Document Rp4jLEzrV3Z7Mn3XkwgvLJZv8

PR5NTS User :018446 05nov85 P08 1 _________________ DIALOG (VERSION 2)_________ DIALOG File 153: MEDLINE - 73-79 * - ">0) R&s 139785 1850993 79325993 Health effects of vinyl chloride. Tamburro CM Tex Rep Biol Med .1978. 37 p!26-AA. M6-5I. ISSN OOAO-A675 Journal Code: VMN Languages: ENGLISH Journal Announcement: 7911 Subf He: INDEX MEDICUS Vinyl chloride Is a basic chemical for plastics manufacturing and has been used as an anesthetic agent. Vinyl chloride's previously unknown carcinogenic capability appears to be related to the body's ability to convert it from a non-toxic or minimally toxic chemical to a toxic and. with prolonged exposure. cancer-forming agent. Early exposure in animals causes body cells to make adaptive changes which may prepare them tor ma1Ignant transformation and appear to precede evidence of morphological Injury. These findings appear to occur before a low-grade chemical injury occurs. Vinyl chloride chemical Injury in man appears to follow the Same pattern. Present clinical data in humans now demonstrate evidence of pre-cancer Injury and cancer transrormatI on of various types of cells in different organs of the body. Manifestations of pre-cancerous injury to organs other than the liver (such as ttie lung, heart. spleen, brain and lymphatic system) may also be occurring and require further Investigation. Early detection of these pre-cancerous chemical Injuries requires a prospective ongoing system of surveillance and the development of diagnostic methods which can Identify specific causal agents in the presence or non-specific injury. Such a systematic approach has been developed and is now in operation. Its Initial achievements appear to be the foundation for future success in controlling the health effects or industrial chemicals. Tags: Animal; Human; Support, U.S, Gov't, P.H.S, Descriptors: *Angiosarcoma--Chein Ica1 1y Induced (Cl); Carcinogens, Environmental; Environmental Exposure: Health Education: `Liver Neoplasms--Chemically Induced (Cl): Lung-*Drug Effects (DEI: Neoplasms, ExperimentaI--Chemlea I 1y Induced (Cl); `Occupational D 1 seases--ChemIcaI 1y Induced (Cl) Rats; Risk; Spleen--Drug Effects (DE): 'Vinyl Ch1 or 1de--Adverse Effects (AC): Vinyl Ch1 oride--MetaboHsm (ME): `Vinyl Compounds--Adverse Effects (AE) I 7 320 1G 791070IG Environmental pollutants and the epidemiology of cancer, I lea t h CW Jr Environ Health Perspect .Dec 1978. 27 p7-!0. ISSN 0091-G765 Journal Code: EIO Languages: ENGLISH Journal Announcement: 790G Subfile: INDEX MEDICUS Cancer etiology Involves the interplay of genetic and environmental factors. Striking geographic differences and changes In cancer Incidence over time have led epidemiologists to tnfer^that probably the major etiologic component is environmq^^Bl Recent experiences with vinyi chloride, kepone. O10556 I tem PAGE : 1 of 18 30 and po1ybrominated biphenyl illustrate the problems involved In epidemiologic studies of proven or suspected nnvi I'onmrnta 1 carcinogens. While epidemiologic studies will continue to be an essential means for monitoring potential human risks, the long latent periods involved in human carcinogenesis severely limit the usefulness of such approaches for disease prevention. While in vitro and animal test systems can novel fully supplant human studies, they represent our only means for detecting potential carcinogenicity before human exposure Isas become widespread or long established. Tags: Animal: Human Descr i p t or" s : Ang i osarcoma--Chem i ca 1 1 y Induced (Cl): Carcinogens, Environmental: Epidemiologic Methods: kepone--PoiSoning (PO ) : Liver Neop1 asms--Chemica1 1y Induced (CM: ' Neop I asms--Chem i ca 1 i y I nduced (CM; Meopi asms--Occurre nce (DC): Occupational Diseases--Chemica11y Induced (Cl); Po1ybromobiphony 1 Compounds--Poisoning (PO 1 ; POLY6R0M0BIPHENVL CPDS--Poisoning (PO ) : United States: Vinyl ChI oride--Poisoning ( PO ) 1722AG3 79097A63 Survey of mortality among employees engaged in the manufacture of styrene and polystyrene at the BASF Ludwlgshafen works. Frontze1 -Bevme R; Thiess AM; Wieland R Scand d Work Environ Health .1978. A Suppl 2 P231-9. Journal Code: UEB Languages: ENGL ISH Journal Announcement: 7905 5ubf i le: INDEX MEDJCUS A mortality survey Of 1.9G0 employees currently or previously exposed to styrene at work has shown that the observed number of deaths from cancer or other causes Is no higher than the number expected in the German populalion or in a group of BASF employees. Analyses of deaths occurring after a minimum period of five years in groups exposed for different durations (5 vears. 10 years. 15 years, more than 15 years) indicated no increase in mortality with exposure time. This latter observation also applied to malignant tumors: therefore it may be inferred that prolonged exposure to styrene is not a cancer hazard. Tags: Human; Male Descriptors'. Adolescence: Adult: Age Factor's; Aged; Chemical Industry: Envi i onmonta I Exposure; Ccrmnny. West: Middle Age: Mor t a 1 i t y; Neop1 asms - -Mor t a 1 ity (MO ) ; Occupa tiona1 Medicine Po I ys t yrenes - - Po i son I ng ( PO ) : Prospective Studio*;; `S I yrenes--PoiSoning (PO1: Time Factors; Vinyt Ch1 oride--Poisoning (PO1 1G93929 790G8929 Vinyl chloride and pulmonary cancer [letter] Wagoner Jk J Environ Pathol Toxicol .Jan-Feb )978, I (3) p3G1-2. (con t. nex t page 1 if I* ' :VAU**N iiv'i; f r- >U' PRINTS User:O18446 O5nov85 P08 1 : PR 1/5/ALL DIALOG (VERSION 2) DIALOG