Document RpMrNRZojQD3G1VYnKXwg7QM7

f iwwim tax pqlooich icnrra or una mr *t * * to tto t m limit yrntwc imm uo, n* n CCWBB30, U4 il ri 'l l ~ ^ ' iU**- ' >- j * ^ i- ittaa iltti mu# e. mtt, a. o. a. ftutu. i. x. 000191 i \ \ i | Asbestos Litig. Saranac Lake 1989 Depos. Exhibit p.78 %_ ntraorocnci One year ago, oa October 30, 1947, an lnteria report vas submittad, eottrlB| the progress of eertda optrlanti vith Lajlo over i total period of 30 aoatha. It wee accessory t that tloe to reeoasead farther experioento eonsemlng eertela phases of the problem. The preseat report deals with the final phases of the sijisii usat than la progress sad with the early observations node la the asa series of stxistIseats The ariglael crparinsst has see bees completed sad the eooelasiaas drew are based apsa tha resalts of a fall three years' upawri to aa atoaoepberle eoapsaalow of Kayla dost. frevlous experience has shove that this la the re- qaaired period ever vfciah ezpoearea to a dost of doubtful Mologieal activity aut be mrutlunad before final aanelnairas are serrated, this experiment, in feet, eoaatitatee aa ensple ef the letiniiaeee af eaah parolnaged etady for, as is to be ahsaw balev, the fladlags at three years vera strikingly different fra these at tee and nedslf years sad the tentative asnalastaa reashed at that tine nast aov be altered. Thas, at tha tine ef the provisos report, the evldeaes Indicated that Kayla mated ae an inert hast la asnal rate aad gelnee pdga| reealtlag only in tha fernatian ef sliiis ef dnet nlthsnt fibrosis. Braver, It vlll be ahovn below that Kayle is sspshla, an prolsnged Ishslatlna, af prsdnelag asbestoeia la tha longs af galas pigs, aad that it should ha bsndlsd ladaatrlally as a hs- I t j j j | Thia rspsrt will ha inssantsit la tear ssatlms as fallawm B. e. B. -V 00019* 15 Asbestos Litig Saranac Lake 1989 Depos. Exhibit p.79 r \ J \ 4. yinal observations. dust Inhalation la aoraal guinea .gtes StrmaM to the Iaterla Bepert of Ootobor 30, 1947, will rore&l that he groups of aoraal gutaoa pigs van placed la the dust roeau one group In rafcru0x7 194$ &ad tbs secead la August 1945* lbs anlaala wn exposed to itaospneric auaponslons of Xajlo dust for eight hours 4*127, fin sad one-half A.ys a vel throughout ttas experlaemt. Ihs dust concentration, vaich varied soasvtat froa tine to tins, has avengsd lit lilies particles pur euMs foot of sir over the entire ewmu of tho axparlaaot to data. 4 brief ruvlsr of tho obaarvutioas described on pugs 4 of tho previous roi**t sill reveal that up to thirty souths tho reset loo la guises pigs vs 3 Halted to tho aaaailatlua of elsups of aooruphagou, anotalulng dust partleles, la groopo of adjaaeot air apaoaa. BUa oueewtowal eelt.1nneleat.ed giant cells were ouea, there eos ae uoduo prallfuratioa of tlaoao hlotloeytes aad fibrosis veo sbaaot. 