Document RjQkzm8nyk3bKZowj24MMDRnz

; "r;v# AWIUJ7S VOL 5/ NO 1 DU PONT MOBILIZES AGAINST THE RISK OF OCCUPATIONAL CANCER Tbi compiny's princi puis it in good position to moot till daling* posed by new findings on tho dingers of long-term, km-itvoi upossrt =- to chemicals. The news msdls recently nave given a great aaai of anantlon to the and screening of new compounoa ana regulate the use ol auoatanees mat search for oauaaa of oanear. with spa- ara toxic. The industry ia concerned, eiai tooi* on the proeiam of cancer however. Ovat soma of tfie oroooaad raauning from orwfta-too exposure to laws grant too broad authority is carcinogens {substances that cauia seraan and taat ensmieali. canear). Chemical company am- ptoyeae understandably may pa con The Long-Term Exposure Hazard cerned by this ouolic Olacuaaion. Mucn of Ufd present concern over Thla Managamant BulfatM attainpu to pfaea Ova proeiam in panpaetiv*. It discusses the reaction of Ou Pont occupationally reiatsd cancer arose aa a result of two incidents at other chemical comoamsa * which it was aid M rw of induatry to me now discovered that employees had dafact* paing uneovaracL and It da- vatooed canear affar tcng-larm axpo senses ova company's efforts to in- aura to carcinogens In one case, vinyl aura a aafa working anvfrcmvant chlonde monomer f mean a rare liver Ou Bent la involved m ova laaua be- oanear in exposed werfcar*. and In me oauaa it maxaa or uses a taw of Ota other, tho chemical Ota ehloromadiyt matartala Ovat tvava earn idanttflad as ether waa (otxvd 10 cauas lung canear. potantlalfy caretnogsme in human be ings. The eomoany's long-standing oammitmant to ova aafacy of tta anv During tha long parted over which those chemicals were produced, nei ther had bean considered carcino pfoyasa extends to ifta eareinogan problem. Aa. daaertbad later, datarmining wnat la sets in Handling car cinogens a mora difficult otan with genic. Substances such aa measles, bata-naphthyiamina and aarutdlna were known to ba canear hazards on tho job. but tha number or occuoatlonal carcinogens was thought to ba Ou Pont bottom ttioso substsnces aa bo handled afofy, but it is comtiuttod to dosing down my limited. Today 17 sueataneaa are ourrantly subject to workpiece control mrough government regulation Be cause ef carcinogenicity operation vnfwrt titty cannot bo "Our understanding of tha poten tial affects of long-term low-teval other kinds of nazarda. Nevertheless. axpoaura to eanam rhaavg a sub Qu Pont beuevaa Oiaaa aubataneaa stances ia clearer man * waa lusi a can ba handled maty, but tea com- taw years ago." says *ruaam H. Gal pany ia oemmlttad to elating down loway. -If.. Ou Ponrs sweeter of en any operation where they cannot ba. vironmental affairs "We've leamsa Ou Pent and otftar cfvamieaf produeara ara supporting lagialatlan mat that soma pravioualy uneuaoectad matartala are mora aangaious man would provide addad oubile profac was thought to ba tha ease. Sul at tion by giving ins Federal government additional power to raquira lasting u Pont wa have several thevqe n our favor. For example, our concern tor DUP 0910068 safety nu lad u* to tightly control qoiur* to product* that have toxic affects, suen a o*itt*g* to body or gan*. Chemical* that ira carcmogtnic am alaoTlkafy to hav* othar toxic aflaet*. Thus, soma cnamicala mat may turn out to M earctnogana ara alraady undar tlgnt eontrol* oacauaa of tftalr toxicity. "In isos wm eatabllahad on* ot th* first inouatnaJ toxicology laboratoria* m tna country, ttia Haakall Laboratory lor Toxicology and Industrial Madicm*. It haa dona outstanding wont m identifying hazard* and halpmg es tablish tala practice*. A mafor axoansion of majaeoratory la undar way. w* hav* aaan monitoring tn* haaith ot our employ*** through partodic physical axam* sine* 