Document RpYKMggbEQGawrZb6EaBRg2Vk

J * TABLE 1 CHEMICALS OR INDUSTRIAL PROCESSES ASSOCIATED WITH CANCER INDUCTION IN MAN (Derived fra ref. 8, with addition of data on worker exposure fra ref. 19; see also footnotes to Table 3.) Chemical or Industrial Process Main Type of Exposure* Aflatoxins 4-Aminobiphenyl Arsenic ^ compounds Asbestos ^ Environmental, occupational0 Occupational Occupational, medicinal, en vironmental Occupational Auramine (manufacture) Benzene L-" Occupational Occupational Benzidine Bis(chloromethyl) ether Cadmium using industries (? cadmium azide) Occupational Occupational Occupational Target Organs in Man Main Route of Exposur^ Liver Bladder Skin, lung, liver0 Oral, inha lation0 Inhalation, skin, oral Inhalation, skin, oral Lung, pleu ral cavity, g.i. tract Bladder poietic system Bladder Long Inhalation, oral Inhalation, skin, oral Inhalation, skin Inhalation, skin, oral inhalation Pro strate, lung Inhalation, oral Estimated No. of lorkers Expo .ed in U.S d 100 1,500,0009 1,600,000 d 1,900,000 2,200 d 1,400,000 - ucc 30. 057572 Chemical or Industrial Process Main Type of Exposure* Chlorampheni col Medicinal Chloronethyl ethyl ether Oiromium (chro mate producing industries) Cyclophospha mide Diethylstilbestrol Haematite aiaing Isopropyl 1 oil Malphalan Occupational Occupational Medicinal Medicinal Occupational Occupational Medicinal Mustard gas 2-Haphthylanine Michel (oxides) Oil rnaphasine Oxymetholone Phenacetin Occupational Occupational Occupational Medicinal Medicinal Medicinal Target Organs in Man Main Boute of Exposure*5' Estimated Bo, of WOrhers Exposed in O.S Hemato poietic system Lung Oral, injec tion Inhalation d d Lung, nasal cavities6 Inhalation Bladder Uterus, vagina Lung Oral, injec tion Oral Inhalation 1,500,000 (chromium . oxides) d d 19,030 Nasal cavi ty, larynx Hemato poietic system Lung,' larynx Bladder Basal cavi ty, lung Bladder Inhalation Oral, injec tion Inhalation Inhalation, shin, oral Inhalation Oral d d d 1,000 l,4 00,00<f d Liver Kidney Oral Oral d d 057573 Chemical or Industrial Process Hein Type of Exposure* Target Organs in Man Main Route of Exposure* Estimated Mo. of workers Exposed in U.S. ihenytoin Soot, tars and oils Vinyl chlo ride Medicinal Occupational, environmental Occupational Lymphoreti cular tis sues Lung, skin, scrotum Liver, brain, lung4 Oral, injec tion Inhalation, skin Inhalation, skin _______d f 2,200,000 *Tb main types of exposure mentioned era those by which the association has been .demonstrated. Th main routes of exposure given may not be the only ones by which such effects could occur. ^Denotes indicative evidence ot recorded in the survey: exposure very small in all cases except aflatoxins. *Ho. of workers exposed to nickel oxide: only about 230 workers exposed to nickel .carbonyl Exposure very large but not characterized numerically 32 ucc 057574