Document Rjb3d868LBqDq8y1wba47rQjX

MANUFACTURING CHEMISTS ASSOCIATION 1825 CONNECTICUT AVENUE, N. W. WASHINGTON, D. C. 20009 (202) 483-6126 August 13, 1969 TO: Food, Drug, and Cosmetic Chemicals Committee SUBJECT: Tentative Agenda for September 11, 1969 Meeting Gentlemen: Enclosed is a copy of the agenda for the September 11, 1969 meeting which will be held in the sixth floor con ference room of the American Cyanamid Company, Time-Life Building, New York City, starting at 10:00 a.m. The TimeLife Building is on the Avenue of the Americas opposite the Radio City Music Hall. Sincerely yours MMH:gr Attachment Distribution "B" M. M. Hoover, Secretary Food, Drug, and Cosmetic Chemicals Committee p&l 00002260 Manufacturing Chemists Associations Tentative Agenda for Meeting FOOD, DRUG, AND COSMETIC CHEMICALS COMMITTEE American Cyanamid Conference Room Sixth Floor Time-Life Building New York, N. September 11, 1969 Starting Time - 10:00 a.m. Introductions Minutes of Last Meeting Personnel a. Membership b. Report of Nominating Committee c. Election of Vice Chairman Liaison Activities a. MCA Board of Directors b. MCA Environmental Health Advisory Committee c. NAS Food Protection Committee Other Committee Activities a. International Food Standards b. Good Manufacturing Practice Regulations c. Proposed Food Additives Procedural Regulations d. Protocols for Safety Evaluation Other Items a. NCI Research Data b. EC Directive on Emulsifiers-Stabilizers, Thickening and Gelling Agents c. Next Meeting Chairman Chairman Secretary, Dr. Sp ncer Chairman Mr. Graham Chairman Dr. White Mr. Mulford Mr. Aalto Dr. Spencer Mr. Ruark Mr. Meyer Secretary Dr. Knapp Secretary Chairman Secretary Chairman ASI 00002261 SCe iC cC o7-^7r7 ,r; V -` v (+ ^ * -* * t+ ' < ` 0 j7 /V^L> '<? ^ rl" -* ^.t -/**< 7 i :Ct *CL t-ti & ^ JA / K * <* T Li: %u T '/; <\ /7/ " 7 <-< ,- v -'iLv j -y*-* ^ m- C* tf ' <- ^ ^ ~ ./' -'r ?fJ ^ *_y rt '*- h *"jr: -v.-.--// ' ..........1, 2T/W7 l^ZC^ *- /" ^ ^ V/ '-1-1 jr^y y^ -- ^F ' . / ^y >v - ^ ^ ^ /* s ^^ ^ - yc * /r /V" . *._y7 l'~~ J(-^V + } r *=*/f' ey<r. / ~y. t-,~ St rc.^ie j1 . --n_ J -*'&, ^c-C.^C 7^c* .>, c i -s/t,',. ^ *.,,/ 6 * fJ /" 7 *" t yO,- / ,. 77 ` " -- #* <..*BVs- <l2t *yyry*30 7 <w- ' ^- r*/\^- f k*0 -' *"*-' ^ 4 i *7i . </ y - / <r /*<-'Cs c-z.. - --<^es -y vy J" --" - '/ \fj /,> --'^` -7/" i- /T 'y ^ ^-t-'" ^^5^ 4f IF- J - "** 7/ ~?/e>t- f* v c S-*` l r- i -y> .^7*^**"-T' /7 ^ y7 /r" ^ <~r* ;, ^ oT ' *; v \7^ J yt ifSer-A**' & * - ~^-<L C* <^-: ^ `-t.Vd i&*--j-^ ~ / /^T? s* tc?~ *>& '.- -tt r-/c^>/<f*;/d~r?f^'_"_/'/*, i&*-y/x i r-y'^}A***s "Z**v*- >^>7 l.(-Xi < eCr'/n-- .* / /* Zffk /* y <i//*if- _ y/- ^^y> ****' <f`jCl'"', y- {fC^`<ref r^-Cv --* y V !. *r 5^ 7^y^4 ^ ASI 00002262 I .,y: C~ /QCC C'ctijc,,, , c\rs - F^e.^Ce.<. cj ?/i.^ SLstUa /' CF/^/XS CS,,........ . y^Y' y `a" ' ------- < , ^ f* /e--,,-. .. 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''--(it,. r, cy cC<~. - 7*>* ^ A- p^C- ^ A**- ASI 00002263 7 C c^ JlJL 1 1969 MANUFACTURING CHEMISTS ASSOCIATION 1825 CONNECTICUT AVENUE, N, W. * WASHINGTON, D, C. 20009 o <202) 483-6126 June 27, 1969 TO: Food, Drug, and Cosmetic Chemicals Committee SUBJECT: Inclusion of Food Additives Produced by MCA Member Companies in International Food Standards Gentlemen: As you know, the Codex Alimentarius Commission will before long take action on a number of commodity standards which will undoubtedly have a pronounced effect on both foreign and domestic usage of food additives produced by MCA member companies. At the April 2, 1969 meeting of the FDCC Committee, it was voted unanimously to request the secretary to notify member companies of those food additives sanctioned for use in this country for which acceptable daily intakes have not been determined by the FAO/WHO Joint Expert Committee on Food Additives, so as to signal those food additives for which toxicological data (and specifications) are needed for consideration by the Expert Committee. Inclusion of specific food additives in commodity standards by the Commission depends on endorsement by the Codex Committee on Food Additives, which can act only after receipt of acceptable daily intakes from the Expert Com mittee . So it is requested that you note from the lists attached to this letter those additives for which toxicological data (and speci fications) are needed, and send to this office such freely available data as you may have for forwarding to the Expert Committee. List No. 1 shows the "generally recognized as safe" substances as listed on pages -7 ^through Jl^of the Code of Federal Regulations, Title 21 - Food and Drugs, Part^ 120 to 129 (Revised as of January 1, 196JB7. List No. 2 shows the list of "Food Additives Permitted in Food for Human Consumption" taken from pages 51-52 of the same