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STUDY SUMMARY FOR WORK PERFORMED DURING 1977-1979 TEST SUBSTANCE Identity: PPeFrfOlAuoarmoomcotnaniouimc ascaildt,, Aammmmoonniiuumm spaelrtf,imuoaryooacltsaonobaeter,efPeFrrOe,d tFoC-as
116, FC-126, FC-169, or FC-143. (Octanoic acid, pentadecafiuoro-
, ammonium salt, CAS # 3825-26-1)
Remarks: The subject material is FC-143. It's purity was not sufficiently cihnafroarcmatteiroinzeidndaitctahteestiitmies tahmeisxetutersetosfw9e6r.e5 c-o1nd0u0c%tetde,sttshuobusgthacnucrereanntd 0 -- 3.5% Cs, Cr, and Cperfiuoro analogue compounds. The attached is an overview created in 1979forstudies completed from o1f9t7h7estoes1t9u79d.ieRso.bOutshterssumhmaavreineosthbaeveen aslrueamdmy baerenidsuzuebemtdiotttheedffaocrtmtahanty the original studies were not found. STUDIES Water solubility; degradation; soil sorption; partition coefficient; aquatic tox Remarks: The attached document includes a solubility value and an oocutraanvoali/lwaabtleerapracrhtiitvieodn rceopeofrftisc.ienTthveailruoeritghianticsotuhledrenfootrebeunckonnfoiwrnm.ed through
DATA QUALITY
Reliability: These studies have varying Kiimisch rankings, though most would be designated a *3". In many cases actual concentrations were not mbieoacsounrceedn.traTthioenvaanlauleywziansg dfeorteFr?)mionreudsibnyg innodimriencatlmceoanscuerntermaetniton(se.(ge..,g., aquatic toxicity). Oftenthetest procedure methodology was not noted. In some cases, the analytical methodology itself was questionable. Additionally, these studies lack sufficient characterizationof the test substance purity.
REFERENCES
3PrMojTeeccth9n7i7ca0l61R2e6p4o3r,t "RFeipnoarltCnoumpmrbeehre0n1s2i,veMaRrecphor2t3:, F19C79143." A. N. Welter,
OTHER
Submitter: 3M Company, Environmental Laboratory, P.O. Box 33331, St. Paul, Minnesota, 55133 Last changed: 5/25/00
04123
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Femara
TECHNICAL REPORT SUMMARY
70: TECHNICAL COMMUNICATIONS CENTER -- 201-20
(important = frapot iprintedanbothidesofprow,sandtwocopies10 TCC.)
arch 23, 197
F"TEnvironmental Laboratory (EE & PC) Fate of Fluorochemicals Final Comprehensive Report: FC 143
woooR. A. Prokop AH er
0r53d5 9970612643
o12
rere09a362
Gow
coms
FETT
Ag1 e
"TkS evweonoSse e:mom aovuer FEEl&uPoCroc-heDimvi.cal ((AAqnuaaltyitci)cal) (s(Doeiglr)adation) Toxicity
CURRENT OBJECTIVE:
Final Report: Ethnecompperaisosde;s a1l9l77-w1o9r7k9.performed during
[T morons ABSTE RACT. (500s3:50 wera Ths aves lermatosendosy oeToc Gommamcsion corr
ie: DR.ILL.. BBaochoonn .Pothapragada
WERT
04124
12 oc
Tet
INTRODUCTION Tonhe frlautoirooncahleemicfaolrs phearsfobremeinngdiesncvuisrsoendmenptraelvioeufsfleyctggtudies Tsinhuerftahsceutbajenentcv,tirowfnhlmiueconhrtohcahassemittchhaielspmooatfteentrthiiiaasll rfeisoproruwtseiddiessbypFrCetah1de43,dTeifsaltoranin(biRuoytniiecn ccohaetmiincgalliynduisstrtyh,e baomtmhoniduommesstailctalolfypearnfdluionrtoe-roneattainonoailclys.eid.Fe 143 wTehiigshtmatoefri4a31l ainsdathwehitcheemgircaanlulasrtrupcowtduerre shhaovwinngbealomwo.lecular
, Fyy COOTNR, FC 143