4 few aaadstakabls eabertoola bodloo were ldoatlflod. Za general, the aooiilatlon of colls of tho typos duourlbed obese aad their porsloteaeo as such over * full three peer purled, without tho duvulopoout of fibrosis, has been fouad to indicate that tho afoot respeeeihle for thea is aot oapehla of producing fibreala. Suah agoats are acre uoaaldured to bo tdnlogloal 1y iiwrt," slneo tho aero oollalar aauMulatlaa has aot boea shoea to affect pulanaary fsactloa or roslataaoe to dlooaao* Boeeeer, of aloe aoiaale sacrificed subeequoot to thirty Booths la the proseat ezperlaeot, ell have shoea hot oaty the above lesloas but also have devaloped true flbreels of a type oharaoterlstl* of tho raapoaae of gulaoa pigs to aabautoe. this la o rather diffuse typo of fibred* rOlsh feme chiefly about the tall air duets, kaoraa aa bronchioloo, tM which tho air apaeoa, or alveoli, of the lung <5 arise, the appended photealoregrephs shoe the aatare of tho leaioae being dis- euaoed. this f^l**"* la Ideatloal with asbeeteds ae caa be seen by coopering Asbestos Litig Saranac Lake 1989 Depos. -2- Exhibit p.80 L Figure 2 with rigure 3* Tbs lesions la tha tracheobronchial lynpfa nodes shoved no change between thirty Months tod three years. Chsaie-1 analysis of the lungs of guinea pigs that bod Inhaled laylo dost for periods op to 36 oaths yielded the dote given la Table 1. It vill be noted that ee the period of exposore beoeao longer the ash value gradually increased, isdloxtlng ea aecaaalatloa of mloeral natter In the lings. There vat t pro nounced laereaee In the elllee eenpontni op to about 30 soothe and then t slight decrease. The reason far this eeaditloay vhleh has beee observed in experiments with other dusts, is not entirely clear. Since only two solatia were analyzed for eaeh apeim period, individual valnas were oeeatloaslly out of lino bat the general tread vaa alatrly ladlaated. m be final shetreetloaa la this axporiasnt with Keyle Ishalatlon In nonal pigs, reported above and Ulnetreted la tha figures, prove that Kaylo is of prednalng the absrooteristic reaction, ashaetoela. it is evldeat, i, that a considerable portlaa of the eehaetee eeapeaeat la Kaylo ranains the naaafeeteriag prsssss or. If It Is changed, that the altered its eapeelty to aneee fibrosis. VhU# the loti one p-tc 30 i showed ao fibreala, eertala aspects of then wore ooapeUble with e proUn stage la the develepuant of aaheetoele. Theee aspoets were nested by the type of roeotloa to the aeterisle ether then aaheetee la the daat. The early stage of the reattlna to aahsetea la the prsdlleetlca of the fibers te localise la the 1mm sad nail of the aasll air dnete, kaoea aa taralaal Thin is la contrast te partlsnlate notarial*, ahiafc lees\Iso ahlofly o ,Asbestos Litig. Saranac Lake 1989 Depos. Exhibit p.81 000194 in the actual air apaeat, or alveoli. la tho present experiment the gr^ste^t portion of the <fauitt being particulate, lodged la the alreoll sod a&s^ed the perlbrrmohlolar depoeltiaa of torn of tho flhroua component. la retrospect, it la peaalhlo to 11 atari that tharo la aaro erldouee of duat call activity la the ragloa of the bronchiole* thaa la ohareeterlrtle of the raeatlaa to aa Inert partlealate daat. Little elf1 flatnet vaa attached to this at the tlae of the previous report heaaaae there van ao aeidoooe of the deeelopeeat of flbroela. the dlfferaoaeo hatoaeo tho early reeatloo to Kayla and that to aabeatoo ay ho iaterpretod aa o natlfflaollao of the loeleoa hy the partiaulata eaopoaaats of Kaylo. ^aftflaatlao* of alllfala la eoll rrtntnlanl uhao laaiooa of that ill aaaaa develop fdlloalag idakttai of a adaad duat pertaining