Document V2zD4rzQ5dqQveeY78xw2558

To: From: Cc: Bcc: Received Date: Subject: Clegg, Patsy M SCC-CHSE-PC <patsy.clegg@shell.com> Bruce Jarnot <jarnotb@api.org> 2005-06-14 21: 12:00 GMT SHS... Study update for HESOC / HESGC Mtg SHS Summary as of 12 / 31 / 2004 ** Study progress updated every 6 months, end of June & December ** latest update was Dec 31 , 2004 ** 725 total # of cases, hematopoietic & lymphoid, I. D.ed during 1st full year of operation (12 mos., through 12/31/04) ** 687 were independently confirmed & entered into the d'base as of that date ** Based on current case-contact rate: 750 - 1000 additional cases expected in 2005 ** Based on current case-contact rate: case goals for all diseases should be met by Dec 31 , 2006 CC ... ** 437 AML cases had been accrued ** 155 NHL cases had been accrued (300-325 thru 2005; 450-500 thru 2006 = end of data collection = target hit) ** 2x controls per case were also processed through JCML lab analysis DP ... ** Unique profile of MDS (myelodysplastic syndrome) I.D.ed in hi-benzene exposed workers ** Characterized as BIMDS (benzene-induced myelodysplastic syndrome) ** MDS subtype profile was established across 100 consecutive MDS cases ** provided a unique profile for this genetic pool and geographic region ** both BIMDS and MDS-subtyping will appear as manuscripts EA (Exposure Assessment) ... ** Fudan Univ. to host Workshop on practical aspects of EA ** Will ensure consistent approach by Investigators (Fu, Wong, Irons, Armstrong) & staff (Fudan School of Public Health, YiMei, etc) ** EA using a combination of IPHS data, readacross to similar factories & data from Chinese literature ** Irons & Fu agree this minimizes any data integrity / data availability issues ME Phase I... ** 400 medical records from 48 factories had been reviewed (of 1800 total medical records from 84 factories) ME Phase 2A... ** Analyses performed on blood/urine from 231 high-exposure workers ME Phase 2B... ** Worker recruitment issues remain... only 3 bone marrow samples obtained SHELL-MCCLURG-062351 ** Metabolite analyses will move to Phase 2A Please call if you need any elaboration, etc... 202/682-8473. Best Regards - Bruce. SH ELL-MCCLU RG-0623S2