Document RpV5aDExB665jpLo30YEVewbB

DRAFT FE93-S71 TO~ Mobile Source Task Group FROM: Richard T. Paul, Secretary DATE: September 27, 1993 SUBJECT: 1.0J.1!93 AAMA/API Meetin1 on Benzene A ~i.al meeting of the Mobile source Task Group wlth API's Benzene Task Force ia acheduled as follows: Thurswiy, October 7, 1993, 9:30a.m. AAMA Board Room 7430 Second Avenue, Suite -300 Detroit, MI 4820l AAMA requested~PI consider possible collaborative efforts on improving the sc~entific -Oasis for predicting low-dose benzene exposure and cancer risk assessment. API has for many yean -SJ1(Jn$0red extensive benzene research projects on epidemiology, occupational exposure, _mathematical modeling for Jow-do.se, a.s well as numerous toxicity and mechanistic studies. The objective-of this meeting is to have tech:.-llcal representatives ofboth associations discuss the data, consider common goals and objectives, identify areas for possible collaboration and in general aet to know one another. 1. IoUOducaoo AGENDA 2. API's BBRA Resm;h Representatives of API, which will include lh~ technical benzene committee membm, will describe-their biologically-based risk assessment--modeling effor'\S. Acopy of API'aconsultant draft report will serve u the basis for an interactive discussion. API-is interested in our views on bow knowledge of biological mechanism can guide modeling. ' I ,. - I ........... .....,' ,....r- , ~ ..J ~e BP-00020064 3. GM Biolo&icai Data QD :eenzene Dr. Lee will present, in summary fashion, data on mechanisms of benzene induced pancytopenia, cbutogenic effe<;t-5 and neoplasia and- the implicatiollJ for a threshold dose effect. 4. SW;ific Area for CollaboratiQJ1 This general discussion will identify areas for possible co]aboration consistent with API'a current and future project objectives and AAMA' s goals and effortJ on incorporation of biological data into the mathematical model for benzene induced carcinogenesis. 5. Other Business, Fywre Interaction' and AdiOJimment RTP/ &0' 39\::lc:l -