publication, with the newer items added at the end. In each of these two lists, an "x" is placed in front of those additives for which an acceptable daily intake has been established by th Expert Committee. The remaining (about 75% of both lists) ASI 00002264 2- - represent those for which toxicological data are needed for an accept able daily intake to be established. Since this marking is probably not 100% accurate, it is suggested that you refer to List No. 3 as well. This list shows those substances for which acceptable daily intakes have been established by the Expert Committee as reported in the Tenth and Eleventh Reports of the Joint FAO/WHO Expert Committee on Food Additives. This letter is being sent to all on the complete mailing list for the FDCC Committee. So, in some cases, it will be received by more than one in a company. It is suggested that your data be sent to this office within the next two months. Sincerely yours, M. M. Hoover, Secretary Food, Drug, and Cosmetic Chemicals committee MMH:gr Enclosures (Lists Nos. 1, 2, 3) Distribution "A" ASI 00002265 LIST NO.l-S' STANCES GENERALLY RECOGNI? AS SAFE (Substances not x'd out are those for which toxicological data are needed.) (1) ANttCAETNO AGENTS Aluminum calcium silicate., .......... Calcium silicate..................................... Calcium silicate................... ............... Magnesium silicate.............................. Sodium aluminaslllcate (sodium slUcoalumlnate). Sodium calcium aluminosilicate, hydrated (sodium calcium silico* Muminate). Trioalcium sllloate................................ (2) CHEMICAL rRXSERVATlVZfl X Ascorbic acid...............--*.***-- * Ascorbyl pilaltate....................... . X Benzoic acid.,--.*............................... X Butylated hydrozyanlsole.................... X Butylated bydroxytoluene.. Calcium ascorbate________ _ X Calcium preplonate......... X'Calcium eorbate............ Capryllc add,.,....___ ____ Dllauryl tbiodipropionate... Erythorbic acid.................................... *Gum Fuaiac................ Methyl paraben (methyl-p-bydrozybenzoate). * Nordlhydroffualaretle add............ Potassium bisulfite...... X Potassium metabisulfite. X Potassium sorbate....... X Propionic acid__________ XPropyl gallate--. Propylparaben (propyl p-bydroxyb*nzoate). XSudium ascorbate.............. ..--.*, XSodium benzoate................................... Sodium bisulfite.,,,............................ XSodium metabisulflte XSodium propionate..,*_____________ Sodium sorbate......... --..*....... XSodium sulfite............................. Vfiorblc add...--........ ............ ..... Stannous chloride,........................... Xfiulfur dioxide................ --*............. XThiodiproptonic ........... . XTocopherols......._ (3> EMULBIFTINQ AOENTS XCbollc add..................... ......... KDesoxychollc add-.............................. . XDlaoetyl tartaric add esters of mono- and dlglycerldes of edible fats or oils, or edible fat-forming fatty acids. Glyoocholic add____ *..*....**-- *Mono* and diglyceridee of edible fats or oils, or edible fat-forming acids. XMono*odium phosphate derivatives of mono and digfyoeridee of edible fats or oils, or edible fat-forming fatty adds. XPropylene glyool..--,...........**___ Ox bfle extract...*.*.... ........... TenrochoUc add (<r Us sodium salt).. <e> xomrotRmvs minmi Ammonium saccharin* **,,.._--*_.*. X Oaldum oyclamate (calcium cyclo- hexyl solfamate). XOaldum aaceharta...***___ .......... Magnesium eydamate (magnesium eydobexyi suuamate). potassium eydamate (potassium eydohexyl solfamate). XSaccharin-...___--.............................. XSodium eydamate (sodium cydo- bexyl solfamate). XSodium saccharin................................. m Nvntmxn and/or dietary SUFFLIMXNTS 1 Alanine (L- and DL-ferms)... Arginine (L- and DL-forms)........... X Ascorbic add...................................... Asparticadd (L-and DL-forms).... Biotin.................................................... XOaldum carbonate....................... X*Caldum dtrate.......... .............. . Calcium glyoeropboaphate.,*......... XOaletum oxide.................................... Oaldum Pantothenate......... **............. XOaldum phoephate /ffionA>di-. tri* basic). Calcium pyrophosphate....... ............ Calcium sulfate................................ . Carotene...................... ................... Choline bitartrate.............. ................ Choline chloride............................ Copper duconate................................. Ouprous iodide....... ................... ......... Cysteine (L- form)............................ Cystine (L* and DL- forms).............. Ferric phosphate.............................. Ferric pyrophosphate................... Ferric sodium pyrophosphate........ Ferrous gluconate............................... Ferrous lactate....................... ....... Ferrous sulfate...... ....................... Glycine (aminoacettc add)........ ........ Histidine (L-and DL- forms)...,... Inositol...................... ...... Iron, roduoed................... ..................... Isoleucine (L and DL-forma),..___ Leucine (L- and DLforms) ........ Linoleic acid \ prepared from edible fats and oils and free from chickedema factor). Lysine (L-and DInforms)................. X Magnesium oxide................. .............. Magnesium phosphate (di-, tribasic) Magnesium sulfate........................... Manganese chloride..*.*................... Manganese citrate,...._________ Manganese gluconate..... *.................. Manganese glycerophosphate--....,. Manganese hypopbosphite................ Manganese sulfate................*,,........... Manganous oxide.................. X*Mannitol,,................................. . Methionine-........... ......................... Methionine hydroxy analog and its calcium salts. Niacin,........ ................................. . Niacinamide...............,*.*--*.-- D-Pantotheriyl alcohol...........___ Phenylalanine (L- and DLforms)... Potassium chloride,..*........................ Potassium glycerophosphate........ Potassium Iodide........... ....................... Prollne (L- and DL-forms),............... Pyrldoxine hydrochlortde..----....... Riboflavin............................................ Rlboflaviu-s-phosphate,......... ... Serine (L* end DL-forms).........,*, Sodium pantothenate..--................. . XSodium phosphate (mono*, di-, tri basic). X Sorbitol................................................... Thiamine hydrochloride..*.......... Thiamine mononitrate....................... Threonine (L- and DL-forms)..,.,,, XTocopherols,......... ......... .................... -Tocopherol acetate*..................*_ Tryptophane (L- and DL-forms).... Tyrosine (L- and DL forms)--........ Valine (L* and PL-forms)...--..... Vitamin A........... *....*._.................... Vitamin A aoetate-- ......... **. Vitamin A pelmitate..... ..................... VUamln Bu--..................--........ vitamin D>............... Vitamin D........ ................................... Zinc sulfate........................................ Zinc gluconate..... ............................... Zinc chloride.................. ................... . Zinc oxide*.......*._____ _ Zinc stearate (prepared from stearic add free from chickedema factor). <e> SIQURSTRANYS 1 X Calcium aoetate..***......__________ XCaldum chloride................. ................ XOaldum citrate................ * Oaldum diacetate...........*............. Calcium gluconate...*___ .......___ Calcium hexametaphosphau......... Calcium phosphate, monobasic......... * Calcium phytats.*......... ..................... X Citric aela..,......... ................... fXDipotassium phosphate*............. ........ Disodium phosphate*............ Isopropyl dtrate............................. XMonotsopropyl citrate..--**........... ... Xpotaasium citrate...--....--............. Sodium acid phosphate--.--*........... * "Sodium dtrate***-*...--...... XSodium diacetate.**..*..*--....... Sodium gluconate...*...*.............. . Sodium nexametapbosphate___ ***.*_ Sodium metaphospbate--................ XSodium phosphate (mono-, di-, tri basic), XSodium potassium tartrate...**.*___ /Sodium pyrophosphate......... .............. '-Sodium pyrophosphate, tetra.*..*-- XSodium tartrate.................................... Sodium thiosulfate*............................. Sodium tripolyphosphate.............. *___ Xfiteeryl citrate*.*.....**......... ............ XTartaric add*............................... (7) STABILIZERS X*Ac&cia (gum arable)___ _ X Agar-agar....*....... ............ X*Ammonium alginate____ X*Calcium alginate........................... . XCarob bean gum (locust bean gum).. Chondrus extract (carrageeuin)....*.. Ghattl gum.......*.*.**............... . XOuargum..................... ........................ x'Potassium alginate..................... X"Sodium alelnaie................................ X *$terculia gum Ocaraya gum).............. X *Tragacantb (gum tragacantb).**___ ($) MISCELLANEOUS AND/OR GENERAL PURPOSE FOOD ADDITIVES X Acetic acid............................................ X`Adipic acid................................. ........ Aluminum ammonium sulfate__..... Aluminum potassium sulfate.............. Aluminum sodium sulfate................... Aluminum sulfate*..*............ *............ X Ammonium bicarbonate.................... X Ammonium carbonate........... *........... X Ammonium hydroxide................... . Ammonium phosphate (mono- and dibasic). Ammonium sulfate*....