Document RabQgdzqYQ5Eq5KqGReaeOpO8

SEVENTH EDITION THE MERCK INDEX OF CHEMICALS AND DRUGS AN ENCYCLOPEDIA FOR CHEMISTS, PHARMACISTS, PHYSICIANS, AND MEMBERS OF ALLIED PROFESSIONS } Paul G. Stecher, editor: Chemical Monographs M. J. Finkel, M.D.: Medical Uses O. H. Siegmund, D.V.M.: Veterinary Uses B. M. Szafransld, assistant editor Published by MERCK & CO., Inc. RAHWAY, N.J., U.S.A. 1960 LAM021514 6113 18210 B0C2361 V s Ids ' :03.6 in soluble trosides. ate). Santos, Bull. 2, ;?%, h Fagara DC.), Forms uble in .7, 362 A. wt. m the rtemi- ana nother n.: E. 895, 1, . 4869 Bitter 203. ; = 3 oiling etate. >iuble vated icetyl amiiihyiihyinolmol. A ' OH 789 '.3 als. jble nee ph- Asearite* 105 /-Arterenol tf-bitartrate monohydrate, crystals, m. I flatulent colic. Dose: horses: 15-60 cc.; dogs: 0.6-1.2 102-104. [a&5 -10.7 (c - 1.6 in H,0). When an- j hydrous, m. 158-169, (some decompn.). Freely soluble I in water. Asaprol. Abrastol; calcium d-naphthol-a-monosulfonate; Med. Use: Sympathomimetic agent employed as j vasopressor in hypotension due to impaired vasomotor I activity. Used as the bitartrate. Dose: Initial--0.25 I to 0.5 cc./lO kg. of body weight of a solution containing j 8 mg. (4 cc. of 0.2% solution) of /-arterenol bitartrate i Calcinaphthol. Ca(OH.CmHi(.SOi)i.3HiO; mol. wt. 540.57. CtoHuCaO*S*.3H*0; C in anhydr. 49.37%, H 2.90%, Ca 8.24%, O 26.31%, S 13.18%, anhydr. salt 90%, HtO 10%, naphthol 53.34%. Reddish-white, odorless powder. Decomposes at in 1,000 cc. of 5% glucose in water or 5% glucose in I about 50. One gram dissolves in 1.5 ml. water, 3 ml. saline i.v. Subsequent rate of flow to be determined by i alcohol. frequent blood pressure determinations. (Average dose i Use: Has been used for plastering wines instead of ranges from 0.5 to 1 cc. of tbesoln. per minute.) Hu-nan i gypsum. Toxicity: Headache, hypersensitivity reactions and I bradycardia may occur. Too rapid administration may i cause severe hypertension. Subcutaneous extravasa- j Med. Use: Has been used as an antipyretic and antirheumatic. tion often produces local tissue necrosis. Antidote: \ As&rone. Asarin; Asarum or Asarabacca camphor; Atropine abolishes the bradycardia which l-arterenol i 2,4.S~trimethoxg~I-propenylbenzene. Ct:H| Oj; mol. wt. sometimes produces. Contraindications: Shock due to j 208.25. C 69.21%, H 7.74%, O 23.05%. From root decreased blood volume. Caution: The risk of ventricu- i of Asarunt europaeum L., Aristolo* lar fibrillation may be increased when l-arterenol is em- i chiaceae by distillation with water. ch=chch3 ployed during the administration of cyclopropane or i Crystals, m. 67. b. 296. other cardiac-sensitizing agents. 1.5719. Insoluble in water; sol ,,QCHj Vet. Use: Recommended in acute vascular hypo- \ uble in alcohol, ether, glacial acetic tension during induction of anesthesia, acute nervous i shock from pain or trauma, surgical shock. Dose: \ Hypotension: 0.001-0.002 mg./kg. i.v. Nervous shock: j acid, carbon tetrachloride, chloro CHjO' form, petrol, ether. Its picrate melts at 82. OCHj 0.01 mg./kg. i.m. Surgical shock: 0.05 mg./kg. in in- I travenous infusion drip. Asarunt. Wild ginger; Canada snakeroot; Indian ginger. Arthropan. Described as choline salicylate. salicylate therapy. Used in ! Dried rhizome and roots of Asarum canadense L., Aristdochiaceae. Habit. Canada to N. Carolina and Kansas. Constit Acrid resin, aromatic volatile oil, Amcase. An extract of aruca: Calea pinnatifida (R. Br.) methyl-eugenol. Less., Compositae. Used in the treatment of intestinal I Med. Use: Has been used as an aromatic. amebiasis. j Asbestos. Amianthus; native calcium-magnesium sili Arzene*. A brand of arsenoeobenzene also called phenyl cate. Monograph: D. U. Rosat, Asbestos, its industrial application* (Reinhold, New York 1959). Fine, slender, flaxy fibers; resists fire and most sol vents. Use: Heat-resistant insulators, cements, furnace and hot pipe coverings, inert filter medium (laboratory 6c commercial), fireproof gloves, clothing, brake linings. arsenoxide. Used for the prevention of cecal coccidiosis in poultry: Smith, U.S. pat. 2,800,425 (1957 to Geo. H. Lee Co.). As&fetida. Devil's dung; food of the gods; asa/oetida. Gum-resin from rhizome and roots of Ferula assafoetida L., F. foetida Regel and some other species of Ferula, Umbelliferae. Habit. Iran, Turkestan, Afghanistan. Constlt. 6-17% ethereal oil; 40-60% resin, consisting of eater of asaresmotannol and ferulic add; pinene, vanillin, about 25% gum. Soft mass or irregular lumps or almost semiliquid; characteristic odor; bitter, acrid taste. When triturated with water, it makes a milky emulsion. The N.F. requires not less than 50% alcohol-soluble extractives. See atso Abiotyl. Use: In India, Iran, etc., as condiment and flavoring for foods. A 2% suspension as repellent against dogs, cats, rabbits, deer. Med. Use: Has been used as carminative and ex pectorant. Homan Toxicity: Prolonged exposure to the dust can result in the development of pneumoconiosis and pulmonary fibrosis. Asesridole. l,4-Peroxido-p-menthene-2; Ascertain. Cto- HiOi; moL wt. 168.23. C 71.39%, H 9.59%, O 19.02%. Constitutes 66-80% of oil of chenopodium. It is an organic peroxide. Synthesis from CHj a-terpinese by treatment with oxygen, chlorophyll, and light: Schenck, Ziegler, Naturwissenschaften 1944, 157. Purifica tion: Beckett, Donbrow, Jolifle, J. Pharm. Pharmacol. 7. 55 (1955). Liquid; unstable; prone to explode when heated or when treated with organic acids, di 1.0103; dg 1.0113. m. +3.3. bo. HjCT'CH, 39-40. {ct)o =fc0.00. Soluble in hexane, pentane, ethanol, toluene, benzene, castor oil. Med. Use: See Oil of Chenopodium. Dose: Oral 0.5 g. Human Toxicity, Contraindications, Caution: See Oil of Chenopodium. Vet. Use: See Oil of Chenopodium. Vet. Use: Extern, to prevent bandage chewing by Asearite*. Asbestos coated with sod. hydroxide. Used dogs. As mild carminative and antispasmodic in for absorbing CO in combustion analysis. Consult the cross index before using this section BCC-862 LAM021515 6113 18211