Document RV4BEQoo7Z95gbvR4yXKknrB

World Health Organization Regional Office for Europe Copenhagen Biological effects of man-made mineral fibres Proceedings of a WHO/IARC Conference in association with JEMRB and TIMA Copenhagen, 20-22 April 1982 Volume 2 Sessions VI-IX and annexes *- 511961 0467 PLAINTIFF'S EXHIBIT AL-1210 -320- Note: elongated particles counted as fibres because their aspect ratio was greater than 3 : 1 are arrowed. Fig. 6. An area of alveolar' proteinosis from the lungs of a rat after 12 months of dusting with ceramic fibre; magnification, 250x Note: the dust, but Fig. 8. Note: the alveolar septa are not thickened but the alveolar spaces are filled with proteinaceous material. 5,,967 0458 dust 6000x -321- fig. 7. An alveolar space from the lungs of a rat 33 months after the start of dusting with ceramic fibre; magnification, ISOOx after , 250x 511961 0459 -322- Fig. 9. The histological pattern shown by a malignant histiocytoma from the lungs of a rat treated with ceramic fibre dust; magnification, 450x Note: most of the cells are of epithelioid type, but several multinucleate giant cells are also present. The importam experimental asbestos (_1-J Since the tei fibres in si: cannot be ru^ inhalation e: fibrogenicit; extrapulmona in comparisoi experimenta1 Material and Dust charact The test com potassium ti reference as distribution an average s asbestos ave fine respira diameter of the dust par considered i was observer samples. Fy while PKT w; 3 Fybe fibres. T 511961 0460