Document RpwMG369y1DogQ54vO1OOQ5LE

/ -' . Study Number SA-15 SA-19 SA-20? SA-91 . ' / . ` .' _ 'r . ' ' " B I P HENYLS . SCIENTIFIC ASSOCIATES AROCLOR STUDIES . Laboratory Author Completion Date Polychlorinated Biphenyl Product Description Scientific Associates Fred M. Younger 11/10/53 Aroclor 1254 Oral LD-50 . Scientific Associates Fred M. Younger 12/11/53 Aroclor 1242 Oral LD-50 Scientific Associates Fred M. Younger 1/13/54 Aroclor 1248* Oral LD-50 Inhalation Study Eye Irritation Scientific . Fred M. Associates . Younger 2/3/55 OS-63 Aroclor 1242 48%* Oral LD-50 Skin Irritation . and Absorption Eye Irritation Vapor Inhalation Y-57-22 Y-62-34 Y-62-35 Y-62-36 YOUNGER LABORATORY STUDIES AROCLORS AND AROCLOR BLENDS. . . Younger Lab Fred Younger 7/9/57 Aroclor 1270 Oral LD-50 Eye Irritation . Skin Irritation Younger Lab Fred Younger 6/19/62 Aroclor 1242 Oral LD-50 Dermal LD-50 Younger Lab Fred Younger 6/19/62 Aroclor 1248 Oral LD-50 Dermal LD-50 Younger Lab Fred Younger 6/25/62 Aroclor 1254 Oral LD-50 , Dermal LD-50 * Denotes Aroclor Blend. EX P-2836 Page 1 of 58 _ PCB-ARCH-EXT0379260 Study Number Y-62-37 Laboratory Younger Lab . Y-62-38 Younger Lab Y-62-41 Younger Lab Y-62-42 Younger Lab Y-62-4 4 : Younger .Lab Y-62-52 Y-63-11 Y-63-12 Younger Lab Younger Lab Younger Lab . Y-63-88 Younger. Lab * Percent Shown for Blends; Author Completion Date Fred Younger . 6/25/62. Fred Younger 6/25/62 Fred Younger . 6/13/62 Fred Younger 6/13/62 Fred Younger 7/3/62 Polychlorinated Biphenyl Product Aroclor 1260 Aroclor 1262 Aroclor 1221 Aroclor 1268 Aroclor 4465 Fred Younger Fred Younger Fred Younger 6/6/62 3/4/63 3/4/63 Aroclor 1232 : Pyranol 1470 Inerteen PPO Fred Younger 12/19/63 Aroclor 1242 74.8%* Aroclor 1221 12.4%* Page 2 Description Oral LD-50 Dermal LD-50 Oral LD-50 Dermal LD-50 Oral LD-50 ... Dermal LD-50 . Oral LD-50 Dermal LD-50 Oral LD-50 . Skin Absorption Skin and Eye Irritation Oral LD-50 ; Dermal LD-50 Oral LD-50 Skin Absorption Oral LD-50 Skin Absorption Skin and Eye Irrita tion Vapor. Inhalation Oral LD-50 Skin Absorption EX P-2836 Page 2 of 58 PCB-ARCH-EXT0379261 Study Number Y-64-49 Laboratory . Younger Lab Y-65-214 Younger Lab Y-66-151 Younger Lab . Y-66-164 . Younger Lab Y-67-105 Y-68-127 Younger Lab Younger Lab Y-68-133 Younger Lab * Percent Shown for Blends. Author Fred Younger Fred Younger Completion Date 6/13/64 1/12/66 Fred Younger 10/17/66 Fred Younger Fred Younger . Fred Younger 11/9/66 10/19/67 1/13/69 Melvin Birch 1/22/69 Page 3 Polychlorinated Biphenyl Product . Description Therminol FRO MCS 29.5%* Oral LD-50 Skin Absorption Skin and Eye .. Irritation Aroclor 1254 10%* Aroclor 1248 43.7%* Oral LD-50 Oral MLD Skin Absorption Skin and Eye Irritation Vapor Inhalation Aroclor 1242 37.7%* Aroclor 1232 6%* Oral LD-50 Skin Absorption Skin and Eye Irritation Vapor Inhalatioi Aroclor 1254 10%*. . Aroclor 1248 43.7%* Oral LD-50 . Skin Absorption MLD ' Aroclor 1242 20%* Oral LD-50 Aroclor 1248 Fluorinated Aroclor 1254 =Oral LD-50 Dermal LD-50 Eye Irritation Skin Irritation Oral LD-50 Skin Absorption Skin,and Eye Irritation EX P-2836 Page 3 of 58 PCB-ARCH-EXT0379262 Study Number Y-69-41 Laboratory Younger Lab Author Melvin Birch Y-69-42 . Younger Lab Y-69-53 Younger Lab Melvin Birch Melvin Birch Y-69-54 Younger Lab Y-70-74 , Younger Lab Y-70-116 Younger Lab . Melvin Birch Melvin Birch Melvin Birch Y-71-14 Younger Lab Melvin Birch * Percent Shown for Blends. Completion Date 5/5/69 5/5/69 7/7/69 6/30/69 8/17/70 12/14/70 2/14/72 Polychlorinated Biphenyl Product Page 4 Description . Aroclor 1242 30%* . . Oral LD-50 Skin Absorption. Skin and Eye Irritation Vapor Inhalation Aroclor 1242 40% .. Oral LD-50 Skin Absorption Skin and Eye Irritation Vapor Inhalation Fluorinated Aroclor 1254 Oral LD-50 . . Skin Absorption Skin Irritation Eye Irritation . Vapor Inhalation Brominated Aroclor 1221 Oral LD-50 . Skin Absorption Skin Irritation Eye irritation Aroclor 60.62 Aroclor 5460 56%* Aroclor 1221 34%* "Oral LD-50 Skin Absorption Skin Irritation Eye Irritation Aroclor 4273 Aroclor 5442 73%* Aroclor 1221 27%* Oral LD-50 Skin Absorption Skin Irritation. Eye Irritation Vapor Inhalation Aroclor 0114 . Oral LD-50 Acute Skin Absorption Skin Irritation Eye Irritation EX P-2836 Page 4 of 58 PCB-ARCH-EXT0379263 Study Number Y-71-105 Laboratory Younger Lab Author Melvin Birch Y-71-187 Younger Lab . Melvin Birch Y-71-189 Y-73-150 Younger Lab Younger Lab Melvin Birch Melvin Birch Y-74-54 ' Younger Lab Y-74-55 .Younger Lab Y-75-0252 Younger Lab Melvin Birch Melvin Birch * Percent Shown for Blends. Completion Date 6/28/71 1/12/72 1/12/72 9/17/73 7/10/74 6/8/74 10/22/75 Polychlorinated Biphenyl Product Aroclor 1272 Aroclor 1016 44%* (German Mine Fluid) Aroclor 1016 43%* MCS 1489 Aroclor 1016 Aroclor 1016 Aroclor 1242 Aroclor 1016 Page 5 Description Oral LD-50 Dermal LD-50 Eye Irritation . Skin Irritation . Oral Lethal Dose Skin Absorption Skin Irritation Eye Irritation Vapor Inhalation Oral LD-50 Skin Absorption . Skin Irritation Eye Irritation Oral LD-50 Acute Skin Absorption Skin Irritation Eye Irritation Vapor Inhalation . Tissue Residue . accumulation and depletion study in rats Tissue Residue accumu lation and depletion study in rats Oral LD-50 Dermal LD-50 Eye Irritation Skin Irritation EX P-2836 Page 5 of 58 PCB-ARCH-EXT0379264 Page 6` Study Number BT-62-0004 INDUSTRIAL BIO-TEST LABORATORIES, INC. AROCLOR STUDIES Completion Polychlorinated Laboratory Author Date: Biphenyl Product Description . IBT . Richard J. Palazzolo, 3/28/63 3/27/63 3/4/63 3/29/63 3/28/63 5/17/63 Aroclor 1221 Aroclor 1242 Aroclor 1248 Aroclor 1254 . Aroclor 1268 Aroclor 4465 Subacute dermal toxicity in rabbits BT-69-0033 IBT BT-70-0016 . IBT BT-71-0001 IBT BT-71-0067 IBT BT-71-0068 IBT BT-71-0069 IBT Carmen Mastri James L. . Stephens Carmen Mastri 6/13/69 6/4/70 3/25/71 Aroclor 1242 Aroclor 1254 Aroclor 1260 Aroclor 1242 Aroclor 1254 Aroclor 1260 Aroclor 1016 Aroclor 1221 Dale Fletcher Sandra Haley Philip S. Smith 6/15/71 11/1/71 11/1/71 11/4/71 11/12/71 Aroclor 1242 Aroclor 1242 Aroclor 1254 Aroclor 1260 Aroclor 1242 Aroclor 1254 Aroclor 1260 96 hr. LC-50 Toxicity reproduction and residue study in white leghorn chickens Oral LD-50 Dermal LD-50 Eye Irritation Skin Irritation' .. Vapor Irritation Toxicity reproduction and residue study in white leghorn chickens Three generation . reproduction study in albino rats Two year chronic oral toxicity in albino rats EX P-2836 Page 6 of 58 PCB-ARCH-EXT0379265 Study Number BT-71-0069A Laboratory . IBT Author D.E. Gordon Completion Date 3/24/75 BT-71-0070 BT-71-0071 BT-71-0072 BT-71-0073 BT-71-0136 BT-72-64 BT-72-0082 BT-72-0103 BT-72-0129 BT-72-131 IBT Bruce R. Burtner 11/1/71 IBT IBT IBT IBT IBT . , . James B. Plank 9/8/71 James B. Plank 9/8/71 James B.. Plank 9/9/71 Dennis Arnold 1/13/72 . -- - . . -- IBT IBT John W. Goode Kenneth Ebbens , 1972 11/17/72 IBT IBT . John Hamlin Unknown 1/12/72 12/30/71 BT-72-0133 IBT Bruce R. Burtner 12/31/72 Polychlorinated Biphenyl Product Aroclor 1242 Aroclor 1254 Aroclor 1260 Aroclor 1242 Aroclor 1254 Aroclor 1260 Aroclor 1242 Aroclor 1254 . Aroclor 1260 roclor 1260 Aroclor 1260 treated Aroclor 1242 Page 7 Description Re-evaluation of original report . . dated 11/12/71 Two year chronic oral toxicity in beagle dogs Teratogenic . study in albino rats Teratogenic study in albino rats Teratogenic study in albino rats Mutagenic study in mice 4-Day fish toxicity studies 96 hr. LC-50 Aroclor 1242 Aroclor 1254 . Aroclor 1260 Aroclor 1016 Aroclor 1221 Aroclor 1221 Aroclor 1016 . 