Document Rmxb2gmM2LxVMeJeJOQK3k18

pK/pS A HUMAN EFFECTS f TCDD (PCDF) No Kr.ovn Exposure to Pure TCDD PCDF Occupational Exposures: Contaminant of Trichlorophenol Trichlorophenate 2,4-D 2,4,5T PCB 's Clinical Features Laboratory Findings CONSTANT Acne INCONSTANT Neuromuscular Symptoms Severe Pain - Chest, Extremities Weakness - Extremities Peripheral Neuritis (Myelin Degen.) INCONSTANT OCCASIONAL Enlarged, Tender Liver Porphyria Cutanea Tarda Decrease Prothrombin Time Increase SGOT Uroporphyrinuria INCONSTANT Hyperpigmentation Skin Increase in Triglycerides INCONSTANT Hirsutism Face INCONSTANT Irritability INCONSTANT Eye Irritation 0 w 4 i ' \ (20 OOZ 81 t2. lipid and carbohydrate metabolism, endocrinologie, behavioral, chronic respiratory and immunobiologie effects, especially susceptibility to infections. The identifiable populations known to have been exposed to TCDD are the good potential sources of such information. These should include populations involved in the manufacture and use of 2,4,5-T, 2,4-D, trichlorophenol, PCB's, as well as known exposures to TCDD and PCDF. These efforts would be most fruitful as a collaborative effort involving exposed populations in several *# countries using a common study protocol. The plan should include studies of individual cases, a retrospective epidemiologic component and a prospective epidemiologic program. y//) l a ' s u -- F* [H'yX ^ - ^ 4^ 17^7 Q ooot-8 7. M 7- - G 4 9 0 9 CANCER DEATHS OF WORKERS EXPOSED TO 2T+r5-*V OMITTED FROM TABLE 10, ZACK-GAFFEY REPORT NAME DATE OF DEATH 1. James Roe 1964 2. Howard Cochran 1971 3. Herman Moore 1978 4. Hugo Tidquist 1978 5. John Workman 1971 6. *Stonewall Farley 1962 7. Howard Hudnall 1970 8. Ralph Westfall 1970 9. Robert Arthur 1973 * Omitted from exposed group, but included in non-exposed group. t SOURCE OF INFORMATION Zack-Suskind Zack-Suskind Zack-Suskind Zack-Suskind Strauss Zack-Suskind Zack-Suskind Zack-Suskind Zack-Suskind -- Number in Table 10 . Number Omitted . . . Cancer Deaths, Total 9 _9 18 Deaths Observed . . 1 8 Deaths Expected . . 10.94 Excess Deaths . . . 65% P K /</></- T Z >j> CANCER DEATHS OF WORKERS EXPOSED TO 2; A ,-5 -*, OMITTED FROM TABLE 10, ZACK-GAFFEY REPORT NAME 1. James Roe 2. Howard Cochran 3. Herman Moore 4. Hugo T idqu ist 5. John Workman 6. *Stonewall Farley 7. *Howard Hudnall 8. *Ralph Westfall 9. *Robert Arthur DATE OF DEATH 1964 1971 1978 1978 1971 1962 1970 1970 1973 * Omitted from exposed group, .but included in non- exposed group. - SOURCE OF INFORMATION Zack-Suskind Zack-Suskind Zack-Suskind Zack-Suskind Strauss Zack-Suskind Zack-Suskind Zack-Suskind Zack-Suskind Number in Table 10 . . 9 Number Omitted . . . . __9 Cancer Deaths, Total . 18 Deaths Observed . . 18 Deaths Expected . . 10.94 Excess Deaths . . . 65% p x /^S' ZACK-GAFFEY REPORT DEATHS IN EXCESS OF EXPECTED CAUSE Lung cancer Genitourinary cancer Bladder cancer ** Lymphatic cancer *** Other sites ** ** All cancers Heart disease NUMBER 10 2 2 3 2 18 27 PERCENTAGE OF DEATHS HIGHER THAN E J E C T E D 143% higher: 108% higher /J \ i 809%/h i g h e r 92% higher 26% higher 43% higher 37% higher * Four deaths omitted from Zack-Gaffey Report -** Completely omitted from Zack-Gaffey Report *** One death omitted from Zack-Gaffey Report ** *** Nine deaths omitted from Zack-Gaffey Report