File 153: MEOLINE - 73-79 R&S 139 Journal Code: I1L Languages: ENGLISH Journal Announcement : 7904 5ubf ile: INDEX MEDICUS Tags: Animal; Human Descriptors: +Lung NeopI asms --Chemica11y Induced (Cl): 'Vinyl Chi oride--Adverse Effects CAE): `Vinyl Compounds--Adverse Effects (AE); 'VINYL CPDS--Adverse Effects ( ae ) 1548347 78183347 Identification and reduction of carcinogens in the respiratory environment. Hoffman D: Wynder EL ZentralbI Oakterlol [Orlg B] ,Mar 1978. (2-3) pi 13-35, ISSN 0300-9661 Journal Code: Y53 Languages: ENGLISH Doc Type: Review Journal Announcement: 7809 Subfile: INDEX MEDICUS Epidemiological studies have implicated three factors in the overall increase of lung cancer--tobacco, especially cigarette Smoking. urban pollution and. to a lesser extent, certain Industrial respiratory environments. Some data were discussed on carcinogenic industrial Inhalants, and on the possible effect of urban pollution. The reduction of pollution and that of specific environmental agents Is stressed. Laboratory studies on the identification or carcinogens in cigarette smoke and their reduction toward the "less harmful cigarette" represent a part of this aspect. (58 Refs.) Tags: Human; Support. U.S. Gov't. P.H.S, Descriptor's: `Air Po 1 1 u t 1 on--Prevent i on and Control (PC); Asbestos --Adverse Effects (AE); Automobile Driving; Benzene--Adverse Effects (AE): 'Carcinogens. Environmental --I- ssI a tI on and Purification (IP): Coal tar - - Adverse Effects (AE) ; BIs(ChIoromethy I) Ethei----- Adverse Effects (AE); Germany, West ; Hydrocarbons--Adverse Effects (AE); Occupational Medicine: Industrial Waste--Prevention and Control (PC): Lung Neoplasms--Chemica11y Induced (Cl): Nitrosamines--Adverse Effects (AE): Smoking; Socioeconomic Factors: United States; Vinyl Ch1 oride--Adverse Effects (AE) 1533828 78168828 Mutagenic and carcinogenic risks associated with halogenated olefins. Infante PF Environ Health Perspect .Dec 1977. 21 p251-4, ISSN 0091-6765 Journal Code: EIO Languages: ENGLISH Journal Announcement: 7809 Subfile: INDEX MEDICUS Receht experimental evidence indicates that structural analogs oT vinyl chloride namely. vinylidene chloride and trichloroethylene, are mutagenic. Carcinogenic response also has boen^^observed In experimental animals following exposure to vj^^Mdene chloride, trichloroethylene, arid 0 10557 I tem page A of t9 30 perch 1 oroe t hy 1 en<->, Mom repent observe t ions demonstrate low- level vinyl chI or i de- induced mammary carcinoma. An additional chlorinated olefin, chloroprene, lias demonstrated a mutagenic response in several test systems. Likewise, several studies have indicated significant excesses of chromosomal aberrations as well as adverse effects on reprodnet i vo function f oI lowing male exposure to ch1 oroprone. Although reports have indicated an increased incidence of lung and skin cancer among workers occupationally exposed to chloroprene, adequately designed studies have not been carried out which would allow the development of valid inferences regarding its carcinogenicity. The question facing the scientific community and society is whether observations In subhuman species are adequate to institute prvident public health practice by controlling these agents as carcinogens or mutagens or whother, once again. epidem i o1 egic onumerat ion of the toll will bo required. lags: Animal: female; Human; Male Descriptors- AngIosarcoma--ChemicaI 1y Induced (CM; Chromosome Aberrations: Environmonta 1 Exposing: 1 Hydrocarbons. Ch1 orinated--Poisoning (PO I ; Hydrocarbons. ChI orinatcd- -I ox i c - i ty (TO); Liver- Neop 1 a sms - - Chem i ca 1 1 y Induced (CM: Lung Noop 1 asms --Chemica1 1y Induced (Cl); Mammary Neoplasms. E xperimen t a 1 - -ChemicaI 1y Induced (Cl): Mice: 1 Mu t a t i on - - Drug E f f ec t S ( DE ) : Neop 1 asms - - Chem i ca 1 I y I nduced (CM: ' Occupa t i ona 1 D i seases --Chem i ca 1 I y Induced (CM; Rats: Reproduction--Drug Effects (DE): Risk: 5k in Neop1 asms--Chemica1 1y Induced (CI); Vinyl Chi oride --Tox i c i tv ( TO ) 1453887 78088887 Mortality among employees of PVC fabricators. Chiazze L Jr; Nichols WE; Wong t) J Occup Med .1977 Sep, 19 (9) p623-8. ISSN 0096-1/36 Journal Code: JFR Languages: ENGLISH Journal Announcement: 7805 SubTile: INDEX MEDICUS A cross - sectiona1 mortality study of 4, 3A I deaths occurring among current and former employees of 17 P V C fabricators during 1964-1973 is presented. The objectives are: (1) to identify any angiosarcoma deaths among the employees of these fabricators. and (2) to examine the distribution of deaths by cause. No angiosarcoma deaths were found among the studs' group. Sex - race - cause - specifIc PropertIonate mortality Ratios (PMR's I wore computed, using the corresponding U.S. mortality as the standard. Among white employees, there appears to be an excess in total cancer mortality, particularly that of the digestive system. Observed deaths were found to exceed the expected in cancers of the breast and urinary organs among white females. Deficit mortality was observed in cirrhosis of liver among) both male and female white employees. Tags: Female: Human; Male Descriptors: Adult: Aged: Angiosarcoma--Mortaiity (MO): (con t . npx t page 1 #DIRU if ir' PRINTS User :018116 O5nov85 POQ 1 t PR 1/5/ALL ( i terns 1-30) __________________ DIALOG (VERSION 2)_________ _________ DIALOG File 153: MEDLINE - 73-79 Breast Neop 1 asms - - Chem 1 cn 1 1 y Induced (Cl); Breast Neop1nsms--MortA I Ity (MO); Gastrolntpstina) Neop1asms--Chemic- Ally Induced (Cl); Gastrointestinal Neoplasms--MortAI Ity (MO) Middle Age; *Neop1 asms --Morta Iity (MO); Occupational D1 senses--Chein lea I)y Induced (Cl); 'Occupational DI senses - -Mor t a I I t y (MO ): 'Polyvinyl Chloride--Adverse E f rec t s ( AE); * Pc 1yvIny1s--Adverse Effects (AE); Urogenital Neop1 asms--Chem i ca1 Iy Induced (Cl): Urogenital Neop1 asms--Mor tal i ty (MO) 1386331 78031231 Confidence Intervals and test of hypotheses concerning dose response relations inferred from animal carcinogenicity data. Crump KS: Guess HA; Deal KL 8 Iome tries .Sep 1977. 