quarto together n> Zt la of lapartaoao ta aota that ytrlla tho porlhrooehlolar reaotlooa cbCaylo oa aapahla of prodnal iig aabaotoalo, they eoalade the peaelhUlty that it oay aaaao aniooalo, elaee, veer fail three year period, there la la ao --1 aqy foaaa of hyaline aortal*r flferoala eharoeterlatie of tho wetlea to quarts* ItrUMaiaa^ it oay ho added that tho adoli ahov ao type of dlffuao glwrii flab haa haao ohaarred la thia laborHas af dlatameoaoa earth duet. Xa regard to hydrated a ajar oaoatLtoaat af Kayla, it aay ha eald that file la aa palatad ovidense aa ta Ito offaot aa pilaoauy tlaaao, there la to ahov that a variety of all If tea, laalmilag warn few of ealalf allleatea, am hlolagftaolly lairl. Zt aoooa likely fat the avlalje alllwto Iha, tho pooalhllltf fgmsaed ly h*tar Oardaar la hla early oooaldermtloo af thia pmhlea, that fayla alght ymdiaoe toe yaameaeoloaea, aabaatoala aad millcoal*, elth the raaaltaat aafaty haaarde, haa haaa af ipatily atndled, aad Asbestos Litig. Saranac Lake 1989 Depos. Exhibit p.82 . 0Oftt9' UUU1* the letter oaodltloa eaa be di--issed. farther eoneidemtion oust be given to esbestosls, hoveeer. The 1*heritor? hea reeeatly o--pleted e large --euat of work vith ssbeato*, >rikieh has bm reported to eertela ether sappartlaf eaapeaise, hat sot ai yet publl whod. The follsslag discseel-- ef the jnUei 1* drmvn lergeljr fro* that vork, sad ve vould reqaeet that theee Ma*et he e--slderad ooafid--tlel. It ie felt that the foil eeleg lefomeitlee aey he ef eld to the Owens-Illinois heelth departasai la for--latlay a safety pragr-- ehleh certainly ie aeoaesary in elev ef the resolta ef Xayla eayeriaaat* latest--la, hath, la aea sad sal--lef le a shr--le, elsvly developing peri- hreaehlolar fibrosis* felah la lecte stages art--de fin-- the original site of In--11--11-- lata the a--rsaadiag el--all* 9m h--aahlalar lo--11--tl-- is appar ently fee to the fib-- --tarn of the niaaral. fayarla--tel etodiee iadieete that the ehlsf node of set!-- Is hf aeahaaleal Irrltetl-- of ties-- by the fibers. The streets-- ef the-- fibers* aai the --psMllty of rep--ted leagltadlaal divi- sl-- te --1--lsr etr--da,la layertaah la the aeahaal-- of --tlon, sin-- the solid fibers of gla-- seel era aet --pabie ef pradnalny the fibrosis. fihaai--1 aotlsa Is ef little er -- lapartaa-- la --eelng i--tl--, rinoo ehrysotile reo- dered pertlealete by aatilag aai eeperetl-- does --t initiate fibrosis. Certala 1--tlgetlu-- hat-- ladl--ted that a eeeorlngly --gllglble proportion of fltr--s sheet-- ie anfflaflaat ta prods-- the ehareetarlstle r--etloa. Thus, -- laheletl-- aeyarla--t --a serried eat sltk hell--Hied asbestos la feiah -- attaayt see aeda ta ellal--te ell fibers fit-- the --terlal* Zt --e fe--d to he lapoeaihle ta break ay ell ef the fibers ead abash --e per a--t of the sir sa^> peaded dost a--elated ef fSbara* 9m feetoatarialia perllrmiehlnlT fibrosis developed la the wipml sal--le eft-- forty a--the. Ibu, It appears that eery Asbestos Litig. Saranac Lake 1989 Depos. Exhibit p.83 00019 'j aaaU auabaxs of flbora ara eapoblo of producing asbastosia, although tho dewalopasnt of tho lssloaa is delayed. Tho prosoot axpariaant with laylo la also na sx&aple of this foot* tho Important