191S. That* pravantlv* maaauraa ttand ua in good stand as w* tackle th* currant problam." _ Th* Cancer Problem "Th* ittamlon that haa Oaan glvan to th* canear problem in th* madia may maka It a**m mat w* ara In a canear apldamle." aay* Calloway, "and mat th* dltaaa* Is Incrsaaatg du* to axpoaura to th* products ot In dustry, and aapaciatty to chemical*. But th* facts gnra a dlffarant picture." It is trua mat canear now causes about one'll fm of all deaths m th* U.3., and that makaa It tha sacone laading caua* of daadi, attar naan dis**a*. Roughly half of all canear deaths ara caused by tn* tnra* moat common form* of tha dlsaaa*--cancar of tha lung, tha large ntastfn* and m* breast. The intidtneirf cucr ta putt up, but that statistic fejb** * bamtsMinc Tha incidence ot canear has gone uo. but that atabaric by itself can b* mialaading. Th* death rat* from eancar has ineraasad in recant caeadaa for man but not lor woman. According to th* lataat analysis of trends by tha American Canear Society, th* daath ram from *U typos ot cancer par tOd.OOO sooulation lags adjusted), daef/nad 9 oar cant among woman o*> twaan th* oariods 1991-53 and 19T1-T3, The rat* ncraaaad 19 par cant among m*n. mainly oua lo a large ineraas* (139 par cam) in lung canear, Thu*, inert**** in tha overall cancer daath rats nav* resulted largely from a higher rat* ot lung cancer. Moat ex perts now anriout# tha ineraas* m lung cancer to cigamtta smoking. Th* u.S.. incicantally, is not th* world laaoar m canear death*. In a World Haaith Organization list of *4 countries it ranka igth m deaths from canear m man, and 15th for woman. Many Watt Eurooaan countries rank anaao of tn* U.S. Furthermore, acme its* inoustnallied nation* nav* higher canear rate* than mera Induttrtallzad cauntnat. Tha medical rtaaareh community a now gradually smiting more of its effort toward idantifylng th* causa* of canear m an effort to prevent it (but tn* main emphasis la still on finding a ours), in th* past research on causa* landed to focus on two araas --virus** and did ganade makeup w* inherit from our parents. So far, virus** nav* b**n linked with canear In animal*. Put not in man. Heredity may turn out to o* implicated in cancar, but more <a a factor that makaa a parson auacaptibf* than as a causa in tmmlf. Lately, th* attention of scientists haa turned to ao-cillad "environmen tal" causa*. Tha term rafara to cancer ratjaah by axpoaura to alt materials in our environment not juat mala riala in tha air and waiar, but sub stance* a* coma in contact with Oacauaa of diet cur ilftatytaa, our occupations. Clgartttt smoking is an environmental factor. Recant esti mate* oy government agencies and private researcher* variously attrib ute 50 to 90 par cant ot all canear to environmental causa*. but there ara big gaps m tn* knowledge on wflien ihaa* aaumataa ara baaed. Th* OonupXtonal RjaX Hew aanous a proMarn is occupa tionally raiatad canear? In on* Sanaa, of course, any incidence cl canear re sulting from on-tna-too Masres is vary aattoua because it Involves human suffanng and proeaeta iota of life. Insofar as It might hava oaan pre van tad It knowledge of th* hazard war* graatar. any tlngit ineidanca of canear a tragic. But tha question must b* asked, how serious is occupationally raiatad canear tn th* context of tha total cancar prooiam? That question naany impossible to answer Oacausa r*search in aoidamiotogy--tn* study of the distribution of diaassa n human poouiattona--naa lacked cats to separata tna occupational causes from other causa* of cancer. Jorn Higgmaon. director of th* intamattonal Agency for Raaaarcn on Cancar, of tha World Haaith Organization, aaumataa that ass than i par cam of all cancan hav* Oaan shown to ba raiatad to occupational factor*. But h* also says that tn* cauaas of moat canear* ar* still