96 hr. LC-50 196 Hr. LC-50 90-Day subacute oral toxicity study in beagle dogs 90-Day subacute oral toxicity study in dogs EX.' P-2836 Page 7 of 58. PCB-ARCH-EXT0379266 Study Number BT-72-0134 Laboratory IBT BT-72-0135 IBT BT-72-0137 IBT BT-72-0138 IBT Author Dennis Arnold Dennis Arnold Philip S. Smith Dale Fletcher Completion Date 1/31/72 Polychlorinated Biphenyl Product Aroclor 1242 1/13/72 Aroclor 1254 4/28/72 Aroclor 1016 Aroclor 1221 6/20/72 Aroclor 1016 BT-72-0139 IBT Dale ' Fletcher 6/20/72 Aroclor 1221 BT-73-0070 IBT . Dale Fletcher 1973 Aroclor 1242 BT-74-69 IBT Gary Rausina ' -- - MSC 1489 Page 8 Description Mutagenic study in mice Mutagenic study in mice " 90-Day subacute oral toxicity study in rats Toxicity reproduc- . tion and residue study in white leg horn chickens . Toxicity repro- . duction and residue study in white leghorn chickens . Toxicity and reproduction study in white leghorn chickens 4-Day fish . toxicity study EX P-2836 Page 8 of 58 PCB-ARCH-EXT0379267  . . . . MISCELLANEOUS STUDIES : Study Number Laboratory Author Completion Date Polychlorinated Biphenyl Product K-54-0050 Kettering : : Joseph F. 6/22/55 Trevon Frank P. Cleveland . : John Cappel' : Frederic E. Shaffer Raleph W. Atchley John P. Torbeck Aroclor 1242 Aroclor 1254 Monsanto , William Incomplete Gaffey Ferdinand Meyer Judith Zack . Various Harvard Medical School C. E. Drinker 1937 Aroclor 1268 Barnard Free Skin & Cancer Hospital L. K. Halpern 1949 Aroclor 1254 Litton Bionetics P. E. Berteau Incomplete Aroclor 1254 Page 9 Description . Inhalation exposure of cats, guinea pigs, mice, rabbits and rats Mortality study of some PCB production workers Inhalation studies on rats Human patch Study Reproduction study in rhesus monkeys EX P-2836 Page 9 ' of58 PCB-ARCH-EXT0379268 - " r `/ ' f 1 r t / f Study Number SA-1 SA-3 - . Laboratory Scientific Associates Scientific Associates TE RP HENYLS SCIENTIFIC ASSOCIATES AROCLOR STUDIES Author Completion Date Polychlorinated Teiphenyl Product Fred M. Younger 9/4/53 Aroclor 5460 . terphenyl Fred M. .Younger 9/9/53 Aroclor 5460 chlorinated terphenyl 60%* Description Skin Irritation Skin Irritation Chloracne Potential YOUNGER LABORATORY STUDIES AROCLORS AND AROCLOR BLENDS Y-62-43 Y-62-45 Y-62-45 Y- 6 2-48 Younger Lab Younger Lab Younger Lab Younger Lab Fred Younger . 7/17/62 Fred Younger 7/5/62 Fred Younger 7/13/62 Fred Younger 5/1/62 Y-68-64 Y-68-87 Younger Lab Younger Lab Fred Younger Fred Younger 5/27/68 8/8/68 * Percent Shown for Blends. Aroclor 2565 halogenated terphenyl Oral LD-50 . Skin Absorption - MLD Aroclor 5442 halogenated terphenyl Oral LD-50 Skin Absorption 60%* chlorinated (same as Aroclor 5460) Oral LD-50 Skin Absorption Benzal SD , (Aroclor 5442) halo genated terphenyl Oral LD-50 Skin Absorption Skin and Eye Irritation Aroclor 5460 halogenated terphenyl 60%* Vapor Inhalation MCS 706 Aroclor 5460 38.5%* Oral LD-50 Skin Absorption Skin and Eye Irritation Vapor Inhalation EX P-2836 Page 10 of' 58 PCB-ARCH-EXT0379269 Study Number Y-70-1 Laboratory Younger Lab Author Melvin Birch Y-70-74 Younger Lab Melvin Birch Y-70-114 Younger Lab Melvin Birch Y-70-12 3 Younger Lab Melvin Birch Y-70-124 Younger Lab Melvin Birch Y-70-125 Y-70-126 Younger Lab Younger Lab Melvin Birch Melvin Birch Y-71-57 Younger Lab * Percent Shown for Blends. Melvin Birch Completion Date 2/4/70 8/17/70 12/2/70 12/30/70 12/30/70 12/30/70 12/30/70 3/31/71 Page 2 Polychlorinated. Teipheny 1 Product Aroclor 5430 halogenated terphenyl Aroclor 6062 Aroclor 5460 56%* Aroclor 1221 34%* Aroclor 6037 Aroclor 6040 (Chlorinated poly phenyl ) Aroclor 6050 (halogenated poly phenyl) Aroclor 6070 (Chlorinated poly phenyl) Aroclor 6090 halogenated poly phenyl Aroclor 5468 halogenated terphenyl . Description Oral LD-50 Skin Absorption Skin Irritation Eye Irritation Oral LD-50 Skin Absorption Skin Irritation Eye Irritation Oral LD-50 Skin Absorption Skin Irritation Eye Irritation Vapor Inhalation Oral LD-50 Skin Absorption Skin Irritation Eye Irritation Vapor Inhalation Oral LD-50 Skin Absorption Skin Irritation Eye Irritation Vapor Inhalation Oral LD-50 Skin Absorption Oral Toxicity Skin Absorption Skin Irritation Eye Irritation . Oral Dosage . Skin Absorption Skin Irritation Eye Page. 11 of 58 PCB-ARCH-EXT0379270 Study Number BT-62-00-4 Laboratory IBT BT 67-0012 IBT BT 67-0012A IBT BT 67-0012B IBT BT-69-0033 IBT BT-71-001 IBT BT-72-0129 IBT Page 3 INDUSTRIAL BIO-TEST LABORATORIES, INC. AROCLOR STUDIES Author Completion Date . Polychlorinated Teiphenyl Product Description Richard J. Palazzolo 3/28/63 .Aroclor 5460 halogenated terphenyl . Subacute dermal toxicity in rabbits Claude Wolf 10/18/67 Aroclor 5460 . halogenated ter-~ phenyl 90 days subacute oral toxicity Greenie Jackson 12/18/67 ; . Aroclor 5460 halogenated terphenyl Chicken toxi city study . Greenie Jackson 7/11/67 Aroclor 5460 halogenated ter- phenyl _ _ Egg hatchability and chick viability study Carmen Mastri 6/13/69 . Aroclor 5460 halogenated , terphenyl 96 hr. LC-50 Carmen Mastri 3/25/71 Aroclor 5442 halogenated ter phenyl Oral LD-50 . Dermal LD-50 Eye Irritation Skin Irritation Vapor Irritation John Hamlin 1/12/72 Aroclor 5432 Aroclor 5442 Aroclor 5460 terphenyls 196 Hr. LC-50 EX P-2836 Page 12 of 58 PCB-ARCH-EXT0379271 Study Number BT-72-130 Laboratory IBT BT-72-0132 BT-72-0137 IBT IBT Author Dennis Yost Completion Date 1/31/72 Polychlorinated Teiphenyl Product Aroclor 5432 terphenyl . Bruce R. Burtner Philip S. Smith 1/31/72 4/28/72 Aroclor 5442 halogenated terphenyl Aroclor 5432 Aroclor 5442 terphenyls Description 90-Day subacute oral toxicity study in beagle dogs 90-Day subacute oral toxicity study in dogs 90-Day subacute oral toxicity study in rats EX P-2836 Page 13 of 58 PCB-ARCH-EXT0379272 ' "__ - _ , Study Number . Laboratory SA-1 Scientific Associates SA-3 Scientific Associates TERP HENYLS SCIENTIFIC ASSOCIATES AROCLOR STUDIES Author Completion Date . Polychlorinated Teiphenyl Product Fred M. Younger 9/4/53 . Aroclor 5460 ' terphenyl , Fred M. Younger 9/9/53 Aroclor 5460 . chlorinated ter- phenyl 60%* Description Skin Irritation. Skin Irritation . Chloracne Potential YOUNGER LABORATORY STUDIES.AROCLORS AND AROCLOR BLENDS Y-62-43 Y-62-45 Y-62-45 Y-62-48 Younger Lab Younger Lab Younger Lab Younger Lab Fred Younger Fred Younger Fred Younger Fred ; Younger 7/17/62 7/5/62 7/13/62 5/1/62 Y-68-64 Younger Lab Y-68-87 Younger Lab . . * Percent Shown for Blends. . . Fred Younger Fred Younger 5/27/68 8/8/68 . Aroclor 2565 halogenated terphenyl Aroclor 5442 halogenated terphenyl 60%* chlorinated . (same as Aroclor 5460) Benzal SD (Aroclor 5442) halo genated terphenyl Aroclor 5460 halogenated terphenyl 60%* MCS 706 Aroclor 5460 , . 