Document RJgy25XYJpRDrBj4yvqE1rkMz

Nr. C. B. Staff Bakellte Company 30 East 42nd Straat Naw York 17# NSw York Nr. 0. 0. Himmler Deoenber 7* 1953 Saar Charila i It la of Interest that In 19*1 our group at Nelloa Institute fell several vinyl films for ninety days to dogs and groups of rats. Four samples af films were utilised, made up from "Vinylits" resin YTNV. Sample F-*0*3 eontalced stabiliser 0-15. 0.75*J dibutyl "Cellosolve* phthalate* 27.00*; and methyl "Cellosolve" oleate. 3.00*. Sample F-4159 eentalned ealelum stearate* 1.00*; methyl "Cellosolve" oleate. 3,0Q*j and trleresyl phosphate* 37.000, Sample F-4164 eontalned stabiliser 2>-22* 1.00*; dibutyl "Cellosolve" phthalate* 27.00*; and methyl "Cellosolve" aleate* 3.00*. _ Sample F-4165 eontalned lead stearate* 1.50*1 dibutyl "Cellosolve" phthalate* 27.00** and methyl "Celloeolve" aleate* 3.00*. As you knew* there mare very minor amounts af other eempoaeats in the above. The result af this study* uhleh eoaslsted af 90-day oral doses te dogs In meat at 1 n./kg./day and to rats as aeneous extroot at 19.4 gs./feg./lay* showed that films F-4043* 4159* 4l64* and 4l&5 gave mo injury except slight bloehemleal Ohanges. The last gave detestable lead In the bleed, this Study would ledlasts that these films mere ef a very lev order f texlelty. Plastlelsere - Ns have done am enormous amount ef werfc am POr which has bea* published. In this applleatlen ucc 063339 Mr. C. S. Staff -2 December 7# 1953 we would bo principally Interested In oral toxicity. The single oral LSbo 6** 3for DO* 1* 30*6 gm./kg. tody weight for rata. Xa regard to trl(2-ethylhexyl) phosphate the aingle oral LXk0 dose is 39*6 gm./kg. body weight. Plasticiser R2H, when t sted on rats, a single oral dose of 63 gm./kg. la lard killed none of alae rata. You will see that all these plasticisers hare quite a low order of toxicity. Stabilisers - The tin stabilisers are much wore toxic. For example, dibutyl tin dllaurate or stabiliser D-22 has a single oral LDc0 dose of 1.2* gm./kg. body weight. Dioctyl tin dlchlorlde has a single oral tDcn dose of 0.19 ga./kf* body weight. The earlous lead stabilisers used in vinyl files are not highly toxic by alngle oral ingestion. Stabiliser C-2, or ealelun ethyl aeetoaeetate, is of a low order of toxicity as erldenced by the single oral LDk0 dose of 9.93 ga.Af * tody weight. X would hate to prediet what the effect might be cm a cow eating a vinyl film of any sort. This opinion is based uepxotrnemtheelyremcienunttedaismcoouvnetsryeof fcthhleoriandavteerdseneapffhetchat leonnecsa. ttlxesohof uld think that the greatest hasard from a cow's eating an ensilage cover made of vinyl film would be that It would be likely to produce an obstruction In erne ef the cow's two stomachs and long Intestinal tract. He have done some extraction studies on the tin stabilisers, and it was found that as far as D-22 Is con cerned, when it was incorporated in film, mane was extracted In two months by water or a buffer at pH of 8,2. However, lard extracted 61 per cent of the stabiliser in seven days. DOF has been shown to be extracted by fats in particular, but not by aqueous solutions. Despite these assertions, X think the best experience can be obtained by experimentation in which ws fed dogs and rats films containing tin stabilisers, etc. Based upon this piece ef work. It would seem that these films are of an extremely low order of toxicity. Xf there arc any further questions, do not hesitate to contact this office. Very truly yours. medical director ' INDUSTRIAL MEDICAL AID TOXICOLOGY XEPAJtTWBT Thos. V. Bale, M. D. nt ucc 063340 ue( lb To (NatnmJ Compwtf IocoHm * Copy* FOR INTERNAL CORRESPONDENCE BAKEL1TE COMPANY ------------------------------------------------- (nas---------------------------------------- 30 EAST 42nd STREET, NEW YORK 17, NEW YORK Dr. T. W. Nale 300 Madison Ave. Room 203 Orieinoting D*pt. November 30, 1953 Answering /offor do** Mr. G. 0. Himmler - BB Subject In considering the use of vinyl films for some agricultural applications, the toxicity of the compound Kill be of some importance* Though the base resins, I know, are non-toxic, I would appreciate any lnfoimation you have on feeding tests on our principal plasticiser, dioctyl phthalate, and lesser plasticisers trioctyl phosphate and 2RH. Also any lnfoimation available on the toxicity of lead and tin stabil izers dispersed in plasticizer or vinyl compounds will be appreciated. We are considering a grant to Rutgers University for some work on ensilage covers and one point of interest will be the toxicity to farm animals in ease they should eat the plasticized sheeting. I would expect that there would be no effect because of the short residence of the compound, but it is a point which will have to be checked and any information on the ingredients will be helpful. CES:mkt RECEIVED DEC 1 1953 INDUSTRIAL IOICAL & T0XIC0L0CY DEPARTMENT ucc 063341