Document RaO8qX5jgo40NvR473nM6rYnv

Younger Laboratories BlockemUti . . . PUasunacal&fUtd. . . . Analyitl 3620 Telegraph iioau St. Louis 29, Mtssoum PHONE! TILDEN 0-2.1 tO Ge/ddicate Cf AnaUjAM. rurjicx - '- Tcodcologieal Hrrertigctian Gf 1 Aroclor kh6$ llcnaento Sample Ifcnbor h6 K-msssto Project [Junbcr I-62-^li . STK 1 CCir UCTU FCR .Monsanto Chemical Caspany, St Louis, Missouri J~l7 3rd, l?6z C -V~Y EXPE -LjZniT'L jtccztuie - ' ;) Orel L s0 ( eta) Ths diluted canound uro to rpr gue-lfwlcy strain r.lbino rts, fter th rp prorJjy^c^tLiR rc.to 'wore fed i^irfSrcrsL four levels .c/crned to bl? calculation- oij |he LTgg ulii of 2. J. a 2- determined, groups of nr.le red ferr lo rererto of 0.1 fractional lo: interr Is cb Unity range thereby supplying. bet-* for ecccrdins to a r.odification of the method Cbserrrtlons wcrcsi^de^dr/toxlc a3r.ptems sal the viscera of the snicrls that succumbed were ned-^croscoolcaily. The date* tecether with the dilution at which the compound was fed, are shewn ta Trbla I. B) Skin bsorptim Ilf (Rabbits) Tha diluted eccnound was applied la increasing dccco at increments of 0.2 fractional log iutcrvrla to th closely clipped, intact &:i& of hoi/ Zc - lead white female rt bbits. The treated areas wore covered with plastic strips end tic ealnrls placed in vo<x'@n stocks for periods up to twoaty-four hours, after which tins they wars BBaigncd to individual erges. Oboorvrtlcns wer made for tcaic symptena anJ tre viscera cf the r.niarIs that succumbed were ex'r.incd m croscopically. The c-t*, together with the dilution rt which the ccmpoun-' w-s applied, rre shew, in Table II. SCM QQZSZ2 THU confidential report U not to be need in any form of adverting without written permiatron 00248 WATER_PCB-SD0000032681 To? l-bnasnto Chortled C ^>cxjy , 't. Louis, Kbnscuri lounger Laboratories Certificate of nslyais - pcge 2 (7/j/62) - r-C2-hk 'J?n Harr,L ? OCTtHS - (Continued) C) Skin Irritcticn (ilabblts) Tbo finely ground powder and a 5o.c solution in com oil were a-Dlls'-' to the clipped, intact skin of ; lbino rabbits an-1 rencrrcd after thirty-four hours ' with soap rod warn voter* The application was covered with pi stle stride to retard evaporation cad rroid eont,rainat, 1nn, * aberrations were nod* error s period of arrcrel days for irritation, Tho data, scored accordInc to the nothod of 'reiae, '-'cod-it! and Calverv (Journal of Phans* and T5^* ttdrpcBtiea, 7clns 02, eeasber, I9U4) ere aho-ua in Table in* I.) E;e Irritcticn (Rabbits) Twenty (20*0) milUcrr-ns of finely ground sample vere placed in the conjunctival sac of the right eye of each of three' clbino rebbita and obscmticas node over a period of covcrcl days for infL\rnntian* The eyas were rirsed with vrm isotonic saline solution after twenty-four hours. The data, scored according to the method of `raise, ei al, axe shown in - T-ble 17. - siu: RT ; roelor kIi6S> ^ A) Oral L fl 0 (Rats) The Orel L ^ for nolo end fenale rcta was placed at 16,000 nilliyrcns par kilogram with lower and taper Units of 13,760 to 10,560 nlllinrrns por" kilocrm. The