Document Rjn9Yb2j3N5xX9p9vDjgbZLR7

O cA __Manufacturing Chemists As'sociation Minutes of Meeting O ~-CL - OO `o'caOV-y SHELL CHEMICAL COMPANY. Environment and Safety RCliVr.D APR 151974 TECHNICAL TASK GROUP ON VINYL CHLORIDE RESE$AR Sheraton O'Hare Hotel Ro senior J* MEMBERS PRESENT: February 20, 1974 MFG. & 01STRIB. Plans & Analysis T. R. Torkelson, CHAIRMAN T. R. Aalto Z Ga Bell/ Jr. R. S. Brookman E. M. Dixon, M.D. for W. A. Knapp R. J. Dowling for W. D. Harris Ba W. Duck M. R. Gasque, M.D. N. V. Hendricks C. A. Johnson, M.D. Flynt Kennedy H. L. Kusnetz for R. L. Maycock . A. B. Lindquist R. W. McBurney, M.D, W. E. Rinehart George Roush, Jr., M.D. H. L. Schmidt, Jr. W. M. Smith R. N. Wheeler, K. D. Johnson Jr. The Dow Chemical Company Tenneco Chemicals, Inc. PPG Industries, Inc. Firestone Plastics Company. Allied Chemical Corporation UNIROYAL Chemical Division/ UNIROYAL, Inc. The British Petroleum Company Limited, England Olin Corporation Exxon Corporation The Goodyear Tire &. Rubber Company Continental Oil Company Shell Oil Company Stauffer Chemical Company Diamond Shamrock Corporation Ethyl Corporation Monsanto Company Borden Chemical/Division of Borden, Inc. Air Products & Chemicals, Inc. Union Carbide Corporation MCA Staff GUESTS PRESENT: L. .H..--.Ballou,:' jyi;D. A. W. Barnes ' Emilio Bartalini, M.D. K. n. c. Bessant R. L. Bourget W. j. Boyne W. C. Cooper, M.D. ( Firestone Plastics Company . ICI, Ltd., Plastics Division, England MONTEDISON, Italy BP Chemicals Int., Ltd., England Monsanto Company Borden Chemical/Division of Borden, Inc. Tabershaw-Cooper Associates, Inc. see 5-0623 Minutes of Technic^ ) Task Group on VinyJL Chloride Research Meeting February 20, 1974 Page Two {) GUESTS (contj C. U. Dernehl, M.D. D. P. Duffield, M.D. B. W. Eley J. D. Forbes, M.D. W. R. Gaffey J. W. Goode D. E. Gordon, D.V.M. R. B. Howard E. Q. Hull, M.D. M. L. Keplinger C. H. Kim J. R. Livingston, Jr. W. F. Madden Richard Maier Cesare Maltoni, M.D. X. S. Pasternak Oddi Pietro D. P. Reid, M.D. D. E. Rhoads Ken Schadeberg X. R. Tabershaw, M.D. C. H. Whetstone, M.D. B. M. G. Zwicker Union Carbide Corporation ICI, Mond Division/ England Monsanto Company UNIROYAL, Inc. Tabershaw-Cooper Associates, Inc. Industrial BIO-TEST Laboratories, Inc. Industrial BIO-TEST Laboratories, Inc. Shell Chemical Company Union Carbide Corporation Industrial BIO-TEST Laboratories, Inc. UNIROYAL Chemical Division/ UNIROYAL, Inc. Exxon Chemical Company ICI, Plastics Division, England Stauffer Chemical Company Institute of Oncology of Bologna, Italy Esso Chemical Canada Montecatini Edison # Italy London School of Hygiene and Tropical Medicine/ England Tenneco Chemicals, Inc. Industrial BIO-TEST Laboratories, Inc. Tabershaw-Cooper Associates, Inc. Continental Oil Company B. F. Goodrich Chemical Company, A Division of The B. F. Goodrich Company 1. Minutes of the Meeting of January 25, 1974 The.subject minutes were .approved as distributed. 2. Industrial BIO-TEST Oral Progress Report As copies of the detailed quarterly progress report had been earlier distributed to members of the Technical Task Group on Vinyl Chloride Research, the oral presentation was primarily a summary report, augmented by slides illustrating the physical see 5-0624 Minutes of Technical Task Group on Vinyl Chloride Research Meeting February 20, 1974 Page Three facilities set up for this project. The tabular data presented by Mr. Schadeberg on his slides is reproduced in Appendix A to these minutes. It was .suggested that, in future progress reports, the summary tables, as exemplified by this appendix, be furnished in the copies provided for general distribution to the group, and that the detailed data be filed with MCA for the record, but not included in the general reports. Mr. Schadeberg agreed to follow this format in the future. The mortality revealed in Table I was discussed