Document RjE5bKg450Zj14NNXJ1Vb68Oa

CI The Shanghui Heallh Study Benzene Health Research Consortium 100.-,-1......' Why ir Undl'J'sIlIIulinM 8,'n;i'm' Important? e Benzene exposure is universal ::= Advandng current Sdentific understanding of benzene exposure would be a significant contribution to heafth and worker safety e Understanding health effects of lowlevel benzene exposures wouki improve benzene risk assessments Recent Epidemiological Sl1!dics C National cancer Institute Shanghai Study (NO) - """""'''01 study puWlshed in 1997 :;: Benzene assodated with AMl and Non Hodgk.in's Lymphoma (NHL): assodatlon with a oon~AML cancer =study design did not add to understanding of threshold (lowest exposure grOlip was ID ppm or less) /zS'iJ8 213/2003 MOC00045067 ---- ------------------- Recenl Epidemi%gicu/ Sludies o Australian Institute of Petroleum's (AlP) Health Watch Study - case-con!rol study released In 2001 ::: AssocIation with atlleukemlas. including chronic lymphocytic leukemia ::: No assocIation with NHL or multiple myeloma Ohsenllrions ()n Current Science :) No definitive epidemiological evldeoce to define a threshold ONCI and AlP studies conflktwith earlier studies by associating benzene exposure with non-AML cancers (NHL andUL) o SHS designed to quantitatively address these issues Shang/wi Hell/lIT SflU.(V PUl'po.\"e ~ To gain a quantifiable understanding of the relationship between benzene exposure and potential associated cancer risks Z Researthers wiN use cutting--edge technologies to advance the understanding of benzene-Induced disease 21312003 2 MOC00045068 - - - - - - - -.......-~. Q Qua/il" Scie",,", SlIund Ethic" =All protocols reviewed and approved by extemallnstitutJooal Review Boards (IRS's) =Govern ~ of hlIlMn subjettS :;: us. anel' China ~entIy U Shanghai Health Study panels fl I~llndeper1dMt Ethics &pert hna >I InurnatI(Inat Independent Sti!ntlflc Expert Panel .. 12 members 6 scient:lllc d15dp1ine:s a Expert panels will partidpate during entire course of studies G Sdel1lijic R"l'it.'u' Panels-.w~_ .-.~..... D<.JonyIO. ...... !OMor).IIoIC: 1It.._(io-.,~u."_ b.Hn;r_~o..t_u.. ........ -'Do.~~.""'u.. \10._.... - - . .... . , - . , Drro_._a'..M...o.t.r.c_Iou,._.u-...O_Io_.:.-... ""-....... ... ~,.~ _ _ c... _""""",,,"""1_ -:=:-:::::::::::: :~ -.o., ..Or;_"""""I~""ClIIoae"-.;t>". _ " , - Wh z.oo~ ~ Whal i.\' Jhe Shaug/wi Hell/,It Sfll~r'! C A long-term dinlcal study to investigate the potential cause and development of IyrnphDhematopoietic diseases (dISeases of the lymphoid organs, blood and bone marrow) ::I A project of FUdan University Medical Center; Colorado Health Sciences Center, University of Colorado; Applied Health Sciences an independent U.S. research finn; Ollnese public health agencies; and Shanghai hllspitals 2/3/2003 3 MOC00045069 Why Shanghai? e Unique Study Environment l: Oatabases documenting exposure :: apc5Ufe across Inclustties c Rangeol~~1evds ::. Committed Collaboration ::;: 0Ilnese government Il UniverSity and hospital based fesea~ ~ CDmrrnmity ho5pita15 P",,,.,,,.,. ro..'" Shanghai Municipal Center O!seuc: CO/'ItTOt and c Institute for Public Health Supervision o CUI'1"elll SO/IS SlallJS c state-oHhe-art laboratory Olnstructed on Fudan lInhlelSlty campus; complete early 2003 ~ SU5tiIInatIle ted1nology tnosfer.an Important pmject ddgn mmpanent ::. ChInese staff recEivtnQ ITalnlnO at UnM:rsity of """'""'"c QUeStlonnalre development. pilot testing In Pl9n>SS o case recruitment begins - lit quarter, 2003 o Research and analysis ~. 2003~2007 CResults pubJishedrup_o.n.l>pGrJoject completion SNS Funding D $22.8 mUlion program total for all costs over 5 years ClnRlal budget lower o lnaeased to $22.8M In response to ethics and sdence recommendations of Independent panels 2/312003 4 MOC00045070 G Who is Sponsoring 'hI! SHS!' o A consortium of petroleum and chemical companies COrteemed about understanding the human health effect5 of benzene :: British Pf!troIeum, OtevronT~ Conoc.oPlulllps, &xonMobil, Shell :: ~ members beinQ recruited ::! American Petroleun Institute, project a4mInIStrator C Individual company product stewardship and corporate responsIbility p10grnms - - - : 0 1. - . . ~V/~\' PaJ'licipCltt..' c Study will advance benzene health stience; results "'lIN be referenced by goyemme:nt and Industry polley """~ " RasparWbIe product stewardship and workplace 5b:Wanisllip ;;: Orqanllaticnal knowledge gilined from mllilbolatiao ifl high quality IrImmatiMal health research =\I15lb11lty wlltI Chinese QO'Iemment;llnd aJmrnl.Wlltles; iI'Itt!mational heakh agencies c ParticIpation Indudes ~ updates, Tedlnkal ConvnIttet!! ~ip, interactions with spa1$DI"5 and~ n-,.J.~I Summary !Iwu!uniI.lt.II:IOIDln I ~~1IdJn.g ollnt ~ of b~ iIv;1.ad dI$Q... it! ! ' u - . o SignrOlll: Impaa IIA br:n:z&oIe rttk .u......,.,.", ...-Hqty:sr PosHtt qt' Sriet\Cc' empIoy'~'Ihe-""~If'dep~ical~ ~Slllr.dpn>dua~d$tIip ~WsI~lnme~tIhIa dIePrtIIIl:pctI~olh:luslry. gove<~~ 213/2003 5 MOC00045071 For Mon' "?/iwlnllli(}J7 o Sill frick, API Il 202.682.8210 :r: f'rid@apl.org o Myron Hanison, ExxonMobil ::: 972444.167) ::: Mvrcn.c.tIaf1ison@exJl)fl(nObilalm o lorraine Twerdok. BHRC Administrator :. 2Q2.6Ii2.83+4 1:1 ~apl.org 213/2003 6 MOC00045072