point X am trying to make. Personal regards. Sincerely yours. Ene Thomas ?. Mancuso, M.D., M.P.H. fTVfw* ----