38.5%* ' . Oral LD-50 Skin Absorption MLD Oral LD-50 . Skin Absorption Oral LD-50 Skin Absorption Oral LD-50 Skin Absorption Skin and Eye Irritation Vapor Inhalation Oral LD-50 Skin Absorption Skin and Eye Irritation Vapor Inhalation EX P-2836 . Page 14 of 58 PCB-ARCH-EXT0379273 Page 2 Study Number Y-70-1 Laboratory Younger Lab . Author Melvin Birch Y-70-74 Younger Lab Melvin Birch Y-7.0-114 Younger Lab Melvin Birch Y-70-123 Younger Lab Melvin . Birch Y-70-124 Younger Lab Melvin Birch Y-70-125 Y-70-126 Younger Lab Younger Lab Melvin Birch Melvin Birch Y-71-57 Younger Lab * Percent Shown for Blends. Melvin Birch .' Completion Polychlorinated Date \ Teiphenyl Product Description .2/4/70 Aroclor 5430 . . halogenated ter- phenyl Oral LD-50 Skin Absorption Skin Irritation Eye Irritation. 8/17/70 Aroclor 6062' Aroclor 5460 56%* Aroclor 1221 34%* Oral LD-50 Skin Absorption Skin Irritation Eye Irritation 12/2/70 Aroclor 6037 hydrogenated poly phenyl . Oral LD-50 . Skin Absorption Skin Irritation Eye Irritation Vapor Inhalation 12/30/70 Aroclor 6040 hydrogenated poly phenyl Oral LD-50 Skin Absorption. Skin Irritation Eye Irritation Vapor Inhalation 12/30/70 Aroclor 6050 (halogenated poly phenyl) . Oral LD-50 ' Skin Absorption Skin Irritation Eye Irritation ` Vapor Inhalation 12/30/70 Aroclor 6070 ; (Chlorinated poly phenyl) Oral LD-50 Skin Absorption 12/30/70 Aroclor 6090 halogenated poly . phenyl Oral Toxicity Skin Absorption Skin Irritation Eye Irritation 3/31/71 Aroclor 5468 halogenated terphenyl Oral Dosage Skin Absorption Skin Irritation Eye IrSXV.$4S6 Page 15 of' 58 PCB-ARCH-EXT0379274 Page 3 Study Number BT-62-004 BT 67-0012 BT 67-0012A BT 67-0012B BT-69-0033 BT-71-001 BT-72-0129 Laboratory . IBT IBT . IBT . IBT . IBT . IBT IBT INDUSTRIAL BIO-TEST LABORATORIES, INC. AROCLOR STUDIES Author Completion Polychlorinated Date , Tejphenyl Product Description Richard J. Palazzolo 3/28/63 Aroclor 5460 halogenated terphenyl Subacute dermal toxicity in . .. rabbits ' Claude Wolf 10/18/67 Aroclor 5460 halogenated terphenyl 90 days subacute oral toxicity Greenie Jackson 12/18/67 Aroclor 5460 halogenated ter- phenyl , Chicken toxi city study Greenie Jackson 7/11/67 Aroclor 5460 halogenated terphenyl Egg hatchability and chick viability study Carmen Mastri 6/13/69 Arbclor 5460 halogenated terphenyl 96 hr. LC-50 Carmen Mastri 3/25/71 Aroclor 5442 . halogenated ter- phenyl Oral LD-50 " Dermal LD-50 Eye Irritation . Skin Irritation Vapor Irritation John . Hamlin 1/12/72 Aroclor 5432 Aroclor 5442 Aroclor 5460 terphenyls 196 Hr. LC-50 EX P-2836 Page 16 of 58 PCB-ARCH-EXT0379275 Study Number BT-72-1'30 Laboratory IBT BT-72-0132 IBT BT-72-0137 , IBT Author Dennis Yost Completion Date 1/31/7.2 Polychlorinated . Teiphenyl Product Aroclor 5432 terphenyl Bruce R. Burtner 1/31/72 . Philip S. Smith 4/28/72 Aroclor 5442 halogenated ter phenyl , Aroclor 5432 Aroclor 5442 terphenyls Page 4 Description 90-Day subacute oral toxicity study in beagle dogs 90-Day subacute oral toxicity study in dogs 90-Day subacute oral toxicity study in rats EX P-2836 Page 17 of 58 PCB-ARCH-EXT0379276 BIPHENYLS YOUNGER LABORATORIES TURBINOL STUDIES Study,Number Y-64-7 Y-64-77 Y-66-151 /4-66-163 Laboratory Younger Laboratories Younger Laboratories Younger Laboratories Younger Laboratories Author Completion Date Polychlorinated Biphenyl Product Description Fred Younger 2/13/64 FH-159 Aroclor 1232 68%* Dibromoethylbenzene 32%* Oral LD-50 Oral MLD Skin absorption MLD Skin irritation Eye irritation Vapor inhalation Fred Younger 7/20/64 FH-159 Aroclor 1232 35%* Oral LD-50 Skin absorption Skin irritation Eye irritation Vapor inhalation Fred Younger 10/17/66 MCS 90 Aroclor 1242 37.7%* Aroclor 1232 6% Oral LD-50 Skin absorption Skin irritation Eye irritation . Vapor inhalation Fred Younger 11/9/66 MCS 153 Aroclor 1242 75.35% Aroclor 1232 12.85% Oral LD-50 Skin absorption MLD SCIENTIFIC ASSOCIATES TURBINOL STUDIES SA-(53)-20 SA-(55)-91 Scientific Associates Scientific Associates Fred Younger Fred Younger 1/13/54 . 2/3/55 OS-54 (functional fliud) Oral LD-50 Formula not available* Inhalation studies OS-63 Aroclor 1242 48% Oral LD-50 Skin absorption Skin irritation Eye irritation Vapor inhalation ^Percents shown for blends in which a polychlorinated biphenyl is a component. EX P-2836 Page 18 of 58 PCB-ARCH-EXT0379277 B I P HENYL S Study Number Laboratory Y-73-158 Younger Y-74-53 Younger YOUNGER LABORATORIES, INC. MCS 1489 STUDIES Author Completion Date_________ Polychlorinated . Biphenyl Product Description . Melvin Birch 9/17/73 MCS 1489 Melvin Birch 6/8/74 MCS 1489 Oral LD-50 Acute Skin Absorption MLD Skin Irritation Eye Irritation Vapor Inhalation . Animal Feeding Study Tissue Residue Analyses BTL - 7.4-69 IBT INDUSTRIAL BIO-TEST LABORATORIES, INC. MCS STUDIES - Gary Rausina 1974 MCS 1489 4 Day Static Fish Toxicity Study EX P-2836 Page 19 of 58 PCB-ARCH-EXT0379278 Study Number Y-63-11 Y-63-12 Y-69-41 . 