*................... Beeswax (yellow wax)..*.....**....... Beeswax, bleached (white wax)*.*... Bentonite................................... ...... Butane.**.............................................. Caffeine.*.,............ ............................. XCalcium carbonate....*................... . XCaldum chloride................................. . XCaldum citrate..*. Calcium gluconate... XCaldum hydroxide... Caldum lactate____ XCaldum oxide .._.**. XCaldum phosphate trlbaric). Caramel....... . Carbon dioxide_____ Caraauba war........... X Citric add................................. .......... Dextrans ?of average molecular weight below 100,000). XEthyfformate............................. . Glutamic acid............ ....................... . Glutamic add hydrochloride*.*. Glyoertn............. ................... ....... Glyceryl moncetearate.**,*......... . Heilum...*................ ......... ......... . X`Hydrochloric add___ ......____ X Hydrogen peroxide........... . XLactic add. ............ . X'Lecithin...................... *................ XMagncslum carbonate................. . XMagnesiura hydroxide*.*..**.............* Magnesium oxide.................................. Magnesium stearate................ .*..*... X Malic acid____..*............................ Methylcellulose (U.8.P. methyl- cellulose, except that the methoxy content shall not be less than 27.5 percent and not more than 31,5 bereent on a dry-weight basis). Mouoammonium glutamate*............ Monopotassium glutamate.,***....... X Nitrogen........... *..........*.................. Nitrous oxide___________ _______ ... Papain___ ______________......*........ XPbospboric acid..................... .--**.. Potassium add tartrate................... . XPotassium bicarbonate...................... XPotassium carbonate.*......**.*........ Potassium citrate........................... XPotassium hydroxide,*.*.*.................. Potassium sulfate.................__ Propane.*_______________ .--*_ XPropylene glycol..-*.................. ....** Rennet (rennia).--*......................... Silica aerogel (finely powdered micro- cellular silica roam having a mini mum silica content of 80.5 percent). Sodium acetate.................................... Sodium add pyrophosphate................ Sodium aluminum phosphate*.*-- XSodium bicarbonate.-....*......... XSodium carbonate*--___ *_--*.*.***. XSodium dtrate...*.............................. **8odium carboxymethylcellulose (the sodium salt of carboxymethylcellu- loss not less than 99,0 percent on a dry-weight basis, with maximum substitution of 0.95 carboxymctbyl groups per anhydroglucose unit, and with a minimum viscosity ol SO cantipolses for 25 percent by weight aqueous solution at 25s C.)\ Sodium caseinate......... ............. XSodium dtrate........ ...........,....*...... XSodium hydroxide..*.................. . Sodium pectinate.*........................... XSodium phosphate (mootv, di-, tri- basic). "Sodium potassium tartrate. Sodium sesqutearbonate...*...****.. Sodium tripolyphosphate-*.----. Succinic acid...................... .......... Sulfuric add................. -- XTartaric acid................................... Triacetin (glyceryl triacetate).--. Triethyl citrate.................................... ASI 00002266 LIST NO * 2"FOOD ADr (Substances not x'd out 121 1001 121.1002 121.1003 *121.1004 121,1005 121 1006 121,1007 *121.1008 121.1009 121.1010 121.1011 121.1012 121.1013 121.1014 121.1015 121.1016 121.1017 121.1018 121.1019 121,1020 #121.1021 121.1022 *121.1023 121.1024 121.1025 121.1026 X121-1027 121.1028 *131.1029 121.1030 121.1031 121-1032 121.1033 *121.1034 *121.1035 121.1036 121.1037 121.1038 121.1039 121.1040 121.1041 Ethoxyquin. Buquinolate (ethyl-4-bydroxy-6. 7- dlleobutoxy - 3 - quinoline - car- boxylate). Neomycin, polymyxin, hydrocorti sone acetate, hydrocortisone so dium succinate in milk from dairy cowe. Glyceryl-lacto esters of fatty acids. Bacitracin, zinc bacitracin, man ganese bacitracin, bacitracin methylene dlsallcylate. Maleic hydrazide. Reserplne, polyoxyethylene (201 sorbltan trl- stearate. Polysorbate 80. Olbberelllc acid and Its potassium salt. Oleandomycin. Sodium lauryl sulfate. Zoalene. Chlortetracycllne. Propylene glycol alginate. Oxystearin. Calcium dlsodlum EDTA, Acetylated monoglycerides. partially defatted, cooked cotton seed flour or similar products de rived from cottonseed intended for human consumption. Inorganic bromide. Hydroxypropyl methylcellulose. Amprollum. Acetone peroxides. Hygromycln B. Streptomycin. Penicillin. Hydroxylated lecithin. Castor oil. Sorbltan monostearate. polysorbate 60 (polyoxyethylene (20) sorbltan monostearate). Food starch-modified. Yellow prussiate of soda. Novobiocin. BHT. BHA. Monoglyceride citrate. Calcium pantothenate, calcium cnlorlde double salt. Tetradiron. Methylene chloride. Ethylene dlchlorlde. Trichloroethylene. 