sTofhoirswpattireoernporsatnodlucbaoiqnlusiaottlyii,cdatpteaosrxitciaitltilyo.navaciTohelefafbilpcerioebinantbfslo,ermdeaentgivroianrdoanitmnieontnth,ael asorriieisask of FC 143 is defined. METHODS
Thaavteerbeseonlubtihleitsyu,bjebcitodoefgratdeacthinoicnalandrepsoortisltlgor8g)f.ion methodology's A) Aquatic Toxicity Testing
TafhteertesthtaitngdpersoctriobceodlsbyutiUlSEiPzAed(1f9o7r5)t(h1i)s, study were modeled 1. Bluegill Sunfish
sTIhtieushdylwueweregerielhloelbdtsauininfneidsfhibfer(roLgmelpaoasmispsrihvmoaalotdreioncghhatitcrahuneekr)sy:tufgieldleSdtioncwkitthhis wcAiatrdhabiolany-f3ip0lh-tomeitrnoueptdeeriwoetldrlanofswiatt1ie6ornhomupareisrnitoaldii,nghetdwasaatndma1i84n-t1h5aoiuCrn.seddark, 4ft8ihsrhohouwugerhsrouetprfietodhreTeattcorcala-inMdmianttjhornoduagialhnyod,uttfetoshotedinghteesiptnergipoewdri.itohdh.eTlhdeFish were acclimated for 14 days prior to testing. wAweeclruletewpaestrhefororrtmo-eftdekrnomonw(nF9C6c-oh1om43up,ro)siltostitoant34i0cw.asaquCusaaertdibconas-bfiiotlahetsesradsyidlsuent. oAfllwagtlearssoraqwuaartiear, pl3u5sxFC2014x320comcmp,risceodntaainsitnugdy 16chalmibteerr.s
b"CDoamlemerFcaitatlig fFisihsh fFoaordm,of Brkandoyw,n
Nebraska
composition.
04125
va
"te
TTsewiseztnetyafnibdshluweewigegirhletl,rsauwnnedfroiemslhyt,esats(esLdiegpnoaetmdiseatcmohacvracorocinhociuersnutsrt)ea,sttiounncihfaofombremFrCsin143.
wwoxieytrgheeinnmai3ln0etveamlii,nneudtaensdatpfH1o9lolTfowia1lglCg. FtCesMto1r4ts3aollaiudttdyii,otinostne.wmepreerTaemtsuetraest,uermepddeirsasatotulrveesd
G2e4n-ehroaulr oibnsteerrvvaaltsionosr urnetlialtivteotatlo patterns were similarly recorded
mbeohratvailoirtaylhaodr oecrcruartriecd.swimming when appropriate. Organisms
uasneddfrienetohfisdissteuadsye.were considered to be generally healthy
2. Ai quatic Invertebrates - 48 hour Static Leg, Dwfeaorprehn4i8eaxhpomouasrgesnd,a,t~otFFiwCresntt1y43i,onrsgtlaaotrnsis3wm4es0repatercvoautrnestyteidngcahancmdobnepcrle,ancterdations m2ianngdncasa.orlbuobni-lfiizietderepdriwoerlltowattheer,adwdiitthionchoefmictahle Daadpdhendia
57I65n0v,megr/t1l0e0b0wr,haitleaendtevse1tr35t0ecbomrngac/te1en.ttreasttioncsonwceernetra7t.5i,ons10,wer1e8, 42302, an5d60, sLhyo8sgOtgUeSmyE.aPlAues(Dwuiltuhth)95%ProcbointfidceonmcpeutelrimiptrsogrwaermeoncatlhceulaBtuedereussing
RESULTS
Twobaattbaelirenes1dolluuibsslitens,gwFa>Ct20er14g3/s,io.lulbotiFlCi3t410y4.3 awndhTehripesarmtaaidttdeeirdoinatlocoweiafsftieecrxiteraneptmpeeladyraetda btayobsoafrobpreamdr,taitgiTeohlnisaclmotaehtofeufrgiihcailefnutirstohfesrli5.gahdtdlBiyatsieoldnispoonopfhitFlhieCsce1a4s3dawteeavrieditenscciaemndilarly beeexmptiecrnoitnccalilundetrdheelattehanitvoinrsFohCnimp1e4nb3te.twwoeueClnhdiotnuohteebtwaiatol'ec)rggcseohnlatuvrbeailtiedteystcorofiabneadacphpaenrmeicciaalble Waehnredrnoritaspipslbyclioonncgsoindcdeeartneatdragtetinooenrbaetfeaadcptporfroo.rxiFmCaItne1l4ty3heoitnoretsoyhsritsdeemrp,roofptohsemaegdansicrtreuildabete.idonship, tfhaicstomratoefriaaplprowxoiumldatebleypr10o.jected to possess a bioconcentration
TABLE 1 Water Solubility and Partition Coefficient of FC 143
Parameter
Test
Results
Solubility
Coarse method
>20 g/1 as gl
Partition Coefficient n-octanol/water
5
04126
.