1 B IP HENYL S YOUNGER LABORATORIES INERTEEN STUDIES Laboratory Younger . Laboratories Author Fred Younger Completion Date 3/4/63 Polychlorinated Biphenyl Product Pyranol 1470 . Description Oral LD-50 Skin absorption MLD; skin irri tation; eye irritation; vapor inhalation Younger Laboratories Fred Younger 3/4/63 Inerteen PPO . Oral LD-50 Skin absorption MLD; skin irritation; eye irritation; vapor inhalation Younger Laboratories Melvin D. Birch 5/5/69 MCS 900 Aroclor 1242 30% * Oral LD-50 Skin absorption Skin irritation Eye irritation * Percents shown for blends in which a polychlorinated biphenyl is a component. EX P-2836 Page 20 of 58 PCB-ARCH-EXT0379279 Page 1 Study Number v/btL 72-0036 B I P H E"-N Y L S INDUSTRIAL BIO-TEST LABORATORIES, INC. SANTOWAX STUDIES Laboratory Author Completion . Polychlorinated Date Biphenyl. Product Description IBT \ John Rice 5/24/72 Therminal 88 4 Day Fish Toxicity Study . EX P-2836 Page 21 of 58 PCB-ARCH-EXT0379280 Study Number Laboratory / Y-62-34 Younger " Laboratory v/ Y-62-35 Younger , Laboratory V Y-62-36 Younger Laboratory v Y-62-41 i/y-62-52 Y-62-94 Younger Laboratory Younger ' Laboratory Younger Laboratory 17 Y-63-61 ' . Younger Laboratory . *Percents shown for blends. YOUNGER LABORATORIES THERMINOL STUDIES Author ` Completion Date Polychlorinated Biphenyl Product Description Fred Younger 6-19-62 Aroclor 1242 trichlorobiphenyl Oral LD-50 Skin Absorption MLD . Fred Younger 6-19-62 Aroclor 1248 Chlorinated biphenyl 4 8 % * . Oral LD-50 Skin Absorption MLD Fred Younger 6-25-62 Aroclor 1254 chlorinated biphenyl 54%* .Oral LD-50 Skin Absorption MLD 6-13-62 Aroclor 1221 . Oral LD-50 Skin Absorption . MLD Fred Younger 6-6-62 Aroclor 1232 Oral LD-50 Skin Absorption Fred Younger 10-29-62 MCS 177 (therminol 77) Oral LD-50 / Approximate Oral LD-50 Fred Younger . ^ 9-4-63 Therminol 77 (MCS 177) ; - ' Oral LD-50 Skin Absorption MLD Skin Irritation Eye Irritation Vapor Inhalation Room Temp. 76 Vapor Inhalation 150 F EX P-2836 Page 22 ' of 58 PCB-ARCH-EXT0379281 Study Number ^Y-64-49 . Laboratory Younger Laboratory Author Fred Younger 17 Y-67-105 i/Y-68-127 Younger Laboratory Younger Laboratory Fred Younger Melvin Birch i/y-69-41 . Younger Laboratory Melvin Birch i/Y-69-42 Younger Laboratory . Melvin Birch /Y-69-50 Younger Laboratory Melvin Birch * Percents shown for blends. -2- Completion Polychlorinated Date Biphenyl Product 6/13/64 MGS 295 halo- . genated biphenyl 10/19/67 1/13/69 (XA-140) Santici zer 1706 Aroclor 1242 20%* CHX 604 5/5/69 MCS 900 Aroclor 1242 30%* 5/5/69 A Functional Fluid Formulation Aroclor 1242 4 0 % * 5/28/69-,. Santicizer 630 Lot EL 9007 HB 40 33%* Description Oral LD-50 Skin Absorption MLD Skin Irritation Eye Irritation Vapor inhalation Oral LD-50 Oral LD-50 Skin Absorption MLD Skin Irritation . Eye Irritation Oral LD-50 1 Skin Absorption MLD Skin Irritation Eye Irritation Vapor Inhalation Oral LD-50 Skin Absorption MLD Skin Irritation Eye Irritation Vapor Inhalation Range Finding Acute Oral Toxicity SkinAbsorption MLD Skin- Irritation Eye Irritation EX P-2836Page 23 of 58 PCB-ARCH-EXT0379282 Study Number i/Y-69-57 Laboratory Younger Laboratory Y-7'2-4-3 Younger Laboratory Author Melvin Birch: Melvin Birch i/Y-72-145 Younger Laboratory Melvin Birch t/Y-72-146 Younger Laboratory Melvin Birch i/y-72-252 Younger Laboratory Melvin Birch -3- Completion Polychlorinated Date Biphenyl Product Description 7/18/69 MCS 9001 (ther- minol FR-LO temp) . ' ' Oral LD-50 , Skin Absorption MLD Skin Irritation . Eye Irritation Vapor Inhalation 3/8/72 v . Therminol 4 4--Lot Oral LD-50 QET 179075 ther- Acute Skin Absorption minol 55 9.5% . Minimal Lethal Dose Skin Irritation Eye Irritation . Vapor Inhalation 8/3/72 Therminol 77 Acute.Oral Minimal (used) from TRW Lethal Dose Systems- . Acute Skin Absorption TSR 43/72 bisphenoxy Minimal Lethal Dose biphenyl Skin Irritation Eye Irritation 8/3/72 Fluidics Alkylate Lot TSR 35/72 1 Acute Oral Minimal Lethal Dose Acute Skin Absorption Minimal Lethal Dose Skin Irritation Eye Irritation Vapor Inhalation 10/22/75 Aroclor 1016 . Acute Oral Toxicity Acute. Dermal Toxicity Acute Eye Irritation Primary Skin Irritation Inhalation Toxicity EX P-2836 Page 24 of 58 PCB-ARCH-EXT0379283 Study Number Y-73-285 Laboratory Younger ` Laboratory Author Melvin Birch n Y-74-53 ' Special Study 7406 ? Y-74-54 * Y-74-55 Y-79-67 < Younger Laboratory Younger Laboratory Younger Laboratory Younger Laboratory Melvin Birch Melvin Birch Melvin Birch Melvin Birch * Percents shown for blends. -4- Completion Polychlorinated Date Biphenyl Product 1/17/74 MCS 1039 biphenyl 26.5%* 6/8/74 .- ' V MCS 1489 6/8/74 Aroclor .1016 Description Acute Oral Toxicity Acute Dermal Toxicity Acute Eye Irritation . Primary Skin Irritation . Inhalation Toxicity Tissue Residue Study Tissue Residue Study 6/8/74 Aroclor 1242 Tissue Residue Study 5/30/79 Santicizer 558 Acute Oral Toxicity Acute Dermal Toxicity Acute Eye Irritation Primary Skin Irritation Inhalation Tcxicity EX P-2836 Page 25 of 58 PCB-ARCH-EXT0379284 B IPHENYLS INDUSTRIAL BIO-TEST LABORATORIES THERMINOL STUDIES Study Number jj1' BTL-62-4 Laboratory . Industrial Bio-Test Lab. Author , Completion Polychlorinated n Date Biphenyl Product R. Palazzolo e John Kay 3-28-63 Aroclor 1254 ' , trichlorobiphehy1 V BTL-69-33 Industrial Bio-Test Lab. Carmen Mastri 6-13-69 M.L. Keplinger Otis Fancher ' . t Aroclor 1242 Aroclor 1254 Aroclor 1260 Aroclor 5460 Toxaphene Technical DDT Halowax 1099 trichlorobipheny1 v/ BTL-7 0-16 J BTL-71-1 Industrial Bio-Test Lab. Industrial BiO-Test Lab. James Stevens Donald Jenkins M.L. Keplinger Otis Fancher 6-4-70 Carmen Mastri 3-25-71 M-L. Keplinger Otis Fancher Aroclor 1242 Aroclor 1254 Aroclor 1260 trichlorobiphenyl Aroclor 1221 MCS 1016 BTL-71-11^ BTL-71-67 Industrial .. Bio-Test Lab. James Plank 9-8-71 M.L. Keplinger Otis Fancher Industrial Bio-Test Lab. Dale Fletcher Donald Jenkins M.L. Keplinger Otis Fancher 6-1^5-71 ' Aroclor 1242 . Aroclor 1242 Lot AK 255 trichlorobiphenyl halogenated biphenyl 5 Description Subacute Dermal Toxicity Toxicity Toxicity Reproduction Residue Acute oral toxicity ' Acute dermal toxici.tv Eye Irritation Skin Irritation Teratogenic Studies Toxicity Reproduction Residue . EX P-2836 Page 26 - of 58 PCB-ARCH-EXT0379285 6 Study Number BTL-71-68 JJj BTL-71-69 BTL-71-70 BTL-71-72 V/' BIPHENYLS INDUSTRIAL BIO-TEST LABORATORIES THERMINOL STUDIES Continued Laboratory Author Completion Polychlorinated Date Biphenyl Product Description Industrial Bio-Test Lab. Sandra Haley 11/1/71 James Plank Paul Wright. ' M.L. Keplinger Aroclor -1-242, \ Halogenated biphenyl Three. Generation Reproduction Study Subadute oral toxicity Industrial Bio-Test Lab. Phillip Smith 11/12/71 James Plank Paul Wright M.L. Keplinger Aroclor 1242 Halogenated biphenyl Two-year chronic oral toxicity Industrial Bio-Test Lab. Bruce Burtner .1/1/71 Dennis Lindberg Paul Wright M.L. Keplinger Aroclor 1254 Aroclor 1242 Aroclor 1260 Halogenated biphenyl Two year chronic oral toxicity Industrial Bio-Test Lab. James Plank 9/8/71 M.L. Keplinger Otis FanCher Aroclor 1254 Halogenated biphenyl Chlorinated biphenyl 54 %* Teratogenic study Percents shown for blends. EX P-2836 Page 27 of 58 PCB-ARCH-EXT0379286 INDUSTRIAL BIO-TEST LABORATORIES THERMINOL STUDIES (Continued) Study. Number Laboratory Author Completion Polychlorinated Date . Biphenyl Product C rM - l l (y BTL-72-32 J BTL-72-35 J BTL-72-59 ^^BTL-72-64 'S BTL-72-82 ^BTL-72-103 Industrial Bio-Test, Lab. Industrial Bio-Test Lab. Industrial Bio-Test Lab. Industrial Bio-Test