33 (3) p137-51. ISSN 0006-311X Journal Code: A50 Languages: ENGLISH Journal Announcement: 7803 Subfile: INDEX MED1CUS Confidence Intervals and hypothesis tests are developed for dose-response relations based on dichotomous data from animal careinogonIcIty experiments. The functional form of the dose-response curve comes from the Armitage-DolI multistage careinogenes I s model and involves a polynomial in the dose-rate, with non-negative coefficients. Asymptotic distributions of the maximum likelihood estimators of these coefficients are used to construct confidence bounds on risk at a given dose and on the dose corresponding to a given risk. Likelihood ratio tests Are developed for the presence of a positive dose-related effect and for the existence of a positive slope to the dose-response curve at zero dose. The latter test Is of practical importance since a positive slope of the dose - response curve at zero dose rules out any "lhreshoId-1 1 ke" behavior and would often mean that any concentration low enough to Insure a negligibly low cancer risk (e.g., 10(-6)) would be too low to be economically useful for applications such as food additives. Simulation experiments are performed to provide guidelines for applying the theory. Tags: Animal; Human Descriptors: 'Carcinogens: Dleldrln: Dime thy 1n1trosamine; Dose-Response Relationship, Drug; DOSE RESPONSE RELAT DRUG: DDT: Mathematics; Models, Biological: Risk; Statistics; Vinyl Cli 1 or 1 de 1318155 77223155 Clinical studies of cancer etiology. L 1 FP Cancer ,Ju 1 1977, 10 (1 Suppl) p115-7. ISSN OOOS-513X Journal Code: CLZ Languages : ENGL ISH Journal Announcement: 77 1 1 Subfile: AIM; INDEX MEDICUS Clues causes of cancer ,ln man can be Identified through c 1 I n I ca I^Kervii t ion of patients. Alert practitioners have, 010550 R&S 139787 I tem PAGE : 7 of 20 30 for example. recently discovered carcinogenic effects of occupational exposure to vinyl chloride and of diethy 1st i 1 bpstroI therapy during gestation. Clinical case studies have also clarified the role of host susceptibility in development of cancer. In most instances, validity of initial cl Inical observations was establ ir.brd tv, more detailed epidemiologic and laboratory studies. Clinicians can contribute to careinogenesis studies by being alert to causes of cancer in their patients. and by referring exceptional observations to clinical epidemio1ogists and basic scientists for further' study. Knowledge of risk factors can be applled to cancer prevention and early detection. Tags: female: Human; Male Descriptors' AdenocArcinoma --Chemica1 1y Induced (Cl): Angiosarcoma-Chemica11y Induced (Cl): Ataxia Telangiectasia-- - Comp I i ca t i ons ( C.0 I ; Ataxia T e I ang I ec t a s i a - - T am i 1 i a I and Gei ietic (TGI; Ataxia Telang1ec tasia--Radiotherapy (RI ) ; Chromosome Aberrations: D i etby Isti 1 bostro1 --Adverse Effects (AE); DNA Repair--Radiat ion Effects (RE): Liver Neop I a sms - - Chem i ca 1 1 y I noticed (Cl); L ymphoina - - E t i o 1 ogy ( E I ) : Lymphoma --Eami 1 ia I and Genetic (TG); MaternaI -FetaI Exchange; ' Neop 1 asms - - E t i o 1 ogy (F.T); Pregnancy: Radiation Tolerance: Vaginal Neop1 asms--Chemicai1y Induced (Cl): Vinyl Ch1 oride--Poisoning (PO) 130IQ73 77206073 Validity and limitations of long-term experimentation in cancer research. T oma tis L I ARC 5ci Pub) .1977. (16) p299-307. IS5N 0300-5038 Journal Code: GEU Languages: ENGLISH Journal Announcement: 7710 Subf i le: INDEX MEDICUS Tags: Animal: Human Descr iptors: 2 - Acety1 aminof1uorene--Toxici ty (T01: Aminos--- Toxicity (10); Bladder Neop1 asms--Chem|ca1 1y Induced (Cl): 'Carcinogens. Environnienta 1 --Toxicity (TO): D i ch 1 oroe t liy 1 encs - - - Tox icily (TO): Bis(ChIoromethy1 ) Ethel----- Toxicity (10); Dose - Response Relationship. Drug; DOSE RESPONSE RELAT DRUG; Lung Neop1 asms --Chemica1 Iy Induced (Cl): NeopI asms --Chemica1 - ly Induced (Cl): NeopI asms--EarniI iai and Genetic (TG): Neop1 asms - - ImmunoIogy (IM); Neoprene--Toxicity (To): Research Design; Vinyl Ch1 oride--Toxic1ty (TO) 1279921 7 7 1819 2 1 Mortality and cancer morbidity in a group of PCV production workers. Byren D: Engholm G: Englund A; Westerholm P Environ Health Perspect .Oct 76. 