Document Ra3ZBBwq396MXM8yXLYMLNQzE
# cV
NOTICE
Enclosed you will find a summary listing of tumor rates in the NTP historical control data base as of late March, 1983. All tumors occurring with a frequency of 0.5% or greater are included. This summary will also be published in a future issue of the NTP Technical Bulletin (as may periodic updates). A revised summary listing will be generated approximately every 6-9 months. I hope that this information will be useful to you.
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SUBJECT TO PROTECTIVE ORDER.
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p Rnnr^'T arnvTROL DATA BASE: The following table summarizes tumor incidences in untreated control F344 rats and B6C?" 1 ce' if\rthje kf<8 historical control data base as of March 1983. Included are all tumors with a spontaneous frequency of Ifast 0.531. The data base consists of those NTP studies with Technical Report number 193 or greater.
' TABLE 6. INCIDENCES OF PRIMARY TUMORS IN UNTREATED CONTROL F344 RATS AND B6C3Fa MICE
MALE RATS Number of SD Range Tumors (i) (%) (*)
FEMALE RATS Number of SD Range Tumors(S) (S) (S)
tegumentary System
2320D
`.euro)F ibroma
107(4.6)
l.euro)F ibr osar coma
27(1.2)
arcoma, NOS
10(0.4)
quamous Cell Papilloma 29(1.2)
auamous Cell Carcinoma 20(0.9)
jsal Cell Neoplasms
22(0.9)
iratcacanthoma
20(0.9)
.poma
12(0.5)
3.2 0-12 1.4 0-4 1.0 0-4 1.7 0-5 1.3 0-4 1.6 0-6 1.4 0-4 0.9 0-4
2370 34(1.4) 20(0.8) 7(0.3) 6(0.3) 15(0.6) 6(0.3) 6(0.3) 1 0.1)
1.5 1.3 0.7 0.7 1.2 0.7 0.8 0.3
0-4 0-4 0-2 0-2 0-4 0-2 0-4 0-2
KALE MICE Number of SD Range Tumors(S) (5) (%)
2343b 28(1.2) 2.7 0-12 66(2.8) 4.4 0-19 40(1.7) 2.5 0-12 3(0.1) 0.5 0-2 4(0.2) 0.7 0-4 2(0.1) 0.4 0-2 0(0.0) 0.0 0(0.0) 0.0
FEMALE MICE Number of SD Range Tumors(S) (S) (S)
2486 1 (<0.1 ) 0.6 0-4
21(0.8) 1.9 0-8 17(0.7) 1.6 0-10
6(0.2) 0.7 0-2 6(0.2) 0.7 0-2 5(0.2) 0.8 0-2 0(0.0) 0.0 0(0.0) 0.0
oiratory System ;ng Alveolar/Bronchiolar
Adenoma Alveolar/Bronchiolar
Carcinoma
2305 35(1.5) 20(0.9)
2.1 0-6 1.6 0-6
2354 18(0.8) 1.4 0-6 9(0.4) 0.9 0-4
2328 282(12.1) 6.7 0-28 119(5.1) 4.3 0-18
2388 131(5.5) 3.6 0-14 47(2.0) 2.3 0-8
estive System
ver 2306
Neoplastic Nodule or
Adenoma
78(3.4)
Carcinoma
18(0.8)
Nodule or Adenoma or
Carcinoma
96(4.2)
-estomach
2276
jquamous Cell Papilloma 5(0.2)
jquamous Cell Carcinoma 1(<0.1)
ili Intestine
2212
idenocarcinoma
9(0.4)
3.5 0-12 1.1 0-4
3.9 0-14
0.6 0-2 0.3 0-2
0.9 0-4
crine System uitary, Pars stalis denoma arcinoma enal orticai Adenoma orticai Carcinoma neochromocytoma neochromocytoma, aalignant :oid -celi Adenoma -celi Carcinoma illicular celi idenoma !arcinoma
reatic lslets
noma
irci noma
2158
468(21.7) 11.7 51(2.4) 3.0
2280 27(1.2) 1.3 5(0.2) 0.6
388(17.0) 9.2
2-52 0-11
0-4 0-2 6-41
23(1.0) 2230
114(5.1) 84(3.8)
1.4 0-6
4.4 0-18 3.3 0-12
22(1.0) 17(0.8) 2226
84(3.8)
46(2.1)
1.4 0-5 1.4 0-7
3.6 0-12 2.3 0-9
2356
71(3.0) 3.0 4(0.2) 0.7
74(3.1) 2329
5(0.2) 2(0.1) 2284 10.1)
3.2
0.8 0.4
0.3
2262
995(44.0)11.4 80(3.5) 4.7
2338 74(3.2) 4.0 7(0.3) 0.7 81(3.5) 3.0
11(0.5) 2265
111(4.9) 81(3.6)
1.0
4.1 3.0
10(0.4) 10(0.4) 2303
18(0.8) 6(0.3)
1.0 0.9
1.5 0.8
2334
-
2469
0-12 0-4
240(10.3) 5.5 0-24 498(21.3) 6.9 8-36
98(4.0) 101(4.1)
3.9 0-18 3.0 0-15
0-12
0-4 0-2
0-2
725(31.1) 7.5 16-58
196(7.9) 4.6 0-20
2252
2336
6(0.3) 0.7 0-2
12(0.5) 1.5 0-4
0(0.0)
^2148 14(0.7)
0.0
1.2 0-4 -, ..
