Document V3RrdqwxrEVNQ7xg3eOM56M1Z

,OBjiuu...uj .-inceraaK , ; PLAINTIFF'S 1 ( exhibit jOGcr>:-i l. good;:/.::, r.*. d. 623 O'HEAn ,V/2::..'2 north charlcston. t. r., zoeca November 10, 1972 Mr. V/illiam S. Simpson, President P.aybcstos-Manhattan, Inc. 205 Middle Street Bridgeport,- Connecticut 06603 Dear Mr, Simpson: This is a review of the meeting in Lyon, France, the subject of which was the Biplqglcal Effects of Asbestos.' The real purpose and impor tance of tliis meeting seems to indicr.te :c me that there is a distinct trend in the thought of people inter nations.'.ly associated with the bio logical effects of asbestos in its relationship to disease, mainly asbes tos i^Si^^^^g^^rcater enter.t its signifi'emt effect on the individual in The translation of this knowledge into future efforts by Raybestos-.Vmnhattan Corporation and its medical personnel in relationship to ihe scientists, the public, and to the government remains to be evaluated. I think it would be appropriate to discuss the future trends and the course of action that was being taken by all parties concerned in this discussion. At jiffifrfthere is r.o doubt - ro question - that the biological cficcjg^ft&rtl&ksftoa -leads to asbestosis Kr.i to carcinoma of the lung; both hroafiAogvmes'C&rcinomn and me sotheliomn-. .As far as the different aspects of the cficct oi' different types oi asbestos arc concerned, ail tyygMlMB5HSSKare4ncriminated." 'ifraiPFTrere paper ? presented whicii oldoma ia causecLV/^WWSblitc, amosite, and chrysotiXetradShese particular car.ccrs of the iur.;- arc of e>:trevr.e importance and lately have been given nationai and in" emotional publicity. Consideration is being given to the i:v .'gabions that wc are pursuing relative to the possibility that other typer of tumors of the body may neve a relationship to asbestos exposure. Tr i; .*u the present time is r.ac firm, hut there was shown a: this particular r.-tting that there is a trend icn.ird this direction relative to gastro-intcsvir.t. tumors and possibly other c/pes of rare tumors, such as ihe pancreas, :pi ogu.'i, parts of the colon, anti ct'uor parts of the iriU;d:;;.il tracl. 'i'l.i u point oi view whicii n'lu.ioi l.crn previously I'cco.piiu;li.a bro.. . and nu.tiic.'iL impticaiion.; of LlliS liC *11,1 V I y ,*m el t'tU'i.'SfilViriUCl t,. in'C it or.tli.wlCiy i 11 u',0 1'L C 111 li^cius...- we r.o-v s.:ij it,.: i iiplinafion,: : diLionel publicity aficctir.;; all organs of the body, ;lithough i. is trur ... iin: rotpirtuory systi.m is a major !>rim-ary organ o' die i .<!y whirl: cern, i.'ii'i i c1 r: cone c v n, .-nl l!u: f:'ecW:d. The comp.'iv;'.; con cu'ii concern, ;ir. d'mmvr m! *, (ri">rl,-M in I 11 ,* ,,l Pi r,. n;vi n, ,u*c."i(- r.i I lmlu;.M'y> I | Iii.'iii.ig.-ltli'ill ,1.1, ill 11 Mil r V rl lv ilic (l.iil ll ill i. in I in l cl y lo tiic importance: of uvicli rclcnsus in liio pr.ir.a. I or to the tT^ce elements, but that there ire indications that the fiber si7.e anti shape are important and that mesotheliomas have been produced with fiberglass and other non-as'oestos materials. In intrapleural experiments ,ilsa^4ta.yfl proutnaatt nivfjrtiitcliorn.'is in rats. A per centage ugura which you might use as a measure is 61% of animals pro duced cancer with crocidolite, 36% with rmosite, 3-1% with antophyllite, 30% with Canadian chrysotilc, and 19% with Rhodesian chrysocilc. A great many of the people felt that the trace metals were extremely rele vant. The greatest conclusion of all was that in employment in asbestos, especially the insulation worker, smoking his a greater affect on arbestosis and lung cancer than anything else, and every one of the asbestos workers should stop smoking. / \ There was great criticism of Dr. Selikofi's paper by Dr. J. C. McDonald. He felt that the statistics presented in this paper were not accurate. He talked about the inebriation workers and hi asked why the insulation workers that were not included in the union were not presented as a part of the study. 