17 p167-70. Journal Code: EIO Languages: ENGLISH Journal Announcement: 7709 (con t. nex t page) Swedish VCM and IS5N 0091-6765 * ' A Mf r | ' [ I'yif f I* If PRINTS User:018446 O5nov85 P08 1 : PR 1/5/ALL (Items 1-30) OIALOG (VERSION 2) DIALOG File 153: MEDLINE - 73-79 Subfile: INDEX MEDICUS The cohort of workers employed In a Swedish vinyl ch1 or Ide/po1y(vIny1 chloride) plant since Its start in the early 1940's has been followed for mortality and cancer morbidity patterns. Only 21 of the 771 persons could not be traced. Difficulties In establishing exposure levels at different work areas In the past makes an evaluation of dose-effect relationships Impossible. A four- to fivefold excess of pancreas/1 Iver tumors was found. Including two cases later classified as angiosarcomas of the liver. The number of brain tumors and suicide do not deviate significantly from expected. Cardiovascular and cerebrovascular diseases, on the other hand, differ significantly from the expected. The discrepancies between previous reports on VCM/PVC workers and this report are discussed. The possible cardiovascular deaths Is also discussed. Tags: Human etiology of the Descriptors: Accidents. Occupational: 'Chemical Industry: Mortality: Neop1 asms--Morta1ity (MO); 'Neop1 asms--Occurrence (OC); Occupational DIseases--Morta11ty (MO): 'Occupational DIseases--Occurrence (OC): 'Polyvinyl Chloride: 'Polyvinyls: Registries; Suicide--Occurrence (OC); Sweden; Time Factors: Vascular DIseases--Morta1 Ity (MO): Vascular D i seases--Occurre - nee (OC): 'Vinyl Chloride; 'Vinyl Compounds: 'VINYL CPDS 12799 1 A 77 1049 I A PVC: health Implications and production trends. Karstadt M Environ Health Perspect ,0ct 76. 17 p107-15, ISSN 0091-6765 Journal Code: E10 Languages: ENGLISH Ooc Type: Review Journal Announcement: 7709 Subfile: INDEX MEDICUS Polyfvlnyl chloride) (PVC) Is a complex plastic system. Individual components of the PVC system, including residual vinyl chloride monomer (RVCM) and certain additives, may pose risks of harm to human health. There have been significant reductions In the RVCM content of PVC resin since 1974. reducing the cancer risk of workers In PVC fabrication plants and consumers of PVC products. A "no-effect" level Tor vinyl chloride monomer (VCM)- 1nduced carcinogenesis has not been found to date: therefore, the significance of human exposure to low levels of RVCM remains to be determined. Exposure to PVC dust may cause pulmonary dysfunctions. Pulmonary and other possible health effects of PVC dust require further study. The PVC plastics system should be character I zed as to Interactions among Its various components and as to Interactions of the components and the PVC system as a whole with biological systems . (31 Ref s . ) Tags: Human Descriptors: Air Pollutants, OccupatIona 1 --Ana 1ys1s (AN); AngIosarcoma--Chem1ca)1y Induced (Cl); Automobiles: 'Chemical Industry; Dust: Food Contamination; Government Agencies: Industry; Liver Neoplasms--Chemleally Induced (Cl); Dccupatlqj*^ DIseases--Chemtca11y Induced (Cl); Particle Size Pheumocoi^^Bi S--E1161ogy (ET); 'Polyvinyl ChlorIde--Adverse 010559 R&S 139788 l tem PAGE : 11 of 2t 30 Effects (AE): 'Po1yvInyIs--Adverse Effects (AE): United States Food and Drug Administration: TDA: United States: Vinyl Ch1 oride--Adverse Effects (AE) 1254782 77159702 Cancer following occupational exposure to asbestos and vinyl chloride. NichoI son WJ Cancer .Apr 1977. 39 ( 4 Suppl) p 1792-80 1. ISSN 0008-543X Journal Code: CL 7. Languages: ENGLISH Doc Type: Review Journal Announcement: 7700 Subfile: AIM; INDEX MEDICUS A review is presented of the various factors important in the identification of carcinogenic disease from occupational and environmental exposure to asbestos and vinyl chloride. The long lapsed period. usually of 20 or more years from first exposure to these materials. is discussed, as well as the requirement for sufficiently long observation periods in prospective epidemiological studies. The mu Itip1e-factor etiology of King cancer involving cigarette smoking and asbestos exposure is illustrated. The risks of asbestos - re 1 ated cancers to other than those directly working with the material are discussed in a variety of circumstances, and finally the effectiveness of control procedures for vinyl chloride and asbestos are compared. (39 Refs. ) Tags: Human; Male Descriptors: *Asbestos--Adverse Effects (ae); Asbestosis--0 - ccurrence (OC ) ; Carcinogens, Environmental - -['oisoiiiiig t PO 1 ; Environmental Exposure; Longitudinal Studies: Lung NeopI asms--Chemica1 1y Induced (Cl): Lung Neop1 asms--Etio1ogy (ET): Lung Neop1 asms --Occurrence (OC ) : Maximum Permissible Exposure Level: MPEL: 1Neop1 asms--ChemicaMy Induced (Cl): Neopiasms--Occurrence (OC 1 ; 'Occupational Diseases--Chemica1 1y Induced (Cl): Prospective Studies: Risk: Smoking--Comp 1icatio- ns (CO); Time Factors: United States: 'Vinyl Chloride--Adverse Effects (AE ) : 'Vinyl Compounds--Adverse Effects (AE): 'VINYL CPDS--Adverse Effects (AE) 1229572 7713-1572 Mortality experience of workers exposed to vinyl chloride monomer In the manufacture of polyvinyl chloride In Great Britain. rox AU; Col 1 ier PF Br J Ind Med .Feb 1977. 34 (1) pi-10. ISSN 0007-1072 Journal Code: AXS Languages: ENGLISH Journal Announcement: 7707 Subf lie: INDEX MEDICUS Identification particulars were obtained for over 7000 men who were at some time between 1940 and 1974 exposed to vinyl chloride monomer in the manufacture of polyvinyl chloride. Approximately 99% of these men have beien traced arnid tt heir r (cont. next page) PRINTS User:018446 05nov85 __________________ DIALOG (VERSION 2) R&S 139789 : 1-30) DIALOG File 153: MEDLINE - 73-79 mortality experience studied. The overall standardised mor t a 1 1 t y ratio, 75 - A . shows a significant reduction compared with the national rates. Four cases of liver cancer were found. Two of these have been confirmed by a panel of liver pathologists as angiosarcoma and two as not angiosarcoma. There Is no evidence to support the hypothesis that cancers other than those of the liver are associated with exposure to vinyl chloride