unknown. John Waitburgar. a widely known canear spe cialist with tn* Naylor Dana institute, racandy said that occupationally re lated canear was probaoly m tha rang* of t.5 to 3 par cant of all canear deaths. But ha ngtad that estimates in this arts must b* largely a matter of guesswork. Th* *aal Is ffot Always a Hapey Story Th* risk* do axtat. and tnay ar* risks that something ean 5a cone about. But it's not simple. Ou Pent's asparfanca oaan mat out. In tha 1930*. me company real ized that an unusually high ncicanc* of 0ladder turners was becoming avi- dart among amptoyaas wise wornso with dyes at tna Chamears wonts n Naw Jarsay. Largaly to mvamtigata th* creciam. tha cemaany astaoutnac Hstkatl Laooratcry near Wilmington It was on# of th* first noustry instal lations oavotad solely to studying potamial hazards PC sad Dy products. Th* ptaddar tumor cava* was idantiflad aa bata-napmhytamina, a oy* intarmadiata. Tight controls war* si tae!ished. exposure to in* product was greatly 'educed, and medical VP 0910069 2 littiJM--ly.-jriHi--" 'Ifal't itit ' ^TlBWlWBil momtcnng ofmprov*** *** o*$un. Pfoettt rtdMiQn wii undartaKtn. m me and. OuTTont stopped manufaeluring in* chemical largely because it was felt axpoaura could not bo reli ably limited to mM tv* when the product reacted customers' plant. Nevertheless, Z78 caMi of bladder tumor among Cttambar* Wonts employaas expoaed to tna chemicals hava boon racoroad ovar tna years-- mainly raaulting from axpotura dur ing a periodof 30 yaara ago. or aariiar. (In addition, S3 oaaaa nava baan racoroad among amptoyaas who wortcad at anotnar slant Wmen Du Pont acauirad ano swnad during tfta t93C* in Wlaeonain.) Significantly, in acisntifle. msdleai and induatnal circles. tltia meidant at tna tlma waa conaidarad aomatning of a rarity, aa explained by Or. John A. Zapp. dlraetdr ot Haskell Laboratory for tna paat 23 yaara. "Tha idaa tnat many aubataneas mlgfit ba carcinoganio waa not grvan a graat daai ot conaidaratian m tna jclantlflc community," Or. Zapp sayv "Aa lata aa 1951 a laadlng pnarmacologiat of Uta Yala Univaraity Senool of Madieina wrota a taxtbooK in wnleh ha aaid tnat only tnraa pura aganta wart known to cauaa cancar in man -- bata-naphthyiamtna. araanie and radiation." In fact otnar matanaia nad baan founa to ba carcmoganic. but tnia rafartnea indlcataa aomatning of tha stata of aciantlftc knowladga In thla ftald at tna uma. In studiaa of naw chamlcala. amphaala traditionally waa on datsmUning acuta toxicity. Uta lever of snow tarm axpoaura that aauaad advaraa raactlona in axpartraaotal animala. Laaa attantlon waa given to onronlo toxicity, Uta effect of low doaa exsoxura ovar tha IlfaUma of axparlmantal anlmaia. Tha Frobieme of Taatlng Haskell ano otnor itporatonoa now do increasing numbers of cnronlc toxicity studies. Tha trand. m part, is dua to Federal lagitlation raouirlng tong-tarm taata an all drags, food additives and apneultural ehamicaia bafore tnay ara marxatao. it'a also dua to ino raeant upaurge ot eoncam ovar earcinogana. and Ou Font's delermtnation to idanufy and oomrol thla hazard. Chronic toxicity taata art cults txpanaiva. TTiay call for large numoars of animals xnd can last two or mraa years, or mart. "Tha coat of doing auch a atudy in igsa waa more than 1100.000." Or. Zaop recall* "Today, tha coat can run five timaa that amount." Testing for carcinogenicity is a camples matter Tasting tor carcinogenicity is a complex matter. One problem is sim ply the lack ot an axact correlation bstween animal earcinogana and hu man carcinogens. Thera ia, however, high probability that a substance wructi cauaaa cancer m appropriate ipecles ot 'iboratory ammala may also be a human carcinogen at lufflciant doaa levels. Thera ara enormous technical prob lems in doing studios that pinpoint Uta affects of vary