3.
FuCnde1r43twhaestefsotundcotnodibteioncsompelmepltoeyleyd'p>g)s.istaTnhte t2o1b/2iomdoegnrtahdation
schualkteurecsultduerrievebdiodfergormadaacttiiovnatesdtudsyluudgteiliizneodcumliacroobbtiaailnedtesftrom
tsyhseteCmh.emolDiutrei,ngDetchaetutrimeandcoTuwrisne CofititehsisMesttruodyPlaanstwraaisnteoftreatment
mtihcisrobmeasterwihailchwocuoludldbedegerxapdeectFeCd 1to43pedrisdisntotindevtehleope,nvihreoncnement
for extended periods of time unaltered by microbial catabolism.
a(Sdrosaionlrgbeseod2r-p7tt4oi)o,BnrioslftlutdhsieaensdFyCha1lv4oe3amsphrsoeowsinlentt(hTaatinblaeappw2ra)otxgiyma>). stoeCllouyntvi5eo%rn,sewlays,
aopiplroxwoiumladtebley 8de0s%orobfedtheaftaemrountthreoef F(C3)14d3esoardpstoirobendtrtioaltshis
dc(eoTnsabvclereritbee2)dd. btyoMHaoamcabkoenris(tl"aniotft,FwyChKer1e4_, b3yWhwiaacsdhsocrrapeltfciluoelncattsecdoetfuhefsiiconriggeantnthisecasrceheme
crinoenltatethniitsve offmaosbhtiihloeintsyoainlod.f thaaTtghriostuhpeinKofvepsetvsiatgliaucteiodrceosuhladscosbuehlodwcnboerrtehdlaetatteertdmhiened
waKoitKho 28p1 evsa1tl2-iu8ce,idoef"whm1io7c,bhilbwiaetsiyn.gtheslIminogshattBlfymloybilinelgses tmphoeibssitlitecesitdt,ehanFpCacceh1dl4o3roanhmabden,
Hefiaker's work(),
---
Table 2 Soil Sorption Tests on FC 143
Parameter
Test
Solution
Soil Sorption Adsorption
Vater
Desorption
Water
Koo
Results
~ 5%, range 2-7% 80% of amount adsorb 17
RN3)Ie.OsSuHl,tBsaFsCeofd14otn3hetwhoaeucludtaequbseattacitocincstiodxaeiqrcueiadttyicprcartcietstitecsrailaalryeesttnaaobbnlu-iltsaehtyeiedcd
b(yTable to
tihse tvoerbetebnroatteeds thaantd those data obtained
tihneveirntveberratteebsratueseddatian
cthoirsreltaetsetiw!e)il
It with
when testing fresh warm wpjepogpecies.
This correlation has been observed repeatedly
.
