Document RoYgkg9oQwKVea1oX09YR5VX

1 INDUSTRIAL HYGIENE FOUNDATION OF AMERICA. INC. 1 * mIcclon Institute, 4400 Fifth Avenue . Pitts bun oh, Pa. issia , June 6, 1966 'V Proposal for Owens -Corning Fiberglas Corporation ' . for The Investigation on the Pulmonary Effects of Filamentous Glass Dust Introduction In order to answer questions regarding the pulmonary effects of filamentous glass dust, the investigation outlined below is proposed. This . investigation will be concerned with the pulmonary effects of three types of filamentous glass dust: (a) glass dust without a binder, (b) glass dust with a phenol formaldehyde type of hinder, and (c) glass dust with the type r??of binder used in glass textiles. . ^ '-\C The feasibility of the investigation hinges upon the ability of the industry to supply this laboratory quantities of filamentous glass that has x!\u -,</ a diameter of lp or less. This diameter of filamentous glass is required ' r. ---------- ------------------------------- /Ay ./ so that when the length of the fiber is reduced to 3 to 5 p , the glass particles ^ -|ft - fwill still be filamentous in character (a filament or fiber has been defined as a particle with a length that is at least three times its diameter). __^ j n if* * 02 212 0623 * ^ ^seowATiON or imdustmics roo the abvanccmcnt or healthful womumo conditions INDUSTRIAL HTDICNC FOUNDATION OF AMERICA,INC. 2. *"* - Proposal Two species of animals, rats and hamsters, will be exposed for the greater portion of their life tims^fo^high concentrations of filamentous glass dust in inhalation chambers. There will be three types of filamentous glass dust Mown into as many chambers: a. without binder .. b. with the phenol-formaldehyde type of binder * (exact formulation to be agreed upon) c. with the textile type of binder (exact formulation .to be agreed upon). ' . * The method of producing the dust will be similar to that used suc cessfully for reducing asbestos fibers to a respirable particle size, namely continuous hammer milling. The apparatus of Holt and Young with some modifications will be employed. It is hoped to attain a dust concentration T? of near 100 mg/m* in the chambers. Dust exposures will be over a period of two years. ^ Zt is anticipated that filamentous glass without binder will not be available and that it will be necessary to prepare binder-free glass dust. For this purpose, filamentous glass dust coated with the textile-type of binder will be used because this binder is more easily destroyed than the phenol-formaldehyde type. The coated glass will be treated with aqua regia to destroy the binder, thoroughly washed and dried prior to dissemination into the inhalation chamber. / ( The air flow through the chamber will be monitored. The exhaust 1 ,c' ir frotxy the chambers will be passed through electrostatic precipitators '& ... .. ' l'- ,\'T~ <*) Holt, P. S. and Young, D. K. A Dust-Feed Mechanism Suitable for 02 212 0624/* Fibrous Dust. Ann. Occ. Hyg. 2:245, I960. INDUSTRIAL HTOICNE FOUNDATION OF AMCNICA.INC. I 3 before venting It to thir outside. The dust collected from the precipitators will be weighed. The weight of this dust divided by the volume of air passing through the chamber during the time that the dust accumulated represents the average dust poncentration in the chamber. . Exposure of the animals will be over a two-year period, six hours per day, five days per week. To determine the progress of the lung dusting, some animals will be killed after six months of exposure and some, after 12 months. The survivors will be killed after 24 months of exposure. All animals will be autopsied and the lungs expanded with buffered formalin under a head of 10-12 cm water. Blocks of lung representative of all lobes will be embedded in paraffin and sectioned at <6p . The sections ## will be stained by appropriate methods and significant fields photographed. A tabular summary of the experimental protocol is given on Page 5. Reports * An interim report based on the findings in the 60 animals killed after ' six and 12 months dust exposure respectively (see tabular summary) will be submitted about 18 months after the beginning of exposure. The final report illiiin|W ^^ *riU be submitted within a year after the conclusion of the investigation and ^ -------------- :---------- --------------------------------------- " ^fiU be in the form of a manuscript suitable for publication. ------------1-------------------------------------------- -------------------------- Publication No advertising, promotional, or publicity matter containing any reference to the Industrial Hygiene Foundation or to any of its employees ` - - -v T* ;' shall be made use of by Owens-Corning Flberglas Corporation or anyoae 02 212 0625 . ... f I . INDUSTKIAl HYOIENC FOUNDATION OF AMERICA.INC. . 4. .' * In their behalf unless approval in writing has been received from the Indus* .. 0 . trial Hygiene Foundation. The Industrial Hygiene Foundation reserves ex . elusive right to publication of material developed in the Foundation's Research laboratory in suitable scientific journals if the results of the research merit publication; however, no findings in association with the name of Owens* Corning Fiberglas Corporation will be published unless permission is given. . ' Cost The cost of this study will be $60, 000; $20,000 a year for three years. OWENS-CORNING FIBERGLAS CORPORATION *1 INDUSTRIAL HYGIENE FOUNDATION OF AMERICA, INC. Managing Director .# 02 212 0626 INDUSTRIAL HYOICNC foundation OF AMCRI6A.INC. .TABULAR SUMMARY ' ' ~OF . PROTOCOL i 5 // Dust Number of Dust Animals Concent. in Chamber rats hamsters mg/m9 Number of Animals' Killed for Sampling at Period 6 months 12 months 24 months rats hamsters rats hamsters rats hamsters Glass Dust without . ' Binder 30 30 1 * ' Glass Dust with Phenol* Formaldehyde Type Binder 30 30 100 5 5 100 5 5 55 20 20 55 20 20 Glass Dust with Textile- 30 30 Type Binder Totals 90 90 100 5' 5 55 20 20 15 15 15 15 60 60 02 212 0627