Document Rp83zLvx2nD64QoqJYEajMwdB

>..R i..\ G/.iG/r-; jgv.v .>'ao/.go;.; 'Tvfi d:: ?o.j .\ i:?;-'".:; br.-v for X'; .:;:: ' aini^r or good 010; r!'H.GUG '/Oil*.'..lOl'.OIL .I L1.V'W 1; so:.:j liniiCTia: ocioo-rTb o:.o c,,.Ai'iii oir-k !) c -:::: .5 i yy.yir o:: ao:m o;^ J^rtTlG by Dr P. S. r I' z (Consult-yut) O'.f-V Aliphatic hydrocarbons are usually considered to be a s inert biochemically as they arc chemically (Uil'JLiar.iu, 1959). ho info:ration is availabls on the metabolism of ingested hexane, but of the little hexane absoy.;! on inhalation most appears to be ecoxcreici unchanged through the lungs art perhaps a little appears in the urine (Sstler, 1939). Acute toxicity Animal Route ^100 mg/kg bedyweighfc _ Reference rat i.p. (at 8C) 4 ooo i.p, (at 26 C) 9 ICO i.p. (at 36C) 530 Koplirger ot el., 1959 Keplinger et al.,- 1959 K&plinger et al., 1959 0.2 ml hexane, '.'hen aspirated by the anaesthetised rat produced convulsions and death vithin a few seconds. Cardiac arrest, respiratory pa.- .lysis and asphyxia occurred (Gararde, 1963). Kexar.e is only a weak anaesthetic' but paralyses the respiratory centre before the spinal reflexes are abolished. It is irritant to skin and mucosa. Acute poisoning in ran leads to1 excitement, delirium, hallucinations, tremor, acrocyanosis and addiction also occurs (Es-iler, 19310. Inhalation of 5000 ppm for 10 minutes caused dizziness and giddiness in man (Fatty, 195d). The U.S. FDA has set a limit of 25 ppm hexane in spice oleoresins. The IVL 3;: 500 ppm (Tatty, 1958), Tbe 1c?uj5 of tills decucri.uit done out eo.mtitcta forrncl pi_U;,'.a; hr'n. It rheu.c oat by roulswod, Rt5tiact;.d cr c; .cP.J without th* c.yzvn'^nX of ttio World fl'alth Ore."istion. Aulhom r.lono an rotpons'Wo far views ovproi-' d In cicnod article. Co dscu^rsoru no c Utuo pa* unr '.ib'cation. II no doit f.U;C IVri'aucun oor:\j .* rendu ou rbsii.nd ni d'aucimo c.-i.lon f-.r.ns I'auto.-isation do I'OrcaniJation Mondi-h. r.' n Cantd. hs op'ninns exprimes dans ler, a. licles Gign*ia n'oiyingont quo laura outours. ASI 00004253 iaV^A/7fl.V; U) iiLilu.:,.' I_- U _ybxieu !'c:io available. Frol an ax;. lull fLailon causes cxvai.c -.lly nnnc.vbn and nephron- thy In and mis. Iny: r; l! eu of G.!> * 1.0 co/'-] into anivals also lo\ .as the I3C and causes oryhhrobiauvusis (ishlc-r, 19 3-'). Sniff -'Id hone ovail.al.'lc:. Soso: studios Seven-1 ot'.v'ior ha;-. ter:, uricr-la.hm `h-- d<->ter:.bu i f.o a~oua!;. of polyeyci is a ron.2 tic hydrocarbons In hexane as these f. .. any have cuvoinofy sic activity . Sons sanplos have I': vi shun to h-vo 1ess tixr 0-01 ran, i.e. tb? liaj.t of the sensitivity of t:v r.aJ hod of ar.'dLysis (Ryder and Sullivan, 1962). bat hexane derived fro:.: crackia^ proconscc x--.y contain tracea (Tv.e ct al., lrr .-). Other invest: pnt.ors have found 0.023 pp." of 3 s 4- baxp-yrira-- (Lijincfcy a:.:. Raha, lSGl). But polycyclic arxv.Iic hydropcu:; have tex-n S nr. acted in such natur'l products as cold preened olive oil to an extent of 0.01 - 0.026 run (Jury and 1.0rand. 1962) and in other crude untreated oils fro:?. 0.0022 - 0.0107 pp:.i (Orix, it and Kildebrandt, 1967). References Pattr'3"l^>'\S,fhhd-h.(h,'1): ****. apjl. Kw.col., % 469 Ryder! I/O.* andTsui: i^pS lye, P.,, Barton. J Si. bL^A Arch. Environ! Kith!,-if j TxicGl^^Illtor"'-;if^ce, bev: York flt/h **; S- 32, *3 ' 1j" 1` "* ',esl0:' norwn, A. (1966), I'rlll.iis, .-4.. (1959), 3Gno::iontion Eechnnisns, Chapirnn -1 Hnll, Lonion t- pySI 000042&4