Document RJqpzVGJv6a7O80Km3yDnjpDE

3M Specialty Matcri;ds 3M Center St. Paul, MN 55144-1000 651 733 1110 1IN January 29, 2003 VIA FEDERAL EXPRESS Document Control Office (DCO) Office of Pollution Prevention and Toxics US Environmental Protection Agency EPA East, Room 6428 1201 Constitution Avenue, NW Washington, DC 20460 (OPPT) Attention: Docket No. AR-226 and the FYI Docket Dear Sir or Madam: This continues 3M's voluntary submissions of data on perfluorooctane sulfonates and related compounds, as part of our ongoing dialogue with EPA regarding fluorochemicals. Included in this submission are the following: 1. Assay Validation Report, Quantitative Determination of PFOS, PFOSA, PFOSAA, N-MeFOSE-OH, N-EtFOSE-OH, POAA, and PFHS in Human Serum by LC/MS/MS, Northwest Bioanalytical (NWt3), Study No. NWBS98-082, Report No. NWBR99-005, May 13, 1999. 2. Assay Revalidation Report, Quantitative Determination of PFOS, PFOSA, PFOSAA, POAA, PFHS, M556 and M570 in Human Serum by LC/MS/MS, Northwest Bioanalytical (NWB), Study No. NWBS00-040, Report No. NWBR00-108, January 24, 2001. 3. Assay Revalidation Addendum Report, Quantitative Determination of PFOS, PFOSA, PFOSAA, POAA, PFHS, M556 and M570 in Human Serum by LC/MS/MS, Northwest Bioanalytical (NWB), Study No. NWBS00-040, Report No. NWBR00-122, November 20, 2001. 4. Sample Analysis Report for Protocol EPI-0011, Quantitative Determination of PFOS and Related Compounds in Human Serum by LC/MS/MS, Northwest Bioanalytical (NWB), Study No. NWBS00-088, Report No. NWBR01-001, November 30, 2001. Page 2 Document Control Office (DCO) 5. Sample Analysis Report for Protocol EPI-0013, Quantitative Determination of PFOS and Related Compounds in Human Serum by LC/MS/NIS, Northwest Bioanalytical (NWB), Study No. NWBS00-128, Report No. NWBR01-066, January 9, 2002. 6. Sample Analysis Report for Protocol EPI-0016, Quantitative Determination of PFOS and Related Compounds in Human Serum by LC/MS/MS, Northwest Bioanalytical (NWB), Study No. NWBS00-145, Report No. NWBR01-155, January 10, 2002. The first three reports listed above refer to the assay validation methods developed by Northwest Bioanalytical. The fourth, fit2h and sixth reports listed are the final analytical reports from Northwest Bioanalytical of the children, adult and elderly serum study data, respectively. The statistical analyses of these data have been previously submitted to the EPA by 3M. We will continue to provide information as it becomes available. Please feel free to contact me if you have any questions. Very truly yours, cc: Dr. Charles Auer Dr. Oscar Hernandez Michael A. Santoro Director of Environmental, Health Safety and Regulatory Affairs Specialty Materials 3M Center, Building 236-1 B- 10 St. Paul, MN 55144 651-733-6374 (phone) 651-733-1958 (fax) E-mail: masantoro@mmm.com