1 could go on for hours with various types of difficulties and prob lems they had with asbestos, but one of the main things I would like to * convey to you is that glass fiber is carcinogenic. With a peritoneal irri tation and the addition of bensopyrine with chrysotile a high rate of inci dences of carcinoma was produced. Chrysotile alone produced a very low Incidence of mesothelioma. In summary, I would say that there are many salient features to the dis- eusoions that were held at Lyon: (1) TLhS8fi6fcbsol.utcly a direct coar.cc- tMfi^SBBMWmpNUU'<a.asbcstos and mepprfcjjftldoma, broncogcnic earci- nocay^tt^4--afesaBSHiL--a8bestosia. {Z) The union representative was adamant in that there will be a revolution in their particular area bring ing about the necessity of industry getting ahead of the problem by intro ducing an educational program that will orient the worker as to what he is exposed to. Of course, this must be done'by medically oriented per- conncl so that an aura of hysteria is not created. Thu facts arc to be presented in a logical sequence in a manner of importance to such an extent that there-will be a complete compliance vnth the OSKA require ments, and yet, not cause fear among employees. It must show tin- company's interest in the employees' health and what the company is doing to protect and safeguard their exposure. (3) There will be in-' creasing publications and press releasee related io the significant "epidemic" of mesothelioma r.nd other types of carcinoma of the G. 1, tract, pancreas, etc., ; and then, anticipation of this particular rela tionship should be combatted by educational orientation of the employee, it should be emphasised lk.it the people vhc art: most at risk are liic workers and they should be taught la use materials safely an.i with con cern. (4) There should be a complete medical program. A complete survey of all the systems including the pulmonary system by u.-e of modern environmental and mcdic-i tr.ea.o; available to u.s and that-a / ro/jtllar VOUlhtri education |u.j,m.u.,i Li o..ordin.u; ! v/ith ii,i-> puyi.iC.il ev.;ot.i*Mioi*. A film strip or ;t film r.hor-.ct be prepared for the orien tation t.f tin: fit pl-tycc, especially since C.hlilA v* ;-.ut.-aion:i altow the iiitlivitlij.il to .*.:! for bin exposure, iito a;..;iunt of exposure, and the dust l, whi'-ii hu it-*ii bc.cn 1 llinsl; t IS,is pm;: i s ot will l,i* n;- abml jyi-.iU'i- j till-1 i>- i-i'tii I intii. I iy wl*<* til i,t,.;il-, *101X01 no 01.tiler wln; ,*1*1*111 lh,riii : public reunions man will prod re* . A public cdtientiou pro*: r;.rn is certainly in order In which one can, 1 believe, through the oto-Jia of television, radio, and newspaper edeoau: the puhtic as to the invnovi.mcc of asbestos, its uses, the itudopical effects of r.::i'.'*los, its coiit.Cua, u1 tii) wii r t and Its indispensahility to our modern technological society. It should be stressed that if properly used unci properly controlled, it is a perfectly safe product. I want to thank you very much for the opi ortunity to come in con- . tact with some of the world's greatest scientists and international experimenters. I had the opportunity of .sitting next to the inves tigator from Moscow who invited me to Moscow to visit his labora tory. 1 also had the opportunity of having long conversations and discussions with Dr. Gilson, Dr. Vfagncr, Dr. V.'cbstcr, Dr. Cctin and many others with international impor'at-.cc and found myself readily acceptable at their level. Of course, there is a great deal more to be discussed about this subject, but I certainly, donlt think tins is (he place for it. There are volumes and volumes oi infor mation ar.d letters that 1 have read and have with me, and perhaps, at an opportunity that presents itself v/c v/ill be able to discuss it person to person. I send my boot personal regards to you. . JLG/shl i.