121.1042 121.1043 121.1044 121.1045 121.1046 121.1047 121.1048 121.1049 121.1050 121.1051 121.1052 X 121.1053 121.1054 121.1055 121.1056 121.1057 121.1058 121.1059 121.1060 121.1061 121.1062 *121.1063 X121.1064 121.1065 *121.1066 121.1067 X121.1068 121 1069 121.1070 121.1071 Acetone. Isopropyl alcohol. Methyl alcohol residues. Hexane. Oxytetracycllne. Calcium stearyl-2-lactylate. Lactylle esters of fatty acids. Tylosln. Coumarone-lndene resin. Dthydroetreptomycin. Metaldehyde. Sorbitol. Promazine hydrochloride. Nystatin. Dlsodlum EDTA. Polyethylene glycol 6000. Silicon dioxide. Chewing gum base. Combustion product gas. Captan. Methyl formate. Sodium nitrate. Sodium nitrite. Octafluorocyclobutane. Carrageenan. Salts of carrageenan. Furcelleran. Salta of furcelleran. Patty acids. Salts of fatty aclda. 'IVES PERMITTED IN FOOD FOP TJMAN CONSUMPTION are those for which toxicological data are needed.) 121.1072 Hydrogen cyanide. ftl.1073 Potassium Iodide. 121.1074 Plperonyl butoxlde. 12U078 Pyrethrlns. 121.1070 Propylene oxide. 121.1077 Terpene reeln. 121.1078 Ronnel 1211079 Paraformaldehyde. 1211080 Stearyl monoglycerldyl citrate. 121.1081 Quinine. 121.1082 Modified hop extract. 1211083 Methyl chloride. 121.1084 Glycerol ester of wood rosin. 121.1085 Azodicarbonamlde 1211083 Sugar beet extract flavor base. 1211087 Ethyl cellulose. 1211088 Boiler water additives. 121.1089 Dehydroacetlc acid. 1211090 Dlsodlum lnoelnate. 121.1091 Chemicals used In washing fruit* and vegetables. 121.1092 Acrylamide-acrylic acid resin. 1211093 DDT. 121.1093a DDT and Its related degradation products In manufactured dairy products. 121.1094 Furaltadone. 121.1095 Nicotinamide-ascorbic acid com plex. X121.1096 Ethyl formate. 121.1097 Safrole-free extract of sassafras. 121.1098 Rice bran wax. 121.1099 Defoaming agents. 121.1100 Iron-chollne citrate complex. 121.1101 Sperm oil. hydrogenated. 121.1102 Calcium Ugnosulfonate. 121.1103 Nihydrazone. 121.1104 Neomycin. 121.1105 Morpholine. 121.1106 121.1107 121.1108 121.1109 `*-131.1110 121.1111 *121.1112 X 121.1113 121.1114 X 121.1116 121.1118 121.1117 121.1118 121.1119 *121.1120 121.1121 121.1123 131.1134 131.1135 131.1126 121.1127 121.1138 131.1139 X1211130 131.1181 X131.1132 131.1183 131.1134 131.1135 121.1188 131.1137 131.1138 -- 121.1189 131.1140 131.1141 131.1143 121.1143 121.1144 121.1145 Ethopabate. Blthlanol. Methlotrlazamlne. Dlsodlum guanylate. Polyvinylpolypyrrolldone. Synthetic glycerin produced by the hydrogenolyele of carbohy drates. Methyl ethyl cellulose. Propylene glycol mono- and dlea- ters of fata and fatty acid*. Xylltol. Mannitol. THBP. Diethyl pyrocarbonate. DlethylstUbestrol. Polyacrylamide. Polyglycerol eater* of fatty acid*. Polyethylene glycol minimum mo lecular weight 1,300. D-Pantothenamlde. Sulfamethazine. Dried yeasts. Ethlon. Progesterone. Estradiol benzoat*. Testosterone propionate. Pumaric acid and *alt* of fumarlc acid. Chlorobutanol. Potaasium nitrate. Fumigant* for grain-mill ma chinery. Ptaroylglutamle acid. Calcium tllloate. Methacryllc add-dlvinyl-benzene copolymer. Dioctyl sodium aulfoaueelnat*. Arsenic. Polyvlnylpyrrolldon*. Salicylic acid. Aluminum nlcotlnate. Polyethylene, oxidized. Erythromycin. Sulfa*thoxypyTldazlne. Furazolidone. 121.1146 121.1147 121.1146 121.1149 White mineral oil. Prednlsolone. lon-exchange resins. Kelp. 121.1150 Estradiol monopalmltate. 121.1151 Methyl glucoslde-coconut oil ester. 121.1152 Fumigants for processed grains used In production of fermented malt beverages. 121.1153 Thiabendazole. 121.1154 Synthetic lsoparaffinlc petroleum hydrocarbons. 121.1155 Chemicals used for the control of micro-organisms in cane-sugar mills. 121.1156 Petroleum wax. 121.1157 Prednisone. 121.1158 Methylparaben. 121.1159 Propylparaben. 121.1160 Hydroxypropyl cellulose. 121.1161 Ethylene oxide polymer. 121.1162 Calcium lactoblonate. 121.1163 Natural flavoring substances and natural substances used In con junction with flavors. 121.1164 Synthetic flavoring substances and adjuvants. 121.1165 Rhlzopus oryzae. 121.1166 Petrolatum. 121.1167 Dlmetrldazole. 121.1168 3,5-Dlnltrobenzamlde. 121.1169 A c e t y l(p-nltrophsnyl) sulfanila mide. 121.1170 Bacterial catalase. 121.1171 131.1172 121.1173 121.1174 121.1175 121.1176 121.1177 121.1178 121.1179 Sodium methyl sulfate. Malathlon. Dlenestrol dlacstate. Arablnogalactan. Chlorbexldlne. 1.3-Butylene glyool. 2-chloro-4- mtrobenzamjde. Aluminum phosphide. Ooatlngs on fresh citrus fruit. 121.1180 Ion-exchange membranes. 121.1181 Chioropentafluoroethane. 121.1183 Odorless light petroleum hydro carbons. 131.1183 Sodium etearyl fumarate. 131.1184 Ethylenedlamlne. 