Eangdg-ftrhyeirsturdeiseusltswerceomcpornitsreacTtaebdlesto 4 EGaRnGd were undertaken to assess the effect of
B5.iomoTmhiecsse FC 143 at
Lstaubdoireastory sublethal
levels (Table
4o)n. hatIcthaibsilgietnye,ralsluyrviavcacle,ptweedigthhtat atndhe leinmgmtahturcehanoFg.es
young stages of an aquatic species are quite sensitive indicators
04127
Le
-a-
Table 3 FC 143, Results of
Test Organisms 96mg/H1r",IC,)
Bluegill Sunfish 569
Daphnia magna
632
632
96 Hour Acute Static Testing Limits
Lower, mg/l Upper mg/l
500
636
570
699
570
698
Table 4
LPeenrgctehntaagnde Eegtg WHeaitgchh,t (Pimephales promelas)
oPfercFeantthaegade MSiunrvniovwalF,ryTotal during Exposure to varying
ConcentraticoonnceHnattrcahtio%nsSuorfviFvC3a0l1D4a%3ysL* PeonsgtthHmatmchWeight mg
mg/1
100
2%
8s
20.5
59.5
50
92.5 01
20
62.5
25
a9
02.5
21
72
12.5
20.5 97.5
21
7
6.2
21.5 03
21
60
Control 96.5 93.5
20.5
68.5
"ork performed by EG&G Bionomics Laboratory, Inc.
PSStu.mmaPrauyl,tabaslepasrutbmiofttefdinatlo Ernepvoirrto.nmental Laboratory, 3H,
woiefnrvecehsoetbmitigacaiatnlielodyn. nionAdtuscteatdhteisttohixiicgchaieltslyty. FsCigInn1i4f3tihcecaonpntacreadnmitefrtfaeterirsoenncuentsdesetred, sa1nu0d0ggwmeges/it1gi,hvet roe3fd0ucadtaiylosantsepnotswteornehsaetrtcehc.oinrdetAdhlethiodneuvgsehulrovtpihmveeasnlet dpaeotfracecnuatmrealative wttehoerxeiceinotvbyis,reornvtmehedentfdaaolrseecxolcneecveeedln,strao(ftsieoFvnCesra1lo4f3oraFdtCerw1sh43i.cofh mtahgensietupdhee)n,omina
C04128
Ata
"Bu
tPaoas3ea0db-dnaooynrmaetlxhephoisrsuetrsoeuplattsthooolf1o0g0tyhmeg(/hTliasbtFlCeopa51)t4.3holdoiBgdoitchnaoltgroecuxopansmtirnioabftuitoen, woaanrsdgans5ie/se1nm0s tinerexhahotitebhditeogdrroguafpnasit,stmys3./l1i0vSercimoinclthaarrnolglyes,s,angdi6l/l120/h10ycpoentrtrpreolalatsseida try.
Table 5 HFriysto(pPaitmheoplhoalgeiscaplpoEmxealmaisn)atieoxnposoefdF3at0h-edaadysMitnonow 100 mg/1 FC 143%
Test Material
ObsNeurmvbaetrioonfs
HistFoipnadtihnoglsogical
Control
-
10
63//1100 fnaotrtmyalliver changes
3/10 gi11 hyperplasia
100 mg/1 FC 143
10
5/10 normal
25//1100 gf4a1t1tyhylpieverrplacshiaanges
DISCUSSION
FTsChoeur1c4p3erimafnaodrryatlpolurppreoonvsvieidreoonfmaentnhtiaasnlalrydesapoitrsatogfeinspeorttaoetneptdrioavrliedleaetnivanigrsoinntmgoelnetal risk.
I(n1)deaveslcohepmiantgiztehdisclaonsaleydsissysttewmo practical model based on use of
emondveilrontmyepnets FC 143 at a
wainldl 2)be adiscussed: manufacturing
site and consumer product usage.
1. Closed System
Tsyhseteemn,virsocnhmeemnatticcaalnlyberceopnrseisdeenrteedd taso: be a closed
SN
So11
N Vatervd Creehqmeuamiiilnciablrcsiounmfeinnbteeedtrwiewneignthtihtniwsoaosrsyisntagelllmemtichgorhmetpearcetosmmtepanabtrltimoserhntpasen,rtubate all phases of the depicted cycle.
