Document RaQXqVwpeYR4431eE2maJXLgE
Table5: ConcentrationfPsFOS inRatScirmiSnanqdesEM)12 Study#FACr-TOX-110Fogowingthe0
(D ID m-u 11@ <
<-Z
nm m
!A a Z Cl
P 1>
Sampling Time (day)
19501
19502
19503
19504
PFOS Concentratio(npg/inL)
Rat Numbcir*
19504F
19505
19505F 19506 1950
0
0.112 0.0701 0.0607
0.0514
NS
0.0550
NS 0.309 NS
7
0.397 0.0535 NS
0.0926
NS
0.0514
NS 0119 NS
15 0.0903 0.0690 NS <LLQ[0.04321<(0.05) NS
0.0609
NS 0.1" NS
21
NS
NS
NS <U.Q[0.0258]<(0.05)0.0845 <LLQ[0.0353]<(O.OS)0.0880 0.0820 0.26
<LLQ = lass dan theLower LimitofQuanticatio(n0.05ug/mL). *Rat Number with"F indicatesfdalsample, NS: No sample,
?Me 13of24
Table 5:
(Coatinned)Concestradons ofPFOS InRat.Semm Sampks from Study#FACT-TOX-1 If Fol 0 mglkg Dose
rALm )>
z m rm ) !A o Z
Swnpling Time (day)
0 7 Is 21
19507F
19509
PFOS Concentratio(npir/mL)
RatNumber*
19509
19509F 19510 19511
19512
NS
0.0548
<LLQ[0.0483]<(0.05) NS
NS <LLQIO.039SM0.05) <LLO[O-04811<@0.05) NS
NS <.AeQ[0.0454]<(0.05<):LLQ[0.0459]<(0.05) NS
0.0942
NS
-,@LLQ[0.02691<(0.05)0-102
0.0664 0.0619 <LLQ[0.0449]
0.0636 0.250
0.197
0.0614 0.176
0.238
NS NS
0.0833
<LLQ = Lem Om theLower LimitofQuoifitatio(n0.05pg/mL). *RatNumbcr wM OF"indicatefseW mnple. NS: No sample.
Pop 14 of24
MAY, 3.2UUU IU:b4AM ENVIRONMENTAL LAD 2 3E 09
NO.1924 P. 4
wt wt wi
Oki
Go z
CY
z 04
coo
%.-a
CY
v fA
e4 W*l
CA
ADVAN CEO BICANAJ-YTCAL SERVICES. INC.
to VA
Z
Table 6: Conomtrationsof PFOS inRat Serum S=ples frgm Study#FACr-TOX-110 Followiogthe9.1
m t)>i(-3< <f
mro )M
!o a
Cl
P
1> r
Sampling Time (day) 19517
19518
PFOS Concentratio(npg/mL) Rat Numbe&
19518F 19519 19519F 19520 19521 19521F 19522 19523 19523F 19524
0
9.07 9.87 NS 9.37 NS 9.73 11.1 NS 9.32 12.8 NS 10.2
7
9.63 10.3 NS 6.83 NS
NS 8.92 NS 8.19 9.65 M
10.4
15
11.5 10.7 NS 9.18 NS
NS 14.1 NS 9.57 10.9 NS 9.20
21
NS
6.84 12.1 3.93 8.52 NS 4.93 11.2 NS 5.35 10.2 4.11
1
*RatNumber with "F" indicatesfetalsample.
NS: No sample.
Pftc 16 or2A
Table6:
(CondavedC)oncentradoonfsPFOS toRatSerumSmplesfromStudy#FACT-TOX-110F, 0.1mglkg Dose
(m0LuPu-
m 9 --@,
< Z,)$ Sampling Time
(I z
(dg)
mim
19524F
19525
0
NS 12.0
p
7
NS 9.62
Is
NS 10.0
21
10.3 NS
19526
9.48 11.2 11.7 NS
PFOS Concaftirat(ipoWnmL) RatNwnbcr* -
19527 19529 19528F 19529 19529F
19530 19531 19532
12.0 10.0 NS 11.6 NIS 9.48 9.10 10.6
8.79 7.80 NS 10.3 NS 7.65 7.57 10.1
8.78 9.04 NS 7.31 NS
11.9 10.4 9.66
M 6.19 10.8 3.04 10.4 NS NS NS
*Rat Number,%itbL"P" indicetesfetalsamplc. NS: No sample.