131.1185 131.1188 131.1187 131.1188 131.1189 131.1190 131.1193 131.1193 131.1194 131.1196 131.1196 131.1197 Polyethylene glycol 400, n-Heptyl p-hydroxybensoat*. Medroxyprogesterone acetate. Hexachlorophent. Phenothiattne. Iron ammonium citrate. Modified polyacrylamide rests. Carrageenan with polysorbate SO. Potassium bromate. Suoclnylited monoglycerldee. Toxaphene. Succlstearln (ataaroyl propylene glyool hydrogen succinate). 131.1198 Sodium carbonate with sodium mono- and dimethyl naphtha lene sulfonates. 131.1199 Fermentation-derived, mllk-clot- 131.1300 131.1201 131.1303 131.1203 131.1304 131.1305 tlng enzyme. Sodium sulfachloropyrazlne mono hydrate. Testosterone. Whole fish protein concentrate. Petroleum naphtha. 2.4-D. N-octylbicycloheptene dlcarboxlmlde. 131.1206 Coordination product of sine Ion and maneb. 131.1207 1.1-Bla (p-chlorophenyl) 2.2.2-trl- chloroetbanol. 121.1208 4-Hydroxymethyl-3, 6-dl - tert-bu- tylphenol. 121.1309 Dlchlorodlfluoromethane. 131.1211 Sodium stearoyl-2-lactylate. 121.1212 Sulfameranlne. 121.1213 SCnnnous chloride 121.1214 Melengestrol acetate 121.1215 Sulfachlorpyrldazinc 121.1216 Sulfadimethoxine 121.1217 Sulfomyxin 121.1224 Xnnthan gum 121.1225 Adjuvants for pesticide use dilutions 121.1218 l-Hethoxycarbonyl-l-propen-2-yl dimethylphosphate end Its beta isomer- 121.1220 2,2-Dlchlorovlnyl dimethyl phosphate 121.1221Ethoxylated mono- and diglycerides (polyoxyethylei (20) mono- and dlglycerldes of fatty aclda). 121.1222Metoserpate hydrochloride 121,1223 Clopidol ASI 00002267 1 LIST NO.3-SUBSTANCES FOR WHICH ADI'S HAVE BEEN ESTABLxSHED BY EXPERT COMMITTEE ACIDS AND BASES Acids Acetic Acid......................................................... Adipic Acid......................................................... Citric Acid......................................................... Fumaric Acid..................................................... Gluconic Acid (see Glucono-delta-Lactone) . . Glucono-delta-Lactone (Gluconic Acid) .... Hydrochloric Acid.............................................. DL-Lactic Acid..................................................... DL-Malic Acid..................................................... Monocalcium Phosphates.................................. Phosphoric Acid.................................................. Tartaric Acid..................................................... Bases Ammonium Carbonate...................................... Ammonium Hydrogen Carbonate....................... Ammonium Hydroxide...................................... Calcium Carbonate.............................................. Calcium Hydroxide.............................................. Calcium Oxide..................................................... Magnesium Carbonate...................................... Magnesium Hydroxide...................................... Magnesium Oxide.............................................. Potassium Carbonate.......................................... Potassium Hydrogen Carbonate....................... Potassium Hydroxide.......................................... Sodium Carbonate.............................................. Sodium Hydrogen Carbonate........................... Sodium Hydroxide.............................................. ANTIMICROBIAL PRESERVATIVES Benzoic Acid.......................................... Benzoate, Potassium............................... Benzoate, Sodium.................................. Benzoate, />-Hydroxy-, Butyl............... Benzoate, p-Hydroxy-, Ethyl .... Benzoate, p-Hydroxy-, Methyl .... Benzoate, p-Hydroxy-, Propyl............... Boric Acid.............................................. Borax..................................................... Diethyl Pyrocarbonate........................... Diphenyl.................................................. Formic Acid.......................................... Hexamethylenetetramine............... . . Hydrogen Peroxide............................... Nitrate, Potassium................................... Nitrate, Sodium...................................... Nitrite, Potassium.................................. Nitrite, Sodium...................................... u-Phenylphenol...................................... u-Phenylphenolate, Sodium................... Propionic Acid...................................... Propionate, Calcium............................... Propionate. Potassium........................... Propionate, Sodium............................... Salicylic Acid.......................................... Sodium Diacetate................................... Sorbic Acid.............................................. Sorbate, Calcium................................... Sorbate, Potassium............................... Sulfur Dioxide....................................... Other