Lab. Industrial Bio-Test Lab. Industrial Bio-Test Lab. John Hamlin Carmen Mastri John Rice Carmen Mastri Gary Rausina J.W. Goode 5-24-72 Gary Rausina J. W. Goode Kenneth Ebbens Carmen Mastri M.L. Keplinger 11-17-72 MCS 1175 Lot QA-1 . therminol 77 . not available Hi Boiling fraction Aroclor 1260 Aroclor 1242 trichlorobiphen.yl Aroclor 1242 Aroclor 1254 Aroclor 1260 chlorinated biphenyl 54%* *Percents shown for blends. Description 4 day static fish toxicity studies 4 day static fish toxicity studies 4 day fish toxicity studies 4 day fish toxicity studies 4 day fish toxicity studies 4 day fish toxicity studies EX P-2836 Page 28 of 58 PCB-ARCH-EXT0379287 Study Number )/ BTL-72-129 INDUSTRIAL BIO-TEST LABORATORIES.THERMINOL STUDIES Continued B IPHENYLS . . Laboratory Author Completion Polychlorinated Date Biphenyl Product ' Industrial John Hamlin 1/12/72 Aroclor 1221 , Bio-Test Lab. Carmen Mas.tri Aroclor 5432 M.L. Keplinger MCS 1016 Description 4 day fish toxicity studies yBTL-72-131 JBTL-72-133 Industrial Bio-Test Lab. Industrial' Bio-Test Lab. BTL-7 2-134 ' y BTL-72-135 / BTL-72-137 Industrial Bio-Test Lab. Industrial Bio-Test Lab. Industrial Bio-Test Lab. v`BTL-72-138 n vj BTL-72-139 Industrial Bio-Test Lab. Industrial Bio-Test Lab. ^BTL-7 3-7 0 Industrial Bio-Test Lab. * Percents shown for blends. Bruce Brutner 12/30/71 Dennis Lindberg Paul Wright M.L. Keplinger Aroclor 1221 90 day subacute oral toxicity Bruce Brutner Dennis Lindberg Paul Wright M.L. Keplinger 1/31/72 MCS 1016 . 90 day subacute oral toxicity Dennis Arnold Gerald Kennedy M.L. Keplinger 1/13/72 Aroclor 1242 halogenated biphenyl Mutagenic study Dennis Arnold Gerald Kennedy M.L. Keplinger 1/13/72 Aroclor 1254 Mutagenic study chlorinated biphenyl 54 % * Philip Smith James Plank Paul Wright M.L. Keplinger 4/28/72 Aroclor 1221 90 day oral toxicity Dale Fletcher Donald; Jenkins M.L. Keplinger 6/20/72 MCS 1016 - Toxicity Reproduction Residue Dale Fletcher Donald Jenkins M.L. Keplinger 6/20/72 Aroclor 1221 Toxicity Reproduction Residue Dale Fletcher Donald Jenkins M.L. Keplinger 7/7/73 Aroclor 1242 halogenated biphenyl Toxicity Reproduction EX P-2836 Page 29 of 58 PCB-ARCH-EXT0379288 Study Number Laboratory / SA-15 /(/ SA-91 Scientific Laboratory Scientific Laboratory Study Number Laboratory BO-7 9--204 EG & G BIPHENYLS SCIENTIFIC ASSOCIATES THERMINOL STUDIES Author F. Younger F. Younger Completion Date 11-10-53 2-3-55 Polychlorinated Biphenyl Product Aroclor 1254 chlorinated biphenyl 54%* OS-63 Aroclor 1248 48%* B IPHENYLS EG & G BIONOMICS THERMINOL STUDIES Author Completion Date Terry Hollister Peter Shuba Rod Parrish 4-79 Polychlorinated Biphenyl Product Therminol VP1 biphenyl 26.5%* Description Acute oral toxicity LD-50 Acute oral toxicity Skin Absorption Skin Irritation Eye Irritation Vapor Inhalation Description Phyotoxicity Percents shown for blends. EX P-2836 Page 30 of 58 PCB-ARCH-EXT0379289 b;i: P..H .E N Y L s 10 ANALYTICAL BIO CHEMISTRY LABORATORIES THERMINOL STUDIES Study Number Laboratory Author AB-80-205 Analytical Bio Chemistry Labora tories, Inc. Jerry Griffen Carl Thompson Alan Forbis James Ault Lyle Johnson Completion Date________ 5-7-79 Polychlorinated Biphenyl Product Terminol VP1 biphenyl 26.5%* Description Acute Toxicity AB-79-206 Analytical Bio Chemistry Labora tories, Inc. Carl Thompson Alan Forbis James Ault Lyle Johnson 8-14-79 Terminol VP1 biphenyl 26.5%* Acute Toxicity *Percents shown for blends EX P-2836 Page 31 of 58 PCB-ARCH-EXT0379290 BIPHENYLS 11 MONSANTO INDUSTRIAL CHEMICALS CO. THERMINOL STUDIES Study Number Laboratory Author Completion Polychlorinated Date Biphenyl Product Description v/ MO-77-625 Special Study Monsanto Indus . V.W..;,,Seager trial Chemicals P.R. Michael Co. J.P. Mieure 6-8-77 Cereclor 42 Primary Biodegrada tion Ultimate Bio degradation ^MO-77-470516 Special Study Monsanto Indus trial Chemicals Co. V.W. Seager 0. Hicks T.G. Kaley J.P. Mieure 7-22-76 Isopropylated biphenyl Ultimate Bio \(Santosol 340) degradation .. Emulsified biphenyl (MCS 1572) \) MO-77-552-595 Monsanto Indus trial Chemicals Co. V.W. Seager J.P. Mieure *Percents shown for blends. 7-29-76 21 %* Chlorinated ' \i Ultimate Bio- ' biphenyl (Aroclor 1221) - degradation 30%* Chlorinated Primary Bio- biphenyl (MCS 1043) degradation (MCS 1414) . Aroclor 1016 Aroclor 1242 Aroclor 1254 EX P-2836 Page 32 of 58 PCB-ARCH-EXT0379291 . Study Number Laboratory . K-5 0 Kettering Laboratory . ' BIPHENYLS . KETTERING LABORATORY THERMINOL STUDIES Author Completion . :Date Polychlorinated Biphenyl Product 12 ^ Description . . J. Treon 6-22-55 F. Cleveland ' F. Shaffer . . R. Atchley J. Torbeck Aroclor 1242 . Aroclor 1254 hydrogenated biphenyl ' Toxicity of vapor inhalation . . ."V . . ' . ' EX P-2836 Page 33 of 58 PCB-ARCH-EXT0379292 ... Study Number Laboratory Y-62-34 Younger b Laboratory Y-62-35 Younger Laboratory Y-62-36 Younger Laboratory Y-62-41 Younger Laboratory Y-62-52 Y-62-94 Younger Laboratory Younger .. Laboratory Y-63-61 Younger Laboratory *Percents shown for blends. BIPHENYLS YOUNGER LABORATORIES THERMINOL STUDIES Author Completion Date . Polychlorinated Biphenyl Product Fred Younger 6-19-62 Aroclor 1242 trichlorobiphenyl Fred Younger 6-19-62 Fred Younger 6-25-62 6-13-62 Aroclor 1248 Chlorinated biphenyl 48%* Aroclor 1254 chlorinated biphenyl 54%* Aroclor 1221 Fred Younger 6-6-62 Fred Younger 10-29-62 Fred Younger 9-4-63 Aroclor 1232 MCS 177 (therminol 77) Therminol 77 (MCS 177) 1 Description Oral LD-50 . Skin Absorption . MLD Oral LD-50 Skin Absorption MLD Oral LD-50 Skin Absorption MLD Oral LD-50 Skin Absorption . MLD Oral LD-50 Skin Absorption Oral LD-50 Approximate Oral LD-50 Oral LD-50 Skin Absorption MLD Skin Irritation Eye Irritation Vapor Inhalation Room Temp. 7 6 c Vapor Inhalation 150 F EX P-2836 Page 34 of 58 PCB-ARCH-EXT0379293 Study Number Y-64-49 Laboratory Younger Laboratory Author Fred Younger Y-67-105 Y-68-127 ---------- Younger Laboratory . Fred Younger Younger Laboratory Melvin Birch Y-69-41 , --1 Younger Laboratory Melvin Birch Y-69-42. ------ -------- . Younger , Laboratory Melvin Birch Y-69-50 . Younger Laboratory Melvin Birch * Percents shown for blends. Completion Polychlorinated Date Biphenyl Product 6/13/64 MCS 295 halogenated biphenyl 10/19/67 1/13/69 (XA-140) Santici zer 1706 Aroclor 1242 20%* CHX 604 5/5/69 MCS 900 Aroclor 1242 30%* 5/5/69 5/28/69 A Functional Fluid Formulation Aroclor 1242 40%* Santicizer 630 Lot EL 9007 HB 40 33%* -2 Description Oral LD-50 ' . Skin Absorption MLD Skin Irritation Eye Irritation Vapor Inhalation Oral LD-50 Oral LD-50 Skin Absorption MLD Skin Irritation Eye Irritation Oral LD-50 Skin Absorption MLD Skin Irritation Eye Irritation Vapor