Document RgQB1gkBQZzQQYVz7ba8YjJk

SUMMARY OF FILE COP PROPOSED PLANS FOR EPIDEMIOLOGIC. MEDICAL. AMD TOXICOLOGIC STUDIES PRESENTED AT THE NIOSH/CDC BRIEFING FOR MANAGEMENT AND LABOR REPRESENTATIVES FROM THE VINYL CHLORIDE AMD POLY VINYL CHLORIDE MANUFACTURING INDUSTRIES . CLEVELAND, OHIO FEBRUARY 12, 1974 EPIDEMIOLOGY . It was agreed that: 1. There appears to he a major health problem In the production of FVC from the monomer vinyl chloride (VC); 2. In consideration of the potential scope and seriousness of this problem, NIOSH/CDC take the leadership in the govern ment to investigate the problem, assign it top priority, and immediately to provide or seek the necessary personnel and funds for implementation. This Implementation shall include cooperation with Interested groups in government, industry, labor, and elsewhere; 3. The Division of Field Studies and Clinical investigations (DFSCI) within NIOSH/CDC take the lead in undertaking such steps as necessary to determine the foil extent of the mortality and morbidity associated with VC exposure among occupational groups. - There appear to be four eategoriesof individuals potentially at ride from exposure to VC end in which exposure end health effects should7' R&S 027919 ^2. The conversion of VC to PVC, both as pure FVC and a. polymers containing other substances;''" ' _________________ a_e_ ` .*.1_____________^-- - '/ 3. The use of FVC In the production of other products; and 4. Consumer uses of FVC products -2- In the light of the unusual frequency of angiosarcoma of the liver in a single polymerization facility, first priority should be given to early ascertainment of the disease experience of the foregoing Group 2. The lannediate program should have the following elements: 1, DFBCI/NIOSH in cooperation with the Office of Occupational Health Surveillance ard Biometrics (OOHSB) would be in volved In: . a. Assisting Tabershaw/Cooper Associates In any way possible to complete the mortality study of workers at the B. F. Goodrich PVC operations in Louisville. b. A governmentally-sponsored epidemiological study of the health hazards associated with the production of FVC. (1) An attempt will be made to: ' <*> Document the incidence of angiosarcoma of the liver in workers in facilities other than the B. F. Goodrich plant in Louisville; (b) Document the incidence of sialignant and nonmallgnant disease In FVC workers; (C) Define the real ox, potential hepatotoxlns . among the materials used In the production of FVC; and .. <d) Document .the state of environmental control ; ' In the VC/FVC operations,'Involving sampling ' and analysis, work practices, ventilation U T 7*S. . design, .etc. - v ;- fio OT (2) .Five criteria are to be used (listed in descending o N> order of priority) to determine which plants will be studied: N NCOJ '. (a) FVC production history of 15 or toore years; O *\* (b) Size of work force; (c) Polymerization Involving vinyl chloride vith and without vlnylldene chloride; (d) Location In States where vital statistics Information is readily available; and (e) In-plant medical program. Mote: Already contact has been made with 18 of the 37 known PVC facilities. Using.the above criteria, there Is a clustering of plants in the trl-State ' area of Ohio, Kentucky and Pennsylvania. R&S 027921 (3) Concurrently, rosters will be developed of both pres ently employed workers in VC/PVC operations as well as those employees who have moved within or out of the Industry. e. A determination of the extent of use and distribution of PVC among users of the polymer to estimate the exposure to VC . or PVC under such circumstances (Contract mechanism). 