Document Rpe8Dan1zK1ZQ5OD2VMzBedGn

l d 50 o r a l t o x ic it y t e s t DATE 7.J&6__________________ MATERIAL PHYSICAL APPEARANCE j PA (/Vo,)*___________,________________ ' MR- /o BK.NO. a. PAGE /VV H.NO. <As?9 T.I. CToi/ctr /,0As<Sc.etc.<sr DEPT.___________ DEPT.NO, ALP Jraae me/ka D20_____________________ PH_____ Material given by stomach tube to er*f(?A.P.D #t s in original om e>g as a %* (solution of ( ) active ingredient in c/`s//'/ko MA7'f < ) suspension original sample Date No. Rats Av? Dosed Wt. Dose ma/ka % Sol. Av. Dose (ml) Av. Surv. Time (days) Mort. Ratio S-Hb /o S70 44 00 4.0 % S-Jt 4-3 -r- a.6 >0 & &00 4i 3-s-V >0 37 fo ~&00 Vo 3.S& to 37*. Aa,oo Vo 4. io_ V/a 8//0 J /to Remarks TS /U5 tie A) 0 Uo LD50 - *T79<3<3 me/ke iSK' ^ ^ S/30 ^-440 .Confidence Limits^ = ^ ________mg/kg 4+~S*~*6** ,fA* *V a. 977^/4^ 1. gms/100 ml 2. "A Simplified Method of Evaluating Dose-Effect Experiments", by J. T. Litchfield and F. Wilcoxon, J. Pharm. Exp. Therap., 96i 99 (1949) DUP040002088 (Ut*Pi>aP : 'JAts ^&sz> -jLeSl/ Pit {aJO-^)^. A> ~C>0 O ^ynj/^ 0t**'pA. tcfftCsts it^teP -ZlryUJks -ftn /f/20 0*1 tPi P4> ^ -&U* a*^J -e+uMsL tmf0&*^ ^v? sr^/ty. )W *W A^ -A^V ef S~<ffO &***/ <*5~f6 . At a* &sz> f 3 /$ 0sryvf//^r/y4 'f/zo ^4^ ^ jfb S' jU+**t*r- W MJu +j . t3U*j l v^U-st-^- ^^^tk^/> jfktrt'i &H4sirla&LS zia^cfds &jjut> 0*i<p tsi/~sig s'- <f <^ay^ <*&* A^- ^ * Me&Jt&ts O </ 'i</^i^^ J-^Lc. dPt^f'vPc^P . DUP040002089