low concentrations-- fractions at one part par million, for aaample. But uta biggest puzzle now ia, what aubataneas mould ba tasted for earclnooanteity? Many tnouaanca of ocmeounca era produced by modem industry, and ail cannot be aublected to lengthy, costly tasting. Thera ara. however, seme indicators aa to which matanaia ire likely to ba hazardous. Far example, it a xubatanea has a chemical structure similar to that of a known carcinogen, it immediately attracts suspicion. But "guilt by aaso elation'' has its limitations. A notori ous instance in winch it did not apply was vinyl chloride monomer. This substance a not ensmicalty related to otnar earcinogana and was in fact long regarded as relatively nonnazardoua. Sow. loxicoiogiata ara look ing ctotaiy at similar chlorinated hydrocarbons Recant interest has focused on de velopment ot relatively short "screen ing" 'mis id determine wmen charm* cals mould ba lasted runner One widely used tcraanmg leal a 'or mutagenicity, tha ability of a sub limes to cause mutations in a call. Rapidly multiplying sactana or yeast calls ara used, and mutagamcity cm be aatablimsd fairty quickly, it ap pears tnat asout S3 oar cam ot all earcinogana ara also mutagens. On the other hand, not avsry chemi cal tnat proves mutagamc will prove carcinogenic aa wall. Vary little is known, in fact, about wnat parcentage of mutagens mignt oe txoectao to cauaa cancer m animals. Thua. me screen could lead to wide resting of noncarcmogenic substances. These ara soma ot tna cMcuititi in tracking down potential cancercausing agents A graat deal of scien tific expertise is now being brougnt to bear on tna problem, and it seams rsaaonabfa te assume that tasting methods will become more retieoie in tha yaara ahead. Uata and Mora UsU m tna meantime. Hats ara being compiled ot aubataneas that, to-tome degree or another, nava bean linked with smear. One auch list contains tJCO sub stances It was published by the Na tional Institute ot Occupational Safety and Health, a Federal agency tnat does research out haa no regulatory power. To be on me list s substance must have baan associated n soma way with cancer m ns aciennnc literature. Ou Pont'a naw >t that many of tha llama should net be included because the evidence cited a xi error, is Inadequate, or is oontredictae oy other evidence. Undoubtedly, research mi continue to identify more caremegsns At pres ent. however, when definite proor of carcinogenicity required, tha lists ara raiauvely snort The American Confarancs of Qo rammental Indus trial Hygienists. let axamore. Iran 23 carcmoganic agsnta fos wracn t nas raeommandad limits at axpoaura. Tha list tnat is pemaoe bear xnown ia tha Occupational Safety and meaitn OOP 09X0070 i ] Administration list of'T carcinogens (or wtiien that sgtncy nas muM ragulatloni. (Mwy at tM tagulations srs based an .niormation originally oavalopta by industry.) The regulauona aim at limiting amptoyaa expo- sura and raauira monitoring ol concantratlon lavala in raguiataO plant areas. ____ Ou Pom maxa* two and usaa ona st ina chimiem on tna Hat. and lormarty mada or uaad cartam otrtsrs. Tha two ara produced at Ctiamoars Works m raiativaly small units. On tna basis ol its experience and on publisltad studias, Ou Pont baliavaa mat ona of mass, sipha-neontnyiemine. is not a carcinogen. Tna otltsr cnamicai identified by OSHA aa a carcinogan is "Moca" curing agsnt. a ruooar cur ing agent Tha cnamicai atnytanimina. also on tna iist. ia purenaaad for uaa at PI. MaOlaon. Iowa, in producing In- tarmadiatas lor coatings, but doaa not appear m tna products as sold. Tha company adharas closaly to all OSHA raculramants m handling tlsaaa sub stance*. Ou Pent's madical survtillanes programs Hava tavaalsd no naaltn problems among smptoyaas working wim these substance*. (A leurtn