Document RpN43Z2jZMpN538mxDqqvMObE

Monsanto Monsanto Company 800 N. Llndba>flh Boulevard St. Louia. Missouri 63167 Phona: (314) 094-1000 June 30, 1982 QHEH CtMTHM. BUS w . DMnt*r or motottt a tMVmOHMCMTM. HtAiJH Howard Maibach, M.D. 2745 Larkin Street San Francisco, California 94109 Dear Dr. Maibach: I spoke with you recently concerning the penetration of the skin by PCBs in various commercial formulations. Ve also discussed the question of whether solvents, and in this case particularly solvents in a band cleaner, would enhance or inhibit this type of penetration of the skin by the PCB molecules. I am enclosing a list of ingredients of a waterless hand cleaner, of course there is no quantification of the amounts by the manufacturer. The question is raised as to whether any of these materials would enhance or inhibit tb* penetration of PCBs on the skin, when the reason for using the hand cleaner is to remove the PCB-contaioing materials. Tests done by an eastern electric company showed that this material on rubber gloves would remove PCBs, at least in order of magnitude, better than washing with soap and water. Many electric utilities have a need for a waterless hand clesner to give to their employees that have to deal with PCBs at sites remote from locations where running water and soap are available to wash up after handling PCB-contaminated material. Ve are seeking to see that this material does not have any enhancing effect in skin penetration so that we can recommend it or similarly formulated materials with confidence that it would not adversely effect the rate of absorption in the direction of increasing it. Sincerely /ab cc: J. Craddock Do r ... Director, Occupational Medicine and Epidemiology HONS 003073