monomer. The two cases of angiosarcoma were found in men who had been exposed to high concentrations of the monomer although the second man died only eight years after first exposure. The industry In Great Britain has expanded considerably since the second world war with over 507- of men having entered with the last decade. Conclusions drawn about the effect of vinyl chloride monomer on the mortality experience or men in this industry must consequently be tempered by the reservation that the full impact may not yet be In evidence. Tags: Comparative Study; Human; Male Descriptors: Ang i osarcoma --Chem I ca 1 1 y Induced (C.M: Chemical Industry; Environmental Exposure: Epidemiologic Methods; Follow-Up Studies: Liver NeopI asms --Occurrence (DC): Occupational DIseases--Chemica11y Induced (Cl): Occupational Diseases--MortaI Ity (MO); +Viny1 Ch1 oride--Adverse Effects (AE): + Viny1 Compounds--Adverse Effects (AE): VINYL CPDS--Adverse Effects (AE) 1195083 77100083 Care 1 nogen 1c, mutagenic and teratogenic risks associated with vinyl chloride. Infante RF ; Wagoner UK; Waxweller RJ Mutat Res . 197G Nov 1. At (1 spel. no 1 p131-At. ISSN 0027-5107 Journal Code: NNA Languages: ENGLISH Journal Announcement: 7705 Subfile: INDEX MEDICUS The data presented demonstrate clearly that vinyl chloride (VC) Is related to a significant excess of mortality from cancer of the liver, lung and brain among workers occupationally exposed to VC. The risk of dying from cancer of the lymphatic and hematopoietic system also appears to Increase with an increase in latency. These cancer sites could have been predicted by the animal bioassay conducted by Maltoni. With regard to the liver, even the hIstophtho1ogfc type of cancer (angiosarcoma) was observed first in experimental animals. A study of cancer mortality among populations residing proximate to VC polymerization facilities also demonstrated an increased risk of dying from CNS and lymphatic cancer. These latter findings raise cause for concern about out-plant emmlssions of VC. but without further study these cancers obviously cannot be Interpreted as being related to out-plant exposure to VC. Various test systems now have elicited a positive mutagenic response to VC, Thus, our observations of a significant excess of fetal mortality among the wives of males, who were occupationally exposed to VC. raise public health concern that VC may be mutagenic In humans, i~'i!i|~fl to the teratogenicity of VC. observations 010560 Item PAGE: 1A of 22 30 of a significant excess of chI 1 dron born with birth defects were reported among populations residing proximate to VC polymerization facilities. Additional epidemiologic study Is needed to determine whether a repeated pattern of excessive numbers of children born with birth defects can be observed in other communities with VC polymerization facilities. Tags: Female: Human; Male Descr iptors: Abnorma1 ities. Mu 1 tip1e--Occurrence (DC) : Care i nogens; Environmental Exposure: Fetal Death; 'Mutagens: Occtipa t i ona I D i seases--Chem i ca 1 1 y Induced (CM: Ohio; Paternal Age; Pregnancy; Risk; 'Teratogens: 'Vinyl Ch1 oride--ToxIcitv (TO): `Vinyl Compounds--I oxic i ty (TO) t 183333 77088333 Low mortality rates in industrial cohort studies due to selection for work and survival in the industry. Tox AJ; Collier PF Br J Prev Soc Med .Dec 7G, 30 (A) p225-30. IS5N 0007- I2A2 Journal Code: B1C Languages: ENGLISH Journal Announcement: 7705 Subflie: INDEX MEDICUS Occupational groups are often described as being relatively healthy because their mortality rates are lower than those of the national average. Although correct this confuses the issue for those who are interested in assessing the effects of exposure to a particular chemical. In a further analysis of data collected in a study of all men ever exposed to vinyl chloride monomer in the manufacture of polyvinyl chloride in Great Britain, three factors have been shown to contribute to the low mortality rates that were observed. Fhe three factors: the selection of a healthy population for employment. the survival In the Industry of the healthier men. and the length Of time that this population has been pursued, have been quantified. The mortality experience within five years of entering this industry was shown to be as low as 37% of that expected; for circulatory disease and respiratory disease it was as low as 21%. There was a progressive increase in s tandardI zed mor tality ratio with t he 1 eng th of time since entry so that the effect had almost disappeared 15 years after entry. To avoid confounding the selection effect with the survival effect the latter was measured by separating men who survived 15 years after entering the industry according to whether or not they were still in the industry after this period. Those who had left experienced an over-all standardized mortality ratio some 507- higher than those still in the industry. This effect, although consistent in the age groups be tween 25 and 7A years and for all cause groups studied, was greatest in those aged between 25 and AA years and for lung cancer and respiratory disease. Tags: Human; Male Descriptors: Adult: Age Factors: Aged: Cardiovascular D i seases --Morta1 ity (MO): Great Britain; Middle Age: Mortality: Neop1 asms--Morta 1 ity (MO): 'Occupational Diseases (cont. next page) = ^PDimJ : imi o)v*a h ii MFivirr^ imf` PRINTS User :018446 05nov85 P08 1 : PR 1/5/ALL (items 1-3 _______________ DIALOG (VERSION 2)________________________________ DIALOG File 153: MEDLINE - 73-79 `Occupational Diseases--Morta1 Ity (MO): `Occupations: Polyvinyl Chi oride--Poisontng (PO): *Polyv1nyIs--Po1 son 1ng (PO): Respiration D1sorders--MortaI 1ty (MO): Time Factors: Vinyl Ch1 oride--Po1 son Ing (PO): *V1nyl Compounds--PoI sonIng (PO); +VINYL CPDS--Po1sonlng (PO) 1165362 77070362 The trade unionist's view of occurpatIona1 cancer. Blyghton AC Legal Department Transport and General Workers' Union Transport Mouse, London, England. I ARC Sc 1 Pub! (FRANCE) ,1976. (13) p425-9. ISSN 0300-5038 Journal Code: GFU Languages: ENGLISH Journal Announcement: 7704 Subfile: INDEX MEDICUS The Transport and General Workers' Union (UK) has an active programme devoted to monitoring the health of its 1.8 million members. Files on members who died of bladder cancer after exposure to beta-naphthy1 amine go back to the late 1920's. From the same period came data on members suffering from asbestosls which Included same cases of lung cancer before the industrial cause of the disease was recognized. These and other more recent examples including Nonox S and vinyl chloride amply Justify the need for setting up registers of all workers who are at risk from industrial exposure. The sclentflc community has a responsibility for communicating data regarding hazards both to employers and employees who can then ensure that all who have been exposed can be notified and screened. The trade unions have a part to play In ensuring that industry accepts conditions of greater control under the new regulations in the United Kingdom. There must be a continuing tripartite discussion between Industrial management. trade unions and the responsible governement official. Descriptors; Bladder Neoptasms--Chemically Induced (Cl); Neop1 asms--Chemica11y Induced (Cl): England: Labor Unions: Legislation. Medical; Liver Neoplasms--ChemicaI Iy Induced (Cl) ; Occupational Diseases--D1agnos1s (DI); *0ccupat1ona1 0iseases--prevention and Control (PC): Registries: Vinyl Chi oride--Adverse Effects (AE) Effects (A E ) ; 2-Naphthy1 amine--Adverse 1165330 77070338 Occupational chemical carcinogenesis: new facts, priorities and perspectives.- Ma1 ton I C Institute of Oncology and Tumour Centre. Bologna. Italy. I ARC Sc I Pub 1 (FRANCE) ,1976, (13) p127-49. ISSN 0300-5038 Journal Code: GFU Languages: ENGLISH Jourhal Announcement: 7704 Subfile: INDEX MEDICUS there need For a hew active approach to the problem of occupati^^^ carcinogenesis. It Is no longer acceptable to 010561 R&S 139790 I tern PAGE : 16 of 23 30 adopt a "wait and see" attitude since: 1. evidence suggests that cancer is an "ecological" disease: 2. The carcinogenic risk has been increasing as industrinIisation increased; 3. Factory workers are the most exposed population and hazards spread from the work-place to the general population as consumer goods and pollution. It is necessary and possible, to identify potential carcinogens before workers and the general population are exposed. That predictive experiments could be done. is exemplified by the history of stiiboostro1. bis (chIoromcthyI ) ether, vinyl Chloride and chromium pigments, all of which were reported carcinogenic in animal tests before any epidemiological results were available. Unfor turn?te1y. these results were received with scepticism because the test methods were thought to be inadequate. It is necessary to develop the ruture policy of prevention by: 1. establishing a priority for testing compounds already produced and widespread in occurence and those about to be produced on a large scale: 2. establishing experimental models for determining carcinogenic risk, especially rapid screening tests; 3. study of the more important compounds by long-term bioassays. Full details are given of the testing of vinyl chloride monamcr and preliminary results are tabulated for tests on Styrene, acrylonitrile and vinylidene chloride. Tags: Animal: Human Descriptors; NeopI asms--Chemica11y Induced (Cl): Neop1 asms--Prevention and Control (PC): * Care i nogens. Environmental: Hamsters; Mice; `Occupational Diseases--Preven tion and . Control (PC); Rats: Time Factors: Vinyl ChI oride--Adverse Effects (AE) I 144990 77049990 [Liver tumors. Laparoscopic aspects] Lebertumoren LaparoskopIsche Aspekte Mor 1 M Fortschr Med .Nov 76 1911. 94 (32) p1876-S. ISSN 0015-8178 Journal Code: F62 Languages; GERMAN Summary Languages: ENGLISH Doc Type: English Abstract Journal Announcement : 7703 Subfi1e: INDEX MEDICUS A review is given on laparoscopic possibilities in th* d i fferentiation of tumours of the liver. Eenign lesions are rare and usually discovered by chance. Primary cancer of the liver can be verified ante f i nem in a maximum of 40/- of the cases. Characteristic is the endoscopic picture in the case of haemangiosarcotna after arsenic. Thorotrast. vinyl chloride (marked capsular fibrosis. net-)ike marking. "restless" surface of thellver). At) the tumours need to be confirmed histologically. A tumour-like appearance is presented by echinococcus alveolar is and coarse-nodu1ar granulomatous changes (sarcoidosis. 