Document Rjyn3KZG4b6nY7owDDrEyo48z

ev9V0V S * Current Intelligence To make an early determination of the distribution and extent of primary liver cancer, and more specifically, angiosarcoma of the liver among workers exposed to vinyl chloride, the National Institute for Occupational Safety and Health (NIOSH), Center for Disease Control, has requested members of the medical community in the United States and abroad to report information on known or suspected cases. As shown in the table, 26 cases have been reported to date from six countries. Sixteen of these ^are from the United States. Although cases have been ob served from four distinct work areas, the majority (81") were formerly employed as reactor cleaners at plants where vinyl rHtviH* wat intn fWwinvl chloride. Fourteen confirmed cases of angiosarcoma of the liver have been reported from four polymerization plants in the United States. While an exact estimate of the risk for polymerization workers must await completion of follow-up, it is already apparent that the disease rate for this group is extremely high. The total work force currently em ployed at U.S. polymerization plants is about 5,000. No adequate data on prior vinyl chloride exposure levels of polymerization workers is available, but it is thought that past exposures may have frequently exceeded the TLV of 500 ppm. For the polymerization workers the median age at diagnosis -of angiosar coma of the liver is 45 years with a range from 36 to 71 years, and the median in terval from first exposure to diagnosis is 20 years with a range from 11 to 30 years. Too few cases have been reported from the other work areas to provide stable estimates of age and latency. Persons interested in obtaining further information should contact |. William Lloyd, Sc.D., Director, Office of Oc cupational Heaith Surveillance and Biometrics, NIOSH, 5000 Fishers Lane, Room 3-32, Park Eu'.'.dmg, Rockville, MO 20SS2. Angiosarcoma of the Liver \/;^w I /*\ I x r\ /i rs / ni v n ly i v_-i u kji iKjszf i uiy v my Chloride Workers cwittn S.adtn Table 1. -- Reported Ces ef Liver taginsresnu in Workers Exposed to v Vinyl Chloride or Polyvinyl Chloride. Cist u Birth 1st TC v nc OX Antra- 4* * Til TL It I* Da. . Tes Hits CiAonns Ssttsai DX Is OX Da. TC tlowiKr ftodicSioc WnrLers er 11-27-11 0340-45 05-15-72 61 27 23 Dit* w Oath 08-16-72 Czsehoxtavalua Cietira*Jrilbi Ciut Britain Nw.fi $*dtn Unilrf Stita United SUtts Unittd Stitts United Sutcs limttd Stitts Unittd Stitts United Stitts Ucittii Str.cs United Stitts United Stitts United Stitts Unittd Stilts United SUtn UniM Stitts W. Gtfininy W. ,, Grtit Britun United Stitts Umttd Strtes W. Gertftiny 01 AWAITING DETAILS oz AWAITING DETAILS 01* 004341 00-00-4S 01* 12-23-15 03-00 50 01* 0623-27 03-14 51 01* 101723 12X9-48 oz- OS-19 33 11-15 55 03* 05-25-15 11-2845 04* 01-1524 07-05-52 OS* 01-25-12 09-1944 OS* 00-0029 01-17X2 07* 05-03 22 08-0044 Ci* 054S-23 09* 00-00-31 05-2845 10* 03-16-13 05-1251 11* 05-2749 101446 12* 11-17-18 09-1349 13* 12-01-21 03 3944 IS* 11-04-27 05X3 50 01 07-26-31 10-14 57 OZ 00-04-30 10-01-57 12X0-72 1210-71 02X0-70 03-03-73 05X0-70 12-19-73 08-1967 04X9X4 02-00-74 00X0X8 OSwXl 03X1-74 05X0X8 03-00-70 05X2X3 05-00-74 000069 00X0-71 00X0X9 71 55 43 49 36 58 43 S2 45 45 41 4} SS 61 SO 53 41 40 39 26 2Z 19 22 14 23 IS 20 1Z 24 15 29 17 23 20 30 17 14 11 CMifwndtrs, Tikiiutns, Etc. OZ* 09-0814 00X048 02X0-70 55 14 00-0013 08 18 33 06X0 73 60 IS* 00-00 75 09X0 00 07 00 72 47 74 3S 00 OtkfT TC Einwuit 03 09-00-00 00X0X3 03X009 (3 14 20 12X0-72 21 01X4-72 IX 10-20 70 IS 03X3 73 13 09 23-71 23 12-19-73 IS 01X7X8 IS 04X9X4 12 AUVE It 03 23X3 15 17 ALIVE 17 0510-5C 23 03-1X70 15 05X2X9 30 07X4-74 4 03-27X5 14 12-14-71 11 01-25X9 11 12X0-70 Non l 00 07X373 7Nste 6 5 00 CM 5 73 3NtU 0-3 00X0X0 4Note Note 1 Pourinj PVC miituif onto h:nc bnes Mott 7 Uuhiftc epentor uwmf with PVC pt*s!c iflsuijtioo Not* J Account**! *i u*'l flints history under tew*) 4 Icziir.i ptsiitiSs uni wrta vC prspc'lint Note S Dupont Sitcom* (possibly 'V.|*ourccm*``). lift*. Poinptitty pi ttneuitied neupuim of the fctituiotfldrtNLdl uQ mlMn unflot fee ruled Mt- imcritcthtA!ty cammed M0G** lfld>itci uftuumn bin d t** Wr.