Page17 of 24
Table7: CojecentratoifoPnFsOS inRatSerumSamplesfromStudy#FACT-TOX-110FoRowimgTheSA
M-0 m @ ><ZZ 0>0 m@m Y)-iD 20
1>
S=ViingTimc (day) I 19533
0
53.9
7
44.3
15
47.3
21
20A
19533F
NS NS NS 42.5
19534
46.9 50.0 56.1 20-5
19534F
NS NS NS 41.4
PFOS Concentrat(iPognhnL) RatNumbcr*
19535 19536 19536F 19537 19538 19539 19540 19541
50.1 38.6 56.6 36.6 48.2 43.3 NS 16.2
NS 56.6 46.5 45.2 42.9 44.4 NS 58.4 49.1 44.6 45.8 NS NS 50.7 53.5 37-2 48.6 NS 32.2 NS NS NS NS NS
*R.atNumber with 'F"indicatesfetalsunple. M: No saniple.
Pap 18 of24-
Table 7:
(Continued)ConcentrationsofPFOS inRat Serum Samples from Study OFACT-TOX-110 FOB, 0.4mgfkg Dose
WM> m0 :0 -< < 10;
5m>rZn
PFOS ConcCatFafiO(nPg/ML)
Smnpling Tivne
RatNumber*
(day) 19542 19543 19543F 19544 19545 19546 19546F 19547 19548
20
0
45.3 46-3 NS 45.8 47.9 43.5 NS 42.2 57.6
1>
7
40.6 46.1 NS 42.8 NS 46.5 NS 42.2 60.0
15
44.0 43.9 NS 49.1 NS 47.3 NS 43.3 59.0
21
NS 23.0 34.1 NS M 35.8 48.4 NS 65.7
*RatNuinbeWrith*F"indicatfeestaslunple. NS: No smnple.
-Pap 19 of24
Table 8: Conceohadons ofPFOS inRat Serum Samples from Study #FACT-TOX-110 FoHowing the1.6
m ,m F, t'1)>f) m@m
1>
SamplingTime (day)
0 7 is 21
19549 19550
166 200
NS
216
NS
160
NS
NS
19551
PFOS Concentration-(p&Lt@D Rat Number
19552 19553 19554 19555 19556 19557
19538
19559
184 165 t82 203 166 199 198 196 171
NS
NS 160 189 195 186 NS
171 160
NS
NS 135 176 225 202 NS
164 192
NS
NS NS NS NS 251 NS
NS 237
NS: No sample.
PW 20 of24
Table 9:
(Cmdnued) Concm&ntions ofPFOS inRat Serum Samples from Study #FACT-TOX-110 Fe 1.6mg/kg Dose
<
0 mqm !D-11)
Sampling Time
(d
1956OF
0
NS
7
NS
is
NS
21
131
19561
193 181 219 NS
PFOS Concenkadon (pg/ML)
RatNumber*
-
19562
19562F
19563
185
NS
163
179
NS
168
142
NS
183
63.7
102
NS
*RatNumbcr with"F'indicatefsdd suvie. NS: No sample,
19564
195 169 159 NS
Page 21 of 24
99
Table 9: Concentrationsof PFOS inRat Serum Samples from Study #FACT-TOX-11(i Followingthe 3.2
MLO-M0 ]]V
<Z ;
01>n
m@m 9):Ja
0 p )>
Swnpling Timc (day) 19565 19566
0
370 337
7
392 280
15
345 311
21
NS
NS
1 *Rat Number with "r indicates fetal NS: No sample.
19567
366 327 294 NS
sample.
PFOS Concentratio(ntigImL) Rat Number*
19569 19568F 19569 19569F 19570 19571 19571F 195
339 NS
334 NS 351 348 NS
351
340 NS
323 NS 337 371 NS
305
336 NS
3t4 NS 269 308 NS
3 l)
241 228
142
176 NS 165
166
123
Pap 22 of U
MM> m -0
mim P-0 20
Table 9: -
(Continued)ConcentrationsofPFOS inRat Serum Samples from Study NFACT-TOX-110 Fol 3.2mgtkg Doze
SamplingTime (day) 19573
19574
19S75
PFOS Concentratio(nag@EL RatNwnber*
19576 19577 19577F 19579
19579
19579F
19.'
0
364
365
413
393
417
NS
373
387
NS
3
7
343
393
387
NS
395
NS
NS
399
NS
3
15
317
299
284
NS
361
NS
NS
396
NS
3
21
NS
NS
NS
NS
221
226
NS
186
181
-- I
*RatNumber with"F" indicatefsetaslanple,
NS: No sample.
Par 23 of24