1ymphogranti 1omatosis. etc.). Tags: Human Descriptors: Diagnosis. Differential: Echinococcosis. Hepa11c--Diagnosis (DI): `Peritoneoscopy; Liver Neop1 asms--Ch em i ca I 1 y I induced (Cl); Liver Neoplasms--Clossification (CL): (cont. next page) _IO =:== ===::: ^TDIfTJP = PRJJVTS User :0ia-1'16 05nov85 P08 1 : PR 1/5/ALL (Items 1-30) _______________ DIALOG (VERSION 2)____ R&S 139791 Item PAGE: 19 of 2-1 30 DIALOG File 153: MEDLINE - 73-79 `Liver NeopI asms--Dlagnos1s (DI ) ; Neoplasm Metastasis; Thorium QI ox Ide--Adverse Effects (AE); Tuberculosis. Hepat1c--DiaqnosIs (DI ) I 13020(5 77035286 Chemical carcinogens in the human environment: problems and quantitative aspects. Preussmann R Institute of Toxicology and Chemotherapy. German Cancer Research Center, Heidelberg. Oncology (Switzerland) .1976. 33 (2) p5 I - 7. ISSN 0030-24M Journal Code: Ol-tW Languages: ENGLISH Journal Announcement: 7702 Subfile: INDEX MEDICUS A short review on environmental carcinogenesis by chemicals Is given. Problems related with the determination of carcinogenicity of chemicals are mentioned. Some critical factors in the monitoring of environmental carcinogens are discussed In relation to a quantIf1cation of human exposure to such compounds. An attempt at risk evaluation is made for polycyclic aromatic hydrocarbons, vinyl chloride. N-nitroso compounds and aflatoxlns. It Is concluded that there Is a "threshold dose" for Individual carcinogens that does not lead to tumor induction within the normal life span. The probability of mu 1t1factor I a 1 cause of human cancer by environmental carcinogens, however, does not allow the definition of "safe" levels or such compounds in view of syncarcI nogen Ic and other enhancing and/or modifying effects. Tags: Animal; Human Descriptors: Af1 atox1 ns--Ana 1ysis (AN); Af1 atoxins --Toxicity (TO); *Neoplasms--Chem1cally Induced (Cl): *CarcI nogens. Environmental: Carcinogens. Env1ronmenta 1 - - Ana 1ys1s (an); Carcinogens. Env1ronmenta 1 --ToxIc1ty (TO): Environmental Po1 1ut1 on--Ana 1ys I s (AN); Nltroso Compounds--Ana 1ys1S (AN); NITROSO CPD5--Ana 1ys1s (AN); Nltroso Compounds--ToxIcIty (TO) NITROSO CPDS--Tox1c1ty (TO); Polycyclic Hydrocarbons--Ana 1ysis (AN); Polycyclic Hydrocarbons --ToxIc1ty (TO): Risk; Smoking: Vinyl Ch1 oride--Ana 1ys I s (AN); Vinyl Ch1 or i de--Toxicity (TO) 1122A6A 77027A6A [Clinical picture and pathology of the so-called vinyl chloride disease] Klinlk und Pathologle der sog. V1ny1 chi or Id-Krankheit Szadkowsk 1 D Fortschr Med .Sep 76 1916, 9A (26) p1412-5, ISSN 0015-8178 Journal Code: F62 Languages: GERMAN Summary Languages: ENGLISH Doc Type: English Abstract Journal Announcement: 7702 Subr Me: INDEX MEDICUS About 26 years ago symptoms or liver and spleen were described for the first time by Tribukh el al. in laborers exposed to vinyl chloride. Besides these symptoms sc Ierodeij^o. acroosteo1ysis and Raynaud's phaenomenon are known be typical for the VC disease. Rather high 010562 concentrations of VC seem to be necessary to cause this disease. After cessation of exposure the symptoms may Improve partly. Haemangiosarcoma of the liver may occur" as the most serious effect of prolonged exposure to vinyl chloride. Presently A8 cases induced by VC exposure are observed alI over the world. Diagnosis is difficult, the prognosis of rhis cancer is practically always fatal. The improvement of working places bv the chemical industries should further reduce the risk of acquiring vc disease as we I I as haemangioma of the I Ivor due to VC exposure. I lags: Animal; Human Oescr ip tors : Ang (osar coma - - Cliem i ca I I y Induced (Cl): Env i ronmenta1 Exposure: r i ngers--Drug Effects (DE); Hepatitis, Toxic- -Diagnosis (DI): Hepatitis. Tox i c- -Et io1Ogy (E T 1 ; Liver NeopI asms - -Chemica1 1y T ndviced (Cl): Liver--Drug Effects (DE): Methods: 'Occupational DIseases- -Chem i ca1 1y Induced (Cl): Osteo1ysIs--Chemica1 1y Induced (Cl): Osteo1ysis--Rad Iography (RA ) ; Rabbits: Raynaud's D1sease- -Chemica1 1y Induced (Cl): Sc 1eroderma, Systemic--Chemica1 1y Induced (Cl); -Vinyl Ch1 oride--Poison 1ng (PO); Vinyl Ch1 oride--Toxic i 1y (TO): -Vinyl Compounds--Po1 Soning (PO ) : -VINYL CPDS--Poisoning 1PO 1 0992197 76182197 A hazardous society? Individual versus community responsibility in cancer prevention. Third annual Matthew B. Rosenhaus Lecture. Higginson J Am J Public Health .Apr 1976, 66 (A) p359-66, ISSN 0090*0036 Journal Code: 3XW Languages: ENGLISH Journal Announcement: 7608 Subfile: AIM; INDEX MEDICUS Tags: rerun 1 e: Human; Male Descriptors: Ang1osarcoma--ChemicaI Iy Induced (Cl): Ashestos--Poisoning (PO): Environmental Exposure: Life Style: Lung Neop1 asms--Chemica11y Induced (Cl): Mesothe 1 ioma--Chemic- ally Induced (Cl); Neop1 asms --ChemicaIIv Induced (Cl): - Neop 1 asms--E t i o 1 ociy (ET); Neop 1 asms--Pr even t i on and Control (PC ) ; Occupa tiona1 Diseases--Chemica1 1y Induced (Cl); Risk; Scrotum; Smoking--Comp 1 ication; (CO); Social Control. Formal; Urogenital Neop1 asms --Chemica1 1v Induced (Cl); Vinyl ChI oride--Poisoning (PO) 0878992 76068992 The Food and Drug Administration and the vinyl chloride problem--an overview. Schaf frier RM; Lombardo P J Assoc Off Anal Chem .Nov 1975. 58 (6) p12 11-3, ISSN OOOA-5756 Journal Code: HFJ Languages: ENGLISH Subf Me: INDEX MEDICUS Recent evidence has shown that chronic exposure to vinyl chloride by inhalation may cause cancer in laboratory animals (cent, next page) _]0 m=.,---------------- -=. =;, = : ^TDlf^JP = PRjJNiTS User:0i8AA6 05nov85 P081 : PR 1/5/ALL (items 1-301 _______________ DIALOG (VERSION 2) ____ DIALOG File 153: MEDLINE - 73-79 nnd In nan. Its possible oral effects are currently being Investigated. The history of the significant events leading to the Investigation of this chemical is presented. The current and future activities of the Food and Drug Administration in tliis area are also described. Descriptors: Carcinogens; EnvIronmentaI Pollutants; food Contamination; Occupational Diseases - -Chem leal i y reduced (C.I) United States Food and Drug Administration: `TDA; -Vinyl Chloride: Vinyl Ch1 or Ide--Adverse Effects f A E ) : *Vinyl Compounds 0832270 76022270 Cancer mortality in U.S. counties with plastics and related industries. Mason TJ Environ Health Perspect .dun 1975. 