item on tna OSHA Hat, beu-proplolactdna. hsa bean datactad in leas man toxic lavala in a eloaad wane stream at Parkeraourg, W.Ve. Tha chemical is deasroyeS in waste treatment) Tha OSHA list at regulated sub stances undoubtedly will ba aspended. Meanwhile, NIOSH and tM National Cancer inatituts intermit tently ralaaaa to ms news madia v tormatlon on other substances that soma researchers ha**"" Ended with esnesr. Ou Pant's OaoWaa 'Tha safety oi our products and of tha people who make and uaa them has always bean of the highest pri ority to ua." says Galloway. "Aa a con sequence. we have developed our own system for managing ms carcino gen problems.'' Whan -mars is suioteion mat a chemical is carcinogenic, in imme diate short is maos to teease me potential hazard end datarmme wnat action is required. Tha manufactur ing daoartmant. m cooperation with Haakali. may determine mat the sub stance u prcpabiy tinned to cancer, and that further steps srs nacssstry. Tha lira! eoncarn is lo saleguaro me heaim st employ***. with a program which may inetuct revision of work practices, rsauirsmsnta tor additionsl protective equipment, proeeee changes, or otnsr imarovea engineer ing controls. Emoloyees era informed why such sttos era necessary. Whin there is suspicion that a chemical is carcinogenic, in immediate effort is made to assess the potential heard A program tor monitoring and maaaunng exposure levels may al ready ba in enact, it not. tha program ia instituted along with an examina tion of tmployaa madical histories to datarmms possible adverse streets on health. Medical surveillance proce dures. as wall aa the recording of em ployes exposures, srs undertaken. Depending on tha circumstances, a variety of grouse--employees, cus tomers. approoriats governmental agencies, other produesre. the meals --may ba notified of tna acuona taken. And if tala handling cannot be aaaured, production is to Pt snut down and salsa haitad until sdaguata safe guards srs developed. Carrying Out tha Intaal Aa William Galloway has pointed out Ou Pont has tha capacity to carry out tna program dsaenbec above. Tha process ol determining whether a aubatance may ce ilnkad with cancar begins with Haaxali Laboratory's ravtaw ol onamicals mama or uaad at Du Pent plants. Tha laboratory has bean assessing tna degree st hazard thaaa substances might present. Tha asiaasmant may ba based on rafarsness to '.ha cnamicai In sciantlllc studies, ma chemical's similahty OOP 0910071 to known csrcmogons, of scrvoning tsu. t/># rtsuiio redesigning the orocesa. to soeciM maintenance procedures. long-arm tasting requiring lifetime Galloway coins out that measures animal teats may be ncicatao. The sucn as these are nothing new re growing demand tar aucn ituc.ee is Ou Pont tna mam raison lor :ha currant ex- "We nave a tremendous amount pansion of Haakall. laboratory space ot axparianea m handling hazardous is Being ineraiaad by 70 oar cant products safely," ha says. 'Just to Whan ail available evidence on a taka two examples, we've been pro chemical hu Been accumulated and ducing tetraethyl leed and cnlorme for evaluated, me decision may o# made many yaars. in lerga quantities. Wa've :a dascriBa it auhar aa causing cancer teamed to control the risk and mixa in human Beings; as causing canear these products safely." m animals; or aa a suspected animal Ou Pom's carcinogen analysis may carcinogen, the evidence Being mod include studies of the incidence ot erate But inconclusive. This identifica haalth proolams among employees tion By Ou Pont la m addition to the exposed lo the cnemicel- Or. Sidney OSHA list of raguiatad substances. Pell, epidemiologist in Ou Pont's Med At this time, nma chemicals nave ical Division, describes inis worx: Bean identified By Ou Pont as cauaing "In :9Sd we esuoiished a cancsr cancer in animals, or aa suspected at registry. It essentially t t racord of doing so: all tmpttyeea wno oevitoo canear. 