sources of sulfur dioxide Potassium Metabisulfite................................... Sodium Hydrogen Sulfite............................... Sodium Metabisulfite.................................. . Sodium Sulfite .................................................. Thiodipropionic Acid.......................................... Thiodipropionate, Dilauryl................................... ANTIOXIDANTS AND ANTIOXIDANT SYNERGISTS Ascorbic Acid............................................................. Ascorbate, Sodium.................................................. Ascorbic Acid, Iso-.................................................. Ascorbate, Iso-......................................................... Ascorbyl Palmitate.................................................. Butylated Hydroxyanisole (BHA)........................... Butylated Hydroxytoluene (BHT)........................... Citric Add................................................................. Citrate, Stearyl......................................................... Ethylenediaminetetraacetate, Calcium Disodium. . Ethylenediaminetetraacetate, Disodium................... Gallate, Dodecyl..................................................... Gallate, Octyl............................................................. Gallate, Propyl......................................................... Guaiac, Gum............................................................. Isopropyl Citrate Mixture...................................... Monoisopropyl Citrate (see Isopropyl Citrate Mixture) Nordihydroguaiaretic Acid (NDGA)....................... Phosphoric Acid...................................................... Tartaric Acid............................................................. Tocopherol, Alpha.................................................. Tocopherols, Mixed concentrate............................... EMULSIFIERS AND STABILIZERS Natural Stabilizers Agar..................................................................... Alginic Acid.......................................................... Alginate, Ammonium.......................................... Alginate, Calcium.............................................. Alginate, Potassium.............................................. Alginate, Sodium.................................................. Carrageen............................................................. Furcellaran.......................................................... Gum, Arabic...................................................... Gum, Carob bean.............................................. Gum, Guar.......................................................... Gum, Karaya...................................................... Gum, Oat.............................................................. Gum, Tragacanth.............................................. Stabilizers made by modifying natural materials Alginate, Propylene glycol................................... Cellulose, Hydroxypropylmethyl-....................... Cellulose, Methyl-.............................................. Cellulose, Methylethyl-....................................... Cellulose, Carboxymethyl-, Sodium................... Fatty Emulsifiers Glycerides, Mono- and Di-............................... Acetic Acid and Patty Acid Esters of Glycerol Citric Acid and Fatty Acid Esters of Glycerol Diacetyltartaric Acid and Fatty Acid Esters of Glycerol................... ..................................... Lactic Add and Fatty Add Esters of Glycerol Mixed Tartaric and Acetic Acid and Fatty Acid Esters of Glycerol.......................................... Sulfoacetic Acid and Fatty Acid .Esters of Gly cerol (Sodium Salt)...................................... Polyglycerol Esters of Fatty Acids................... Polyoxyethylene (20) Sorbitan Monolaurate . . Polyoxyethylene (20) Sorbitan MonoOIeate. . . Polyoxyethylene (20) Sorbitan Monopalmitate . Polyoxyethylene (20) Sorbitan Monostearate . . Polyoxyethylene (20) Sorbitan Tristearate . . . Polyoxyethylene (8) Stearate.............................. Polyoxyethylene (40) Stearate........................... Propylene Glycol Esters of Fatty Acids .... Propylene Glycol Monopalmitate....................... Propylene Glycol Monostearate....................... Sorbitan Monopalmitate...................................... Sorbitan Monostearate...................................... Sorbitan Tristearate.............................................. Sucrose Esters of Fatty Acids........................... Steroid Emulsifiers Cholic Acid (and Sodium Salt)........................... Cholic Acid, Deoxy- (and Sodium Salt) . . . . Miscellaneous Emulsifiers Lecithin...................................... i...................... Lecithin, Hydroxylated...................................... Salts