Document RJQw0Vgj0LEwYbkjRvwDpe1kk

AR226-2366 DRAFT -^(--------^ Purpose: Scope: Proposal to Conduct a Genera) Human Health and Envlronmenta! Effects Risk Analysts on C-8 08 The piHpose of this environment from project is to evaluate the risks to human health and the and disposalof exposure to C-8. The analysis duringmanufacture, will transport, product use, semi-quantitative estimates of risks be conducted in a fashion so that exposures yielding that wiB provide can be identified ami recommendations on reducing these the bfgftestrisks developed.. Risks from a way (hat will facilitate manufacture, transport and nsks can be product use will developed future comparisons of risks estimated for potential C-8 caoltnedrnuacttievdesin. TpahreaBpero!,jiencwt whilcl hbehucmonadnuhcteeadlthin (Nee parts. The first two will be characterized. The final part wBdevsfcp and ecological conclusions nsks will be contrifamaihetiigtiesrtisks strategies so that s-sccminendaiions on for exposures risk that- and alternatives can be developed. months to complete from the management' ^ The project is estimated to takal 3 betow will require time collaboration of initiation. The Exposure analyses fisted ---- presented assume a Feb. 1,199w7ithSaBpUpraoppprrioatvealpdlaantet .p)ersonnel. (The dates 1. Human Health Risk A. Hazard Identification Time Line 4/18/97 Est.Cost($) 8000 08 Hazards to human critical toxicity health will be reviewed and summarized in this endpoints of relevance to human health risk will be section. identified The dpiostceunstisael dd.osTihmeetHearsskteollbteoxuisceitdy forinterspecies extrapolation of risk will be and summary wit) be updated as part of this task. B. Dose-Response Anatysis cTohnedduocstien-gresponse characteristics of 9/307 wBl be evaluated. This 43,200 where benchmark dose analyses necessaiy. Appropriate to identify no-observed may adverse include effect levels developed be based on the likely dosimeters for mode of action. interspecies extrapolation The phaimacola'netics will also be reviewed. If possible, rudimentary physiologically-based of C-8 will also dapopseroraeclahteiosnwsihllibpsewdieltvbeelodpeevdetloopfaecdiliintattheisinptheraespeecies extrappohlaatrimonacoofkriinsekt.icRsisks vs. C. Bcposure Analysis Reasonable exposure airborne, drinking scenarios for C-8 will be 9/3W37 developed. This are 16,000 likely to include durations of water, dermal, and other exposure will be developed. oral ingesta'onpathways. Intake rates and from the plant site to help characterize Haskell these will work with an assigned person (s) transport, product use, and waste disposal exposure pathways tor manufacturing, Hastes!!wriih ua!a These data will on u,-iC5rm-a{fon3 of C-S operations. The business in ths affected media (air, will provide be tabulated. Monte Cario techniques may be used water, soil). to calculate dexaptae.ctTehdeucpopsetracsosnofcidiaetnecdewliimthittshifsortathseksineceluxpdeossuornelsy, dependingthe availabilityof HaskeB personnel time. D, Risk Characterization Risks will be summarized according to the major 12/1S97 routes of 16.000 dennat, other oral) for each ). The risks will C-fl application (manufacture, exposure transport, (air, water, product disposal concentrations to the be characterized dose-response by comparing the likely exposure use. to as a Margin of Exposure. The charraeclatetiroiznasthioipn. wTihllis method is generally referred provide the risk manager with ^ EI0093162 EID093162 DRAFT information that will help identify the operations and exposure pathways that present the highest risk. The characterizations will also enable future comparisons to be made of potential risks posed by 08 alternatives. 11 Ecological Effects Time Line EsLCost(S) A. Hazard Identification Hazards to key environmental health indicator species wilt be reviewed and summarized in this section. The critical toxicityendpotntswBI be identified. Based on the current literature search, chronic studies in aquatic species will need to be undertaken. Avian reproduction and avian food-chain aecumulationwili need assessment; however this may be extrapolated using mammalian toxicology and P&PK data and E Fate information. The Haskell toxfcitysummary wilt be updated as part of this task. 1.) Hazard Assessment 8/15/97 2.) Tssting (Fish B^ and Daphrsid Chronic) 8/15/97 (This is w8h stalk renewal and analytical) $10,000 $80,000 3.) Avian fifneeded) 8/15/97 $80,000 B. Exposure Analysis Reasonable exposure scenarios for C-8 will be developed for the higher environmental exposure areas at the three manufacturing sites. Includingtheir respective disposal sites and a customer site. Intake rates and durations of exposure wfll be developed. Haste)! will work with an assigned person(s) from the plant site to help characterize these exposure pathways for manufacturing, transport, product use. and waste disposal operations. The business will provide Haskell with data on 08 concentrations of in the affected media (air, water, soil). These data wilt be tabulated. Monte Carto techniques may be used to calculate expected upper confidence limits for these exposures, depending oh the availability of data. The cost associated with this task includes only Haskell personnel time. 1.) Exposure Assessment-Washington Works 6/15/97 2.) Exposure Assessment-Dordrecht 8/15/87 3.) Exposure Assessment-Shimizu 9/15/97 4.) Exposure Assessment-Customer 10/15/97 8.000 6,000 2,000 2,000 0. Risk Characterization Risks win be summarized according to the major media of environmental exposure 08 (water, soil, air) for each application (manufacture, transport, product use, disposal). The risks will be characterized by comparing the likely Predicted Environmental Concentrations (PEC) to the Predicted No Effect Concentrations (PNEC). This method is generally referred to as Hazard Quotient. The characterization will provide the risk managerwith information mat will help identify the operations and exposure pathways that present the highest risk. The characterizations wili also enable future comparisons to be made of potential risks posed bv 08 alternatives. 12/15/&7 16,000 III. Recommendations on Risk Management Strategies and Alternatives 12/1507 4800 This section win evaluate collectively the risks identified to human health and ecological receptors. Based on these analyses, recommendations will be made as to which operations could be targeted to ensure risks are appropriately managed in the most cost effective manner. This will be a very subjective exercise (narrative) and will require some Mereactbn with the appropriate people from the business. 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