aottor of pngrsssiaa of rsaotloa aftar sxposura to .abaetoa dost eum bos hoot sactoaol--ly in--stlgatad. Tho --suits iadieats that is con trast to aillsesla, whsxo pwpowlao osatlsuss for mm tins, tha-- is no aigaiflaaai dag--o of fngTMcks la aitad of tho laaioon. Xathsr, tho siss of tho 1salons dsffsajaa la hsatosla tea to tho taodsnsy of tho fibrous tiaras to eootrsot oftar tho oil--lao to Its parodootloa is raawl. tho irritation of tisaus ly at aohostoo flhar la aunwUy aifsstod within a fsv onirths aftsr it sntsrr tho lsag hr tho fa--atlas of tho *sohostool o body* (a sooting of tho flhar by ironoeotalalag Qatarial), with tho --salt that tho existing fibrous tlssao santrsota. thothsr this ouatrostloa ousts a hoaoflalal or dolstsrioos offoot oa lung funo- ffofOrt-- loly, tho stodloo with sabsstop to-- sot as yst aoaplataly alarlflsd tho prohl-- of Its offtot aa sssoslatsd tubsroolmis lafsstioo. It appaan that Kayla ay assart a Slightly -- osshod ad--o Infl-aa aa tho lafsatioa than teas poo asbestos. tta dUTur--ss asy soil bo doo to tha proaooaa of tha eoall amt of iparts la Kayla or pasha-- to sthsr Inoidaotal futon. OQa parpooo of tho stadl-- a-- --iar --y is to clarify this prohlau. C. IntiatlfiHr 1. hpUy toasoso of its aaotaat of -- apgraalabla swat of fibrous hyoHlt( is aapablo at prodaolag osbaatoala sod should to 2* Kayla doss aot prodaos slllaosls la solasIs. Asbestos Litig. Saranac Lake 1989 Depos. Exhibit p.84 oooi9; it: V r V 3. Inylo dose net prodn-- tea diffuse eallular fibrevia of tb# lungs new meognlied ns rssoiling from Inhalation of diet- 0. Process Rsport m ns* series of wrlnsats. tea three {bases of tbs cpcl --1, ss sellInert in tbs report of October 1947 and in s loiter dated Mu* 3, 1948* aro aov water on/. Vhils litUo of alguiflst-- has dsselepad tens far, a rswisw of ten eark is presented bars. Progress and respite to dote of teas# trpsrlneats aro glean below uniter tha J Mth boCoxo 1 ori la tho test roes* It the preheat tiae the first two psapt tun bm plto*d la Uw teat roaa| tt* third is to go In on OsssabT 15, 1948. nty t <--< of ttaa first troop has* bee* oaerlfieed as yet, after te* agate la tea test* Hlaroaseple observations has* not bB Mte, bat la tha gross, tbs liilns wn tsoptnbls vith those la control (3) te affost of ted tqrla la ths loafs oa a sabasinset tuberculous fttvbr aasasl (aiaaa pifi 190, sad ea h|ut 12, 190 basllli* five salsals vast of test Zsslsas la the glased la the test room oa Hay 12, vlth the attaaastod taberel* at this tla* for abasioal oaalysls , Coatrel aalaala *r* infested oa rsssatly, tv* aoatha after lafsstlaa. I saatral galea!s vers eosgarehle, rasalts te tete la this mt little alas* the la a te tea late!sties of test of m te , it m to sal* that ths sai that v* uttol^to aoas of ths is dsh later- fend vith 1 latorjnUtlsa of ths yswlaaa sspsHesat la te tha offset S iMfIs Asbestos Litig. Saranac Lake 1989 Depos. Exhibit p.86 00019S 00S2u0 Asbestos Litig Saranac Lake 1989 Depos. Exhibit p.87 ' tJ- ' r* r 0OO2Cir I Asbestos Litig. Saranac Lake 1989 Depos. Exhibit p.90 A. T--" n. 5 00020., -13- Asbestos Litig Saranac Lake 1989 Depos. Exhibit p.91 sm Eu Tbl 1 irju.rura rj lu*os 07 suim nios ZXPOCVD TO con IV ix&iurioi szpanon ~rra jutlo cost