canpound was classod as pre ctically ncn-tcccic by oral ingestion in nrlo r.rsd fernle rsts. , B) Skin bserptien I-L- ( abbits) Th3 Ilinirrun Lethal oce by skin absorption in fenrlo r bbita was founl to be Creator than 2000 nilligrcrifl per kilograa and lcS3 than 3160 niHIgruus per kilogr-n. Tho ccnpound wee classed as slightly tcccic by akin absorption 1". fcarle rabbits. C) Skin Irritation (Rabbits) The eeopeund was classed as a moderets skin irritant, Tho ever: go suxinm score was 3*6 art of a possible 8 in twontyfour heurs. v) Ere Irritation (Rabbits) The eenpound was dr sad as a nild eye irritant* Tire eve rage maxima. score was 19*6 cut of a possible 110 in four hours* YOQKET: L'BCR TORES SCM 002623 WATER PCB-SD0000032682 Tot Jbna-'nto Gxr,ic -1 Company . St. louia, Missouri Younger Laborr.torles Certifies to of /n.-lysis - Page 3 (7/3/62) - 1-62-14; T BLE I TIE Cfl/L LS ao OF ' / roclor 14165' ; (31 PATS Sample Fed A* A jrOCi Solution la Com Oil ninal Ko. - Sex 'eight .Ga, Sosa Hf. /Kg. 1- Ferrrla 2-- Fcr.sle 3- Fencla k- 16 la 5~ Main 6- Kale 7- 'emole 8- Female p- Female 10- Mrla 11- Kale 12- Kale 13- Ferric lh- Far. c la 15- Female 16- Krle 17- tale lo- Mala ' 1?- Foul* 20- Mala 200 10,000 190 10,000 215 10,0.00 230 10,000 225 10,000 2h0 12,600 210 12,600 225 12,600 215 12,600 2h0 12,600 250 15,300 235 15,300 220 15,300 215 15,600 210 15,300 2I| 20,000 250 20,000 230 20,000 215 20,000 2ho 20,000 Fata Survived Survived Survived Survived Survived Survived Survived Survived Survived I lad Survived :ied Survived ' led Survived led Survived Tied Died riad risccssics - The Cr.-l L"8o for tv 1b end ferule r ts wrs placed rt 16,000 jailHcrrr.s per kilogrra ulth lover mci upper limits of 13,760 to 10,560 nilligrcrae per kilocrrr.. Tbs exjapound w*s olsasod r.s practically non-toxic by orsi Incest ion In nclo end female rata . Survivnl tine vea two to six days with cost deaths occurring in three to fair drjs Tarie aynptana included severe dinrrhar, leas of rppotita, and increreirc ve?kresa. At utopsy thoro i-rs inflanrr.tian of the gastric rucosc, liver discolor tion, -nc renal hyperanir. cvcroocopic-'Ily, SC M 002b2<t 00251 WATER PCB-SD0000032683 Tot Kcnaccto Choiic-1 Ccripnny rt, Louis | Kiasou rl Tooncer Luborctorios Certificrte of An^lyaia - Peg* k (7/3/62) - v-C2-hli TABLE H THE K'NIKOH LETLL - 037 07 L'roclor IMS' di sra .Bsaunca is rabbds S.-atpls Applied Am 50.02 Solution In Com OH /ni-al No* - Sex 1/eigfafe Kg. "osa M.;* /Kg. '.."eight Qtangt 5 I ays later ft. 1 Ferula 2 - Female 3 - rental I; -- Fenala 5 - Fenala 6- 2.3 2.6 2.$ 2.7 2.* 2*6 <9h 1260 ' 20CX) 2000 3160 5010 0.2 * 0.1 - 0,2 - 0.1 - 0*3 - 0*3 Fate Survived Survived Survived Survived Tied - 21 Cays Tied - 9 isya . riSCUCCIOT - tj . The Kinir.ua LetirrJ. oao by Skin Absorption is, fer.-le rrbbits vna fount to bo pro .'.ter then 2030 aillicrcras per klegrA2a nd less thaa 3160 nilligrtna par Jdlogrtra, Ths cccpound was cl.'