Inhalation Oral LD-50 . Skin Absorption MLD Skin Irritation Eye Irritation Vapor Inhalation Range Finding Acute Oral Toxicity Skin Absorption MLD Skin Irritation Eye Irritation EX P-2836 Page 35 of 58 PCB-ARCH-EXT0379294 Study Number Y-69-57 Laboratory Younger Laboratory Y-72-43 Younger Laboratory Author Melvin Birch Melvin Birch Y-72-145 Younger Laboratory Melvin Birch Y-72-146 Younger. Laboratory Melvin Birch Y-72-252 Younger Laboratory Melvin Birch -3- Corapletion Polychlorinated Date Biphenyl Product Description 7/18/69 MCS9001 (therminol FR-LO temp) Oral LD-50 Skin Absorption MLD Skin Irritation Eye Irritation Vapor Inhalation 3/8/72 >. Therminol 44--Lot Oral LD-50 QET 179075 ther- Acute Skin Absorption minol 55 9.5% Minimal Lethal Dose . Skin Irritation Eye Irritation Vapor Inhalation 8/3/72 Therminol 77 Acute Oral Minimal (used), from TRW Lethal Dose Systems- Acute Skin Absorption TSR 43/72 bisphenoxy Minimal Lethal Dose biphenyl Skin Irritation Eye Irritation 8/3/72 Fluidics Alkylate Lot TSR 35/72 Acute Oral Minimal Lethal Dose ; Acute Skin Absorption Minimal Lethal Dose Skin Irritation Eye Irritation Vapor Inhalation 10/22/75 Aroclor 1016 Acute Oral Toxicity Acute Dermal Toxicity Acute Eye Irritation Primary Skin Irritation Inhalation Toxicity EX P-2836 Page 36 of 58 PCB-ARCH-EXT0379295 Study Number Y-73-285 Laboratory Younger Laboratory Author Melvin Birch -M . Y-74-53 Special Study 7406 Y-74-54 Y-74-55 Y- 7 9-67 Younger Laboratory Younger Laboratory Younger Laboratory Younger Laboratory Melvin Birch Melvin Birch Melvin Birch Melvin Birch Completion Polychlorinated Date Biphenyl Product 1/17/74 MCS 1039 biphenyl 26.5%* 6/8/74 MCS 1489 6/8/74 6/8/74 5/30/79 . Aroclor 1016 Aroclor 1242 Santicizer 558 * Percents shown for blends. -4- Description Acute Oral Toxicity Acute Dermal Toxicity Acute Eye Irritation Primary Skin Irritation Inhalation Toxicity Tissue Residue Study Tissue Residue Study Tissue Residue Study Acute Oral Toxicity Acute Dermal Toxicity Acute Eye Irritation Primary Skin Irritation Inhalation Tcxicity EX P-2836 Page 37 of 58 PCB-ARCH-EXT0379296 Study Number BTL-62-4 BTL-71-1 B I P H E NY L S INDUSTRIAL BIO-TEST LABORATORIES THERMINOL STUDIES Laboratory Industrial Bio-Test Labk Author . R. Palazzolo John Kay Completion Date 3-28-63 Polychlorinated Biphenyl Product Aroclor 1254 trichlorobiphenyl Industrial Bio-Test Lab. Carmen Mastri 6-13-69 M.L. Keplinger Otis Fancher Aroclor 1242 Aroclor 1254 Aroclor 1260 Aroclor 5460 Toxaphene Technical DDT Halowax 1099 trichlorobipheny1 Industrial Bio-Test Lab. . ; James Stevens Donald Jenkins M.L. Keplinger Otis Fancher 6-4-70 Aroclor 1242 Aroclor 1254 Aroclor 1260 trichlorobiphenyl Industrial Bio-Test Lab. Carmen Mastri 3-25-71 M.L. Keplinger . Otis Fancher Aroclor 1221 MCS 1016 BTL-71-11 BTL-71-67 Industrial Bio-Test Lab. Industrial Bio-Test Lab. James Plank 9-8-71 M.L. Keplinger ' Otis Fancher Dale Fletcher 6-15-71 Donald Jenkins M.L. Keplinger Otis Fancher Aroclor 1242 Aroclor 1242 Lot AK 255 trichlorobiphenyl . halogenated biphenyl . 5 Description Subacute Dermal Toxicity Toxicity Toxicity Reproduction Residue Acute oral toxicity Acute dermal toxicit Eye Irritation Skin Irritation Teratogenic Studies Toxicity Reproduction Residue EX P-2836 Page 38 of 58 PCB-ARCH-EXT0379297 tudv Nuir.ber TL-71-68 IL-71-69 TL-71-70 6 BIPHENYLS . INDUSTRIAL BIO-TEST LABORATORIES TKERMINOL STUDIES Continued . Laboratory .. . Author . Completion Polychlorinated . Date Biphenyl Product Description Industrial Bio-Test Lab. Sandra Haley 11/1/71 James Plank Paul Wright . M.L. Keplinger Aroclor 1242 ^ Halogenated biphenyl ' , V . . . Three. Generation Reproduction Study Subacute oral toxicity Industrial . Bio-Test Lab. Phillip Smith 11/12/71 James Plank . Paul Wright M.L. Keplinger Aroclor 1242 Halogenated biphenyl . Two-year, chronic oral toxicity Industrial Bio-Test Lab. Bruce Burtner 1/1/71 Dennis Lindberg Paul Wright M.L. Keplinger Aroclor 1254 Aroclor 1242 Aroclor 1260 Halogenated biphenyl Two year chronic oral toxicity Industrial Bio-Test Lab. . . James Plank 9/8/71 M.L. Keplinger Otis Fancher Aroclor 1254 Halogenated biphenyl Chlorinated biphenvl . 54 % * '* Teratogenic study Percents shown for blends. EX P-2836 Page 39 of 58 PCB-ARCH-EXT0379298 7 biphenyls INDUSTRIAL BIO-TEST LABORATORIES THERMINOL STUDIES (Continued) Study Number Laboratory Author Completion Date Polychlorinated Biphenyl Product BTL-72-32 BTL-72-35 BTL-72-59 BTL-72-64 BTL-72-82 B.T.L-72-10 3 Industrial . Bio-Test Lab. Industrial Bio-Test Lab. Industrial Bio-Test Lab. Industrial Bio-Test Lab. Industrial Bio-Test Lab. Industrial Bio-Test Lab. John Hamlin Carmen Mastri John Rice Carmen Mastri Gary Rausina J.W. Goode 4-4-72 5-24-72 Gary Rausina J. W. Goode Kenneth Ebbens Carmen Mastri M.L. Keplinger 11-17-72 MCS 1175 Lot QA-1 therminol 77 not available Hi Boiling fraction Aroclor 1260 AroclOr 1242 trichlorobiphenyl , Aroclor 1242 Aroclor 1254 Aroclor 1260 chlorinated biphenyl 54%* Percents shown for blends. Description 4 day static fish toxicity studies 4 day static fish toxicity studies 4 day fish toxicity studies 4 day fish toxicity studies 4 day fish toxicity studies 4 day fish toxicity studies EX P-2836 Page 40 of 58 PCB-ARCH-EXT0379299 Study Number BTL-72-129 INDUSTRIAL BIO-TEST LABORATORIES THERMINOL STUDIES Continued BIPHENYLS Laboratory . . Author Completion Date Polychlorinated Biphenyl Product Industrial Bio-Test Lab. ` . John Hamlin Carmen Mastri M.L.; Keplinger 1/12/72 Aroclor 1221 Aroclor 5432 MCS 1016 8 Description 4 day fish toxicity studies BTL-7 2-1.31 Industrial Bio-Test Lab. Bruce Brutner 12/30/71 Dennis Lindberg n. Paul Wright M.L. Keplinger Aroclor 1221 90 day subacute oral toxicity BTL-72-133 Industrial Bio-Test Lab. Bruce Brutner Dennis Lindberg Paul Wright M.L. Keplinger 1/31/72 MCS 1016 90 day subacute oral toxicity BTL-72-134 Industrial . Bio-Test Lab. Dennis Arnold Gerald Kennedy M.L. Keplinger 1/13/72 Aroclor 1242 halogenated biphenyl Mutagenic study BTL-72-135 Industrial Bio-Test Lab. Dennis Arnold Gerald Kennedy M.L. Keplinger 1/13/72 Aroclor 1254 Mutagenic study chlorinated biphenyl 54 BTL-72-137 Industrial Bio-Test Lab. Philip Smith James Plank Paul Wright M.L. Keplinger 4/28/72 Aroclor 1221 90 day oral toxicity BTL-72-138 industrial . Dale Fletcher Bio-Test Lab. Donald Jenkins M.L. Keplinger 6/20/72 MCS 1016 Toxicity Reproduction Residue BTL-72-139 Industrial Bio-Test Lab. Dale Fletcher 6/20/72 Donald Jenkins M.L. Keplinger Aroclor 1221' Toxicity Reproduction Residue BTL-73-70 Industrial Bio-Test Lab. * Percents shown for blends. Dale Fletcher Donald Jenkins M.L. Keplinger 7/7/73 Aroclor 1242 halogenated biphenyl