Document RpYvGnzvD6yLbgbqnJO1omB5a

Ljonssrta * TO E. P. Wheeler - Medical December f ,, 1968 Aroelors - Minutes of Cur Discuss ion. with Dr. Calandra W. R. Richard WHICH o K. A. Vella - OZLL P-. E. .Heller - RXELL__ H. *7. Johnson"- fccH*' C. Pat or. - CPATC P. B. Hodges - FHODG R. E.'Kelly, H.D. - RKELL s^t^ . - %l believe the following summarises briefly cur discussions 5' ^Friday: . l) Dr. Calandra is tc dose several chicken* with th? /peelers to make available aample tissues fer analysis by Scott Tucker. ' The doses to be used will approach the lethal dose levels. Appropriate tissues and organs will be fressn arid forwarded to St. Louis for analysis. This Is Intended to yield some gross indication of retention sites and levels in fowl.* . : . RWrdfc "Hr?- ** H 4tf <*w uC *CPOO :O 2. Dr'. C lxndra* Is to begin 30-day "range finding* toxicity studies with rats on each of the four Aroelors which have . been seat to him. The purpose Is tc establish levels which ' will be appropriatefor chronictwo-yearstudies.Additionally, * . analysis of excretaand appropriate organs andtissues will provide goes Information as to metabolic pathvrays, retention and/or accumulation and balances (as indicated by -chemical analysis using "cold"., material). . ; : .. , , : . 3) It is anticipated that the long range (tve-year studies) . could be initiated soon after completion of the 30-day studies - ! . within the next CQ to ?0 days. This is not a commitment, : however, to begin the twe-year studies ,,at that time. . ,i . 4) The actual preparation of "hot" material is tc be held in abeyance but exploration as to the availability and cost of tagged material is to be continued and firmed up. | ; j 5) The advisability of determing the character and possibility i of Isolating the"eajor fraction" in each of the Aroelors to | be studied is to be explored. j T~6) It would'be helpful for Scott Tucksr: to obtain appropriate ! ! animal organs and tissues, t** become familiar with the extraction j and analytical techniques using actual specimens. (I have i already arranged with Fred Younger of'. Younger Laboratories for j appropriate specimens from rats with no known exposure to , chlorinated compounds. We will have these by Dec. 12. 'secondly . I have caked Fred to provide us some specimens from some rats which he is currently dosing with one of the Aroelors in a ' ^lubricating oil. Thsaa should be available in about two weeks.) ^Equally important, it will urovide Scott an opportunity to ' look for the C. C. p.-sks imported in the literature. . PRR 022096 SCM 0173IS WATER PCB-00049072 Z. to Wheeler - St. Louis October 22* 296B Polyehlorina ted Biphenyls In the Environment ft V.. K. liebsrd . WRXCS C. Payton - CPATT E. Bergen - HBERO w. X. Johnson - VJOHB H9s.unt a* Attached la a Xerox copy of a technical paper which Scott Tuelcer and X picked up in Washington recently. This waa provided us by Donald A. Spencer of the National Agricultural Chemicals Association. Mr. Speneer requested that the paper ba held "confidential"1 until such tise as it nay be published. Spencer indicated that If this paper were distributed one . of his principal "sources" would refuse to give him prepublica tion information in the future. , , 1 ; j ! Rlsebrough's presentation (the attached) was nads at a masting of 20 to 30 toxlcoleglsta held at the University of Rochester la June. The meeting waa billed as "The First Annual Conference on Toxicology? and was underwritten presumably by the ABC which has had contracts at Rochester for many years. Attendance was by invitation only. . ` ', { The meeting dealt "exclusively" with pesticides with about j one-third of the papers relating to mercury. As far as Spencer j knows the. papers, including the attached, will undoubtedly be .; printed ea proceedings of the conference although X suspect j individual authors were given permission to publish elsewhere. j * | Xa a few words, Rlsebrough has. found PGBs along with chlorinated ! pesticides in a nuaber of species of fish and birds along the . i. California coast as well as In waters off Baja. California and j Central America. He further reports PCB in fish from the ; Channel Islands and Puget Sound. No PCB was detected in the . ; liver of tuna taken In the Oalapagos Archipelago. 'Scott Tucker -s la going to scrutinize the analytical aspects and particularly . ' tbs validity of some of the assumptions mad by the author. mmmr P. WhMlor Attaohaaat V PRR 022097 scm oa?s.i<- WATER_PCB