Document RjkQGE8OgR0R9w82bM7EgdGdv

RROM (NAM E LO CATI ON .RHONE) Dept, of Medicine & Environmental Health SUBJECT: January 17, 1983 TCDD ca F.R. Johannsen G.J. Levinskas flEFEfteiVCE; Memo CDRB to G R ) , 20 Dec. 82 TO GyiRoushy1 In response to item 1 of D.R. Bishop's memo (DRB to GR, 20 Dec. 82, attachment C) a literature search was conducted by Mary Davis to identify synthetic substances which have some evidence of toxicity at doses comparable to 2,3,7,8-TCDD. In reviewing the 295 cita tions produced, a toxic response level of 0-10 parts per billion (ppb)- was chosen as the range of toxicity for identifying such substances. Attachment A lists the single commercial synthetic substance and several naturally occurring substances which fell into the above category. With regard to item 2 of the memo, the melting point of 2,3,7,8^ TCDD is 305OC (5810F) and no boiling has ever been reported. This fact was confirmed by F. Hileman, MAC, Dayton, and is supported by the literature references cited in attachment B. <11j attachments J- Timothy J. Long SUBJECT TO PROTECTIVE ORDER. (REV. 2/78) b'joui# Attachment A Substance Toxic Effect/Specie Tested I . Commercial Substances Platinum (II) , diammine- intradermal TDLQ*/man dichloro-,cis- (toxic effects upon skin) II. Natural Substances a) Botulinus toxin oral LD50**/unspecified b) Batrachotoxinin A, 20-alpha-(2,4,5trimethyl-lH-pyrrole3-carboxylate) subcutaneous LD50/mouse c) Castor bean, beta fraction intraperitoneal LD50/mouse Dose 0.04 ppb(yg/kg) 0.01 ppb(yg/kg) 1 ppb(yg/kg) 1 ppb (yg/kg) *TDL0 = the lowest dose of the substance reported to produce any toxic effect. **LDS0 = the calculated dose of the test substance which will be expected to kill 50% of a population of test animals. T TT 1/17/83 Attachment B 1) EPA Dioxins; Industrial Environmental Research Laboratory (IERC) Cincinnati, Ohio; EPA document no. EPA-600/2/80/197, November, 1980. 2) Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products; R.D. Kimbrough (ed.), Elsevier/ North-Holland Biomedical Press, New York, 1980; pg. 50. T TT 1/17/83 Attachment C FROM R. Bishop - A3NB(N A M E -- L O C A T IO N -- P H O N e D December 20, 1982 TCDD REFERENCE TO : Dr. George Roush - G2WG GC; i In your follow-up conversation with Dr. Neal, I would like to have additional information or confirmation of the following items: 1. Examples of other synthetic substances (in commerce) that are more acutely toxic ) to some test animals than 2,3,7,8 t c d B? 2. 2,3,7,8 TCDD has a high boiling, about~500F. D R B :ec Ch Dan R. Bishop IN - lO l R E V . 8/77 I