Toxicity Reproduction EX P-2836 Page 41 of 58 PCB-ARCH-EXT0379300 Study Number Laboratory SA-15 . - . Scientific Laboratory SA-91 Scientific Laboratory BIPHENYLS SCIENTIFIC ASSOCIATES THERMINOL STUDIES Author F. Younger F. Younger Completion . Polychlorinated Date ' Biphenyl Product 11-10-53 Aroclor 1254 chlorinated biphenyl 54 %* ` 2-3-55 OS-63 Aroclor 1248 4 8 % * Study Number Laboratory BO-79-204 EG & G B I P HENY LS ` ' EG & G BIONOMICS THERMINOL STUDIES Author Completion Date Terry Hollister Peter Shuba Rod Parrish 4-79 Polychlorinated Biphenyl Product Therminol VP1 biphenyl 26.5%* Description Acute oral toxicity LD-50 Acute oral toxicity Skin Absorption Skin Irritation Eye Irritation Vapor Inhalation Description Jr- Phyotoxicity *Percents shown for blends. EX P-2836 Page 42 of 58 PCB-ARCH-EXT0379301 10 BIPHENYLS ANALYTICAL BIO CHEMISTRY LABORATORIES THERMINOL STUDIES Study Number Laboratory Author ' Completion' Polychlorinated . Date Biphenyl Product Description AB-80-205 AB-79-206 Analytical Bit) Chemistry Labora tories, Inc. Jerry Griffen Carl Thompson Alan Forbis James Ault , Lyle Johnson Analytical Bio Chemistry Labora tories, Inc. Carl Thompson Alan Forbis James Ault Lyle' Johnson . 5-7-79 I ' 8-14-79 Therminol VP1 biphenyl 26.5%* Therminol VP1 biphenyl 2 6.5.%* Acute Toxicity Acute Toxicity *Percents shown for blends EX P-2836 Page 43 of 58 PCB-ARCH-EXT0379302  * -' B I PHENYLS 11 MONSANTO INDUSTRIAL CHEMICALS CO. THERMINOL STUDIES Study Number Laboratory Author ' :* MO-77-625 ' Monsanto Indus Special Study trial Chemicals Co. V.W. Seager P.R. Michael J.P. Mieure Completion Polychlorinated Date Biphenyl Product 6-8-77 Cereclor 42 Description Primary Biodegrad tion Ultimate Bio degradation MO-77-470 516 Special Study Monsanto Indus trial Chemicals Co. V.W. Seager 0. Hicks . T.G. Kaley J.P. Mieure 7-22-76 Isopropylated biphenyl (Santosol 340) Emulsified biphenyl (MCS 1572) Ultimate Bio degradation MO-77-552-595 Monsanto Indus trial Chemicals Co. V.W. Seager J.P. Mieure *Percents shown for blends. 7-29-76 21%* Chlorinated biphenyl (Aroclor 1221) 30%* Chlorinated biphenyl (MCS 1043) (MCS 1414) Aroclor 1016 Aroclor 1242 Aroclor 1254 Ultimate Bio degradation Primary Bio degradation EX P-2836 Page 44 of 58 PCB-ARCH-EXT0379303 Study Number Laboratory K-50 Kettering Laboratory BIPHENYLS KETTERING LABORATORY THERMINOL STUDIES Author Completion Date Polychlorinated Biphenyl Product J. Treon F. Cleveland F. Shaffer R. Atchley J. Torbeck 6-22-55 - . Aroclor 1242 Aroclor 1254 hydrogenated biphenyl 12 Description Toxicity of vapor inhalation EX P-2836 Page 45 of 58 PCB-ARCH-EXT0379304 * e* Page 1 Study Number BTL-71-1 TERPHENYLS INDUSTRIAL BIO-TEST LABORATORIES THERMINOL STUDIES Laboratory * Author Completion Polychlorinated Date Terphenyl Product Industrial Bio-Test Lab. Carmen Mastri M.L. Keplinger Otis Fancher 3-25-71 Aroclor 5442 Description Acute oral toxicity Acute dermal toxicity Eye irritation Skin irritation , MONSANTO INDUSTRIAL CHEMICALS CO. THERMINOL STUDIES Study Number Laboratory Author Completion Polychlorinated Date Terphenyl Product Description MO-77-470-516 Special Study Monsanto Industrial Chemicals Co. V.W. Saeger P.0. Michael J.P. Mieure 7-22-76 Polychlorinated ter phenyl (Aroclor 5432) Polychlorinated ter phenyl (Aroclor 5460) Ultimate Biodegrada tion Primary Biodegrada tion Study Number BIO-77-328 I LITTON BIONETICS THERMINOL STUDIES Laboratory Author Completion Polychlorinated Date Terphenyl Product Litton D. R. Jagannath Bionetics, Inc. D. J. Busick 12-77 B 0-77-328 CP 2321 . SR terphenyls, mixed isomers Description Mutagenicity Plate EX P-2836 Page 46 of 58 PCB-ARCH-EXT0379305 1 Study Number /btl-70-11 BTL-71-1 'ZBTL-7.2-19 \/ BTL-72-20 TERPHENYLS INDUSTRIAL BIO-TEST LABORATORIES THERMINOL STUDIES Laboratory Author Completion . Date Polychlorinated Terphenvl Product Industrial Bio-Test Lab. Carmen Mastri M.L. Keplinger Otis Fancher 9-11-70 HB-40 (therminal 66) ' .. hydrogenated terphenvl Industrial Bio-Test Lab. Carmen Mastri M.L. Keplinger Otis Fancher 3-25-71 , Industrial Bio-Test Lab. Dale Fletcher Donald Jenkins M.L. Keplinger. 6-26-72 Industrial Bio-Test Lab. Dale Fletcher Donald Jenkins M.L. Keplinger 12-18-72 Aroclor 5442 therminol 66 hydrogenated terphenvl therminol 66 hydrogenated terphe.nyl Description Acute .Oral Toxicity Acute Dermal Toxicz-iy Eye . Irritation Primary Skin Irrita tion . Acute.oral toxicity Acute dermal toxicity Eye irritation Skin irritation 30 day feeding . study Toxicity Reproduction . Residue V BTL-72-21 ' / JBTL-72-34 t ' V BTL-72-36 BTL-72-129 Industrial Bio-Test Lab. M.S. Reyna . . Paul Wright M.L. Keplinger 9-14-72 Industrial John Rice Bio-Test Lab. Carmen Mastri 5 - 2'4 - 7 2 ` Indusrria^ Bio-Tesf. Lab. Industrial . Bio-Test Lab. John Rice Carmen Mastri John Hamlin Carmen Mastri M.L. Keplinger 5-24-72 1-12-72 Therminol 66 ' heat transfer liquid. hydrogenated terphenvl 10 week subacute oral toxicity study therminol 66 4 day static fish hydrogenated terphenvl .toxicity studies therminol 88 .4 day static fish terphenyl, mixed isomer toxicity studies Aroclor 5442 Aroclor 5460 4 day fish toxicity studies EX P-2836 Page 47 of 58 PCB-ARCH-EXT0379306 Study Number , Laboratory ; . . ; 2 . TERPHENYLS INDUSTRIAL BIO-TEST LABORATORIES THERMINOL STUDIES (continued) Author . Completion Polychlorinated Date Terphenyl Product Description ./ BTL-74-74 w/BTL-7 4-8 2. Industrial . Bio-Test Lab. Industrial Bio-Test Lab.. Terry Myers John Goode 2-7-75 Santosol 340 (HB40) hydrogenated terphenyl , . Acute aerosol inhalation toxicity William Brewer 9-20-76 , , Santosol 340 John Goode Florence . Kinoshita M.L. Keplinger 30 day pilot aerosol . inhalation toxicity ' EX P-2836 Page 48 of 58 PCB-ARCH-EXT0379307 Study Number Laboratory , 7/ BN-79-20.4 EG & G TERPHENY. LS . EG & G Bionomics Therminol Studies Author . Completion , Polychlorinated Date______Tdrphenyl Product Terry Hollister Peter Shuba Rod Parrish 4-79 Therminol, 66 hydrogenated terphenyl . 3 Description : Phyotoxicity EX P-2836 Page 49 of 58 PCB-ARCH-EXT0379308 T ER PHENYLS 4 MONSANTO INDUSTRIAL CHEMICALSCO. THERMINOL STUDIES Study Number Laboratory Author Completion Polychlorinated Date Te'bphenyl Product Description . MO 77 625 Special Study . Monsanto Industrial Chemicals Co. . MO-77-470-516 Special Study Monsanto . Industrial Chemicals Co. ' . . . ' . , V.W. Saeger P.P. Michael J.P. Mieure 6-8-77 V.W. Saeger P.O. Michael J.P. Mieure . . 