Document RjrZZzRe8GpaNMk1mmgkOK7y8

(conference on November 2 and 3). It will cover water and sewerage treatment and water re-use, water resources, pipes, pipelaying and desalination. Enquiries to International Conference and Exhibitions Ltd., 6 Porter Street, Baker Street, London, W1M 1HZ, England (telephone 01-486 8730; telex 21879 CONFEX). 307. Algeria Algeria's five year plan was recently passed by the National Assembly. Amongst others it includes: Water resources programme referring to the irrigation of 200.000 ha by 1990 plus the construction of 10 to 11 more dams by 1984, in addition to the nine already in progress; and building materials, ceramics and glassware programme (worth 9 billion dinars over 1980/84) in cludes the expansion of existing annual capacity by a further 4 billion tonnes of cement, 800,000 tonnes of bricks and tiles, and 200.000 tonnes of plaster, plus the development of pipe and sanitaryware manufacture to meet the needs of the water resources programme. 308. Bahrain Aluminium plant extension. A 2 million contract for extensions at the Bahrain Aluminium Works includ ing two additional pot lines involving the installation of more than 150 pots, has been won by Cleveland Bridge and Engineering, Middle East (Private) Ltd. Part of this contract is being carried out jointly with Arenco. a local firm. Stadium construction. A 9 million contract vizc * by the Bahrain Ministry of Works and Water forth construction of the Bahrain National Stadium has hi*1 won by Jalal Costain WLL. 04(511 309. Iraq Flooring. Contract flooring worth 800,000 is beina supplied to Iraq by Marley Floors Ltd., U.K. The client is the State Establishment for Prefabricated Buildinw Some 220.000 m2 of fully flexible vinyl flooring will be supplied, together with adhesive, pvc skirting and stair nosing. 310. Libya Cladding and insulation. H. H. Robertson (UK) Ltd is supplying 1,250,000 worth of protected metal build ing cladding and insulation products for use in the con struction of a medical stores building in Tripoli. 311. Saudi Arabia Cladding and insulation. Some 300,000 worth of protected metal building cladding and insulation products are being supplied to Jubail in Saudi Arabia by H. H. Robertson (UK) Ltd. The products have been specified for the North West Water Works Project. 312. UAE Pumping equipment worth more than 2 million has been ordered from Weier Pumps Ltd. of Scotland, for two water supply projects in the United Arab Emirates. tfi any Any jibmissi 30 days nee- 22 In p: jeeking ^termi: fjnier s; product *31 not to order Bi B; DFi M a Pi si C! D R O H' T. II S; 315. PART 11 ASBESTOS HEALTH HAZARDS, PRECAUTIONS 313. European plan would reintroduce blue asbestos urged in its report to the government that the existing into Britain non-use of blue asbestos be made a statutory ban. The Occupational Health & Safety, Vol. 3. No. 25, HSC has said that it is still collecting and studying com Dec. 8, 1980 ments on the Committee's report, and has declined to A proposed amendment to regulations governing the European Economic Community (EEC) could, if passed, result in the resumed import and use ofblue(croeilodite) asbestos in Britain. The Euro-plan, as the draft amendment is called, would make it impossible for EEC member countries to ban blue asbestos and articles containing it - most nota bly asbestos cement pipes (especially large diameter take a stand supporting or opposing the recommenda tion for the ban. Both the HSC and British asbestos industry repre sentatives have presented evidence before a government sub-committee studying the Euro-plan. Not surprisingly, the industry opinion contradicts the Advisory Com mittee's recommendation, calling for effective control rather than an outright ban, on the use of blue asbestos. water supply pipes) as well as acid-resisting seals, gaskets and similar items. Blue asbestos is widely used in conti 314. CPSC Publishes General Order On Asbestos nental Europe for these purposes, since it offers a high The long-expected Consumer Product Safety Com degree of impermeability and acid resistance. mission General Order on Asbestos (N&N Nov.) has The substance, considered by British authorities to be been cleared by the General Accounting Office and pub more dangerous than the white (chrysotile) or brown lished in Federal Register of Dec. 22. Manufacturers and. (amosite) types, has not been used in Britain for 10 years, importers of certain asbestos-containing consumer pro following the passage of regulations limiting blue asbestos ducts must comply by Feb. 12,1981. levels to 0.2 fibres/cc in air. At that time British industry, General Order requires affected parties to furnish unable to comply with the regulation, simply stopped information concerning use of asbestos in products, using this type of asbestos. form in which asbestos is present, purpose served by Last year an Asbestos Advisory Committee, appoint asbestos, marketing and use patterns of products, ident ed by Britain's Health and Safety Commission (HSC), ity of possible substitutes for asbestos, and information The ogy of whethe wines.. beverar X rays a meth bility concn. has th partich gressivi length 30 anc wine l Compa those asbestc less th KME. 66 ASARCO ALV 0007501 occurring in potable waters or added during the passage of such waters through asbestos-cement pipes are so small that one would not expect them to induce gut cancer: all epidemiological studies are consistent with this view. 321. The Clinical