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APPENDIX A Ex perOmental Design for Vinyl Chi or 1 G C) Group Control Ti* 12* T3* T4* * Mice 11 F 100 100 100 100 100 ICO 100 100 __ Number of Amima 1 s Pats id r 100 100 100 100 100 100 100 100 lOOf Merns ter a MF 100 100 100 100 100 100 lO'O 100 -- Specifi' ( 1 Exposure If -.vU 00 ppm vinyl ciilor id' 2C0 p pm viny1 rhl or idr 2000 ppm vinyl chloric!.. 2500 ppm vinyl chlorick *Mo food, water, or' bedding in cages during closure *`food, water, and beddina lo remain in cages during exposure It All ra'ts of same sex, females were exposed. SL 095831 APPEHPl*. B TISS: JE ACCOIJN T A B I L I T Y 5 b'MMA R V Accordinq to: I. Tissues Required by Protocol II- Tissues Examined by IBT III- Total T issues Available According to IBT Inventory RATS - MALE Tissues Required by Protocol Total Tissues Examined by IBT Total Tissues Available RATS - FEMALE Tissues Required by Protocol Total Tissues Examined by IBT Total Tissues Available MICE - MALE Tissues Required by Protocol Total Tissues Examined by IBT Total Tissues Available MICE - FEMALE Tissues Required by Protocol Total Tissues Examined by [BT Total Tissues Available HAMSTERS - MALE Tissues Required by Protocol Total Tissues Examined by IBT Total Tissues Available HAMSTERS - FEMALE Tissues Required by Protocol Total Tissues Examined by IBT Total Tissues Available Untreated Contro1s Totals Per Cent 4,000 590 993 14.75 24.95 3,900 ais 1, 28 1 20.89 32 . 3B 4 , O'JO *0} 2 107 0.5 i 12.42 1,000 3 14 402 B. 0 5 10.30 4,000 333 511 6.32 12.77 3,900 222 372 5.69 9-53 Gt ou n T- 1 Totals Pt-x Cent 4,000 5B0 930 14.70 23.25 3, 900 47 5 85 3 12. 17 2 1. B7 4,000 34 5 54B B. 72 13.70 3,900 294 599 7 . 56 15.35 4,000 384 485 9.60 12 . 12 3,900 217 406 5.56 10.41 Group T- 2 Totals Per c-rit 4,000 706 1,06 L 17.63 26.52 3,900 395 903 10.12 23 . 28 4,000 284 739 7. U) 10.47 3,900 239 94 2 7.41 2 V. 14 4,000 453 743 11 . 32 18.5 7 3,900 485 677 12.43 17.35 Gr'i> ur. T- 3 Tot a 1s Per Cent 4,0 00 3 86 1, 10 3 9.65 27.57 j , 9QU 299 970 4,11 u 0 20 _> 76b 7.66 24 . U 7 >. 1 2 19. 1 > 3 , 900 20B 9 10 "3 . 13 2 1.13 4 . OOu 315 761 3, 900 16 1 434 7.87 19 u2 4.28 11. l. i G roup T-4 To ta1s Per Cent 3,900 3 77 856 9.66 21.94 SL 095832