at some length. Members were somewhat relieved to note the improving picture, particularly with respect to losses from hamster cannabilism. It was agreed not to try to replace any animals lost to date, on the grounds that the stresses introduced by such disturbances to established orders of social dominance in the populations in any given cage would tend to perpetuate the earlier situation. The reduced weight gain of the TE-IV Group rats (those with bedding and food in the cages during exposures) was noted, but the significance of this observation, if any, could not be determined. This group will be observed carefully for evidence of systemic toxicity. 3. Report of European Research Dr. Maltoni repeated his presentation of the results of the European research programs, and the description of on going experiments, that he had earlier presented to the OSHA hearing on February 15 in Washington. An updated version of his report, with the inclusion of the tabular data that appeared on his slides, will, upon receipt, be distributed as a separate mailing. The' only experiment that is now essentially complete- is the initial`series of exposures of Sprague-Dawley rats to levels of.10,000 ppm VCM down to 50 ppm. With the exception of the highest exposure group for which early mortality limited the incidence of such cancers, the rats showed a dose-related incidence of angiosarcomas of the liver, as shown in the fol lowing table: 5- SCC 625 Minutes of Technic^ ^Task Group on Vinyl Choride Research Meeting February 20, 1974 Page Four Exposure levelsa (p_- P m - ) Rats with liver angio sarcomas Number of rats exposed 10,000 6,000 2,500 500 250 50 6 11 9 7 2 0 69 72 74 67 67 64 a Atmospheric exposure of Sprague-Dawley rats to vinyl chloride, four hours daily, five days a week, for 12 months. Note; No liver angiosarcomas were observed in controls or rats exposed similarly to 2500 p.p.m. vinyl acetate. 4. Support of Dow Proposals The TTGVCR voted to request their managements to provide $80,000 for the support of the Dow research as described in their proposal distributed to the group in the MCA mailing of January 29, 1974. 5. Support for Other Research The TTGVCR endorsed the position of the Research Coor dinators with respect to current support of research in the areas of mutagenicity, three-generation feeding studies, and 90-day feeding studies, recommending that these be deferred for the present. 6. Revision of SD-56 - Vinyl Chloride This matter will be attended to after completion of the sub-task groups of their tasks of the development of work practices standards, medical surveillance, and industrial hygiene monitoring and analysis. 7 ,, Progress Report from Tabershaw-^Cooper Association on, the Epidemiology Study The staff of TCA distributed copies of an updated progress report (copy attached to these minutes as Appendix B). They pointed out that, in its present format and state, their tabulation merely reflects a distribution of death and is not see 5-0626 1: Minutes of Technl-ihl Task Group on Vinyl Chloride Research Meeting February 20, 1974 Page Five intended to indicate the existence or non-existence of any specific risk or excess mortality in any category. 8. Tabershaw-Cooper Associates Proposals for Expanded Epidemiological Research Dr. Tabershaw summarized his pending proposals for new studies involving (1) intensifying their efforts to trace missing cases, (2) clinical study of suspect deaths in the mortality study, and (3) undertaking a prospective epidemiology study among high-risk segments of the worker population. He indicated that he would soon be submitting formal proposals for these projects. (Prior to the publication of the present minutes, these proposals were received and distributed to the Technical Task Group by MCA under date of March 12, 1974.) 