04129
Cre
-6-
Sinpectiheficfaollllyowwiengcmaannnreerp:resent the impact of FC 143
No Photodegradation Air --<YOLSHUYY gi VolRaattieli?ty rlaaitenr? of0a%dsorbs
No degradation
/sadsorbed
>20 g_/1 W(agteel)r 4 _____._ Sseodripmteinotn,pNhoenboimoedneagrasadasteieonn in soil
Absy mielalnusstroaftetdh,e FwCate1r4w3ayesntearnsd stehceonednavriirloynmevnita ptrhiemarily
tdoeersresntortiaaldseorcbosypsetrmeamneanntdlyatmtoospehietrhee.r soTihlisamnadt/eorrial
sediment, It is not
rkneomwaniniwnhgethheorwevFCer 14i3n
tihsevwolaatteirlec,ompaarftamcetnt.
wFhCic1h43adsoseusmesnotimupnodretragnocephiontolliygshits.of fhe Bfaisneddingonthtahte
sfionrekgofionrg,FCth1e43.wateIrnwtaeyrsmedaipaptaerenrtelcyeptaorresthheaveenvniotronbemeenntal
identified.
2. Manufacturing and Consumer Model
TwhheerefionllFoCwin1g43cmoanystreunctteritlhleusetnrvaitreosnmveanrtiouast ptahtehwparyoscessing site.
04130
70143Anentc Srtactant
,
:
[--
b
PhotographicIndustr$-- Process Teflon"Coating
~~ Consumer
A wastes --
Ligue
| ----
. TasteTre|atment--
|
Nne&toerate
aN
L.
Commj
(rVeANaan
x Mr
on 3
5
To --
rt LLTRasLN L1ep7"ach Vo|latiSlea
_-
\PyNl 5 7
ve
1
Ce
Ce.
Tmihgehtaboevneterfigthuereendveipriocntmsenptr.ojecItneddispcatuhswsaiynsg wusheeroefinFCFC141343 bDry. thM.e TPiekfel,onComm"ceoractiianlg aChnedmipchaoltoDgirvaipshiiocn,indI uwsatsrieisnfwoirtmhed btyhatthetotTehfeliorn{k"g'ocwolaetdigneg nproocFeCss1.43 wBaassteedsownoutlhdisbeingfeornmeartaitoend, sIighna;vepod.epicted this no waste situation by the following CIhnemdoilsictues,sinagsitmhielamranuofbasecrtvuarteioonf tFoC t1h4a3twoiuthtliJneerrdyaHboofvfeer, was made. cIonncveinetwraoftiotnheunadbeorvecwoendicatnionpsrowjhecetreitnhealelnviFrCon1m4e3ntmaalnufactured is 10st to the environment. Ssiinmcpeliswtatiecrwmaoydsel aurteiltihzeinegnviarsoinmnegnltealpoisnitnksofuorrceFCfo1r43,FCa143 acnodnceantrriavteironwouflodr FeCnab1l43e ounndeertoapwroorjescttcaanseessittiumaattieodn.environmental Wteo htahvies msaidmeplsiesvteircalmodaesls:umptions which are considered basic 1) Tiostadliscphraordguecdt.ion is at Chemolite and all FC 143 produced 2) No FC 143 is removed by the treatment facility. 3) All effluent is discharged into the Mississippi River. 4) FC 143 is discharged uniformly. 5) Rhievnecre nfoltowsuabnjdecatlltootsheearsopnaarlameatnedr/soracrelicmoantsitcant,
perturbations.
