Document Rjb8grYr15Mr8nJeGLq0b0nwv

CM|ZS\ Chemical Manufacturers Association March 17, 1997 Michael J. Butler, Ph.D. Manager, Business Development Huntingdon Life Sciences, Inc. P.O. Box 2360, Mettlers Road East Millstone , NJ 08875-2360 RE: Amendment #1 to Agreement No. VCHC 10.0-HLS-Repro/Develop Dear Dr. Butler: The Chemical Manufacturers Association, on behalf of its Vinyl Chloride Health Committee, hereby amends Agreement VCHC 10.0-HLS-Repro/Develop dated, October 3, 1995 as follows: The cost of the contract is increased by $29,582 for additional analytical work as described in the attached facsimile of letter from Butler to Shah of February 20,1997 and the storage of tissues and data for ten (10) years from the date of the final reports, which brings the total amount authorized under this contract to $584,582.00. You may invoice CMA for : $15,332.00 upon execution of this amendment; $7,125.00 along with the invoice for Reproductive Effects Study Progress Report No. 1 on April 14,1997; and the remaining $7,125.00 along with the invoice for Reproductive Effects Study Progress Report No. 2 on August 31,1997. All other terms and conditions of Agreement VCHC 10.0-HLS-Repro/Develop remain the same. If you are in agreement with the terms of this Amendment, please sign both copies, retain one for your files and return the other to Dr. Has Shah. If you have any questions regarding this amendment, please call Dr. Shah at 703/741-5637. 1300 Wilson Boulevard, Arlington, VA 22209 Telephone 703-741*3000 Fax 703-741-6000 CMA 118163 On all correspondence, invoices and reports, please use CMA reference number VCHC lO.O-HLS-REPRO/DEVELOP. Attachment: Facsimile of letter from Butler to Shah of February 20,1997. ACCEPTED FOR: Huntingdon Life S< Name Sign Alan Staple Name Typed C President, Chief Operating Officer Title April 10, 1997 Date CMA 118164 '3-27-97 THU 07:33 PM Hvtfngaon He Scenes*, me. P.O. Box 2360. Msdlan Rt<J East Mason*. NJ 0687W360 Telephone: (90S) 873-2530. exMrarion 7000 PMBfnls: (008) 873-3892. S899 P, 01 Huntingdon Ufe Sciences Tbs Dr. Hasmukh C. Shah Fronu Dr. Michael J. Butler Fax: (703) 741-6091 Pages! 1 Phones Datei February 20,1997 Res Vinyl Chloride chemistry costs Comments! CCi Dear Has, This is to confirm the analytical chemistry price for the Inhalation two-generation reproduction and developmental toxicity study as $28,000. The price is broken down as follows: Method Development/validationrtriais $13,000 In-iife analysis $13,000 The in-iife price is based upon 10 days according to the sampling schedule, plus three additional days spent overcoming problems of test material adsorption to the original teflon lines and switching to stainless steel. In addition. I am adding the cost of materials specific to this project and a price for additional storage. Chromatographic column Air sampling bags 10-year tissue storage $ 982 $ 1,350.10 $ 1,250 We are passing along the cost of the analytical column and air bags because for our practical purposes, they will not be reusable. In the case of the column, we do not foresee a need to use that type again. Of course, we will gladly forward the column to one of your members if it isofuse. The air bags have proven to be increasingly difficult to purge with time, with the result that we run the risk of cross-contamination, or the time we spend cleaning them will become prohibitive, and tne cost passed on to you. Sincerely, fULl srjtMsr-- Michael J 8utler, Ph.D. Manager, Business Development CMA118165