.ascd re slightly toxic bp skin ibsorpticn In Lena Is rabbits. Survival tira was nine to twontycm day*, Ta-rie synntaas included Tstharsj and reduced Eppetite after ocvcrel days. Those succtsabing developed tmaors and cn rnemic-lila eppermeo cevercl dr.yn before death* t autopsy there was liver diacolorat cn and puiRcn-xy hyperemia nceroscopically. ___iu uus report is to be used in development of the product and may be given to responsible sales contacts, but it is not to be used by them in advertising copy. The source of this material is not to be divulged until it appears informal publications. No exceptions to thoestablished rule may be made without the approval of the Medical Departmeat in St. Louis. Customers' inquiries regarding matters of toxicity are to he referred as before to the Medical Depart ment in St. Louis for reply. -- Monsanto Chemical Company SCM 002o 25 0025 1 WATER PCB-SD0000032684 To I Monsanto Timier! Canpary .t, Louis| tisarari, lounger Laboratories Certificate of Anal sis - Page $ (7/3/62) - T-62-^4 i? ^ 2 ^ J* SETH EmiT.TICN IN R 33ITS AFTST. /rPLICL'TICH CF roclor 446$' Srjipla /'ppliod Finely Ground Powder Sraxpl* Applied Aa A $0,(& Solution In Com OIL Anir.al Hunter Jtaerie.'l ~yi lurtica t The End Gf 1 Hour It Hours 24 Hours 46 Hours 72 Hours 1 0 Hours 168 Hours minx mcror. pcwier 1 02 k3 2 1 2 01 3 3 3 1 0 3 02 320 /.verrge 0.0 1*6 3*6 3.6 3.0 1,6 0,3 I:c 33III - The ecnpcund was elrssed as a noderrte skin irritant. 72.TLF CP CllT POT EP.t Ho skin change was noted after orb hour. Slight to well define! erythcrw with no edcr.a evuloped within four hours for rn tverr go score of 1.6 out of n possible 8.' Overnight there ves alight e:cna, incie.'Sirg the nrer.-ge score to 3,6. Although tho -pplic-ticn vra ten eyed, no suvGt;ntirl change vrs noted until the fifth day then the ever.'go scow dropped to 1.6. Econo had disappeared but slight -redness wn@ still present 50* SOLOTICN IN CCRN OUl i 50,o solirtion In com oil produced clr.c3t identic'1 d.-ta to that ahem hovet placing it in the *noder to !dn inlt-nt* e-to gory. . SCM OOZoZo 00252 WATER PCB-SD0000032685 To I Kcnar.nto Chcr.ic 1 Cccipaay St Louis, Msscuri Touncor L; tor. tories Certificate of /nalysis - Page 6 (7/j/c2) - y-C2-kk T /. S L E If EE EPdET/TICN IN PJ B'.'ITS /FTZR A? PLICAHU OS '/roclor Ui^Jt SazpIJS (20*0 Milligrcna) Applied As Finely Ground Powdr Aninnl number Ituncricc.1 Pyalusticn t The Thd Of 1 Ecur U Hours 2li Hours U8 Hours 72 Hours 120 Hoars 160 Hoars 1 1$ 18 13 9h 2 0 2 12 18 18 U 8 h 0 3 15 21 18 ih 8 h 0 Averse li**0 19.6 16.3 11.6 6.6 2.6 0.0 ' ISCISSICN Bio ccnpound was classed as a nild eye irritant* f!k . isccnfoit was r.ild imxd lately following applic. tier. after one hour there was nodorata discharge, nUd redness of tiro conjunctivas, mild edena, and slight Iris concostim for an averago score of lU.O cut of a possible 110* Dullness increased slightly in four hours end little change vas noted overnight. After ir igaticn the infl'.xanatico gr..du* ly reduced so that by tho fifth da iris road cornea wore noracl. Slight redness of the palpebral conjunct free remined for an aver: c score of 2*6, idrt ClU2o27 no2.^a WATER PCB-SD0000032686