The formulae used in these projections include: by e/ewm . {River Flow, CTPoMd)uc(tCioonnv,erspieorn,agnanlu/m?t>3)(Time,min) 2) MG/min x 1440 = MG/Day 3) Lbs/day = (mg/l x wt. lbs. HyO per gal)(MG/Day)
MlioswsifslsoiwppriecoRridveris fl1o0w,00at0 CHFaSs.tings, MN, based on a 10 year TChoemmetroctiaall 5ChyeemaircaplrsodDuicvtiisoinonf.igurIens uwteirliezipnrgovitdheedsebyfiDg.uRr.es Ricker, aMnisessistsiimpaptiedReinvveirrobnemleonwtaClhecmoolnicteentrwaatsiocnalcouflaFtCed1.43 Diunrithneg the period 1973-1978, the EEC for FC 143 was calculated
04132
teen
-0-
tfoorbethe1.6peprgi/o1d a1t97H8a-s1t9i8n3gsi,s pMnr.o,jecwtheidleatthe2.4EECpgp/rl.ojecStiendce titheiwsatdeertercmoimnpeadrtmtehnatt iats tthhee pernevsiernotnmeanntdalprosjiencktefdorlFeCvel1s43, oefnviprroondmuecnttiaoln FrCisk143unwdielrlwonrosttprceasseentsitaunatuinornesa.sonable CONCLUSIONS Usnedleerctetdhephtyessticoccohnedmiitciaolns anedmpleonyveidronimnencthaalrapcrtoepreirztiinegs of FC 143 it has been determined that this material 12)) hiassexatnrenm-eolcytawnaotle/rwatseorlubplaer,titfioornmincgoefafigeclienatt o20f~g/5l. 43)) iiss erxetsriestmaenlty mtoobimliecroibniaBlrildlegrsaadnadtyiolnoam soil 5) siunrvainvaelg,g-flreyngtshtudoyr wdeiidghntotfaoflfleocwtinghatach3a0bidlaiytye,xposure
stoignFCifi1c4a3ntatdesgurbelee.thalSimlielvaerllsy,tonoa sadtvaetrisseticeaflfelcyt wiansducneodtedpatohnoltoigsys.ues examined for evidence of chemical 6) hiesncteo bietsfeonunvdiropnrmiemnatraillysiinnk.theNowatseprecciofmipcaritnmteenrtm,ediate 7) wroeucledptohrasvehaanveebseteinmatieddenetnifviierdo.nmental concentration oafll aFpCpro1x43imawteerleyma1n.u6f-a2c.4tpugr/e1d, atundCehremoclointdeitiaondnsdwihsecrheairnged 8) wiinltlo ntohte pMriessseinstsipapniuRnirveears.onable environmental risk buassaegde opnattperrenssentetca.nd projected production levels,
BIBLIOGRAPHY 1. Menadnedl,SuAp.p,ortT"e,chnJiacnaularyRep1o7r,t:1979".Analytical Methodology 2. ReiSnteurd,iesE.Ao.f, `FTleucohrnoiccaarlbonRsepo-rtI:II","BJiuoldyegr19a,dat1i97o8n. 3. Welasnhd, FCS.K1.4,3 TonechSnoiilc"a,l RFeepborruta:ry 2"7A,dso1r97p8t.ion of FC 95 + 4. US/MEaPcAro--iMnevtehrotdesbraftoersAcaundteATmpohxiibciiatnys,TesEtcowliotgihcaFlish,
Research Series 660/3-75-009, 1975. 5. Chiaonud, RoCdagryerT.L,. VKiorhngeirlt:H. PFraeretdi,tioDnaviCdoefW.ficSicehnmteddainndg,
BEinovaicrcoummeunltaatlionSciofencSeeleacndtedTeOcrhngoalnoigcy,Che1m1i(c5a):ls,475-478, 1977.
04133
an
/
:
-10-
6. HamEaxkpeerr,imeJn.Wt.s," i"nInCtheermpirceatlast,ionHumoafnSoHielaltLheacanhdingthe VEonlv.iro1,nmeDnotw,'ChAemCioclallectUiSoAn MoifdlDaonwd,ScMiiecnhtiigfainc 4P8a6p4e0r.s,
7. Reg1i7s6trEyditoifonT,oxiCchriEsftfeencstesn,ofHC.Eh.e,micaanld SE.uJb.staFnaciersc,hild, aEdnsd. Wpel.fxavrea;ndNaCit,ionUaSlDeIpnasrttimteuntte offorHOecalctuhp,atiEodnuaclation, Safety and Health, Washington, D.C., June, 1976.
8. WelStteurd,iesA,.N.,FCTe2c1h4n-i3c0allotRep5o6r6t,: FebArquuaartyic16T,oxi1c97i9t.y 9. WelStteurd,iesA,.N.F,C 2T3e2chnliotcal610R,epoJratn:uaryAqu1a7,tic197T9o.xicity 10. WelRteepro,rt,A.NF.C,'95TechManriccha,l R1e9p79o.rt: Final Comprehensive 11. TodSdt,udyJ.Wu.s,ingTecShinmiuclaaltedRepSourntl:ightF,C F1e4b3ruPahroytol2,ysi1s979. 12. WelRteepro,rtA.oNn. FTMec3h4n22i,calFebRreupoarrty: 2, Fi1n9a79l.Comprehensive
94134
