Document RpzVkb11MOK5RRVqxJ0wx2EvB

July 23, 1953 Dr. Norman A4/. Karr Director, Cuemic&l Research Biker Laboratories, Inc. P. O. Box 3157 Terminal Annex Loo Angeles 54, California Dear Doctor Kavr: I regrs: very much to have to tell you, even alter this long colcy in replying to your letter o' Juno 4, that we Lave not been Tie, on yot, to obtain the Inform tion on the cacec of tetraethyl lead poisoning treated by Dr. Kitsmlller in Panama. The reports have been promised repeatedly out they have not been delivered. I am &u:r ihyou Lao-.- that the .supply of calcium disod turn EDTA v/hich your p/i. .1:. tried to got to Dr. Kitcmiller at my request, was nos received by him while he was in Panama, and therefore he hud only a. small auentity v/hich he took with him from the Laboratory. W c should have adequate information on how the supply which you furnished wac used when it ciid arrive, bat we haven't it yet. This fact merely iliui trat-.ic cho frustrations that confront the experimental, observer when he attempts to work outside of hir. own field cf complete control. 1 suspect, therefore, that the most we shall learn from this'experience is that this ay eat w?.s well tolerated by very sick men, and that there was some excretory resaonso {utcrease'- in urinary lead concentration) to its administration. V/'e shall improve on this as much as v/e can witii details, when v/e can.. ..A shell do so eventually, if one of us has to return to Panama to get the case records. We carried out scores of analyses, and I don't intend to lose their value entirely. On the other hand, I am much more interested in being able, to make some observations of a more detailed type in cases of inorganic lead poisoning, than I am in the Panama results, since at best thf latter cannot tell us much about the tilings I most wish, to know ~ that :s, (1) whether cr net the administration of the product induces significant clinical improve ment in inorganic lead poisoning, (which has not been proved oy the reports which I have seen as yet), and (2) what change occurs in the distribution of lead in the body, following its administration. At last v/e have overcome the hurdle which developed here in the use of the product in the treatment of children. This is the point at which a good 0006530