Significance of Ferruginous Bodies in Sputa McLarty, J. W.; Greenberg, S. D.; Hurst, G. A.; Spivey, C. G.; Seitzman, L. H.; Hieger, L. R.; Farley, M. L.; Mabry, L. C. Journal of Occupa tional Medicine 22(2): 92--96, February, 1980 The clinical significance of ferruginous bodies in sputa was examined in a study of 674 former asbestos workers. Data from occupational histories and smoking behaviour questionnaires, chest radiographs, spirometric measure ments. and counts of ferruginous bodies were obtained as part of a 5-year surveillance programme. Statistical analysis demonstrated that ferruginous bodies found in the sputa were significantly related to radiographic find ings of interstitial pulmonary disease and pleural fibrosis and to spirometric findings of restrictive lung disease. Age and cigarette smoking were also found to be related to the presence of ferruginous bodies (p<0.02). (Auth. Abs.) greatly enhanced rate of BP uptake into rat liver mllPl somes when compared to uptake from aqueous sions of BP microcrystals. Simple mixtures of BPmS?' crystals and particulates do not display enhanced rSS* somal uptake rates, an observation which indicates th* -1 adsorption of BP to the surface of the particle is nece! W" ary for enhanced microsomal uptake. BP was not relelHl into microsomes from carbon black. Most important?" : the data indicate that asbestos particles are more effect' ive than silica and iron oxide in enhancing the micro somal availability of BP. These observations suggest that particles, and especially the fibrous mineral particulates could be cocarcinogenic as a result of their ability to* adsorb polynuclear aromatic hydrocarbons and to tramport these carcinogens into cells. Except for chrysotile the particles did not disrupt microsomal integrity as determined by NADPH- dependent lipid peroxidation activity. Binding of the microsomes to the particles did not affect the BP uptake rates. In addition, these BP uptake rates were independent of both the concentra tions of microsomes and of particles. These observations are consistent with the mechanism of particle-enhanced transport being an increased rate of BP solubilization from the adsorbed state into the aqueous phase, follow ed by rapid partitioning of BP into the microsomal membranes. 322. Asbestos body phagocytosis by human free alveo lar macrophages McLemore. T. L.: Mace. M. L. Jr.: Roggli. V.: Marshall. M. V.: Lawrence, E. C.; Wilson. R. K.: Martin. R. R.; Brinkley, B. R.; Greenberg, S. D. (Dep. Cell Biol.. Baylor Coll. Med., Houston. TX 77030. USA) Cancer Lett., 9(2), 85-93(1980) - En;en. Phagocytosis of asbestos bodies by human free alveo lar macrophages (FAMs) was studied by light microscopy and scanning electron microscopy which demonstrated morphological and surface membrane changes in FAMs following phagocytosis of asbestos bodies. FAM via bility was evaluated following 24-72-h incubation of cells with asbestos bodies at a final concentration of 250 ptg/ml. Slight, but significant, cytotoxicity was observed following the initial 24-h culture period. No further cytotoxicity was observed when cells were further incubated for 48-h and 72-h intervals. Asbestos bodies are readily phagocytized by cultured FAMs and are only slightly cytotoxic to these human lung cells. 323. Effects of asbestos, iron, oxide, silica, and carbon black on the microsomal availability of benzo[ajpyrene Lakowicz, J. R. and Bevan, D. R. - Dept. Biochem., Univ. Minnesota, Navarre, Minn. USA-- Biochemistry (Wash.) 1979 18/23 (5170-5176) Particulate matter and polynuclear aromatic hydro carbons are known to be cocarcingenic. Using fluores cence spectroscopy, we determined that adsorption of benzo (a) pyrene (BP) to iron oxide, silica, and asbestos (anthophyllite and Canadian chrysotile) results in a 324. Thickening of pulmonary interlobar fissures: Exposure-response relationship in crocidolite and amosite miners Solomon A., Irwig L.M.. Sluis-CremerG.K. etalNat. Res. Inst. Occupat. Dis. South African Med. Res. Council. Johannesburg SAF --Br.J.Ind.Med. 1979 36/3(195-198) In a cross-sectional study of all white and mixed-race men employed at South African crocidolite and amosite mines, data on duration of asbestos exposure and radio logical findings were available for 1692 men, 94% of the total population. Postero-anterior radiographs were read by three experienced readers. Abnormality was regarded as present if reported by at least two of them. The reading included an assessment of whether inter lobar fissures were not visible, were visible but not thick ened. or were thickened according to criteria shown in a reference radiograph. Fissures which were visible but not thickened were seen in almost half the men and were not more common in men with longer asbestos exposure. On the other hand, thickened fissures increased in preva- iance from about 2% in those who had worked with asbestos for 7 years or less, to 25% in those with more than 15 years' asbestos exposure. Some other asbestos- associated pleural or parenchymal abnormality occuied in 69% of men with thickened fissures. The prevalence of thickened fissures as an isolated abnormality was also related to the duration of asbestos exposure. Because its prevalence is related to duration of exposure, and its recognition is not subject to excessive inter-observer variation, we suggest that thickening of the fissures is a valuable sign in the radiological assessment of workers exposed to asbestos. .( 68 ASARCO ALV 0007503