11 p79-8A, ISSN 0091-6765 Journal Code: EIO Languages: ENGLISH SubfIle: INDEX MEDICUS Counties in the United States have been identified with chemical establishments whose primary manufacturing processes Use vinyl ch1 oride. Site-Specific cancer norta 1 ily corapnrisons have revealed an excess or multiple myeloma in males associated with two of the manufacturing categories, synthetic rubber and synthetic fibers. A causal relationship between these manufactur1ng categories and multiple myeloma could not be established. An industry-based assessment of the occupational contribution to tills excess Is needed to evaluate the ettologic importance of this relationship. Tags: Female: Human; Male Descriptors: Ce11u1ose--Toxicity (TO): Chemical Industry: Fnv I ronmenta1 Exposure: Rubbei----- Toxicity (10): Liver Noop I asms--Chemlea 11y Induced (Cl); Lung Noop I asms --CliemIca11y I nduced (Cl): Mu 1 t I p 1 e Mye I oina - - Chem i ca 1 1 y I nduced (Cl); Neop1 asms--Chem(ca1 Iy Induced (Cl); Neop1 asms--MortaI Ity (MO) ; *P1 astics--Tox(city (TO): Rectal Neoplasms--Chemicaiiy Induced (Cl); Rubber--Toxicity (TO): Time factors; United States: Vinyl Ch1 or Ide--Toxicity (TO): *Vinyl Compounds--ToxIc(ty (TO) 07 A 5560 75165560 A simple after-loading technique for the treatment of cancer of the cervix. Haybittle JL: Mitchell JS Br J Radiol .Apr 1975. A8 (568) p295-8. ISSN 0007-1285 Journal Code: B28 Languages: ENGLISH Subfile: AIM: INDEX MEDICUS A simple manual after-1oading system for the treatment of carcinoma of the cervix has been developed. Radiochemica1 Centre J-type caesium sources are used made up in PVC tubes which can be inserted into PVC uterine tubes or rubber ovoids after these have been packed In position In the patient. Rad I a t I on^^xposure to theatre staff has been reduced by a factor o^Aout four. 010563 R&S 139792 PAGE : 23 of 25 30 Tags: Animal; Female Descriptors: -Cervix Neop1 asms--Radiotherapy (RT); Cesium Isotopes: Disposable Equipment: Polyvinyls: Radiation Dosage: Radiotherapy Ri.ibt.ier Dosage: Radiot lierapv--I nstrumentatiOn (IS): 0653991 75073991 Editorial: Vinyl chloride and cancer. Can Med Assoc J .8 Feb 1975, 112 (3) P269-70. ISSN 0008-AA09 Journal Code: CKW Languages: ENGLISH Subfile: AIM; INDEX MEDICUS Tags: Animal; Human; Male Descriptors: Aged: Alkaline Phosphatase--BIood (BL): Angiosarcoma--Chemica1 1y Induced (Cl): Angiosarcoma--Occurre- nee (DC ) : Ang(osarcoma--Diagnosis (DI ): Bile Due t Neop1 asms--Chemica)1y Induced (Cl); Brain Neop1 asms--Chem I ca1 - ly Induced (Cl): Environmental Exposure: Gnllhlndder Neop1 asms - -ChemicaI 1y Induced (Cl): Liver Neop1 a sms - -Chemica - 1 I y Induced (Cl); Lfver Neop1 asms --Occurrence (DC): Liver Neop1 asms--Diagnosis (DI): Lung Neop1 asms--Chemjca1 1y Induced (Cl): Nasopharyngeal Neop1 asms--Chemica1 Iy Induced (Cl): Occupational Diseases--Chemica11y Induced (Cl): Rats; Raynaud's Disease--Chemica11y Induced (Cl): Thyroid Neop1 asms--ChemicaI Iy Induced (Cl): *V(nyt Compounds--Adverse Effects (AE) 0635937 75055937 Editorial: More facts on vinyl chloride and cancer, Br Med J .30 Nov 197-1. A (59A3) pA86-7. ISBN 0007-1AA7 Journal Code: RAW Languages: ENG( I SH Subfile: AIM: INDEX MEDICUS Tags: Animal: Human: Male Descriptors: Adult: Air Pollution; Angiosarcoma --Chemica1 1v Induced (Cl): Chemical Industry: Env i ronmenta1 Exposure; Liver Neop1 asms --Cliemica1 1y Induced (Cl); Mice: Middle Age; Occupational Oiseases--Chemicallv Induced (C J ): Rats: -Vinyl Compounds--Poisoning (PO) 051796A 7A25296A Editorial: Vinyl chloride. P.V.C., and cancer. Lancet (England) .29 dun 197A. 1 (870) p1323-A. ISSN 0023-7507 Journal Code: LOS Languages: ENGLISH Subfile- AIM; INDEX MEDICUS Tags: Human; Male Descriptors: AGED: Po1yviny1s--Adverse Effects (AE); , Ch1 orides--Adverse Effects (A E ) : 'Occupational Diseases--Chem- icnlly Induced (Cl); 'Liver Neop1 asms--Chemica1 1 y Induced (Cl) ; Angiosarcoma--Chemica1 1y Induced (Cl I: Environmenta I Exposure: Time Factors i = l Mf ! I't' 1A Mrl| " f iiyiri R M'" PR3MTS User ;018446 O5nov85 __________________ DIALOG (VERSION 2) DIALOG File 153: MEDLINE - 73-79 1/5/Al.L (items t-30) R&s 139793 1 17275 7 A 152275 Letter: Vinyl chloride and cancer. Roe F J Br Med J (England) .20 Apr 0007-14A7 Journal Code: B4W Languages: ENGLISH 197 A 2 (911) p 176, ISSN Subfile: AIM; INDEX MEDICUS Tegs: Animal; HUMAN Descriptors: CARCINOGENS: CHLORIDES: `NEOPLASMS --Client I ca I I y Induced (Cl); OCCUPATIONAL DI SEASE S --Client 1 ca 1 1 y Induced (Cl); Polyvinyl A 1 coho 1--Adverse Effects (AE): SARCOMA--ChemIcn1 Iy Induced (Cl) 0AO3000 7 A 138000 Editorial: Vinyl chloride and cancer, Br Med U (England) ,30 Mar 197A. 1 (908) p590-I . ISSN 0007-I'M7 Journal Code: BAW Languages: ENGLISH Subfile: AIM; INDEX MEDICUS Tags: HUMAN; MALE Descriptors: ANGIOSARCOMA--Chem ca 1 1 y Induced (Cl): CHLORIDES--Adverse Effects (AE); GREAT BRITAIN: `LIVER NEOPLASMS--Chemleal 1y Induced (Cl); `OCCUPATIONAL DISEASES--Chemleal 1y Induced (Cl): UNITED STATES; `VINYL COMPOUNDS--Adverse Effects (AE) Item PAGE: 29 of 26 30 010564 1A 1 I' * * I