T*
2(0.1) 0.4 2234
2(0.1) 0.4 T- N y ;u -3*T A J s Z l <! il 1
0-2
L.0-2
V
1903 SUBJECT TO PR O TfrlVE ORDER.
18-70
11(0.6) 1.5 0-6
0-19
1(0.1) 0.3 0-2
2240
0-24
53(2.4) 3.0 0-15
0-2 3(0.1) 0.6 0-4
0-16
28(1.2) 1.9 0-6
163(7.9) 8(0.4)
2306 7(0.3) 10.1)
16(0.7)
8.5 0.9
1.1 0.3 1.2
0-32 0-5
0-4 0-2 0-4
0-4 2(0.1) 0.4 0-2
2178
0-13
0(0.0) 0.0
0-12
0(0.0) 0.0
0(0.0) 0.0 2203
2(0.1) 0.4 0-2 0(0.0) 0.0
0-4 22(1.0) 1.6 0-6 0-2 5(0.2) 0.6 0-2
2237
0-7 8(0.4) 0.9 0-4 0-4 0(0.0) 0.0
40(1.8) 2.1 0-9 6(0.3) 1.5 0-10
220
9(0.4) 0.8 0-2 2(0.1) 0.4 -Z
V INCIDENCES Dr PRIMARY TUMORS IN UNTREATED CONTROL F344 RATS AND B6C3F1 MICE8 (con'L)
MALE RATS Number of SD Tumors() (S)
Range (5)
FEMALE RATS Number of SD Range Tumors(5) (5) (S)
HALE MICE Number of SO Range Tumors(S) (S) (S)
FEMALE MICE
Number of so Range
Tumors (5)
/\
\*> t
(S)
roductive System
-imary Cl and *ibroadencma Adenocarcinoma
2320 51(2.2) 6(0.3)
2.0 0.7
putial Gland Adenoma
2320 50(2.2) 3.4
Carcinoma estate Adenoma
63(2.7) 2154
14(0.6)
3.0 2.0
stis
2285
Interstitial Cell
Tumor
2002(87.6) 8.9
itoral Gland
Adenoma
Carcinoma
erus
Endometrial Stromal Polyp
Endometrial Stromal Sarcoma
ary
Granulosa Cell Neoplasms
Tubular Adenoma
2370 0-8 572(24.1) 10.1 2--44 0-2 48(2.0) 2.4 0-8
0-16 0-10
0-10
59-98 2370 28(1.2) 1.8 0-6 46(1.9) 2.7 0-12 2318 424(18.3) 8.1 4-37 25(1.1) 1.7 0-6 2321 13(0.6) 1.0 0-4 0(0.0) 0 . 0
atopoietic System .eukemi a .ymphoma _eukemia/Lymphomac
2320 648(27.9) 10.2
51(2.2) 3.4 699(30.1) 10.5
0-46 0-16 10-54
2370 414(17.5) 7.4 0-38 36(1.5) 2.2 0-10 4-48(18.9) 7.0 6-38
2343 0(0.0) 0 . 0 0(0.0) 0. 0
2343 2(0.1) 0.4 0-2 0(0.0) 0. 0
2343 0(0.0) 0 . 0
2312
8(0.3) 0.9 0-4
-
2343 17(0.7) 1.7
280(12.0) 7.2 297(12.7) 7.3
0-10 2-32 2-32
2486 8(0.3) 1.1 0-6
40(1.6) 2.3 0-12
2486 0(0.0) 0(0.0)
2360 22(0.9) 13(0.6)
2167 2(0.1)
19(0.9)
0.0 0.0
1.4 0-6 1.2 0-4
0.4 0-2 1.4 0-7
2466 52(2.1) 4.6
625(25.1) 10.0 677(27.2) 9.9
0-28 8-62 8-62
rulatory System nangioma nangiosarcoma
2320 4(0.2)
12(0.5)
0.6 1.1
0-2 0-4
2370 2(0.1) 3(0.1)
0.4 0-2 0.5 0-2
2343 34(1.5) 3.3 0-16 64(2.7) 2.6 0-10
2486 39(1.6) 1.9 0-6 48(1.9) 2.3 0-8
/ous System 3in Astrocytoma
2301 9(0.4) 1. 0
0-4
2348 12(0.5)
1.1 0-4
2303 0(0.0) 0 . 0
2378 0(0.0) 0 . 0
:ial Sense Organs rderian Gland Adenoma larcinoma
2320 1 0. 1) 0.3 1 0. 1) 0.3
0-2 0-2
2370 0(0.0) 0(0.0)
0.0 0.0
2343 50(2.1) 2.8 0-12 ' 2(0.1) 0.4 0-2
2486 32(1.3) 1.7 1 0 . 1 ) 0.3
0-6 0-2
ruloskeletal System 2320
leosarcoma
12(0.5)
ibdomyosarcoma
0(0.0)
1.0 0.0
0-4
2370 7(0.3) 2(0.1)
0.8 0-4 0.4 0-2
2343 3(0.1) 0.7 0-2
12(0.5) 1.6 0-8
2486 14(0.6) 1.1 0-4 2(0.1) 0.4 0-2
r Tumors lothelioma (tunica iginalis) scthelioma (other)
2320
30(1.3) 23(1.0)
1.7 1.7
0-8 0-8
2370 1 0. 1) 0.3 0-2
lduoes 11 lumors occurring with a frequency of 0.55 or greater.
2343
2486
0(0.0) 0 . 0 3(0.1) 0 . 5 0-2
0(0.0) 0. 0
:T
ll & & V
S U B J E C T T O P R O T E C T I V E O R D !rR
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inner of animals examined histopathologically (or, for certain lesions, the number of animals necropsied).
:s combination is incluoed because certain early studies in the data base tended to use these terms interchangeably.