2, CDC will follow through with Its surveillance program in the development of a registry for the identification, review, and workup of cases certified as having angiosarcoma, other liver cancers, and other diseases thst may appear to be pertinent on .death certificates. At the start, this will entailtracing such . cases from death certificates recorded for recent years at the National Center for health Statistics and to vital record deapartment* within individual ^states. Suffieientdetail.Arf.il be obtained for each confirmed case.'to permit evaluatlon of ease incidence with respect togeographic distrlbutiou^secular trends, and occupation. : k the surveillance programdevelops, / additional sources of case ascertainment 'will beusediocluding '- ~ .^contacts with tumor-registries, cancer treatment centers, and Industry ''groups; 3, NIOSH/CDC will cooperate with other Federal agencies, such ; as the Food and Drug Administration and the Consumer Product Safety Commission in obtaining information on the use (past and present).and distribution of VC/PVC In aerosol sprays and other household products. NIOSH will also work closely . with the National Cancer Institute regarding the state of knowledge of hepatic cancer. tk Note: All of the above activities are to proceed apace and concurrently. -4- HEDICAL A major immediate concern both for VC-related Industries and for the government In.Its projected epidemiologic Investigation of the angio sarcoma question will be screening of industrial populations for clinical evidence of disease potentially related to the VC'polymerization process. Such disease enconqtasses not only angio sarcoma of the liver, but also non-malignant hepatic conditions `(cirrhosis), and perhaps other types of cancer and non-hepatle .disorders as well. To consider what medical screening procedures are appropriate in this setting, NIOSH/CDC plans in the near future to convene a panel of medical consultants specializing in liver disorders, this panel will review the clinical and pathologic material accumulated to date concerning VC related disease in this country and abroad, and will make specific recommendations to the government with respect to medical screening and followup of potentially at-risk industrial populations. t TOXICOLOGY NIOSH/CDC will take the lead role in determining needs for experi mental animal toxicologic studies. Before developing the protocols, it will be necessary to evaluate the world literature on toxicology and to review the potocol and results of recent and current experi DO ments conducted in the U.S. and Italy. In developing, research protocols, NIOSH will work with members of the HEN Conmittee to (/) Coordinate Toxicology and Related Programs. Many factors and o parameters will have to be considered in the development of the ro c-oj experimental design of the study, including species differences, metabolic fate of the inhaled or absorbed VC;- dehalbgeniratlon of ro VC, alkalatlng properties and mechanisms, gas-off products pf PVC, toxicology of PVC dust, and effects of low-level exposures to VC. -i'- NIOSH does not envision the experiments being done in-house, but. rather in one of the other government facilities or by private Attcnflees at NICSH/CDC briefing on vinyl chloride, Cleveland; 2/12/74 Prom Industry V. K. IIIff, tJniroyal Chemical Division, Fslnesvllle, Ohio B. K. teach, Cnlroyal Che-lcal Division, Painesville, Ohio V* B. Katzenmeyer, B. F. Goodrich, Akron, Ohio Herman Waltemate, B, F. Goodrich Chemicals, Cleveland, Chio R. S, Mather, B. F. Goodrich Chemicals, Avon Lake, Ohio ,B. Cohen, Great American Chemical Corp,, Fitchburg, Mass. John C. Pieros, Great American Chemical Corp., Fitchburg, Mass, 0, Paul Cohen, Great American Chemical Carp., Fitchburg, Mass, Carl H. Dernehl, Onion Carbide Corp.