Document RpeX0M9exGOwO4oOVV944mxqa

66 INDUSTRIAL HYGIENE AND OCCUPATIONAL MEDICINE nature; the chief pathological changes were damage of the liver and subserosal hemorrhages. Similar experimental information concerning aldrin and dieldrin is extremely meager. The preliminary work 4 indicates that single doses of 95 to 105 mg. of aldrin per kilogram of body weight may represent Table 1.--Information Concerning Men Examined Subject 1 2 3t 4t 5 6t n 8J 9t 10 11 12 13 14 15. 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 Length of Work, Mo.* 30% 12 12 33 33% 33% 32% 33% 32% 36 12 36 14 37 36 34 36 30 11 35 ... 32 ' 36 30% 16 12 36 30 36 36 28 11% 18% 27 36 Age, Tr.t 23 27 39 26 28 24 31 25 25 34 29 42 26 37 49 40 36 33 24 31 25 48 32 24 32 51 29 85 38 28 28 21 60 29 Area in Which Subject Worked Sales service lab. Operation M-101 Operations chlordan, 118, 497 Operations chlordan, 118, 497 Operation M-101 Operations chlordan, 118, 497 Operations chlordan, 118, 497 Operations chlordan, 118, 497 Operations chlordan, 118, 497 Development lab. Control lab. and plant lab. Control lab. and plant lab. Control lab. and plant lab. Development lab. Plants area Plants area Plants area Control lab. and plant lab. Control lab. and plant lab. Office Office Sales service lab. Bioassay lab. Control lab. and plant lab. Control lab. and plant lab. Office Control lab. and plant lab. Sales service lab. Development lab. Control lab. and plant lab. Sample room Store room Office spaces Control lab. and plant lab. * The average number ot months employed was 28. f The average age of men employed was 82.6 years. t These men are chief operators on rotating shift work, and their duties necessitate working in each of the units mentioned. the LD50 of the material to dogs. Kitselman and co-workers 5 have studied the effect of aldrin on steers, heifers, dairy cows and sheep. They have described degenerative changes in the liver and the kidneys which were uniformly observed in those animals that died from 4. Borgmann, A. R.: Unpublished data, 1950. 5. Kitselman, C. H.; Dahm, P. A., and Borgmann, A. R.: Toxicological Studies of Aldrin (Compound 118) on- Large Animals, Am. J. Vet. Research, to be published.