Acetate, Calcium.................................................. Chloride, Calcium.............................................. Citrate, Calcium.................................................. Citrate, Potassium.............................................. Citrate, Sodium.................................................. Phosphate, Monosodium................................... Phosphate, Disodium.......................................... Phosphate, Trisodium.......................................... Phosphate, Monopotassium.............................. Phosphate, Dipotassium...................................... Phosphate, Tripotassium................................... Phosphate, Di- Disodium ...................................... ................... Tetrasodium.................................................. Phosphate, Tri-, Pentasodium........................... Phosphate, Poly-, Sodium................................... Tartrate, Sodium.................................................. Tartrate, Potassium Sodium............................... (CONTINUED) ASI 00002268 f f LIST NO.3 (CONTINUED) FLOUR TREATMENT AGENTS Azodicarbonamide.... Bromate, Potassium . . . Chlorine........................... Chlorine Dioxide .... Todate, Calcium............... lodate, Potassium .... Monocalcium Phosphates Nitrogen, Oxides of . . . Peroxides, Acetone . . . Peroxide, Benzoyl .... Peroxide, Calcium .... Persulfate. Ammonium. Persulfate, Potassium . . Stearyl-2-Lactylate, Calcium Stearyl Tartrate ............... FOOD COLOURS Colours in toxicological categories A, B, and Cl Amaranth ..... Brilliant Blue FCF . Canthaxanthine . . Beta-Apo-8'-Carotenal Beta-Carotene ... Beta-Apo-8'-Carotenoic Acid, Methyl or Ethyl Ester............... Citrus Red No. 2. Erythrosine . . . Fast Green FCF . Idanthrene Blue RS Indigotine .... Orange I . . . . Patent Blue V . . Ponceau 4R . . . Quercetin and Quercitron Quinoline Yellow. Sunset Yellow FCF Tartrazine .... Titanium Dioxide. Wool Green BS . Colours in toxicological categories CIla, CIII*, which are used in some countries Acid Fuchsin FB.......................................... Azo Rubine.................................................. Benzyl Violet 4B.......................................... Black 7984...................................................... Blue VRS...................................................... Brilliant Black BN " Specially Pure "... Brown FK...................................................... Chocolate Brown HT................................... Chrysoine...................................................... Eosine.......................................................... Fast Red E.................................................. Fast Yellow AB.......................................... Light Green SF Yellowish........................... Methyl Violet.............................................. Naphthol Yellow S...................................... Orange G...................................................... Orange GGN.............................................. Ponceau 2R.................................................. Ponceau 6R.................................................. Red 10B.......................................................... Red 2G.......................................................... Rhodamine B.............................................. Scarlet GN " Specially Pure "................... Sudan G ...................................................... Sudan Red G.............................................. Violet 5 BN.................................................. Yellow 27 175N " Specially Pure" . . . . OTHERS Brominated vegetable oils.......................................... Mannitol............................................................. Polyvinylpyrrolidone.............................................. Propylene Glycol...................................................... Sorbitol..................................................................... FLAVOURING SUBSTANCES AND NON-NUTRITIVE SWEETENING AGENTS leoamyl Butyrate trana-Anethole Bemaldehyde Benzyl Acetate (-f-)-Carvone and (--)-Carvone Clnnemaldehyde Cltral Cltronellol, 90% and 99% total alcohole Ethyl Acetate Ethyl Butyrate Ethyl Formate Ethyl Heptanoata Ethyl Lactate Ethyl Laurata Ethyl Methylphanylglycldate Ethyl Nonanoata Ethyl Vanillin Eugenol Geranyl Acetate a-lonona A-lonone Linelol, 90% and 95% Llnalyl Acetate, 90% and 99% Maltol ()-Menthol and (--)*Menthol Methyl Anthranllate Methyl Salicylate y-Nonalactona Nonanal Octanal Plperonal r-Undecalactone Vanillin Calcium Cyclamate I Sodium Cyclamate i p-Phenetylearbamlde (Duleln) e Saccharin | Calcium Saccharin > Sodium Saccharin ) A$I 00002269