% Mem York City , Laurence H. Ballou, Firestone Tire h Rubber Co,, Akron, Ohio George L. Wilson, Firestone Tire A Rubber Co., Akron, Ohio 027923 George Roush Jt., Monsanto Company, St, leuis, Mo. Rob^^^^^^t^t,^ Monsanto laId, Mass. ;; V, Small, Monsanto Company, Tens City, Texas Theodore Torkelson, Dow Chemical Co>, WdlandMich, - C, A, Christian, Dow Chemical Co., Freeport, Texas ^ - . D. A, Rausch, Dow Chemical Co,, Midland, Mich, * Charles B. Kramer, Dw Chemical Co,, Midland, Mich. George Harris, Liberty Mutual Insurance Co., Cleveland, Ohio Frew Industry (continued) V. E. Rlnehart, Ethyl Corp.* Hew York City ft A.B. Lindquist* Stauffer Cheeical Company M, M. Johnson, M), B. F. Goodrich Co. V. R. MiUer* Goodyear Tire ft Rubber Co. Herbert H. Krster* Booker Cheaical Co. F. R. Klebacher, 01In Cocp.-PVC Reains J. F . Gabbett* Conoco Chealcala Stanley J. Anton* Panaaote Co. Roy V. McCune* Fantasote Co. of New York* Inc. J. R. Mudd* General Tire ft Rubber Co. Henry Rxenpoluch* Pantabote Co. of Hew York Albert Kover* Diamond Sheerock Co. J. Robert Mehall* Dlanond Shamrock Co. ', ' \- ' . Richard Meier* Stauffer Cheeical Co. ' L. H. "Mb, Conoco, '~ -i ] Mlayo iS__w__l_th__f'_A__ir__.F_g_e_ W^^Chmtfcftlft Henry X. Darwin K.fthoads. '* .T*`*> L:W8&r?"-'' lorden Chemical Division ' SSL'.iAv, * .-J-.-. .,** * . * ,. V.</ ,, Chemicals Co. sf ; * RayeondJ.Abrandwi ..,'C J. C. Pallnsky, Universal PVC Resina Inc. ' Vi Jenea P. Turner* Manufacturing Chenists Association R. W. Modrell* Goodyear Tire ft Rubber Co. Clifford A. Johnson* M), Goodyear Tire ft Rubber Co. R&S 027924 Vayne T. Brooks* Organisation Resources Couhselors R. R. Wheeler Jr Union Carbide Corp. . \V *. ' V -3- I I Pro* Industry (continued) i--: i .Berry A. Lloyd, Georgia Pacific Corp., Flaquemine, La. * R.'B. Howard', Shell Chemical Co. Kenneth Q Johnson, Manufacturing Chemists Association, Washington, D.C. J, H. Johnston, Imperial Oil Limited, Toronto, Ontario, Canada ` L. F. Sargert, PPG Industries, Pittsburgh, Pa. V. A. Knapp, Allied Chemical Corp., Morristown, N. J. P. H. Toca, M>, Gulf Oil Corp., Pittsburgh, Pa. Zeb G. Bell Jt., PPG. Industries, Pittsburgh, Pa. Lloyd M. Wdlker, Western Electric, Columbus, Ohio H. Hendricks, Exxon Corp., Hew York City J. K. Livingston Jt., Exxon Chemical Co., Linden, H.J. From labornDnions George Perkel, Text lie.Workers Onion of America Jeanne Stallman, Oil, Chemical and Atomic Workers Steve Vodka, Oil, Chemical'and Atomic Workers' Tony Haxaocchi, Oil, Chemical and Atmlc Workers mn ' l-*v' ' tm I'Meumrsa^ .. ited Rubber Workers^^%^;.".;v ,.v j^k* s .r-Ti'nv`; ^ - f. Louis 8. _Belicsy, United lubber Workers i\............. ... flatten JUSmltiu Ohio AFLJCIO ..'. ' .->' .-J-'*-, " ^ ***>''. ; r* _.r- - , i ,**- Salvatore J. Falletta, International Chemical Workers Onioi . 4." - . - Sheldon Svauelftj Indust<ini Union Departmntv AFL-CIO 33 So 03 h? $ From Colleges and Universities Henry A. Anderson, HD, Mt, Sine! School of tfediclne, Hew York {Irving J. Selikoff, MD, Mt. Sinai School of Medicine, New York RutbWilik, *D, Mt. Sinai School of Medinine, New York David A. Fraser, University of North Carolina Robert L. Harris, University of North Carolina Samuel S. Epstein, Case-Western Reserve Medical School Rudolph J* Jaeger, Harvard University School of Public Health Free Government Robert L. Knarr, 05HA, Cleveland, Ohio John Fierro, Ohio Department of Industrial Relations Gray Holcomb, Ohio Department of Industrial Relations Gary Bryner, Ohio Superintendent for Safety fc Hygiene Jon M. Cope, Ohio Department of Industrial Relatione Warren Fiver, National Insitutute for Environmental Health Sciences Howard L. Kusnetz, NIOSH (retired), Houston, Terse" Donald J. Btllmaler, M), Ohio Department of Health-,.; From The Press John Nussbaum, The Plain Dealer, Cleveland, Ohio Jane Brodie, The New York Times, New York City '* Tom Feare, Chemical and Engineering News,.Washington, D. C. Rick Snider, Occupational Hazards magazine, Cleveland, Chio Hank Cox, Bureau of National Affairs, Washington, D. C. Arthur Zimmerman, McGray-Hill News Bureau Robert Varmstedt, Business Week