7-22-76 . . ^ Santosol 340 hydrogenated terphenyls . . Primary Biodegrada tion - Ultimate Biodegra- dation 30%* hydrogenated terphenyl (Santosol 300) 40%* hydrogenated terphenyl (Therminol 66, Santosol 340) o,m,p-Terpheny1 (Ther- minol 88)(MCS 1284) , Polychlorinated terph- enyl (Aroclor 5432) Polychlorinated terph- enyl (Aroclor 5460) Ultimate Biodegradation Primary Biodegrada tion : . . * Percents showns for blends EX P-2836 Page 50 of 58 PCB-ARCH-EXT0379309 . TE RP H ENY L S \ . ANALYTICAL BIO CHEMISTRY LABORATORIES THERMINOL STUDIES Study Number . Laboratory Author Completion Polychlorinated ' Date . Terphenyl Product AB-79-135 Analytical Bio ' Chemistry . Laboratories, Inc. Carl Thompson Alan Forbid James Ault Lyle Johnson 7-10-79 Therminol 66 hydrogenated terphenyls AB-79-136 .Analytical Bio Chemistry Laboratories, . Inc. Carl Thompson Alan Forbis James Ault Lyle Johnson 6-7-79 Therminol 66 hydrogenated terphenyls Description Acute toxicity Bioassay Acute toxicity EX P-2836 Page 51 of 58 PCB-ARCH-EXT0379310 Study Number Laboratory ^DA-7 8-184 . DMEH . T E R P H. E N Y L S DMEH .THERMINOL. STUDY Completion Author Date F. A. Kulik W. D. Ross 12-5-78 . 6 Polychlorinated Tferphenyl Product Description HB 40 hydrogenated Mutagenicity terphenyl Study Number V BlO-77 -328 ' I Study Number S K- 4 8 LITTON BIONETICS THERMINOL STUDIES . Laboratory Author Litton Bionetics, Inc. D.R. Jagannath D.J. Busick Completion Date 12-77 Polychlorinated Biphenyl Product Description B 0-77-328 CP 2321 SR terphenyls, mixed isomers Mutagenicity Plate Laboratory Kettering Laboratory KETTERING LABORATORY THERMINOL Studies . Author Completion Date Polychlorinated Biphenyl Product Description S. Withercup H. Schlecht A. Bacon F. Cleveland ' R. Kehoe 4-9-52 HB-40 hydrogenated Oral doses . terphenyls EX P-2836 Page 52' of 58 PCB-ARCH-EXT0379311 Study Number Laboratory i/y-5 7-3 Younger Laboratory TERPHENYLS YOUNGER LABORATORIES THERMINOL STUDIES Author Completion Polychlorinated Date Terphenyl Product 2-13-57 Santowax R terphenyls, mixed isomers j/y-72-249 Younger Laboratory Melvin Birch 10-2-72 Therminol 66 Lot AB10 7 Description Acute Oral Toxicity Skin Irritation Eye Irritation Skin Absorption Vapor Inhalation EX P-2836 Page 53 of 58 PCB-ARCH-EXT0379312 :. * - Study Number Y-60-49 Laboratory Younger Y-62-34 Y-62-35 Younger Younger Y-62-52 Y-66-163 Younger Younger Y-67-105 Y-68-127 Younger Younger BIP HENYLS . 1 YOUNGER LABORATORIES SANTOLUBE STUDIES Author Fred Younger Completion Date 8/6/60 Polychlorinated Biphenyl Product Santolube 830 formula missing Description Oral LD-50 Skin Absorption MLD Skin Irritation Eye Irritation Vapor Inhalation Fred Younger 6/19/62 Santolube 64 Aroclor 1242 Therminol FR-1 . Oral LD-50 . Skin Absorption MLD Fred Younger 6/19/62 Fred Younger 6/6/62 Santolube 65 Aroclor 1248 chlorinated biphenyl 48%* Santolube 63 Aroclor 1232 chlorinated biphenyl 32%* Oral LD-50 Dermal LD-50 Eye Irritation Skin Irritation Oral LD-50 Dermal LD-50 Fred Younger 11/9/66 MCS 153 Turbinol 153 Aroclor 1242 Aroclor 1232 * 75.35% 12.85%* Oral LD-50 Skin Absorption MLD Fred Younger 10/19/67 (XA-140) Santicizer 1706 Aroclor 124220%* Oral LD-50 Fred Younger Santolube 65 Aroclor 1248 Therminol FR-2 chlorinated biphenyl 48%* Oral LD-50 Dermal LD-50 Eye Irritation Skin Irritation *Percents shown for blends in which a polychlorinated biphenyl is a component. EX P-2836 Page 54 of 58 PCB-ARCH-EXT0379313 2 *- ' 4 ' ' * ' .' ' ' .. ' . - ' - ' YOUNGER SANTOLUBE STUDIES (con't) Study Number Laboratory Author Completion PolychlorinatedBiphenyl Date Product Description Y-69-41 . Younger Melvin Birch MCS 900 . Aroclor 1242 30.%* . Oral LD-50 . Skin Absorption MLD Skin Irritation , Eye Irritation Vapor Inhalation Y-69-42 Younger Melvin Birch 5/5/69 Function Fluid Formulation Aroclor 1242 40%* . Oral LD-50 Dermal LD-50 . - Eye Irritation Skin Irritation . Vapor Inhalation Y-74-55 Younger Melvin Birch 6/8/74 Aroclor 1242 Animal Feeding Study Tissue Residue Analyses * Percents shown for blends in which a polychlorinated substance is a component. EX P-2836 Page 55 of 58 PCB-ARCH-EXT0379314 3 Study Number BT 69-33 INDUSTRIAL BIO-TEST LABORATORIES, INC. SANTOLUBE STUDIES Laboratory Author Completion Date Polychlorinated Biphenyl Product Description IBT Carmen Mastri 6/13/69 Santolube 64 Aroclor 1242 Aroclor 1254 Aroclor 1260 96 Hour LC-50 BT 70-16 IBT BT 71-67 IBT BT 71-68 IBT BT 71-69 IBT BT 71-70 IBT James Stephens Donald Jenkins M. L. Keplinger Otis Francher 6/4/70 Dale Fletcher 6/15/71 Sandra Haley James Plank Paul Wright i . M. L. Keplinger 11/1/71 / Phillip Smith James Plank Paul Wright M. L. Keplinger 11/12/71 Bruce Bu.rtner Dennis Lindberg Paul Wright M. L. Keplinger 1/1/71 Santolube 64 Aroclor 1242 Aroclor 1254 Aroclor 1260 trichlorobiphenyl Santolube 64 Aroclor 1242 Santolube 64 Aroclor 1242 halogenated biphenyl Santolube 64 Aroclor 1242 halogenated biphenyl Aroclor 1254 Aroclor 1242 Aroclor 1260 halogenated biphenyl Interpretation Toxicity, Reproduc tion and Residue Study in Leghorn Chickens interpretation Toxicity, Reproduc tion and Residue Study in White Leghorn Chickens Interpretation 3 Generation Reproduction Study Interpretation Two-year chronic oral toxicity Interpretation Two-Year Chronic Oral Toxicity EX P-2836 Page 56 of 58 PCB-ARCH-EXT0379315 j-., INDUSTRIAL BIO-TEST LABORATORIES, ING. SANTOLUBE STUDIES (con't) Study Number Laboratory Author Completion Date________ Polychlorinated Biphenyl Product BT 71-71 IBT James B. Plank 9/8/71 . Aroclor 1242 BT 71-73 IBT James B. Plank 9/9/71 Aroclor 1260 VbT 72-134 IBT Dennis Arnold . 1/31/72 Aroclor 1242 4 . Description Interpretation Teratogenic Study in Albino Rats Interpretation Terotogenic Study in Albino Rats Interpretation Mutagenic Study in Mice EX P-2836 Page 57 of 58 PCB-ARCH-EXT0379316 5 Study Number Laboratory SCIENTIFIC ASSOCIATES SANTOLUBE STUDIES Author Completion Date Polychlorinated Biphenyl Product Description SA 53-0020 T Scientific A M>- Associates Fred Younger 1/13/54 SA-55-0091 Scientific Associates Fred Younger 2/3/55 OS-63 OS-54 K 54-0050 iMO-77-58 8 \ vli>77-589 V /mo-77-591 jf /MO-77-592 V . j/MO-77-59 3 \ KETTERING LABORATORY SANTOLUBE STUDY Kettering Laboratory Joseph Treon 6/22/55 Aroclor 1242 Aroclor 1254 MONSANTO INDUSTRIAL CHEMICALS COMPANY SANTOLUBE STUDIES Monsanto W. W. Saeger 7/29/76 Aroclor 1221 chlorinated Monsanto W. W. Saeger 7/29/76 . MCS 1043 Monsanto Monsanto Monsanto . W. W. Saeger W.W. Saeger W.W. Saeger 7/29/76 7/29/76 7/29/76 Aroclor 1016 Aroclor 1242 Aroclor 1254 Acute Oral Toxicity Inhalation of Fumes Ocular Irritation by OS-54 Acute Oral Toxicity Skin Absorption Skin Irritation Eye Irritation Vapor Inhalation Vapor Toxicity Microbial Biodegradation Biodegradation Studies and Interpretations *Percents shown for blends in which a polychlorinated biphenyl is a component. EX P-2836 Page 58 of 58 PCB-ARCH-EXT0379317