9. Establishment of a Vinyl Chloride Pathology Register The full task group endorsed the recommendations of the Research Coordinators that the University of Michigan be requested to reactivate and expand their acro-osteolysis registry program to include all categories of occupational illnesses specifically related to vinyl chloride exposure. They requested that MCA pursue this matter with the University, and if necessary, to seek other agencies willing to perform such a service. 10. Report of the Working Group on Analysis and Monitoring The report of the group, in the absence of its chairman, was read, and is attached to these minutes as Appendix C. The tenor or the resulting discussion was that member companies should submit their candidate analytical and monitoring methods for consideration by the working group as soon as possible. The latter should attempt to draft its recommendations in format that provided the maximum flexibility of implementation, as long as the methods employed met appropriate standards of sensitivity, selectivity, and precision. 11. Report of the Working Group on Medical Surveillance The recommendations of this group have been incorporated in the work practices draft submitted by that group (see the following item in these minutes). It was pointed out that the recommended surveillance is required to document the effectiveness scc 5- 062 `9ndu4.t/ual B I O - T E S T O 9*ic. Appendix A TABLE I TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, and Golden Hamsters Summary of Mortality Data Month No. 1 2 3 4 5 Total Number of Mortalities at End of Month ALBINO RATS Control T-I T-II T-III MF MF MF .MF 00 00 01 02 23 00 20 20 41 51 00 10 10 30 61 00 00 14 14 34 T -IV M F 0 0 0 0 0 Month No. 1 2 3 4 5 Control MF 00 00 20 51 82 ALBINO MICE T -I T- II MF MF 00 03 64 1.9 5 26 6 00 00 30 41 42 T- III MF 00 00 10 47 87 Month No. Control MF 1 54 2 8 11 3 ' 8 ' 13 4 9 15 5 9 18 GOLDEN HAMSTERS T -I T -II MF MF T -III MF 44 10 12 12 14 16 16 16 16 75 9. . 16 12 18 15 19 16 20 2 . 1C 14 15 15 5 11 . 13 13 15 0 see 5-0628 S 3 - O I 9i ^*6 TABLE II TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, Golden Hamsters Summary of Mean Body Weight Values - Rats Group and Test Level Control TE-I 50 ppm TE-II 200 ppm TE-tll 2500 ppm Sex 0 M 205 F.' 160 M - ' 209 F 168 M 201 F ' . 171 M 200 F 165 Mean Body Weights at Week Indicated (grams) 12 348 258 294 335 363 456 188 214 223 235 275 246 286 331 346 448 184 207 223 232 274 261 301 335 360 457 200 208 228 242 289 245 302 326 351 453 185 216 228 240 287 12 498 299 491 297 490 302 499 303 Total We Gain (grams /an 293 139 282 129 289 131 299 138 T E -1V F- 181 209 223 236 251 282 2 500 ppm 288 107 see <3-0 >2^ iai B IO -T E S T A TABLE III TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice, Golden Hamsters Summary of Mean Body Weight Values - Mice Group and Test Level Control Sex 0 M ' 35 F .29 Mean Body We ights at Week Indicated (grams) 1 2 3 4 8 36 37 39 40 41 29 29 30 32 33 12 43 35 Total Weight Gain (g rams /animal) 8 6 TE-I 50 ppm M 33 34 35 37 39 39 F ' 30 29 31 31 34 34 43 37 10 7 TE-II M 36 37 37 40 40 38 ZOO ppm F 28 29 29 31 31 34 TE-I1I M 36 35 35 38 38 40 Z 500 ppm F 28 28 27 30 31 34 42 35 43 34 6 7 7 6 see .1 9 ! I- 'o TABLE IV TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats Albino Mice, Golden Hamsters Summary of Mean Body Weight Value s - Hamsters It Group and Test Level Sex 0 Mean Body W eights at Week Indicated (grams) 12 348 12 Total Weight Gain (grams / animal) Control M 73 F 77 74 86 99 98 no 80 91 102 104 108 120 118 47 41 TE-I 50 ppm M 71 F 78 72 79 78 85 89 90 101 96 95 102 114 112 43 34 TE-II 200 ppm TE-III 2500 ppm M 63 FT 74 M' 60 F' 69 61 82 75 82 66 83 70 87 83 89 95 94 94 99 86 87 91 95 92 100 99 108 93 106 36 34 33 37 sT o 120 M A L E . H A M S T E R B O D Y W E IG H T G A IN S WEEKS ,. ' i oww h ><<X) l l III O W Cd W l X o oo CO FEMALE HAMSTER BODY WEIGHT GAINS