1. m-Tolusnedlamina (MTOI, a dye in exeapt for nontatal types ot inn can termediate maos at Cham&ers Works. csr. Whan company amployeex as a i. 3. Zinc and Isad chromates, used group are compared to urge popula m making pigments frequently found tions outside me company mat have in pemta--But not in Ou Pont's major been studied, there is no significant lines ot consumer paints. Made at difference between the employees Newark, N.J. and comparison groups." 4. EttiylaneVkourea. onmahly a neo Studies are tlao done at employees prana curing agent made at ChamOars exposed to e specific chemical. In tms Works. type of study, emoioyeee wtvy nave 5. Dloxane. purchased far use aa a been expoeed at soma ama m the past solvent in making adhesive products are followed to me preeant to deter at PartIn, N.J, and South San Fran mine whether they have experienced cisco. Calif.. td precious metal oom- an excessive incidence of some form poaitiona at Niagara Fails. N.Y. of cancer. 4. Beta-orootolsetcne (aaa above). Or. Pall has done one study, of 7. Hexamedtytpnoapnoramlde (HMFA), Ou Pont employees wonting wim cmc a servant uaad in making "Keytar" and lead cnromatas, m which mere aramid fiber, made at Chambers was soma suggasuon ol t higher man works and used at the Spruanca normal incidence of lung dancer. The plant Richmond. Va. mis ware too limned to support defi a. Carbon tetrachloride, made at nite conclusions. A mum-company Carpus Chhttl, Texas, uaad at several study sponsored By members of ms other plants is an intermediate for industry is nearly complete: and it may fkionocarbona and "Hyps!on" syn provide conclusive evidence is to thetic rubber. whether mere is a problem. ft 1.-4 Olehloro-butane-2 (DCS). Inter In another current study oemg done mediate for nylon and neoprene, made by Or. Pell, mere will Be enough date at PonteftartraJn, la., and Victoria. to support reliable oonctusMna Or Taxes. Pell is studying he medical rustor.es The steps taken to reduca axscsure of employees exposed to entoroorene. may range from setting up restricted a neoprene intermediate once msoe areas where no one is allowed with tt ChamDeri worxs and now maoe at out protective clothing, to installing Victoria, Texes, and Pcntenanrain. new vent and scrubber systems, to la, and used at Pontcnartram ana DU? 0910072 s Louisville. Ky. Meant reoorta in Soviat technical literature daimed a higher incidence of eanear among workers in aneoorens plam.anatfiaaareports prompted the Ou Pont atudy. So far. Or. Pall says, ma data do not Indicate a statistically tignllleant axcaaa mor tality from any form ot eanear among amoloyeaa aa a raault of axooaura to ehlorooreneTThe atudy is continuing. What fa "Safe?" But ifta question still persists. what ia a "safe" level of axooaura to a carelnogan? It la a vary difficult question to answer. JThe problam ia not tha aama aa with acuta toxicity, whara tafa lavata can uauaiiy da fully damonatratad m ma laboratory. "tf you want ma to give you an aoaolutaty guarwitaad laval ot safa ax ooaura to a carcinogan. I can do it Tha laval la zero." aaya Or. Zapp. "But thafa Sacauaa It's logically Imeoaalbta to prove that |uat ona molacula of tha substance would navar hava a harmful affact on anyona who might coma in contact with It "Wat wt consider oursaivesobliged to do is to optnti responsibly in tta liltrt of t)i bast knowiodgo wa - an obtain." "On tha othar hand, wo know mat tha earcmoganle affact la dcaa-re lated." Or. Zapp aaya. "That la. ma Ineldanea of eanear and ma tuna it takaa for a eanear to davalop ara dtraetty nalatad to tha laval of exposure. Thla meant mat ara can taduea expo sure to a point whara oanoar wM not oeeur In a paraon'a tfedaaa. Thara