Document RJLk2Om06YdVx677Yq1MOjrD7

MONSANTO C.HEM..V.L COMPANY >( ftl If Ml General Offices September 1, 1961 Aroclor 121(2 5r w /-LTD c : R. S. Gordon L. J. Machlin W. J. McCarvi lie df: University / TO 1 Elmer P. Wheeler 0* leu have ashed for a status report on Aroclor 12^2 with regard to chick edema. O'Dell is not planning to do any more vork beyond that that he has already told us about. However, the word hac gotten around in toxicology circles and more studies are under way. Samples of Aroclor 12h2 have been cubmitted to Proctor and Gamble, to M2T, and to the national Dairy Products Corporation, for evaluation in chick edema studies. The Proctor and Gamble people spent a day with us about six weeks ago and gave us a detailed report on their work with chick edema factor. It appears that Aroclor 12^(2 does indeed produce the same symptoms in chickens as docs the chick edema factor that has occurred in commercial fats. However, the Proctor and Gamble people are convinced that the degree of toxicity is so much less for Aroclor 12k 2 than for tlic naturally occurring material, that the two arc not identical. Furthermore, their physical-chemical data available on the chic); edema factor indicates that it is structurally different from Aroclor 12^2. 1 believe that we arc pretty much out of the woodc on this problem because of this marked difference in degree of toxicity. Most researchers in tills field realize that many cexpounds can produce the chick edema factor and 1 believe tliat the p rob lam will be solved within the nxt six raonthc, and that Aroclor 12k 2 will not be involved. KHM:cs Kenneth H. Maddy 9/19/61 Talked with Maddy and he is sure it won't bother ue. R.E.K. TRAN OI6778 HARTOLDMONOOQ7968