la avidanea that wa now dona fuel that wim certain industrial ehamleala mat wa now know cause oanoar In anknala and could export to cauaa eanear in man. But thara la no indication may hava cauaed eanear In axpoaaO employees." Another parapaedva la oflarad by Qalloway: "What wa conudar our- saivaa obliged to eo ia to ooarata raaponalbly m tha light of fha boat knowlabga of hazarda that wa can obtain. Fortunately, our amoloyaaa are vary cooperative In tha procasa of eatabllsning safety procaduras xnd may understand ma imoortanea of following them. They ara accustomed to enangos In procedures aa nazarea ara conatamly radaflnad. All thia works in our favor." Taste Substances Act Tha Toxic Subatancaa Act now Being considered in committaei of Congress may eventually give the government a strong hand in requir ing manufacturers to datact and manags ma carcinogen nek. Whan passed, ha legislation would give tha Environmental Protection Agency tne power to require tasting ot subatancaa. including taeta tot car cinogenicity. It would permit tha EPA to raquirs 'sating and screening of new chemicals before they ara marketed. Richard E. Heekert. Ou Pont senior vice praatdant, recandy outlined ma company's raseonae to proposed leg islation. a position snared By many othar chemical Arms. "Tha chemical industry sueporta sddltlenai Federal legislation on toxic suostancaa hat will cloaa tne gasa In pmeant taws ana offer greater protec tion to workers, cortuman and ma general ouotle." Hacked said. "Wa support Federal autnortty to require taetmg ot selectee chemicals, and pmmarkat notification or sorearing of new ehetmeaia and sign!(leant new usee or established chemicals. Wa also support tha authority to restrict or limit uses, or ban production ot chemical subatancaa." Thera ara two proposed bills which give the EPA broad power to require tasting and screening of a wtda range ot suostancaa. Ou Pont and omen would prater to focus efforts on sub stances mat appear to praeam sig nificant risks. The nduatry is also concerned mat excassneiy broad pramarksf tearing and screening require ment* could inhibit the industry's traditional ampnaaia on Innovation ana Cavetacment of new products. in tha dsvaloomant stages, new chermcala ara already routinely handled with gnat ears until their degree of toxicity ia eatabliihed. Ou Pont favors, m general, a bill sponsored by John Y. McCoilister (R.-Neb.), according ta Heekert. Tha McCoilister bill limits tasting and screening to significant risk areas. It also rsouiras that the least Burden some controls Be imposed to prevent or sufficiently reduce the risk. 9annkig would taka place only if neces sary. Consideration of tha economic impact would be required whan a substance is controlled. The Ford Administration has endorsed the McCoilister bill, with eartam amend ments which Ou Pont finds accept able. A new Pill containing Blast amendments has bean introduced is H.R. 12338. Tha Industry initJathr* Tha chemical industry n initiating Its awn positive action. Ou Pont and 17 othar chemical ccmpamae hava Joined to aster* left in* Chemical in dustry Institute of Toxicology. Tha companies hava piaogad about SIS milion tor initial cotta, and a need- quartan site net Dean satectad near Raleigh. N.C. CUT will first cancamrata on the carcinogenic potential of "onprocnetary, widely used chemicals. The drat two to be investigated will ba atftytana and toluene. Emphaaia will be on ootn lasting chemicals and on deveiooing new teat methods for studying toxic ity. Results ot the studies will oe made public. Tha new institute is evidence.cf tha Industry's belief mat tha "larirda can ba identified and precautions can ba taken to aataonsn sate wonting conditions. DUP 0910073 a CLINTON COLLINS. EDITOR *OC*l 1074 OU PONT iUILOINO WILMINGTON. 0(UUV4*C